LOCUS       NM_001256875            2371 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cell division cycle associated 8 (CDCA8), transcript
            variant 1, mRNA.
ACCESSION   NM_001256875
VERSION     NM_001256875.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Cui,Y. and Jiang,N.
  TITLE     CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis
            in Hepatocellular Carcinoma
  JOURNAL   Appl Biochem Biotechnol 196 (3), 1481-1492 (2024)
   PUBMED   37428386
  REMARK    GeneRIF: CDCA8 Facilitates Tumor Proliferation and Predicts a Poor
            Prognosis in Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Zhou,Q., Huang,W., Xiong,J., Guo,B., Wang,X. and Guo,J.
  TITLE     CDCA8 promotes bladder cancer survival by stabilizing HIF1alpha
            expression under hypoxia
  JOURNAL   Cell Death Dis 14 (10), 658 (2023)
   PUBMED   37813876
  REMARK    GeneRIF: CDCA8 promotes bladder cancer survival by stabilizing
            HIF1alpha expression under hypoxia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Wu,Y., Zeng,S., Miao,C., Wu,H., Xu,X., Chen,L., Lu,G., Lin,G. and
            Dai,C.
  TITLE     A 1-kb human CDCA8 promoter directs the spermatogonia-specific
            luciferase expression in adult testis
  JOURNAL   Gene 866, 147350 (2023)
   PUBMED   36898512
  REMARK    GeneRIF: A 1-kb human CDCA8 promoter directs the
            spermatogonia-specific luciferase expression in adult testis.
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Wu,H., Liu,S., Wu,D., Zhou,H., Sui,G. and Wu,G.
  TITLE     Cell division cycle-associated 8 is a prognostic biomarker related
            to immune invasion in hepatocellular carcinoma
  JOURNAL   Cancer Med 12 (8), 10138-10155 (2023)
   PUBMED   36855818
  REMARK    GeneRIF: Cell division cycle-associated 8 is a prognostic biomarker
            related to immune invasion in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Sauer,G., Korner,R., Hanisch,A., Ries,A., Nigg,E.A. and Sillje,H.H.
  TITLE     Proteome analysis of the human mitotic spindle
  JOURNAL   Mol Cell Proteomics 4 (1), 35-43 (2005)
   PUBMED   15561729
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Sampath,S.C., Ohi,R., Leismann,O., Salic,A., Pozniakovski,A. and
            Funabiki,H.
  TITLE     The chromosomal passenger complex is required for chromatin-induced
            microtubule stabilization and spindle assembly
  JOURNAL   Cell 118 (2), 187-202 (2004)
   PUBMED   15260989
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Gassmann,R., Carvalho,A., Henzing,A.J., Ruchaud,S., Hudson,D.F.,
            Honda,R., Nigg,E.A., Gerloff,D.L. and Earnshaw,W.C.
  TITLE     Borealin: a novel chromosomal passenger required for stability of
            the bipolar mitotic spindle
  JOURNAL   J Cell Biol 166 (2), 179-191 (2004)
   PUBMED   15249581
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   Walker,M.G.
  TITLE     Drug target discovery by gene expression analysis: cell cycle genes
  JOURNAL   Curr Cancer Drug Targets 1 (1), 73-83 (2001)
   PUBMED   12188893
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   Li,F., Ambrosini,G., Chu,E.Y., Plescia,J., Tognin,S.,
            Marchisio,P.C. and Altieri,D.C.
  TITLE     Control of apoptosis and mitotic spindle checkpoint by survivin
  JOURNAL   Nature 396 (6711), 580-584 (1998)
   PUBMED   9859993
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001651.2 and BC008079.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001256875.1.
            
            Summary: This gene encodes a component of the chromosomal passenger
            complex. This complex is an essential regulator of mitosis and cell
            division. This protein is cell-cycle regulated and is required for
            chromatin-induced microtubule stabilization and spindle formation.
            Alternate splicing results in multiple transcript variants.
            Pseudgenes of this gene are found on chromosomes 7, 8 and 16.
