LOCUS       NP_073753                836 aa            linear   PRI 09-FEB-2025
DEFINITION  CUB domain-containing protein 1 isoform 1 precursor [Homo sapiens].
ACCESSION   NP_073753
VERSION     NP_073753.3
DBSOURCE    REFSEQ: accession NM_022842.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Do,J.S., Arribas-Layton,D., Juan,J., Garcia,I., Saraswathy,S.,
            Qi,M., Montero,E. and Reijonen,H.
  TITLE     The CD318/CD6 axis limits type 1 diabetes islet
            autoantigen-specific human T cell activation
  JOURNAL   J Autoimmun 146, 103228 (2024)
   PUBMED   38642507
  REMARK    GeneRIF: The CD318/CD6 axis limits type 1 diabetes islet
            autoantigen-specific human T cell activation.
REFERENCE   2  (residues 1 to 836)
  AUTHORS   Liu,D., Wang,M., Murthy,V., McNamara,D.M., Nguyen,T.T.L.,
            Philips,T.J., Vyas,H., Gao,H., Sahni,J., Starling,R.C.,
            Cooper,L.T., Skime,M.K., Batzler,A., Jenkins,G.D., Barlera,S.,
            Pileggi,S., Mestroni,L., Merlo,M., Sinagra,G., Pinet,F., Krejci,J.,
            Chaloupka,A., Miller,J.D., de Groote,P., Tschumperlin,D.J.,
            Weinshilboum,R.M. and Pereira,N.L.
  TITLE     Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of
            CDCP1 and Cardiac Fibrosis
  JOURNAL   Circ Res 133 (10), 810-825 (2023)
   PUBMED   37800334
  REMARK    GeneRIF: Myocardial Recovery in Recent Onset Dilated
            Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
REFERENCE   3  (residues 1 to 836)
  AUTHORS   Liu,C.L., Tsai,H.W., Peng,S.L., Chang,C.P., Chang,Y.H. and
            Huang,H.S.
  TITLE     CDCP1 (CUB domain containing protein 1) is a potential urine-based
            biomarker in the diagnosis of low-grade urothelial carcinoma
  JOURNAL   PLoS One 18 (3), e0281873 (2023)
   PUBMED   36862682
  REMARK    GeneRIF: CDCP1 (CUB domain containing protein 1) is a potential
            urine-based biomarker in the diagnosis of low-grade urothelial
            carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 836)
  AUTHORS   Urabe,F., Kosaka,N., Yamamoto,Y., Ito,K., Otsuka,K., Soekmadji,C.,
            Egawa,S., Kimura,T. and Ochiya,T.
  TITLE     Metastatic prostate cancer-derived extracellular vesicles
            facilitate osteoclastogenesis by transferring the CDCP1 protein
  JOURNAL   J Extracell Vesicles 12 (3), e12312 (2023)
   PUBMED   36880252
  REMARK    GeneRIF: Metastatic prostate cancer-derived extracellular vesicles
            facilitate osteoclastogenesis by transferring the CDCP1 protein.
REFERENCE   5  (residues 1 to 836)
  AUTHORS   Saponaro,M., Flottmann,S., Eckstein,M., Hommerding,O., Klumper,N.,
            Corvino,D., Hosni,S., Schmidt,A., Monig,N., Schmidt,D.,
            Ellinger,J., Toma,M., Kristiansen,G., Bald,T., Alimonti,A.,
            Ritter,M., Holzel,M. and Alajati,A.
  TITLE     CDCP1 expression is frequently increased in aggressive urothelial
            carcinoma and promotes urothelial tumor progression
  JOURNAL   Sci Rep 13 (1), 73 (2023)
   PUBMED   36593286
  REMARK    GeneRIF: CDCP1 expression is frequently increased in aggressive
            urothelial carcinoma and promotes urothelial tumor progression.
            Erratum:[Sci Rep. 2023 Feb 17;13(1):2838. doi:
            10.1038/s41598-023-28942-0.. PMID: 36801926]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 836)
  AUTHORS   Uekita,T. and Sakai,R.
  TITLE     Roles of CUB domain-containing protein 1 signaling in cancer
            invasion and metastasis
  JOURNAL   Cancer Sci 102 (11), 1943-1948 (2011)
   PUBMED   21812858
  REMARK    GeneRIF: CUB domain-containing protein 1 (CDCP1) is a substrate of
            Src family kinases and has been shown to regulate anoikis
            resistance, migration and matrix degradation during tumor invasion
            and metastasis in a tyrosine phosphorylation-dependent manner.
            Review.
            Review article
REFERENCE   7  (residues 1 to 836)
  AUTHORS   Conze,T., Lammers,R., Kuci,S., Scherl-Mostageer,M., Schweifer,N.,
            Kanz,L. and Buhring,H.J.
  TITLE     CDCP1 is a novel marker for hematopoietic stem cells
  JOURNAL   Ann N Y Acad Sci 996, 222-226 (2003)
   PUBMED   12799299
REFERENCE   8  (residues 1 to 836)
  AUTHORS   Hooper,J.D., Zijlstra,A., Aimes,R.T., Liang,H., Claassen,G.F.,
            Tarin,D., Testa,J.E. and Quigley,J.P.
