LOCUS       NM_017955               2448 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cell division cycle associated 4 (CDCA4), transcript
            variant 1, mRNA.
ACCESSION   NM_017955
VERSION     NM_017955.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Tan,J., Chen,F., Wang,J., Li,J., Ouyang,B., Li,X., Li,Y., Zhang,W.
            and Jiang,Y.
  TITLE     ALKBH5 promotes the development of lung adenocarcinoma by
            regulating the polarization of M2 macrophages through CDCA4
  JOURNAL   Gene 895, 147975 (2024)
   PUBMED   37949419
  REMARK    GeneRIF: ALKBH5 promotes the development of lung adenocarcinoma by
            regulating the polarization of M2 macrophages through CDCA4.
REFERENCE   2  (bases 1 to 2448)
  AUTHORS   Feng,S., Cao,H., Sui,Y., Shen,Z., Wu,J., Ma,R. and Feng,J.
  TITLE     CDCA4 interacts with IGF2BP1 to regulate lung adenocarcinoma
            proliferation via the PI3K/AKT pathway
  JOURNAL   Thorac Cancer 14 (8), 724-735 (2023)
   PUBMED   36737405
  REMARK    GeneRIF: CDCA4 interacts with IGF2BP1 to regulate lung
            adenocarcinoma proliferation via the PI3K/AKT pathway.
REFERENCE   3  (bases 1 to 2448)
  AUTHORS   Fang,H., Sheng,S., Chen,B., Wang,J., Mao,D., Han,Y., Liu,Y.,
            Wang,X., Gui,S., Zhang,T., Zhang,L., Li,C., Hu,X., Deng,W., Liu,X.,
            Xu,H., Xu,W., Wang,X., Liu,R. and Kong,W.
  TITLE     A Pan-Cancer Analysis of the Oncogenic Role of Cell Division
            Cycle-Associated Protein 4 (CDCA4) in Human Tumors
  JOURNAL   Front Immunol 13, 826337 (2022)
   PUBMED   35251007
  REMARK    GeneRIF: A Pan-Cancer Analysis of the Oncogenic Role of Cell
            Division Cycle-Associated Protein 4 (CDCA4) in Human Tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2448)
  AUTHORS   Zhang,J., Xia,S., Liu,X., Qi,D., He,X. and Chen,D.
  TITLE     STAT1 Mediates the Transcription of CircIFI30 and Promotes the
            Progression of Triple-Negative Breast Cancer by Up-Regulating CDCA4
  JOURNAL   J Environ Pathol Toxicol Oncol 41 (1), 1-13 (2022)
   PUBMED   35378000
  REMARK    GeneRIF: STAT1 Mediates the Transcription of CircIFI30 and Promotes
            the Progression of Triple-Negative Breast Cancer by Up-Regulating
            CDCA4.
REFERENCE   5  (bases 1 to 2448)
  AUTHORS   Hu,J., Xiang,X., Guan,W., Lou,W., He,J., Chen,J., Fu,Y. and Lou,G.
  TITLE     MiR-497-5p down-regulates CDCA4 to restrains lung squamous cell
            carcinoma progression
  JOURNAL   J Cardiothorac Surg 16 (1), 330 (2021)
   PUBMED   34772428
  REMARK    GeneRIF: MiR-497-5p down-regulates CDCA4 to restrains lung squamous
            cell carcinoma progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2448)
  AUTHORS   Tategu,M., Nakagawa,H., Hayashi,R. and Yoshida,K.
  TITLE     Transcriptional co-factor CDCA4 participates in the regulation of
            JUN oncogene expression
  JOURNAL   Biochimie 90 (10), 1515-1522 (2008)
   PUBMED   18572021
  REMARK    GeneRIF: an important role of CDCA4 in the context of
            transcriptional regulation and cell fate determination through the
            JUN oncogene
REFERENCE   7  (bases 1 to 2448)
  AUTHORS   Wang,L., Zhu,G., Yang,D., Li,Q., Li,Y., Xu,X., He,D. and Zeng,C.
  TITLE     The spindle function of CDCA4
  JOURNAL   Cell Motil Cytoskeleton 65 (7), 581-593 (2008)
   PUBMED   18498124
  REMARK    GeneRIF: Data suggest that CDCA4 is involved in spindle
            organization from prometaphase, and when anaphase begins, it may
            play a different role as a midzone factor involved in chromosome
            segregation or cytokinesis.
