LOCUS       NP_114148                450 aa            linear   PRI 03-SEP-2024
DEFINITION  cell division cycle-associated protein 7 isoform 1 [Homo sapiens].
ACCESSION   NP_114148
VERSION     NP_114148.3
DBSOURCE    REFSEQ: accession NM_031942.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 450)
  AUTHORS   Hardikar,S., Ren,R., Ying,Z., Zhou,J., Horton,J.R., Bramble,M.D.,
            Liu,B., Lu,Y., Liu,B., Coletta,L.D., Shen,J., Dan,J., Zhang,X.,
            Cheng,X. and Chen,T.
  TITLE     The ICF syndrome protein CDCA7 harbors a unique DNA binding domain
            that recognizes a CpG dyad in the context of a non-B DNA
  JOURNAL   Sci Adv 10 (34), eadr0036 (2024)
   PUBMED   39178265
  REMARK    GeneRIF: The ICF syndrome protein CDCA7 harbors a unique DNA
            binding domain that recognizes a CpG dyad in the context of a non-B
            DNA.
REFERENCE   2  (residues 1 to 450)
  AUTHORS   Wan,Z. and Liu,G.
  TITLE     Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell
            malignant behaviors through miR-520f-3p/CDCA7 axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (7), 85-91 (2024)
   PUBMED   39097891
  REMARK    GeneRIF: Circ_0006220 (circ-TADA2A) accelerates prostate cancer
            cell malignant behaviors through miR-520f-3p/CDCA7 axis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 450)
  AUTHORS   Wang,Y., Zhao,Y., Zhang,Z., Zhang,J., Xu,Q., Zhou,X. and Mao,L.
  TITLE     High Expression of CDCA7 in the Prognosis of Glioma and Its
            Relationship with Ferroptosis and Immunity
  JOURNAL   Genes (Basel) 14 (7), 1406 (2023)
   PUBMED   37510310
  REMARK    GeneRIF: High Expression of CDCA7 in the Prognosis of Glioma and
            Its Relationship with Ferroptosis and Immunity.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 450)
  AUTHORS   Li,H., Wang,S., Li,X., Weng,Y., Guo,D., Kong,P., Cheng,C., Wang,Y.,
            Zhang,L., Cheng,X. and Cui,Y.
  TITLE     CDCA7 promotes TGF-beta-induced epithelial-mesenchymal transition
            via transcriptionally regulating Smad4/Smad7 in ESCC
  JOURNAL   Cancer Sci 114 (1), 91-104 (2023)
   PUBMED   36056599
  REMARK    GeneRIF: CDCA7 promotes TGF-beta-induced epithelial-mesenchymal
            transition via transcriptionally regulating Smad4/Smad7 in ESCC.
REFERENCE   5  (residues 1 to 450)
  AUTHORS   Cai,C., Peng,X. and Zhang,Y.
  TITLE     Downregulation of cell division cycle-associated protein 7 (CDCA7)
            suppresses cell proliferation, arrests cell cycle of ovarian
            cancer, and restrains angiogenesis by modulating enhancer of zeste
            homolog 2 (EZH2) expression
  JOURNAL   Bioengineered 12 (1), 7007-7019 (2021)
   PUBMED   34551671
  REMARK    GeneRIF: Downregulation of cell division cycle-associated protein 7
            (CDCA7) suppresses cell proliferation, arrests cell cycle of
            ovarian cancer, and restrains angiogenesis by modulating enhancer
            of zeste homolog 2 (EZH2) expression.
REFERENCE   6  (residues 1 to 450)
  AUTHORS   Gill,R.M., Gabor,T.V., Couzens,A.L. and Scheid,M.P.
  TITLE     The MYC-associated protein CDCA7 is phosphorylated by AKT to
            regulate MYC-dependent apoptosis and transformation
  JOURNAL   Mol Cell Biol 33 (3), 498-513 (2013)
   PUBMED   23166294
  REMARK    GeneRIF: CDCA7 associates with MYC and this association is
            modulated in a phosphorylation-dependent manner.
