LOCUS       NM_022842               5963 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens CUB domain containing protein 1 (CDCP1), transcript
            variant 1, mRNA.
ACCESSION   NM_022842
VERSION     NM_022842.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5963)
  AUTHORS   Do,J.S., Arribas-Layton,D., Juan,J., Garcia,I., Saraswathy,S.,
            Qi,M., Montero,E. and Reijonen,H.
  TITLE     The CD318/CD6 axis limits type 1 diabetes islet
            autoantigen-specific human T cell activation
  JOURNAL   J Autoimmun 146, 103228 (2024)
   PUBMED   38642507
  REMARK    GeneRIF: The CD318/CD6 axis limits type 1 diabetes islet
            autoantigen-specific human T cell activation.
REFERENCE   2  (bases 1 to 5963)
  AUTHORS   Liu,D., Wang,M., Murthy,V., McNamara,D.M., Nguyen,T.T.L.,
            Philips,T.J., Vyas,H., Gao,H., Sahni,J., Starling,R.C.,
            Cooper,L.T., Skime,M.K., Batzler,A., Jenkins,G.D., Barlera,S.,
            Pileggi,S., Mestroni,L., Merlo,M., Sinagra,G., Pinet,F., Krejci,J.,
            Chaloupka,A., Miller,J.D., de Groote,P., Tschumperlin,D.J.,
            Weinshilboum,R.M. and Pereira,N.L.
  TITLE     Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of
            CDCP1 and Cardiac Fibrosis
  JOURNAL   Circ Res 133 (10), 810-825 (2023)
   PUBMED   37800334
  REMARK    GeneRIF: Myocardial Recovery in Recent Onset Dilated
            Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
REFERENCE   3  (bases 1 to 5963)
  AUTHORS   Liu,C.L., Tsai,H.W., Peng,S.L., Chang,C.P., Chang,Y.H. and
            Huang,H.S.
  TITLE     CDCP1 (CUB domain containing protein 1) is a potential urine-based
            biomarker in the diagnosis of low-grade urothelial carcinoma
  JOURNAL   PLoS One 18 (3), e0281873 (2023)
   PUBMED   36862682
  REMARK    GeneRIF: CDCP1 (CUB domain containing protein 1) is a potential
            urine-based biomarker in the diagnosis of low-grade urothelial
            carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5963)
  AUTHORS   Urabe,F., Kosaka,N., Yamamoto,Y., Ito,K., Otsuka,K., Soekmadji,C.,
            Egawa,S., Kimura,T. and Ochiya,T.
  TITLE     Metastatic prostate cancer-derived extracellular vesicles
            facilitate osteoclastogenesis by transferring the CDCP1 protein
  JOURNAL   J Extracell Vesicles 12 (3), e12312 (2023)
   PUBMED   36880252
  REMARK    GeneRIF: Metastatic prostate cancer-derived extracellular vesicles
            facilitate osteoclastogenesis by transferring the CDCP1 protein.
REFERENCE   5  (bases 1 to 5963)
  AUTHORS   Saponaro,M., Flottmann,S., Eckstein,M., Hommerding,O., Klumper,N.,
            Corvino,D., Hosni,S., Schmidt,A., Monig,N., Schmidt,D.,
            Ellinger,J., Toma,M., Kristiansen,G., Bald,T., Alimonti,A.,
            Ritter,M., Holzel,M. and Alajati,A.
  TITLE     CDCP1 expression is frequently increased in aggressive urothelial
            carcinoma and promotes urothelial tumor progression
  JOURNAL   Sci Rep 13 (1), 73 (2023)
   PUBMED   36593286
  REMARK    GeneRIF: CDCP1 expression is frequently increased in aggressive
            urothelial carcinoma and promotes urothelial tumor progression.
            Erratum:[Sci Rep. 2023 Feb 17;13(1):2838. doi:
            10.1038/s41598-023-28942-0.. PMID: 36801926]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5963)
  AUTHORS   Uekita,T. and Sakai,R.
  TITLE     Roles of CUB domain-containing protein 1 signaling in cancer
            invasion and metastasis
  JOURNAL   Cancer Sci 102 (11), 1943-1948 (2011)
   PUBMED   21812858
  REMARK    GeneRIF: CUB domain-containing protein 1 (CDCP1) is a substrate of
            Src family kinases and has been shown to regulate anoikis
            resistance, migration and matrix degradation during tumor invasion
            and metastasis in a tyrosine phosphorylation-dependent manner.