REFERENCE   8  (bases 1 to 2448)
  AUTHORS   Hayashi,R., Goto,Y., Ikeda,R., Yokoyama,K.K. and Yoshida,K.
  TITLE     CDCA4 is an E2F transcription factor family-induced nuclear factor
            that regulates E2F-dependent transcriptional activation and cell
            proliferation
  JOURNAL   J Biol Chem 281 (47), 35633-35648 (2006)
   PUBMED   16984923
  REMARK    GeneRIF: CDCA4 participates in the regulation of cell
            proliferation, mainly through the E2F/retinoblastoma protein
            pathway
REFERENCE   9  (bases 1 to 2448)
  AUTHORS   Walker,M.G.
  TITLE     Drug target discovery by gene expression analysis: cell cycle genes
  JOURNAL   Curr Cancer Drug Targets 1 (1), 73-83 (2001)
   PUBMED   12188893
REFERENCE   10 (bases 1 to 2448)
  AUTHORS   Abdullah,J.M., Jing,X., Spassov,D.S., Nachtman,R.G. and Jurecic,R.
  TITLE     Cloning and characterization of Hepp, a novel gene expressed
            preferentially in hematopoietic progenitors and mature blood cells
  JOURNAL   Blood Cells Mol Dis 27 (3), 667-676 (2001)
   PUBMED   11482882
  REMARK    GeneRIF: Isolation of the mouse ortholog and comparison to the
            human protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN427719.1, AF322239.1,
            AL512802.2 and BG354577.1.
            
            On May 17, 2019 this sequence version replaced NM_017955.3.
            
            Summary: This gene encodes a protein that belongs to the E2F family
            of transcription factors. This protein regulates E2F-dependent
            transcriptional activation and cell proliferation, mainly through
            the E2F/retinoblastoma protein pathway. It also functions in the
            regulation of JUN oncogene expression. This protein shows
            distinctive nuclear-mitotic apparatus distribution, it is involved
            in spindle organization from prometaphase, and may also play a role
            as a midzone factor involved in chromosome segregation or
            cytokinesis. Two alternatively spliced transcript variants encoding
            the same protein have been noted for this gene. Two pseudogenes
            have also been identified on chromosome 1. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG354577.1, SRR1660809.107568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336219.4/ ENSP00000337226.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                CN427719.1         29-73
            46-2080             AF322239.1         29-2063
            2081-2371           AL512802.2         90957-91247         c
            2372-2448           BG354577.1         2371-2447
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2448
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
                     /note="cell division cycle associated 4"
                     /db_xref="GeneID:55038"
                     /db_xref="HGNC:HGNC:14625"
                     /db_xref="MIM:612270"
     exon            1..85
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            86..2448
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..817
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
                     /note="hematopoietic progenitor protein"
                     /codon_start=1
                     /product="cell division cycle-associated protein 4"
                     /protein_id="NP_060425.2"
                     /db_xref="CCDS:CCDS9996.1"
                     /db_xref="GeneID:55038"
                     /db_xref="HGNC:HGNC:14625"
                     /db_xref="MIM:612270"
                     /translation="MFARGLKRKCVGHEEDVEGALAGLKTVSSYSLQRQSLLDMSLVK
                     LQLCHMLVEPNLCRSVLIANTVRQIQEEMTQDGTWRTVAPQAAERAPLDRLVSTEILC