REFERENCE   7  (residues 1 to 450)
  AUTHORS   Goto,Y., Hayashi,R., Muramatsu,T., Ogawa,H., Eguchi,I., Oshida,Y.,
            Ohtani,K. and Yoshida,K.
  TITLE     JPO1/CDCA7, a novel transcription factor E2F1-induced protein,
            possesses intrinsic transcriptional regulator activity
  JOURNAL   Biochim Biophys Acta 1759 (1-2), 60-68 (2006)
   PUBMED   16580749
  REMARK    GeneRIF: JPO1/CDCA7 is a unique transcription regulator whose
            expression is activated by E2F1 as well as c-Myc.
REFERENCE   8  (residues 1 to 450)
  AUTHORS   Osthus,R.C., Karim,B., Prescott,J.E., Smith,B.D., McDevitt,M.,
            Huso,D.L. and Dang,C.V.
  TITLE     The Myc target gene JPO1/CDCA7 is frequently overexpressed in human
            tumors and has limited transforming activity in vivo
  JOURNAL   Cancer Res 65 (13), 5620-5627 (2005)
   PUBMED   15994934
REFERENCE   9  (residues 1 to 450)
  AUTHORS   Prescott,J.E., Osthus,R.C., Lee,L.A., Lewis,B.C., Shim,H.,
            Barrett,J.F., Guo,Q., Hawkins,A.L., Griffin,C.A. and Dang,C.V.
  TITLE     A novel c-Myc-responsive gene, JPO1, participates in neoplastic
            transformation
  JOURNAL   J Biol Chem 276 (51), 48276-48284 (2001)
   PUBMED   11598121
REFERENCE   10 (residues 1 to 450)
  AUTHORS   Walker,M.G.
  TITLE     Drug target discovery by gene expression analysis: cell cycle genes
  JOURNAL   Curr Cancer Drug Targets 1 (1), 73-83 (2001)
   PUBMED   12188893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY029179.1, DA531905.1,
            AC092573.2 and BC015124.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 28, 2006 this sequence version replaced NP_114148.2.
            
            Summary: This gene was identified as a c-Myc responsive gene, and
            behaves as a direct c-Myc target gene. Overexpression of this gene
            is found to enhance the transformation of lymphoblastoid cells, and
            it complements a transformation-defective Myc Box II mutant,
            suggesting its involvement in c-Myc-mediated cell transformation.
            Two alternatively spliced transcript variants encoding distinct
            isoforms have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.197646.1, AK027628.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306721.8/ ENSP00000306968.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     Protein         1..450
                     /product="cell division cycle-associated protein 7 isoform
                     1"
                     /note="c-Myc target JPO1; cell division cycle-associated
                     protein 7"
                     /calculated_mol_wt=51314
     Region          341..439
                     /region_name="zf-4CXXC_R1"
                     /note="Zinc-finger domain of monoamine-oxidase A repressor
                     R1; pfam10497"
                     /db_xref="CDD:463117"
     CDS             1..450
                     /gene="CDCA7"
                     /gene_synonym="ICF3; JPO1"
                     /coded_by="NM_031942.5:93..1445"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2252.1"
                     /db_xref="GeneID:83879"
                     /db_xref="HGNC:HGNC:14628"
                     /db_xref="MIM:609937"
ORIGIN      
        1 mdarrvpqkd lrvkknlkkf ryvklismet ssssddscds fasdnfantk pkfrsdisee
       61 lanvfyedsd nesfcgfses evqdvldhcg flqkprpdvt nelagifhad sddesfcgfs
      121 eseiqdgmrl qsvregcrtr sqcrhsgplr vamkfparst rgatnkkaes rqpsensvtd
      181 snsdsedesg mnflekraln ikqnkamlak lmselesfpg sfrgrhplpg sdsqsrrprr
      241 rtfpgvasrr nperrarplt rsrsrilgsl dalpmeeeee edkymlvrkr ktvdgymned
      301 dlprsrrsrs svtlphiirp veeiteeele nvcsnsreki ynrslgstch qcrqktidtk
      361 tncrnpdcwg vrgqfcgpcl rnrygeevrd alldpnwhcp pcrgicncsf crqrdgrcat
      421 gvlvylakyh gfgnvhaylk slkqefemqa
//