  TITLE     Subtractive immunization using highly metastatic human tumor cells
            identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated
            glycoprotein antigen
  JOURNAL   Oncogene 22 (12), 1783-1794 (2003)
   PUBMED   12660814
  REMARK    GeneRIF: antibodies generated by subtractive immunization used to
            purify, identify and partially characterize SIMA135/CDCP1;
            properties indicate it is a multidomain cell surface antigen,
            highly expressed by certain cancer cells and normal and cancerous
            colon
REFERENCE   9  (residues 1 to 836)
  AUTHORS   Scherl-Mostageer,M., Sommergruber,W., Abseher,R., Hauptmann,R.,
            Ambros,P. and Schweifer,N.
  TITLE     Identification of a novel gene, CDCP1, overexpressed in human
            colorectal cancer
  JOURNAL   Oncogene 20 (32), 4402-4408 (2001)
   PUBMED   11466621
REFERENCE   10 (residues 1 to 836)
  AUTHORS   Xia,Y., Gil,S.G. and Carter,W.G.
  TITLE     Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin)
            regulates tyrosine phosphorylation of a membrane-associated 80-kD
            protein
  JOURNAL   J Cell Biol 132 (4), 727-740 (1996)
   PUBMED   8647901
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY167484.1 and AY026461.1.
            
            On May 7, 2003 this sequence version replaced NP_073753.2.
            
            Summary: This gene encodes a transmembrane protein which contains
            three extracellular CUB domains and acts as a substrate for Src
            family kinases. The protein plays a role in the tyrosine
            phosphorylation-dependent regulation of cellular events that are
            involved in tumor invasion and metastasis. Alternative splicing
            results in multiple transcript variants of this gene. [provided by
            RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY167484.1, AY026461.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296129.6/ ENSP00000296129.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     Protein         1..836
                     /product="CUB domain-containing protein 1 isoform 1
                     precursor"
                     /note="transmembrane and associated with src kinases;
                     membrane glycoprotein gp140; subtractive immunization M
                     plus HEp3-associated 135 kDa protein"
                     /calculated_mol_wt=90143
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2807
     mat_peptide     30..836
                     /product="CUB domain-containing protein 1.
                     /id=PRO_0000226249"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H5V8.3)"
                     /calculated_mol_wt=90143
     Site            39
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            122
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            180
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            205
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Region          225..>297
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cl00049"
                     /db_xref="CDD:412131"
     Site            270
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            310
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            368..369
                     /site_type="cleavage"
                     /note="Cleavage, by ST14/MT-SP1; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            386
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            668..688
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Site            734
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:14739293; propagated from
                     UniProtKB/Swiss-Prot (Q9H5V8.3)"
     Region          776..836
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H5V8.3)"
     CDS             1..836
                     /gene="CDCP1"
                     /gene_synonym="CD318; SIMA135; TRASK"
                     /coded_by="NM_022842.5:92..2602"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS2727.1"
                     /db_xref="GeneID:64866"
                     /db_xref="HGNC:HGNC:24357"
                     /db_xref="MIM:611735"
ORIGIN      
        1 maglncgvsi allgvlllga arlprgaeaf eialpresni tvliklgtpt llakpcyivi
       61 skrhitmlsi ksgerivftf scqspenhfv ieiqknidcm sgpcpfgevq lqpstsllpt
      121 lnrtfiwdvk ahksiglelq fsiprlrqig pgescpdgvt hsisgridat vvrigtfcsn
      181 gtvsrikmqe gvkmalhlpw fhprnvsgfs ianrssikrl ciiesvfege gsatlmsany
      241 pegfpedelm twqfvvpahl rasvsflnfn lsncerkeer veyyipgstt npevfkledk
      301 qpgnmagnfn lslqgcdqda qspgilrlqf qvlvqhpqne snkiyvvdls neramsltie
      361 prpvkqsrkf vpgcfvcles rtcssnltlt sgskhkisfl cddltrlwmn vektisctdh
      421 rycqrksysl qvpsdilhlp velhdfswkl lvpkdrlslv lvpaqklqqh thekpcntsf
      481 sylvasaips qdlyfgsfcp ggsikqiqvk qnisvtlrtf apsfqqeasr qgltvsfipy
      541 fkeegvftvt pdtkskvylr tpnwdrglps ltsvswnisv prdqvacltf fkersgvvcq
      601 tgrafmiiqe qrtraeeifs ldedvlpkps fhhhsfwvni sncsptsgkq ldllfsvtlt
      661 prtvdltvil iaavgggvll lsalgliicc vkkkkkktnk gpavgiyndn intemprqpk
      721 kfqkgrkdnd shvyaviedt mvyghllqds sgsflqpevd tyrpfqgtmg vcppspptic
      781 sraptaklat eeppprsppe sesepytfsh pnngdvsskd tdipllntqe pmepae
//
