LOCUS       NM_018719               2883 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cell division cycle associated 7 like (CDCA7L),
            transcript variant 1, mRNA.
ACCESSION   NM_018719 XR_017853
VERSION     NM_018719.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2883)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2883)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2883)
  AUTHORS   Ji,Q.K., Ma,J.W., Liu,R.H., Li,X.S., Shen,F.Z., Huang,L.Y., Hui,L.,
            Ma,Y.J. and Jin,B.Z.
  TITLE     CDCA7L promotes glioma proliferation by targeting CCND1 and
            predicts an unfavorable prognosis
  JOURNAL   Mol Med Rep 20 (2), 1149-1156 (2019)
   PUBMED   31173217
  REMARK    GeneRIF: CDCA7L is highly expressed in human glioma tissues and
            that a high CDCA7L expression predicts a poor prognosis of glioma
            patients. CDCA7L promotes glioma U87 cell growth through CCND1.
REFERENCE   4  (bases 1 to 2883)
  AUTHORS   Tirosh,A., Mukherjee,S., Lack,J., Gara,S.K., Wang,S., Quezado,M.M.,
            Keutgen,X.M., Wu,X., Cam,M., Kumar,S., Patel,D., Nilubol,N.,
            Tyagi,M.V. and Kebebew,E.
  TITLE     Distinct genome-wide methylation patterns in sporadic and
            hereditary nonfunctioning pancreatic neuroendocrine tumors
  JOURNAL   Cancer 125 (8), 1247-1257 (2019)
   PUBMED   30620390
  REMARK    GeneRIF: Results identified and confirmed to have downregulated
            gene expression of SFRP5 in sporadic nonfunctioning pancreatic
            neuroendocrine tumors (NFPanNETs) and CDCA7L and RBM47 in
            MEN1-related NFPanNETs.
REFERENCE   5  (bases 1 to 2883)
  AUTHORS   Ou,X.M., Chen,K. and Shih,J.C.
  TITLE     Glucocorticoid and androgen activation of monoamine oxidase A is
            regulated differently by R1 and Sp1
  JOURNAL   J Biol Chem 281 (30), 21512-21525 (2006)
   PUBMED   16728402
  REMARK    GeneRIF: monoamine oxidase A activation of glucocorticoids and
            androgens is regulated differently by R1 and Sp1
REFERENCE   6  (bases 1 to 2883)
  AUTHORS   Maertens,G.N., Cherepanov,P. and Engelman,A.
  TITLE     Transcriptional co-activator p75 binds and tethers the
            Myc-interacting protein JPO2 to chromatin
  JOURNAL   J Cell Sci 119 (Pt 12), 2563-2571 (2006)
   PUBMED   16735438
REFERENCE   7  (bases 1 to 2883)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 2883)
  AUTHORS   Huang,A., Ho,C.S., Ponzielli,R., Barsyte-Lovejoy,D., Bouffet,E.,
            Picard,D., Hawkins,C.E. and Penn,L.Z.
  TITLE     Identification of a novel c-Myc protein interactor, JPO2, with
            transforming activity in medulloblastoma cells
  JOURNAL   Cancer Res 65 (13), 5607-5619 (2005)
   PUBMED   15994933
REFERENCE   9  (bases 1 to 2883)
  AUTHORS   Chen,K., Ou,X.M., Chen,G., Choi,S.H. and Shih,J.C.
  TITLE     R1, a novel repressor of the human monoamine oxidase A
  JOURNAL   J Biol Chem 280 (12), 11552-11559 (2005)
   PUBMED   15654081
REFERENCE   10 (bases 1 to 2883)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292490.1, BC009352.2, AL576822.3, AA922229.1, AK022955.1 and
            BU753973.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018719.4.
            
            Transcript Variant: This variant (1) encodes the predominant and
            longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.8454.1, BC039823.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406877.8/ ENSP00000383986.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-888               AK292490.1         1-888
            889-1534            BC009352.2         806-1451
            1535-1959           AL576822.3         169-593             c
            1960-2189           AA922229.1         19-248
            2190-2838           AK022955.1         1752-2400
            2839-2883           BU753973.1         15-59               c
FEATURES             Location/Qualifiers
     source          1..2883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..2883
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="cell division cycle associated 7 like"
                     /db_xref="GeneID:55536"
                     /db_xref="HGNC:HGNC:30777"
                     /db_xref="MIM:609685"
     exon            1..119
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1460
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle-associated 7-like protein; transcription
                     factor RAM2"
                     /codon_start=1
                     /product="cell division cycle-associated 7-like protein
                     isoform 1"
                     /protein_id="NP_061189.2"
                     /db_xref="CCDS:CCDS5374.1"
                     /db_xref="GeneID:55536"
                     /db_xref="HGNC:HGNC:30777"
                     /db_xref="MIM:609685"
                     /translation="MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESC
                     DSFDSLESGKQQDVRFHSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMV
                     VESDLSDDGKASLVSEEEEDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKN
                     SSSEQLFSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRT
                     MNIKENKAMLAQLLAELNSMPDFFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSAR
                     PPEKFALENFTVSAAKFAEEFYSFRRRKTIGGKCREYRRRHRISSFRPVEDITEEDLE
                     NVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDV
                     RSALLDPDWVCPPCRGICNCSYCRKRDGRCATGILIHLAKFYGYDNVKEYLESLQKEL
                     VEDN"
     exon            120..260
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..398
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..776
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..848
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1016
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1142
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1292
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1429
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..2883
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2853..2858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="hexamer: AATAAA"
     polyA_site      2883
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="major polyA site"
ORIGIN      
        1 gctcgggcgc ggggcgttct tggtgcgccg ggccgtggtg agtccgggct cccgtggccg
       61 cgtgctggga ggagactgga gcccggttag gaagaatgga gttggcgact cgctaccaga
      121 tccctaaaga agtggctgac atctttaacg cccccagtga tgatgaagag tttgttggct
      181 tccgagatga tgttcccatg gaaaccctct cgtcagagga gagctgcgat agttttgact
      241 cactagagtc agggaaacag caggatgtgc gctttcattc caaatacttc acagaagagc
      301 taagaagaat ttttatagag gacactgact cagagactga ggattttgca ggatttacgc
      361 agagtgatct gaatggaaag actaacccag aagtaatggt cgtggagtca gatttgagtg
      421 atgatggcaa agcatctttg gtgagcgagg aagaggaaga tgaagaagaa gataaggcta
      481 cccctagaag aagcaggtct agaagaagta gtattggtct tcgagtagcc tttcagttcc
      541 ccaccaagaa gctggccaac aaaccagata aaaacagttc ttccgagcag ttgttttcta
      601 gcgcacgctt acagaatgag aaaaaaacaa ttcttgaaag aaagaaagac tgtagacagg
      661 tgatacaaag ggaagattct acctctgagt ctgaggatga ctctcgggat gagagccagg
      721 agagttcaga tgctttgctg aaaaggacca tgaacatcaa ggagaacaaa gccatgcttg
      781 cccagttatt ggcggaattg aactcgatgc cagatttctt cccagtacga accccaacct
      841 cagcttctag gaagaagaca gtgaggcggg ccttctcgga gggacagatc acgcggcgta
      901 tgaacccaac ccggagtgcg cggcctcctg agaagtttgc tctagagaac ttcactgtct
      961 cagccgctaa atttgcggaa gagttttaca gcttccgaag aaggaagaca attgggggga
     1021 aatgccggga gtacagacga cgtcaccgta tatcttcttt tcggccagtg gaggatatca
     1081 ccgaagagga cttagaaaat gttgccataa ctgttcgaga taaaatctat gataaagttc
     1141 tgggtaacac gtgccatcag tgtcgacaaa agaccatcga caccaagaca gtgtgtcgga
     1201 accagggttg ctgtggtgtg cgaggacagt tctgtggacc atgcctgcgg aaccgctatg
     1261 gggaggatgt cagatcggca ttgctggacc cggattgggt gtgtcccccc tgtcgtggga
     1321 tctgcaattg cagctactgt cggaagcgtg acggccgctg tgccacagga atcctcattc
     1381 atctggccaa gttttatggt tatgacaatg ttaaggaata tctggagagc ttacaaaagg
     1441 agctggtaga agacaattaa gaggaaaaca aacagaacca gccacctcac catagagtac
     1501 tccaacaaga catgcatacc attggtgcct aagaaagatt tttttacagt tgtgttttta
     1561 tacagaaatt ctttgtagaa attactattt tttgttaaag attgtttata tgcttacaaa
     1621 gatttctcag gaagacagca gagcagagga atctatatag atgtatgcac agacctgtct
     1681 gtatgctgaa ctttgttaaa aatatctgcc agttattaaa aagcacagtt taaatggggt
     1741 ggggttaaag ttcaggtaag taagttagag agaaaacatt gtatgatcag ctcctgcact
     1801 tgatctatct atctttggct tcccaaacag taactcactc caggccaagt gtgccttagc
     1861 acgagtgacc acagtttaat agaccacaca catcgtttaa cctgctcttg gtcattggaa
     1921 atttacactg aacaaagtgc aattaactgt agaacagttt tatttttatt aaaacttgac
     1981 tgaacaaaag gggaccatca acattgtaga cactggacac tggaggcctt acagagtgct
     2041 agcctcttcc ttcaggactc acctggggcc tgctgctttt atattttgaa agagtttaag
     2101 ggctaataat ttaatttgtt gtttgttaaa aattaaaatc tccgttcttt ccggctgcat
     2161 tgcttttgca tgttcacata tgatgtactt ttatgatgta cttttttttt tttgagatgg
     2221 agtcttgttc tgttgcccag gagggagtgc agtggtgcaa cctcggctca ctgcaacctt
     2281 tgcctcctag gttcaagtga ttctcctacc tcctgagtaa ctgggattac agtcgtgtgc
     2341 caccacgctc agccctgagt tagtttctag tatttttttc tgactttcac tctaaggata
     2401 gcgttgaaaa aagaatgcac gtgtgagtta ctaaaaagtt agaataatgt gcatgggaac
     2461 agtgcagcaa catgctagaa aatcctcact gcactccagc agaggctaga ggaatgccag
     2521 tgttacctta cgcttctaga agcagagcca ctccagccag aacccatttt gcagtcttct
     2581 cttcgctctt cagcctgaag gtccagatgt agctggggcc tctcagtttg gttctataca
     2641 cagggcactc gtaggtctgt ttggtttctt gtctgtccac gggggtggct tttgcaaaga
     2701 tgaccggcat agggcatgcc agctccttga gacgggcttc aacaatggtt cctgcttggg
     2761 tgtcccagcg ggcgcctatg gcaaaaacac agcggttgca attgtgtggc agcttgctac
     2821 taatgataat gatcaagtaa gttgtttgat gcaataaaca ttcaacattc tggttttgtc
     2881 ata
//
