LOCUS       NM_031942               2778 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens cell division cycle associated 7 (CDCA7), transcript
            variant 1, mRNA.
ACCESSION   NM_031942
VERSION     NM_031942.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2778)
  AUTHORS   Hardikar,S., Ren,R., Ying,Z., Zhou,J., Horton,J.R., Bramble,M.D.,
            Liu,B., Lu,Y., Liu,B., Coletta,L.D., Shen,J., Dan,J., Zhang,X.,
            Cheng,X. and Chen,T.
  TITLE     The ICF syndrome protein CDCA7 harbors a unique DNA binding domain
            that recognizes a CpG dyad in the context of a non-B DNA
  JOURNAL   Sci Adv 10 (34), eadr0036 (2024)
   PUBMED   39178265
  REMARK    GeneRIF: The ICF syndrome protein CDCA7 harbors a unique DNA
            binding domain that recognizes a CpG dyad in the context of a non-B
            DNA.
REFERENCE   2  (bases 1 to 2778)
  AUTHORS   Wan,Z. and Liu,G.
  TITLE     Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell
            malignant behaviors through miR-520f-3p/CDCA7 axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (7), 85-91 (2024)
   PUBMED   39097891
  REMARK    GeneRIF: Circ_0006220 (circ-TADA2A) accelerates prostate cancer
            cell malignant behaviors through miR-520f-3p/CDCA7 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2778)
  AUTHORS   Wang,Y., Zhao,Y., Zhang,Z., Zhang,J., Xu,Q., Zhou,X. and Mao,L.
  TITLE     High Expression of CDCA7 in the Prognosis of Glioma and Its
            Relationship with Ferroptosis and Immunity
  JOURNAL   Genes (Basel) 14 (7), 1406 (2023)
   PUBMED   37510310
  REMARK    GeneRIF: High Expression of CDCA7 in the Prognosis of Glioma and
            Its Relationship with Ferroptosis and Immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2778)
  AUTHORS   Li,H., Wang,S., Li,X., Weng,Y., Guo,D., Kong,P., Cheng,C., Wang,Y.,
            Zhang,L., Cheng,X. and Cui,Y.
  TITLE     CDCA7 promotes TGF-beta-induced epithelial-mesenchymal transition
            via transcriptionally regulating Smad4/Smad7 in ESCC
  JOURNAL   Cancer Sci 114 (1), 91-104 (2023)
   PUBMED   36056599
  REMARK    GeneRIF: CDCA7 promotes TGF-beta-induced epithelial-mesenchymal
            transition via transcriptionally regulating Smad4/Smad7 in ESCC.
REFERENCE   5  (bases 1 to 2778)
  AUTHORS   Cai,C., Peng,X. and Zhang,Y.
  TITLE     Downregulation of cell division cycle-associated protein 7 (CDCA7)
            suppresses cell proliferation, arrests cell cycle of ovarian
            cancer, and restrains angiogenesis by modulating enhancer of zeste
            homolog 2 (EZH2) expression
  JOURNAL   Bioengineered 12 (1), 7007-7019 (2021)
   PUBMED   34551671
  REMARK    GeneRIF: Downregulation of cell division cycle-associated protein 7
            (CDCA7) suppresses cell proliferation, arrests cell cycle of
            ovarian cancer, and restrains angiogenesis by modulating enhancer
            of zeste homolog 2 (EZH2) expression.
REFERENCE   6  (bases 1 to 2778)
  AUTHORS   Gill,R.M., Gabor,T.V., Couzens,A.L. and Scheid,M.P.
  TITLE     The MYC-associated protein CDCA7 is phosphorylated by AKT to
            regulate MYC-dependent apoptosis and transformation
  JOURNAL   Mol Cell Biol 33 (3), 498-513 (2013)
   PUBMED   23166294
  REMARK    GeneRIF: CDCA7 associates with MYC and this association is
            modulated in a phosphorylation-dependent manner.
REFERENCE   7  (bases 1 to 2778)
  AUTHORS   Goto,Y., Hayashi,R., Muramatsu,T., Ogawa,H., Eguchi,I., Oshida,Y.,
            Ohtani,K. and Yoshida,K.
  TITLE     JPO1/CDCA7, a novel transcription factor E2F1-induced protein,
            possesses intrinsic transcriptional regulator activity
  JOURNAL   Biochim Biophys Acta 1759 (1-2), 60-68 (2006)
   PUBMED   16580749
  REMARK    GeneRIF: JPO1/CDCA7 is a unique transcription regulator whose
            expression is activated by E2F1 as well as c-Myc.