            Review.
            Review article
REFERENCE   7  (bases 1 to 5963)
  AUTHORS   Conze,T., Lammers,R., Kuci,S., Scherl-Mostageer,M., Schweifer,N.,
            Kanz,L. and Buhring,H.J.
  TITLE     CDCP1 is a novel marker for hematopoietic stem cells
  JOURNAL   Ann N Y Acad Sci 996, 222-226 (2003)
   PUBMED   12799299
REFERENCE   8  (bases 1 to 5963)
  AUTHORS   Hooper,J.D., Zijlstra,A., Aimes,R.T., Liang,H., Claassen,G.F.,
            Tarin,D., Testa,J.E. and Quigley,J.P.
  TITLE     Subtractive immunization using highly metastatic human tumor cells
            identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated
            glycoprotein antigen
  JOURNAL   Oncogene 22 (12), 1783-1794 (2003)
   PUBMED   12660814
  REMARK    GeneRIF: antibodies generated by subtractive immunization used to
            purify, identify and partially characterize SIMA135/CDCP1;
            properties indicate it is a multidomain cell surface antigen,
            highly expressed by certain cancer cells and normal and cancerous
            colon
REFERENCE   9  (bases 1 to 5963)
  AUTHORS   Scherl-Mostageer,M., Sommergruber,W., Abseher,R., Hauptmann,R.,
            Ambros,P. and Schweifer,N.
  TITLE     Identification of a novel gene, CDCP1, overexpressed in human
            colorectal cancer
  JOURNAL   Oncogene 20 (32), 4402-4408 (2001)
   PUBMED   11466621
REFERENCE   10 (bases 1 to 5963)
  AUTHORS   Xia,Y., Gil,S.G. and Carter,W.G.
  TITLE     Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin)
            regulates tyrosine phosphorylation of a membrane-associated 80-kD
            protein
  JOURNAL   J Cell Biol 132 (4), 727-740 (1996)
   PUBMED   8647901
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY167484.1 and AY026461.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022842.4.
            
            Summary: This gene encodes a transmembrane protein which contains
            three extracellular CUB domains and acts as a substrate for Src
            family kinases. The protein plays a role in the tyrosine
            phosphorylation-dependent regulation of cellular events that are
            involved in tumor invasion and metastasis. Alternative splicing
            results in multiple transcript variants of this gene. [provided by
            RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY167484.1, AY026461.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296129.6/ ENSP00000296129.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5716              AY167484.1         2-5717
            5717-5963           AY026461.1         5707-5953
FEATURES             Location/Qualifiers
     source          1..5963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5963
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /note="CUB domain containing protein 1"
                     /db_xref="GeneID:64866"
                     /db_xref="HGNC:HGNC:24357"
                     /db_xref="MIM:611735"
     exon            1..173
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2602
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane and associated with src kinases;
                     membrane glycoprotein gp140; subtractive immunization M
                     plus HEp3-associated 135 kDa protein"
                     /codon_start=1
