LOCUS       NM_080668               2475 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cell division cycle associated 5 (CDCA5), transcript
            variant 1, mRNA.
ACCESSION   NM_080668
VERSION     NM_080668.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Xiong,Y., Shi,L., Li,L., Yang,W., Zhang,H., Zhao,X. and Shen,N.
  TITLE     CDCA5 accelerates progression of breast cancer by promoting the
            binding of E2F1 and FOXM1
  JOURNAL   J Transl Med 22 (1), 639 (2024)
   PUBMED   38978058
  REMARK    GeneRIF: CDCA5 accelerates progression of breast cancer by
            promoting the binding of E2F1 and FOXM1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Zhang,Q., Zhang,R., Li,Y. and Yang,X.
  TITLE     CDCA5 promoted cell invasion and migration by activating TGF-beta1
            pathway in human ovarian cancer cells
  JOURNAL   J Ovarian Res 17 (1), 68 (2024)
   PUBMED   38539247
  REMARK    GeneRIF: CDCA5 promoted cell invasion and migration by activating
            TGF-beta1 pathway in human ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Chen,X., Zhou,M., Ma,S., Wu,H. and Cai,H.
  TITLE     KLF5-mediated CDCA5 expression promotes tumor development and
            progression of epithelial ovarian carcinoma
  JOURNAL   Exp Cell Res 429 (1), 113645 (2023)
   PUBMED   37247719
  REMARK    GeneRIF: KLF5-mediated CDCA5 expression promotes tumor development
            and progression of epithelial ovarian carcinoma.
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Hu,H., Xiang,Y., Zhang,X.Y., Deng,Y., Wan,F.J., Huang,Y., Liao,X.H.
            and Zhang,T.C.
  TITLE     CDCA5 promotes the progression of breast cancer and serves as a
            potential prognostic biomarker
  JOURNAL   Oncol Rep 48 (4) (2022)
   PUBMED   36004470
  REMARK    GeneRIF: CDCA5 promotes the progression of breast cancer and serves
            as a potential prognostic biomarker.
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Huang,X., Huang,Y., Lv,Z., Wang,T., Feng,H., Wang,H., Du,S., Wu,S.,
            Shen,D., Wang,C., Li,H., Wang,B., Ma,X. and Zhang,X.
  TITLE     Loss of cell division cycle-associated 5 promotes cell apoptosis by
            activating DNA damage response in clear cell renal cell carcinoma
  JOURNAL   Int J Oncol 61 (1) (2022)
   PUBMED   35642672
  REMARK    GeneRIF: Loss of cell division cycleassociated 5 promotes cell
            apoptosis by activating DNA damage response in clear cell renal
            cell carcinoma.
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Schmitz,J., Watrin,E., Lenart,P., Mechtler,K. and Peters,J.M.
  TITLE     Sororin is required for stable binding of cohesin to chromatin and
            for sister chromatid cohesion in interphase
  JOURNAL   Curr Biol 17 (7), 630-636 (2007)
   PUBMED   17349791
  REMARK    GeneRIF: data indicate that sororin interacts with chromatin-bound
            cohesin and functions during the establishment or maintenance of
            cohesion in S or G2 phase, respectively
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 2475)
  AUTHORS   Rankin,S., Ayad,N.G. and Kirschner,M.W.
  TITLE     Sororin, a substrate of the anaphase-promoting complex, is required
            for sister chromatid cohesion in vertebrates
  JOURNAL   Mol Cell 18 (2), 185-200 (2005)
   PUBMED   15837422
  REMARK    Erratum:[Mol Cell. 2005 May 27;18(5):609]
REFERENCE   9  (bases 1 to 2475)
  AUTHORS   Walker,M.G.
  TITLE     Drug target discovery by gene expression analysis: cell cycle genes
  JOURNAL   Curr Cancer Drug Targets 1 (1), 73-83 (2001)
   PUBMED   12188893
REFERENCE   10 (bases 1 to 2475)
  AUTHORS   Fallone,C.A.
  TITLE     Epidemiology of the antibiotic resistance of Helicobacter pylori in
            Canada
  JOURNAL   Can J Gastroenterol 14 (10), 879-882 (2000)
   PUBMED   11111111
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC011000.2 and AP003068.3.
