LOCUS       NP_001340584             540 aa            linear   PRI 13-OCT-2024
DEFINITION  CUB domain-containing protein 2 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_001340584
VERSION     NP_001340584.1
DBSOURCE    REFSEQ: accession NM_001353655.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 540)
  AUTHORS   Li,Y.J., Deng,J., Mayhew,G.M., Grimsley,J.W., Huo,X. and Vance,J.M.
  TITLE     Investigation of the PARK10 gene in Parkinson disease
  JOURNAL   Ann Hum Genet 71 (Pt 5), 639-647 (2007)
   PUBMED   17388942
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357673.12.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2197857.1,
                                           SRR1660809.210190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530059.3/ ENSP00000489959.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     Protein         1..540
                     /product="CUB domain-containing protein 2 isoform 1
                     precursor"
                     /calculated_mol_wt=56865
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2211
     mat_peptide     23..540
                     /product="CUB domain-containing protein 2.
                     /id=PRO_0000305071"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5VXM1.2)"
                     /calculated_mol_wt=56865
     Region          30..141
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(38,40,42,69,74,113,137,139,141)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            40
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5VXM1.2)"
     Region          145..254
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(153,155,157,184,189,225,249,251,253..254)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          257..370
                     /region_name="CUB"
                     /note="CUB domain; pfam00431"
                     /db_xref="CDD:395345"
     Site            267
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5VXM1.2)"
     Site            377
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5VXM1.2)"
     Site            435
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5VXM1.2)"
     Site            436
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5VXM1.2)"
     Site            517..537
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5VXM1.2)"
     CDS             1..540
                     /gene="CDCP2"
                     /coded_by="NM_001353655.3:79..1701"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS85977.1"
                     /db_xref="GeneID:200008"
                     /db_xref="HGNC:HGNC:27297"
                     /db_xref="MIM:612320"
ORIGIN      
        1 mlaewgacll lavallgpgl qaqamegvkc ggvlsapsgn fsspnfprly pyntecswli
       61 vvaegssvll tfhafdleyh dtcsfdflei yngaspdkgn llgrfcgkvp pppftsswhv
      121 msvifhsdkh vashgfsagy qkdvcggvlt glsgvltspe ypnnypnsme chwviraagp
      181 ahvklvfvdf qvegneecty dyvavlggpg ptrghhycgs trpptlvslg helqvvfksd
      241 fniggrgfka yyfsgecqev ymamrgnfss pqypssypnn irchwtirlp pgyqvkvffl
      301 dldleepnsl tktcdfdhla afdgaseeap llgnwcghhl pppvtsshnq lllllhtdrs
      361 ttrrgfsvay igvvpmnvsc srtdfqilis tqalaplert kvylgsrsca aqevggnlri
      421 qarfdtcgte sqrrnntsvi vsvlyidfsa agrediheye vrceprrkea svhllsgshw
      481 lgpyaataeh lqeappmdea ealegpvsmv aqdtsdivfl glcilagilm viaivvlmll
//