                     /product="CUB domain-containing protein 1 isoform 1
                     precursor"
                     /protein_id="NP_073753.3"
                     /db_xref="CCDS:CCDS2727.1"
                     /db_xref="GeneID:64866"
                     /db_xref="HGNC:HGNC:24357"
                     /db_xref="MIM:611735"
                     /translation="MAGLNCGVSIALLGVLLLGAARLPRGAEAFEIALPRESNITVLI
                     KLGTPTLLAKPCYIVISKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSG
                     PCPFGEVQLQPSTSLLPTLNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVT
                     HSISGRIDATVVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIK
                     RLCIIESVFEGEGSATLMSANYPEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCER
                     KEERVEYYIPGSTTNPEVFKLEDKQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLV
                     QHPQNESNKIYVVDLSNERAMSLTIEPRPVKQSRKFVPGCFVCLESRTCSSNLTLTSG
                     SKHKISFLCDDLTRLWMNVEKTISCTDHRYCQRKSYSLQVPSDILHLPVELHDFSWKL
                     LVPKDRLSLVLVPAQKLQQHTHEKPCNTSFSYLVASAIPSQDLYFGSFCPGGSIKQIQ
                     VKQNISVTLRTFAPSFQQEASRQGLTVSFIPYFKEEGVFTVTPDTKSKVYLRTPNWDR
                     GLPSLTSVSWNISVPRDQVACLTFFKERSGVVCQTGRAFMIIQEQRTRAEEIFSLDED
                     VLPKPSFHHHSFWVNISNCSPTSGKQLDLLFSVTLTPRTVDLTVILIAAVGGGVLLLS
                     ALGLIICCVKKKKKKTNKGPAVGIYNDNINTEMPRQPKKFQKGRKDNDSHVYAVIEDT
                     MVYGHLLQDSSGSFLQPEVDTYRPFQGTMGVCPPSPPTICSRAPTAKLATEEPPPRSP
                     PESESEPYTFSHPNNGDVSSKDTDIPLLNTQEPMEPAE"
     exon            174..383
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     exon            384..746
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1115
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1337
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1718
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2084
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2172
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..5963
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5705..5710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /note="hexamer: AACAAA"
     polyA_site      5722
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /note="major polyA site"
     regulatory      5934..5939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /note="hexamer: AATAAA"
     polyA_site      5963
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
ORIGIN      
        1 agggcggagc gcagctgcgc cgggcttggg cgcctggggc cgccgctccc caccgtcgtt
       61 ttccccaccg aggccgaggc gtcccggagt catggccggc ctgaactgcg gggtctctat
      121 cgcactgcta ggggttctgc tgctgggtgc ggcgcgcctg ccgcgcgggg cagaagcttt
      181 tgagattgct ctgccacgag aaagcaacat tacagttctc ataaagctgg ggaccccgac
      241 tctgctggca aaaccctgtt acatcgtcat ttctaaaaga catataacca tgttgtccat
      301 caagtctgga gaaagaatag tctttacctt tagctgccag agtcctgaga atcactttgt
      361 catagagatc cagaaaaata ttgactgtat gtcaggccca tgtccttttg gggaggttca
      421 gcttcagccc tcgacatcgt tgttgcctac cctcaacaga actttcatct gggatgtcaa
      481 agctcataag agcatcggtt tagagctgca gttttccatc cctcgcctga ggcagatcgg
      541 tccgggtgag agctgcccag acggagtcac tcactccatc agcggccgaa tcgatgccac
      601 cgtggtcagg atcggaacct tctgcagcaa tggcactgtg tcccggatca agatgcaaga