            
            On Nov 24, 2018 this sequence version replaced NM_080668.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011000.2, BG354578.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275517.8/ ENSP00000275517.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BC011000.2         13-70
            59-108              AP003068.3         43999-44048         c
            109-203             AP003068.3         43695-43789         c
            204-269             AP003068.3         43551-43616         c
            270-305             AP003068.3         43430-43465         c
            306-740             AP003068.3         39419-39853         c
            741-2442            AP003068.3         37552-39253         c
            2443-2473           BC011000.2         2454-2484
            2474-2475           AP003068.3         37519-37520         c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2475
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /note="cell division cycle associated 5"
                     /db_xref="GeneID:113130"
                     /db_xref="HGNC:HGNC:14626"
                     /db_xref="MIM:609374"
     exon            1..108
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..821
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /note="isoform 1 is encoded by transcript variant 1; p35;
                     cell division cycle-associated protein 5"
                     /codon_start=1
                     /product="sororin isoform 1"
                     /protein_id="NP_542399.1"
                     /db_xref="CCDS:CCDS8091.1"
                     /db_xref="GeneID:113130"
                     /db_xref="HGNC:HGNC:14626"
                     /db_xref="MIM:609374"
                     /translation="MSGRRTRSGGAAQRSGPRAPSPTKPLRRSQRKSGSELPSILPEI
                     WPKTPSAAAVRKPIVLKRIVAHAVEVPAVQSPRRSPRISFFLEKENEPPGRELTKEDL
                     FKTHSVPATPTSTPVPNPEAESSSKEGELDARDLEMSKKVRRSYSRLETLGSASTSTP
                     GRRSCFGFEGLLGAEDLSGVSPVVCSKLTEVPRVCAKPWAPDMTLPGISPPPEKQKRK
                     KKKMPEILKTELDEWAAAMNAEFEAAEQFDLLVE"
     exon            109..203
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /inference="alignment:Splign:2.1.0"
     exon            204..269
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /inference="alignment:Splign:2.1.0"
     exon            270..305
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /inference="alignment:Splign:2.1.0"
     exon            306..740
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /inference="alignment:Splign:2.1.0"
     exon            741..2475
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2453..2458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /note="hexamer: ATTAAA"
     polyA_site      2475
                     /gene="CDCA5"
                     /gene_synonym="SORORIN"
                     /note="major polyA site"
ORIGIN      
        1 cttcccggtt ggcgcgcgcc cggggcggcg gcgctggagg agctcgagac ggagcctaag
       61 ttatgtctgg gaggcgaacg cggtccggag gagccgctca gcgctccggg ccaagggccc
      121 catctcctac taagcctctg cggaggtccc agcggaaatc aggctctgaa ctcccgagca
      181 tcctccctga aatctggccg aagacaccca gtgcggctgc agtcagaaag cccatcgtct
      241 taaagaggat cgtggcccat gctgtagagg tcccagctgt ccaatcacct cgcaggagcc
      301 ctaggatttc ctttttcttg gagaaagaaa acgagccccc tggcagggag cttactaagg
      361 aggacctttt caagacacac agcgtccctg ccacccccac cagcactcct gtgccgaacc
      421 ctgaggccga gtccagctcc aaggaaggag agctggacgc cagagacttg gaaatgtcta
      481 agaaagtcag gcgttcctac agccggctgg agaccctggg ctctgcctct acctccaccc
      541 caggccgccg gtcctgcttt ggcttcgagg ggctgctggg ggcagaagac ttgtccggag
      601 tctcgccagt ggtgtgctcc aaactcaccg aggtccccag ggtttgtgca aagccctggg
      661 ccccagacat gactctccct ggaatctccc caccacccga gaaacagaaa cgtaagaaga
      721 agaaaatgcc agagatcttg aaaacggagc tggatgagtg ggctgcggcc atgaatgccg
      781 agtttgaagc tgctgagcag tttgatctcc tggttgaatg agatgcagtg gggggtgcac
      841 ctggccagac tctccctcct gtcctgtaca tagccacctc cctgtggaga ggacacttag
      901 ggtcccctcc cctggtcttg ttacctgtgt gtgtgctggt gctgcgcatg aggactgtct
      961 gcctttgagg gcttgggcag cagcggcagc catcttggtt ttaggaaatg gggccgcctg
     1021 gcccagccac tcactggtgt cctgtctctt gtcgtcctgt ccttcctatc tccccaaagt
     1081 accatagcca gtttccagat gggccacaga ctggggagga gaatcagtgg cccagccaga
     1141 agttaaaggg ctgagggttg aggtgagagg cacctctgct cttgttggga ggggtggctg
     1201 cttggaaata ggcccagggg ctctgccagc ctcggcctct ccctcctgag ttgccttctg
     1261 ttggtggctt tcttcttgaa cccacctgtg taaagaggtt ttcagttccg tgggtttccc
     1321 ctttgattct gtaaatagtc ccagagagaa ttcgtgggct gagggcaatt ctgtcttgga
     1381 ggaagaagct ggacattcag cctgtggagt ctgagttttg aaggatgtag ggagccttag
     1441 ttgggtctca gaccataagt gtgtactaca cagaagctgt gttttctagt tctggtctgc
     1501 tgttgagatg tttggtaaat gccaggttga tagggcgctg gctgcttgga gcaaagggtg
     1561 catttcaggg tgtggccacc aggtgctgtg agtttctgtg gctcatggcc tctgggctgg
     1621 tcccttgcac agggcccacg ctggagtctt accactctgc tgcaggggtg gaaggtggcc
     1681 cctcttgtca cccataccca tttcttacaa aataagttac accgagtcta cttggcccta
     1741 gaagagaaag ttgaagagtc ccagacctac tagcattttg caactatgct tgtaaagtcc
     1801 tcggaaagtt tcctcgcgta ccagacagcg gcgggggctg atagcaattt tagtttttgg
     1861 cctccctatc ctctcacatg agaacactgc ctggatgcat ctcatgatct ctggagaatt
     1921 tccccatctt tctcttcttt ccatcgtgtg gattcaatag tgtggatttg aaggctgccc
     1981 tgcccccgac tctcctgccg cacccctggc cattgtacct tttgatgttt agaagttcgt
     2041 ggaagtagac gctgaggtgt gcagaggagc tggtggataa cagagaatgc cagggaagat
     2101 gagtgctggg tcagggtact tggatgaaac ggtgcaggcc aggcgggccc taataaaacc
     2161 ctctgccagg tctgggagtc ccaggccatc tgctcaacgc tctgtggttt gtcagacctg
     2221 caagcaagcc ccctgctggg gaagcctagg tgtccttgag ctgaaccgca ctgaagaact
     2281 cttgtcctca ctggctgatg cagcagaact cttgggaaat gtcttagtcc tgcagaatca
     2341 ggagtcacca gatgatgcag agttgagatc atcattgcaa agttctctgt tcctgaggaa
     2401 ctaaatttaa ggaaaaaatg ggattttgtt ttagagttgg aaaaaaagcc tgattaaaga
     2461 gtttctgcct gttca
//