            [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein. Both variants 1 and
            2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.651233.1, BC000703.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373055.6/ ENSP00000362146.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1966              BC001651.2         30-1995
            1967-2371           BC008079.2         1838-2242
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2371
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /note="cell division cycle associated 8"
                     /db_xref="GeneID:55143"
                     /db_xref="HGNC:HGNC:14629"
                     /db_xref="MIM:609977"
     exon            1..269
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1018
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /note="Dasra B; dasra-B; cell division cycle-associated
                     protein 8; pluripotent embryonic stem cell-related gene 3
                     protein; hDasra-B"
                     /codon_start=1
                     /product="borealin"
                     /protein_id="NP_001243804.1"
                     /db_xref="CCDS:CCDS424.1"
                     /db_xref="GeneID:55143"
                     /db_xref="HGNC:HGNC:14629"
                     /db_xref="MIM:609977"
                     /translation="MAPRKGSSRVAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQ
                     NLLKEVDNLYNIEILRLPKALREMNWLDYFALGGNKQALEEAATADLDITEINKLTAE
                     AIQTPLKSAKTRKVIQVDEMIVEEEEEEENERKNLQTARVKRCPPSKKRTQSIQGKGK
                     GKRSSRANTVTPAVGRLEVSMVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGNG
                     SPLADSKEIFLTVPVGGGESLRLLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSSI
                     RTHK"
     exon            270..398
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            399..439
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            440..512
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            513..598
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            599..663
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            664..759
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            760..886
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            887..973
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            974..2371
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /note="hexamer: AATAAA"
     polyA_site      2371
                     /gene="CDCA8"
                     /gene_synonym="BOR; BOREALIN; DasraB; MESRGP"
                     /note="major polyA site"
ORIGIN      
        1 gtagagccgc tctctctcac tggcacagcg aggttttgct cagcccttgt ctcgggaccg
       61 caggtacgtg cctggcgact tcttcgggtg gtccccgtcc gccctcctcg tccctaccca
      121 gtttcttgct tccctgcccc atctccgccg ctccccgcag cctccgccga gcgccatggc
      181 tcctaggaag ggcagtagtc gggtggccaa gaccaactcc ttacggaggc ggaagctcgc
      241 ctcctttctg aaagacttcg accgtgaagt ggaaatacga atcaagcaaa ttgagtcaga
      301 caggcagaac ctcctcaagg aggtggataa cctctacaac atcgagatcc tgcggctccc
      361 caaggctctg cgcgagatga actggcttga ctacttcgcc cttggaggaa acaaacaggc
      421 cctggaagag gcggcaacag ctgacctgga tatcaccgaa ataaacaaac taacagcaga
      481 agctattcag acacccctga aatctgccaa aacacgaaag gtaatacagg tagatgaaat
      541 gatagtggaa gaggaagaag aagaagaaaa tgaacgtaag aatcttcaaa ctgcaagagt
      601 caaaaggtgt cctccatcca agaagagaac tcagtccata caaggaaaag gaaaagggaa
      661 aaggtcaagc cgtgctaaca ctgttacccc agccgtgggc cgattggagg tgtccatggt
      721 caaaccaact ccaggcctga cacccaggtt tgactcaagg gtcttcaaga cccctggcct
      781 gcgtactcca gcagcaggag agcggattta caacatctca gggaatggca gccctcttgc
      841 tgacagcaaa gagatcttcc tcactgtgcc agtgggcggc ggagagagcc tgcgattatt
      901 ggccagtgac ttgcagaggc acagtattgc ccagctggat ccagaggcct tgggaaacat
      961 taagaagctc tccaaccgtc tcgcccaaat ctgcagcagc atacggaccc acaaatgaga
     1021 caccaaagtt gacaggatgg acttttaatg ggcacttctg ggaccctgaa gagacttctt
     1081 cccttcaggc ttattgtttg agtgtgaagt tccagagcaa ggagccatgt tcctctaagg
     1141 gaattcagga attcagacgt gctagtccca caccagttag gtagagctgt ctgttcaccc
     1201 tcccatccca gctgatccca gtcactgctt gctggggcca tgccatggaa gcttcccatc
     1261 agtctcccag ctgaatcctc cctgctctct gagctgctgc cttttgcctc ctgcaactca
     1321 acatcctctt caccctgccc tgcctgcagt tgagggggcg aagaagaacc ctgtgttctc
     1381 aggaagactg cctccaccac cgctacccag agaacctctg catctggcat ttctgctctc
     1441 tatgcttgag accgggaggt ttaggctcag ataagtgagc tctgggccat gagagggtag
     1501 gtccagaagg tggggggaac tgtacagatc agcagagcag gacagttggc agcagtgacc
     1561 tcagtaggga acatgtccgt ctaccctctc gcactcatga cacctccccc taccagccct
     1621 cctcttcctc ctcctcctcc tcctgtggga ggtggtcagt gggacttagg gatctttcac
     1681 ctgctgtgcc cagtagttct gaagtctgct tgtggagcag tgttttatgt ttatccctgt
     1741 ttactgaaga ccaaatactg gtttggagac aacttccatg tcttgctctt ctacctccct
     1801 agttagtgga aatttggata agggaactgt agggcccaga ttctggaggt tttatgtcat
     1861 tggccacaga ataactgtct ctaagctatc catggtccag tggtccctgc caagtctgta
     1921 gacttcagag agcacttctc tcttatgggg ttcatgggaa caggggtggg tgtgacttgc
     1981 ttggtggcct cattccatgt gtgcctgtgc ctggggcatg gactttgtta agcagagtca
     2041 gcagtgaggt cctcattctc cagccagcct ctctgccctg gagaatcatg tgctatgttc
     2101 taagaatttg agaactagag tcctcatccc caggcttgaa ggcacatggc tttctcatgt
     2161 agggctctct gtggtatttg ttattatttt gcaacaagac cattttagta aaacagtcct
     2221 gttcaagttg tattctttta agttctttta ttctcctttc cctgagattt ttgtatatat
     2281 tgttctgagt aatggtatct ttgagctgat tgttctaatc agagctggta cctactttca
     2341 ataaattctg gttttgtgtt ttcttttgta a
//