      661 aggagtgaaa atggccttac acctcccatg gttccacccc agaaatgtct ccggcttcag
      721 cattgcaaac cgctcatcta taaaacgtct gtgcatcatc gagtctgtgt ttgagggtga
      781 aggctcagca accctgatgt ctgccaacta cccagaaggc ttccctgagg atgagctcat
      841 gacgtggcag tttgtcgttc ctgcacacct gcgggccagc gtctccttcc tcaacttcaa
      901 cctctccaac tgtgagagga aggaggagcg ggttgaatac tacatcccgg gctccaccac
      961 caaccccgag gtgttcaagc tggaggacaa gcagcctggg aacatggcgg ggaacttcaa
     1021 cctctctctg caaggctgtg accaagatgc ccaaagtcca gggatcctcc ggctgcagtt
     1081 ccaagttttg gtccaacatc cacaaaatga aagcaataaa atctacgtgg ttgacttgag
     1141 taatgagcga gccatgtcac tcaccatcga gccacggccc gtcaaacaga gccgcaagtt
     1201 tgtccctggc tgtttcgtgt gtctagaatc tcggacctgc agtagcaacc tcaccctgac
     1261 atctggctcc aaacacaaaa tctccttcct ttgtgatgat ctgacacgtc tgtggatgaa
     1321 tgtggaaaaa accataagct gcacagacca ccggtactgc caaaggaaat cctactcact
     1381 ccaggtgccc agtgacatcc tccacctgcc tgtggagctg catgacttct cctggaagct
     1441 gctggtgccc aaggacaggc tcagcctggt gctggtgcca gcccagaagc tgcagcagca
     1501 tacacacgag aagccctgca acaccagctt cagctacctc gtggccagtg ccatacccag
     1561 ccaggacctg tacttcggct ccttctgccc gggaggctct atcaagcaga tccaggtgaa
     1621 gcagaacatc tcggtgaccc ttcgcacctt tgcccccagc ttccaacaag aggcctccag
     1681 gcagggtctg acggtgtcct ttatacctta tttcaaagag gaaggcgttt tcacggtgac
     1741 ccctgacaca aaaagcaagg tctacctgag gacccccaac tgggaccggg gcctgccatc
     1801 cctcacctct gtgtcctgga acatcagcgt gcccagagac caggtggcct gcctgacttt
     1861 ctttaaggag cggagcggcg tggtctgcca gacagggcgc gcattcatga tcatccagga
     1921 gcagcggacc cgggctgagg agatcttcag cctggacgag gatgtgctcc ccaagccaag
     1981 cttccaccat cacagcttct gggtcaacat ctctaactgc agccccacga gcggcaagca
     2041 gctagacctg ctcttctcgg tgacacttac cccaaggact gtggacttga ctgtcatcct
     2101 catcgcagcg gtgggaggtg gagtcttact gctgtctgcc ctcgggctca tcatttgctg
     2161 tgtgaaaaag aagaaaaaga agacaaacaa gggccccgct gtgggtatct acaatgacaa
     2221 catcaatact gagatgccga ggcagccaaa aaagtttcag aaagggcgaa aggacaatga
     2281 ctcccatgtg tatgcagtca tcgaggacac catggtatat gggcatctgc tacaggattc
     2341 cagcggctcc ttcctgcagc cagaggtgga cacctaccgg ccgttccagg gcaccatggg
     2401 ggtctgtcct ccctccccac ccaccatatg ctccagggcc ccaactgcaa agttggccac
     2461 tgaggagcca cctcctcgct cccctcctga gtctgagagt gaaccgtaca ccttctccca
     2521 tcccaacaat ggggatgtaa gcagcaagga cacagacatt cccttactga acactcagga
     2581 gcccatggag ccagcagaat aacttgatcc attccagacg ctttgctgag tttcataaag
     2641 cagggcactg agacacccgt ccgtgttcct aaccagaaat cctaaagaag aggaattata
     2701 cagaaggaac agcaggaggt tttcctggac accgccaact tcacattgct cagtggactc
     2761 attctaaggg caagacattg aaaatgatga attccaatct ggatacagtc atgacagctc
     2821 atgtgctcct caacttaggc tgtgcggtta gccagcctgt aatgagagga gagaggcctg
     2881 agtcacctag catagggttg cagcaagccc tggattcaga gtgttaaaca gaggcttgcc
     2941 ctcttcagga caacagttcc aattccaagg agcctacctg aggtccctac tctcactggg
     3001 gtccccagga tgaaaacgac aatgtgcctt tttattatta tttatttggt ggtcctgtgt
     3061 tatttaagag atcaaatgta taaccaccta gctcttttca cctgacttag taataactca
     3121 tactaactgg tttggatgcc tgggttgtga cttctactga ccgctagata aacgtgtgcc
     3181 tgtcccccag gtggtgggaa taatttacaa tctgtccaac cagaaaagaa tgtgtgtgtt
     3241 tgagcagcat tgacacatat ctgctttgat aagagacttc ctgattctct aggtcggttc