REFERENCE   8  (bases 1 to 2778)
  AUTHORS   Osthus,R.C., Karim,B., Prescott,J.E., Smith,B.D., McDevitt,M.,
            Huso,D.L. and Dang,C.V.
  TITLE     The Myc target gene JPO1/CDCA7 is frequently overexpressed in human
            tumors and has limited transforming activity in vivo
  JOURNAL   Cancer Res 65 (13), 5620-5627 (2005)
   PUBMED   15994934
REFERENCE   9  (bases 1 to 2778)
  AUTHORS   Prescott,J.E., Osthus,R.C., Lee,L.A., Lewis,B.C., Shim,H.,
            Barrett,J.F., Guo,Q., Hawkins,A.L., Griffin,C.A. and Dang,C.V.
  TITLE     A novel c-Myc-responsive gene, JPO1, participates in neoplastic
            transformation
  JOURNAL   J Biol Chem 276 (51), 48276-48284 (2001)
   PUBMED   11598121
REFERENCE   10 (bases 1 to 2778)
  AUTHORS   Walker,M.G.
  TITLE     Drug target discovery by gene expression analysis: cell cycle genes
  JOURNAL   Curr Cancer Drug Targets 1 (1), 73-83 (2001)
   PUBMED   12188893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY029179.1, DA531905.1,
            AC092573.2 and BC015124.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031942.4.
            
            Summary: This gene was identified as a c-Myc responsive gene, and
            behaves as a direct c-Myc target gene. Overexpression of this gene
            is found to enhance the transformation of lymphoblastoid cells, and
            it complements a transformation-defective Myc Box II mutant,
            suggesting its involvement in c-Myc-mediated cell transformation.
            Two alternatively spliced transcript variants encoding distinct
            isoforms have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.197646.1, AK027628.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306721.8/ ENSP00000306968.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AY029179.1         53-291
            240-476             DA531905.1         237-473
            477-1674            AY029179.1         292-1489
            1675-2649           AC092573.2         113075-114049
            2650-2771           BC015124.1         1869-1990
            2772-2778           AC092573.2         114172-114178
FEATURES             Location/Qualifiers
     source          1..2778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2778
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /note="cell division cycle associated 7"
                     /db_xref="GeneID:83879"
                     /db_xref="HGNC:HGNC:14628"
                     /db_xref="MIM:609937"
     exon            1..113
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1445
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /note="isoform 1 is encoded by transcript variant 1; c-Myc
                     target JPO1; cell division cycle-associated protein 7"
                     /codon_start=1
                     /product="cell division cycle-associated protein 7 isoform
                     1"
                     /protein_id="NP_114148.3"
                     /db_xref="CCDS:CCDS2252.1"
                     /db_xref="GeneID:83879"
                     /db_xref="HGNC:HGNC:14628"
                     /db_xref="MIM:609937"
                     /translation="MDARRVPQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASD
                     NFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNE
                     LAGIFHADSDDESFCGFSESEIQDGMRLQSVREGCRTRSQCRHSGPLRVAMKFPARST
                     RGATNKKAESRQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESF
                     PGSFRGRHPLPGSDSQSRRPRRRTFPGVASRRNPERRARPLTRSRSRILGSLDALPME
                     EEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCS
                     NSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDAL
                     LDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA
                     "
     exon            114..239
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..476
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..713
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..791
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..986
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1127