                     RAAWGQEGAHPAPGLGDGHTQGPVSDLCPVTSAQAPRHLQSSAWEMDGPRENRGSFHK
                     SLDQIFETLETKNPSCMEELFSDVDSPYYDLDTVLTGMMGGARPGPCEGLEGLAPATP
                     GPSSSCKSDLGELDHVVEILVET"
     regulatory      1272..1277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
                     /note="hexamer: TATAAA"
     polyA_site      1315
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
                     /note="major polyA site"
     polyA_site      1318
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
     polyA_site      1442
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="CDCA4"
                     /gene_synonym="HEPP; SEI-3/HEPP"
ORIGIN      
        1 gctccttcct cagcggcggg aagctggcgg cagcggcggt ggcggtggct gagcagagga
       61 cccggcgggc ggcctcgcgg gtcaggacac aatgtttgca cgaggactga agaggaaatg
      121 tgttggccac gaggaagacg tggagggagc cctggccggc ttgaagacag tgtcctcata
      181 cagcctgcag cggcagtcgc tcctggacat gtctctggtg aagttgcagc tttgccacat
      241 gcttgtggag cccaacctgt gccgctcagt cctcattgcc aacacggtcc ggcagatcca
      301 agaggagatg acgcaggatg ggacgtggcg cacagtggca ccccaggctg cagagcgggc
      361 gccgctcgac cgcttggtct ccacggagat cctgtgccgt gcagcgtggg ggcaagaggg
      421 ggcacatcct gctcctggct tgggggacgg ccacacacag ggtccagttt ctgacctttg
      481 cccagtcacc tcagcacagg caccaaggca cctgcagagc agcgcctggg agatggatgg
      541 ccctcgagaa aacagaggaa gctttcacaa gtcacttgat cagatatttg aaacgctgga
      601 gactaaaaac cccagctgca tggaagagct gttctcagac gtggacagcc cctactacga
      661 cctggacaca gtactgacag gcatgatggg gggtgccagg ccgggcccct gcgaagggct
      721 cgagggcttg gctccggcca ccccaggccc tagctccagc tgcaagtccg acctgggcga
      781 gctggaccac gtggtggaga tcctggtgga gacctgagca ggagccctga gtgctcacag
      841 ccgcctctga cgcattgaca cgtgagcact ggctcccacg gagggtgcgc ctgccgccag
      901 cggcccagcc ttgctgccct gtctgctgat tctgagaaat cccagaacag cccattacca
      961 gtggggctgc agccctaggc ccgtcccact cacctccccc ctgtggagcg ccaggcagag
     1021 gctgttctgg aaggcttctt gtcttctgac gtccccacag ccctgggccc ctcgtgtctc
     1081 tttgtgtccc ccactgtaga ggacggtgag ccgcagctgc atcaacctcc ttttaccttt
     1141 agataggtga atttttacaa ttcagtttta catgttttgg gcagtatttt gtcttaagat
     1201 atatttttta aactttttat accttatctc tttagatttt ttcagctatt ttcttaaaag
     1261 tatatttttt ctataaacat cctttgctgc tacattagaa cttttatagc ctaaacaatt
     1321 gcagttggtg tgtttcattt ttttaaggtt taaataaggg ttttttgttt tgttttgttt
     1381 tttgcagtga gcatcactac agtctcagtc aacagtgtga atgtatcatg ttttacttta
     1441 aatgtgtgtg tgatacttct tcattatgtc ctgcgctgca gtgagacctg ggtgaaaatc
     1501 aggagccgca cacagccaca tcttcctaga cctaagagta aattatggag gattttattt
     1561 atgtctattt atatgtaaat gtcattgaag acaaaggtca aatatttgtc tgtttgtaga
     1621 tcacaggcac cagttggtct tcagggacct catagcccct cggtggtgcc ttctcaaggc
     1681 agtgttcctg gaggctccca tcagggtcag cccatgcacc tgccctgggt gaggaagtag
     1741 cattgctgct ggatgagaaa cgcctgcgct gctctgttag actggtgctg aaacaaaagg
     1801 ttaaggctag gttgaagtct agaatgaaag aaatctgaat ccatgtcatt cataacccct
     1861 tgatctgtag tgtcatgggt gctgccgcag gcagggagtg agctgggggt gcctgcagcc
     1921 ttccactcct gccccgcctc accccacatg ctccctgttt ctcatgcttt ctctaacttc
     1981 ctcacccctt aaccaaaaag gtgtgttttc ttttgtgcat atagccattc ttaaatatca
     2041 gtgatgtaaa cctcacttta ttaaaaaatt atccagcaaa caaaatggga atgtggtgtt
     2101 agttacgacc acggcctgac cctccagcaa cctttctgca ggatcagttc tgctgtatta
     2161 tctggtggtg ctttctaagg tggggaaagg aattgcactt ggctgcatta aatggacgct
     2221 gggttacttt tatttccccc ccccacaggg ttgcagagca aattcttttt acattgttca
     2281 gcgcccggct ggagttgggg gtgtccacga cctctgacag cccccgatgt cgaaagttaa
     2341 tcctcatgga ccctagttta aagggtatgt gttttatagg aataaatcta aagcactatt
     2401 ttgtttctgt atagcatttt tatcttttag aaacatcatt tgttcagc
//