     3301 gtggttatcc cattgtggaa attcatcttg aatcccattg tcctatagtc ctagcaataa
     3361 gagaaatttc ctcaagtttc catgtgcggt tctcctagct gcagcaatac tttgacattt
     3421 aaagagaaat ttagagaata ttctcatcct ctaaaaatgt ttaaatatat accaaacagt
     3481 ggccccctgc attagttttc tgttgccact gcaacctatt acttggtagc ttaaaaacaa
     3541 cacattagct tatagtcctg gggatcagaa ttccaaaatg gatgtccctg aatgaaaatc
     3601 aaggtgtcag cagagctgtg ctccttctga aggctctagg gagaagccgg ttccttgcca
     3661 tttcaagctt ctagaggctg gctgcattcc caggctccag tggctggtca agcttttctc
     3721 acatggcatc actgtgacac tggccctccc acttccctct ttgacttaca aagcccacca
     3781 ggaagatcca ggataatctc tccatctaaa gttccttcat catcctggaa gagccttttg
     3841 ccatgcaaga caacatagcc acaggtgggg attaggacca gaacatcttt ggggtgctgt
     3901 tattctgcct accacacctt cctgccactg actcccacag gagaggctac aaaatgatct
     3961 ggcgcacagg gatgttttgt ttagcttgcg gactctaaca cttaaaaaaa aacccagatc
     4021 agaagatctg gccatgctgg ggctcacatt ctcacctagc aacaactggc tggagctggg
     4081 caccagctct gcctttagaa ggggtgtcca cttcaccagg tcaccacagc ccacactacg
     4141 ccctatcact tcccacaatg aggctgagtg tttgtttcta ctgatcaatg cccctgcagg
     4201 ttgcatttat tgtaatgaaa aagaaagact gggattaatc tctaatcagg tgagtagacc
     4261 atgagaccaa tgtgtgctca cattaccctt tttctttttt ttctttttct ttttcttttt
     4321 ttttttaatg tgagacagga tctcattctg ttgcctaggc tggagtgcag tggcgcaatc
     4381 tcggctcact gcaacctctg cctcctgggc tcaagcaatt ctcccacctc agcctcccaa
     4441 atagctggga tcactggcac aaaccaccat gcccagctaa ttttgtattt tttgtagaga
     4501 cagggtttca ccatgttgcc caggctggtc tcaacctcct gggctcaagc aatcctcctg
     4561 cctcggcctc ccaaagtgct gggattacag atgtgagcca ccgcatccag ccccacaccc
     4621 tcatttatac caattacctg cccagtaact gtggactttt gcttcctcac ccctgctctg
     4681 atctggaagg agagggatta tgttatagct tgtcagcaca gtcccaagtt caatatttct
     4741 gcggcaaaaa cttccttcaa aaaataaatg tacttcattg tattcaatga attcaccttg
     4801 gaaatgcacc gcctcaactt gttcacatgg cataaatgaa aggaatttta tagtctccta
     4861 aatggcgtgt actgcaagac ctcttgaaca ctttccagag gataggatat ttaagtcatg
     4921 cccttggcgt tgcctatggc acctttccct tctgaaagtc tggttcctgc ccagtgaccc
     4981 ttggccttgt gagccgagat gctgaccctg cataaagggc caaaggaggg ctgcggcttc
     5041 cttccctcac tgaagagccc ttatttgaat tcactgtgtg gagccctagc cctccattct
     5101 cgacattccc caacctccca gccccttcca agcaggacta ggtgccctgc attccaccca
     5161 aggtgggatt ggccttcctt aggctggcta cttgtcacca tcaccgacat cactgttgcc
     5221 tgcaaggaca ccacgtggcc attttccttc aactgagggc tcaaaactcc tggacaagtt
     5281 gctggctcct gagaccagta tttcctggag ctgtgcctca gtgaaggggc ccagcctgag
     5341 gaaccctggc tcttttcttt aaagcccagg ccccacttac gtaaaacatt tcagggtcac
     5401 tggaaacagt gaagtgccat ttgttgaagc ctactgcatg ccagcccact gctcatccac
     5461 gtggtctgcc atgcctacga ggaaggccag cgcatgcagg actggtctct aatgctgtgg
     5521 tcattgcaca gaagggaaag gtctcaagga agagtcaact ggaacaagca caagcccacc
     5581 ggacatggcc ttggtaaagg ttagcagact ggtgtgtgtg gatctgcagt gcttcactgg
     5641 aaataattta ttcattgcag atacttttta ggtggcattt tattcatttc ctgtgcttta
     5701 aataaacaaa tgtaccaaaa aacaagtatc aagctgttta agtgcttcgg ctacttgtcc
     5761 cctggttcag tagaggcccc ggtttcccag ttgttgactg tgacaggctc agcatgggct
     5821 cagcagatgc tgtcttaatt tgtggatgat acagaaagcc aggctttggg atacaagttc
     5881 tttcctcttc atttgatgcc gtgcactgtg tgaagcagat gtttttgtcc ggaaataaaa
     5941 ataatagtct tggagtctcg cca
//
