LOCUS       NM_001127370            2937 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cell division cycle associated 7 like (CDCA7L),
            transcript variant 2, mRNA.
ACCESSION   NM_001127370
VERSION     NM_001127370.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2937)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2937)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2937)
  AUTHORS   Ji,Q.K., Ma,J.W., Liu,R.H., Li,X.S., Shen,F.Z., Huang,L.Y., Hui,L.,
            Ma,Y.J. and Jin,B.Z.
  TITLE     CDCA7L promotes glioma proliferation by targeting CCND1 and
            predicts an unfavorable prognosis
  JOURNAL   Mol Med Rep 20 (2), 1149-1156 (2019)
   PUBMED   31173217
  REMARK    GeneRIF: CDCA7L is highly expressed in human glioma tissues and
            that a high CDCA7L expression predicts a poor prognosis of glioma
            patients. CDCA7L promotes glioma U87 cell growth through CCND1.
REFERENCE   4  (bases 1 to 2937)
  AUTHORS   Tirosh,A., Mukherjee,S., Lack,J., Gara,S.K., Wang,S., Quezado,M.M.,
            Keutgen,X.M., Wu,X., Cam,M., Kumar,S., Patel,D., Nilubol,N.,
            Tyagi,M.V. and Kebebew,E.
  TITLE     Distinct genome-wide methylation patterns in sporadic and
            hereditary nonfunctioning pancreatic neuroendocrine tumors
  JOURNAL   Cancer 125 (8), 1247-1257 (2019)
   PUBMED   30620390
  REMARK    GeneRIF: Results identified and confirmed to have downregulated
            gene expression of SFRP5 in sporadic nonfunctioning pancreatic
            neuroendocrine tumors (NFPanNETs) and CDCA7L and RBM47 in
            MEN1-related NFPanNETs.
REFERENCE   5  (bases 1 to 2937)
  AUTHORS   Ou,X.M., Chen,K. and Shih,J.C.
  TITLE     Glucocorticoid and androgen activation of monoamine oxidase A is
            regulated differently by R1 and Sp1
  JOURNAL   J Biol Chem 281 (30), 21512-21525 (2006)
   PUBMED   16728402
  REMARK    GeneRIF: monoamine oxidase A activation of glucocorticoids and
            androgens is regulated differently by R1 and Sp1
REFERENCE   6  (bases 1 to 2937)
  AUTHORS   Maertens,G.N., Cherepanov,P. and Engelman,A.
  TITLE     Transcriptional co-activator p75 binds and tethers the
            Myc-interacting protein JPO2 to chromatin
  JOURNAL   J Cell Sci 119 (Pt 12), 2563-2571 (2006)
   PUBMED   16735438
REFERENCE   7  (bases 1 to 2937)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 2937)
  AUTHORS   Huang,A., Ho,C.S., Ponzielli,R., Barsyte-Lovejoy,D., Bouffet,E.,
            Picard,D., Hawkins,C.E. and Penn,L.Z.
  TITLE     Identification of a novel c-Myc protein interactor, JPO2, with
            transforming activity in medulloblastoma cells
  JOURNAL   Cancer Res 65 (13), 5607-5619 (2005)
   PUBMED   15994933
REFERENCE   9  (bases 1 to 2937)
  AUTHORS   Chen,K., Ou,X.M., Chen,G., Choi,S.H. and Shih,J.C.
  TITLE     R1, a novel repressor of the human monoamine oxidase A
  JOURNAL   J Biol Chem 280 (12), 11552-11559 (2005)
   PUBMED   15654081
REFERENCE   10 (bases 1 to 2937)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA041070.1, AK095965.1, BC009352.2, AL576822.3, AA922229.1,
            AK022955.1 and BU753973.1.
            
            On May 31, 2019 this sequence version replaced NM_001127370.2.
            
            Transcript Variant: This variant (2) includes an alternate exon in
            the 5' UTR which results in the use of a downstream start codon,
            compared to variant 1. Isoform 2 has a shorter N-terminus compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.204542.1, AK095965.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA041070.1         26-46
            22-970              AK095965.1         1-949
            971-1588            BC009352.2         834-1451
            1589-2013           AL576822.3         169-593             c
            2014-2243           AA922229.1         19-248
            2244-2892           AK022955.1         1752-2400
            2893-2937           BU753973.1         15-59               c
FEATURES             Location/Qualifiers
     source          1..2937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..2937
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="cell division cycle associated 7 like"
                     /db_xref="GeneID:55536"
                     /db_xref="HGNC:HGNC:30777"
                     /db_xref="MIM:609685"
     exon            1..119
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            120..173
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            174..314
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1514
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="isoform 2 is encoded by transcript variant 2; cell
                     division cycle-associated 7-like protein; transcription
                     factor RAM2"
                     /codon_start=1
                     /product="cell division cycle-associated 7-like protein
                     isoform 2"
                     /protein_id="NP_001120842.1"
                     /db_xref="CCDS:CCDS47559.1"
                     /db_xref="GeneID:55536"
                     /db_xref="HGNC:HGNC:30777"