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1277
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1414
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..2778
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /note="hexamer: AATAAA"
     polyA_site      2685
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /note="major polyA site"
     regulatory      2747..2752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /note="hexamer: AATAAA"
     polyA_site      2778
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /note="major polyA site"
ORIGIN      
        1 gctgctgctg ctcctcctgc tgtgggaccg ctgaccgcgc ggctgctccg ctctccccgc
       61 tccaagcgcc gatctgggca cccgccacca gcatggacgc tcgccgcgtg ccgcagaaag
      121 atctcagagt aaagaagaac ttaaagaaat tcagatatgt gaagttgatt tccatggaaa
      181 cctcgtcatc ctctgatgac agttgtgaca gctttgcttc tgataatttt gcaaacacga
      241 aacctaaatt caggtcagat atcagtgaag aactggcaaa tgttttttat gaggactctg
      301 ataatgaatc tttctgcggc ttttcagaaa gtgaggtgca agatgtatta gaccattgtg
      361 gatttttaca gaaaccaagg ccagatgtca ctaacgaact ggccggtatt tttcatgccg
      421 actctgacga tgaatcattt tgcggtttct cagagagtga gatacaagat ggaatgaggc
      481 tgcagtcagt tcgggaaggc tgtaggaccc gcagccagtg caggcactct ggacctctca
      541 gggtggcgat gaagtttcca gcgcggagta ccaggggagc aaccaacaaa aaagcagagt
      601 cccgccagcc ctcagagaat tctgtgactg attccaactc cgattcagaa gatgaaagtg
      661 gaatgaattt tttggagaaa agggctttaa atataaagca aaacaaagca atgcttgcaa
      721 aactcatgtc tgaattagaa agcttccctg gctcgttccg tggaagacat cccctcccag
      781 gctccgactc acaatcaagg agaccgcgaa ggcgtacatt cccgggtgtt gcttccagga
      841 gaaaccctga acggagagct cgtcctctta ccaggtcaag gtcccggatc ctcgggtccc
      901 ttgacgctct acccatggag gaggaggagg aagaggataa gtacatgttg gtgagaaaga
      961 ggaagaccgt ggatggctac atgaatgaag atgacctgcc cagaagccgt cgctccagat
     1021 catccgtgac ccttccgcat ataattcgcc cagtggaaga aattacagag gaggagttgg
     1081 agaacgtctg cagcaattct cgagagaaga tatataaccg ttcactgggc tctacttgtc
     1141 atcaatgccg tcagaagact attgatacca aaacaaactg cagaaaccca gactgctggg
     1201 gcgttcgagg ccagttctgt ggcccctgcc ttcgaaaccg ttatggtgaa gaggtcaggg
     1261 atgctctgct ggatccgaac tggcattgcc cgccttgtcg aggaatctgc aactgcagtt
     1321 tctgccggca gcgagatgga cggtgtgcga ctggggtcct tgtgtattta gccaaatatc
     1381 atggctttgg gaatgtgcat gcctacttga aaagcctgaa acaggaattt gaaatgcaag
     1441 cataatatct ggaaaatttg ctgcctgcct tctacttctc aaatctttct tgtaaaagtt
     1501 tccaattttt tcactgaaac ctgagttaaa aatcttgatg atcagcctgt ttcataagaa
     1561 actccaatca agttaatctt agcagacatg tgtttctgga gcatcacaga aggtatattg
     1621 ctagttacac tttgccctcc tgcagtttct tctctgctcc caacccccat ctcacagcat
     1681 ccccctctat ttccaatgct cctctccaac cgcttagttt ctgaatttct tttaaattac
     1741 agttttatga aagcatattt tatttacttg gtgttgaaat agccctcata aaacctaagc
     1801 acttggaaac acaataatag tattaactaa ctagatctat tgaatttcag agaagagcct
     1861 tctaacttgt ttacacaaaa acgagtatga tttagcattc atactagttg aaatttttaa
     1921 tagaatcaag gcacaaaagt cttaaaacca tgtggaaaaa ttaggtaatt attgcagatt
     1981 gatgtctctc aatcccatgt attgcgctta tgttacaagt tgttgtcaca gttgagactt
     2041 aatttctcct aatttcttct gcccgaaggg taagtggtgc gtccagctta cacaatcata
     2101 attcaaaggt tggtgggcaa tgtaatactt aattaaaata atgatggaag agctatctgg
     2161 agattatgag taagctgatt tgaattttca gtataaaact ttagtataat tgtagtttgc
     2221 aaagtttatt tcagttcaca tgtaaggtat tgcaaataaa ttcttggaca attttgtatg
     2281 gaaacttgat attaaaaact agtctgtggt tctttgcagt ttcttgtaaa tttataaacc
     2341 aggcacaagg ttcaagttta gattttaagc acttttataa caatgataag tgcctttttg
     2401 gagatgtaac ttttagcagt ttgttaacct gacatctctg ccagtctagt ttctgggcag
     2461 gtttcctgtg tcagtattcc ccctcctctt tgcattaatc aaggtatttg gtagaggtgg
     2521 aatctaagtg tttgtatgtc caatttactt gcatatgtaa accattgctg tgccattcaa
     2581 tgtttgatgc ataattggac cttgaatcga taagtgtaaa tacagctttt gatctgtaat
     2641 gcttttatac aaaagtttat tttaataata aaatgtttgt tctaacttgt ctgctttttt
     2701 aaaaataatc ttactgtact taattctaat tttttcctca tatttaaata aaaggccatt
     2761 tccacctttt ctaaaaaa
//