                     /db_xref="MIM:609685"
                     /translation="METLSSEESCDSFDSLESGKQQDVRFHSKYFTEELRRIFIEDTD
                     SETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEEEDKATPRRSRSR
                     RSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKKDCRQVIQRED
                     STSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDFFPVRTPTSASR
                     KKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFRRRKTIGGKC
                     REYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCR
                     NQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCATGI
                     LIHLAKFYGYDNVKEYLESLQKELVEDN"
     exon            315..452
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..830
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..902
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1070
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1196
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1346
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1483
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..2937
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2907..2912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="hexamer: AATAAA"
     polyA_site      2937
                     /gene="CDCA7L"
                     /gene_synonym="JPO2; R1; RAM2"
                     /note="major polyA site"
ORIGIN      
        1 gctcgggcgc ggggcgttct tggtgcgccg ggccgtggtg agtccgggct cccgtggccg
       61 cgtgctggga ggagactgga gcccggttag gaagaatgga gttggcgact cgctaccaga
      121 gcacttcgca ggcatagttt ggaagtcatc agggctggtt cttttccttc cagatcccta
      181 aagaagtggc tgacatcttt aacgccccca gtgatgatga agagtttgtt ggcttccgag
      241 atgatgttcc catggaaacc ctctcgtcag aggagagctg cgatagtttt gactcactag
      301 agtcagggaa acagcaggat gtgcgctttc attccaaata cttcacagaa gagctaagaa
      361 gaatttttat agaggacact gactcagaga ctgaggattt tgcaggattt acgcagagtg
      421 atctgaatgg aaagactaac ccagaagtaa tggtcgtgga gtcagatttg agtgatgatg
      481 gcaaagcatc tttggtgagc gaggaagagg aagatgaaga agaagataag gctaccccta
      541 gaagaagcag gtctagaaga agtagtattg gtcttcgagt agcctttcag ttccccacca
      601 agaagctggc caacaaacca gataaaaaca gttcttccga gcagttgttt tctagcgcac
      661 gcttacagaa tgagaaaaaa acaattcttg aaagaaagaa agactgtaga caggtgatac
      721 aaagggaaga ttctacctct gagtctgagg atgactctcg ggatgagagc caggagagtt
      781 cagatgcttt gctgaaaagg accatgaaca tcaaggagaa caaagccatg cttgcccagt
      841 tattggcgga attgaactcg atgccagatt tcttcccagt acgaacccca acctcagctt
      901 ctaggaagaa gacagtgagg cgggccttct cggagggaca gatcacgcgg cgtatgaacc
      961 caacccggag tgcgcggcct cctgagaagt ttgctctaga gaacttcact gtctcagccg
     1021 ctaaatttgc ggaagagttt tacagcttcc gaagaaggaa gacaattggg gggaaatgcc
     1081 gggagtacag acgacgtcac cgtatatctt cttttcggcc agtggaggat atcaccgaag
     1141 aggacttaga aaatgttgcc ataactgttc gagataaaat ctatgataaa gttctgggta
     1201 acacgtgcca tcagtgtcga caaaagacca tcgacaccaa gacagtgtgt cggaaccagg
     1261 gttgctgtgg tgtgcgagga cagttctgtg gaccatgcct gcggaaccgc tatggggagg
     1321 atgtcagatc ggcattgctg gacccggatt gggtgtgtcc cccctgtcgt gggatctgca
     1381 attgcagcta ctgtcggaag cgtgacggcc gctgtgccac aggaatcctc attcatctgg
     1441 ccaagtttta tggttatgac aatgttaagg aatatctgga gagcttacaa aaggagctgg
     1501 tagaagacaa ttaagaggaa aacaaacaga accagccacc tcaccataga gtactccaac
     1561 aagacatgca taccattggt gcctaagaaa gattttttta cagttgtgtt tttatacaga
     1621 aattctttgt agaaattact attttttgtt aaagattgtt tatatgctta caaagatttc
     1681 tcaggaagac agcagagcag aggaatctat atagatgtat gcacagacct gtctgtatgc
     1741 tgaactttgt taaaaatatc tgccagttat taaaaagcac agtttaaatg gggtggggtt
     1801 aaagttcagg taagtaagtt agagagaaaa cattgtatga tcagctcctg cacttgatct
     1861 atctatcttt ggcttcccaa acagtaactc actccaggcc aagtgtgcct tagcacgagt
     1921 gaccacagtt taatagacca cacacatcgt ttaacctgct cttggtcatt ggaaatttac
     1981 actgaacaaa gtgcaattaa ctgtagaaca gttttatttt tattaaaact tgactgaaca
     2041 aaaggggacc atcaacattg tagacactgg acactggagg ccttacagag tgctagcctc
     2101 ttccttcagg actcacctgg ggcctgctgc ttttatattt tgaaagagtt taagggctaa
     2161 taatttaatt tgttgtttgt taaaaattaa aatctccgtt ctttccggct gcattgcttt
     2221 tgcatgttca catatgatgt acttttatga tgtacttttt tttttttgag atggagtctt
     2281 gttctgttgc ccaggaggga gtgcagtggt gcaacctcgg ctcactgcaa cctttgcctc
     2341 ctaggttcaa gtgattctcc tacctcctga gtaactggga ttacagtcgt gtgccaccac
     2401 gctcagccct gagttagttt ctagtatttt tttctgactt tcactctaag gatagcgttg
     2461 aaaaaagaat gcacgtgtga gttactaaaa agttagaata atgtgcatgg gaacagtgca
     2521 gcaacatgct agaaaatcct cactgcactc cagcagaggc tagaggaatg ccagtgttac
     2581 cttacgcttc tagaagcaga gccactccag ccagaaccca ttttgcagtc ttctcttcgc
     2641 tcttcagcct gaaggtccag atgtagctgg ggcctctcag tttggttcta tacacagggc
     2701 actcgtaggt ctgtttggtt tcttgtctgt ccacgggggt ggcttttgca aagatgaccg
     2761 gcatagggca tgccagctcc ttgagacggg cttcaacaat ggttcctgct tgggtgtccc
     2821 agcgggcgcc tatggcaaaa acacagcggt tgcaattgtg tggcagcttg ctactaatga
     2881 taatgatcaa gtaagttgtt tgatgcaata aacattcaac attctggttt tgtcata
//
