LOCUS       NM_031299               1144 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cell division cycle associated 3 (CDCA3), transcript
            variant 1, mRNA.
ACCESSION   NM_031299
VERSION     NM_031299.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Zhang,H., Zheng,Y., Yu,L., Liu,M. and Zhang,Y.
  TITLE     Identification of circ_0038632 as a Promoter of Breast Cancer
            through miR-520a-3p-Dependent Modulation of CDCA3
  JOURNAL   Ann Clin Lab Sci 53 (4), 562-572 (2023)
   PUBMED   37625824
  REMARK    GeneRIF: Identification of circ_0038632 as a Promoter of Breast
            Cancer through miR-520a-3p-Dependent Modulation of CDCA3.
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Gong,S., Bai,B., Sun,G., Jin,H. and Zhang,Z.
  TITLE     CDCA3 exhibits a role in promoting the progression of ovarian
            cancer
  JOURNAL   Tissue Cell 79, 101903 (2022)
   PUBMED   36081320
  REMARK    GeneRIF: CDCA3 exhibits a role in promoting the progression of
            ovarian cancer.
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Liu,W., Shen,D., Ju,L., Zhang,R., Du,W., Jin,W., Xiong,K., Wang,G.,
            Qian,K., Zhang,Y., Xiao,Y. and Wang,X.
  TITLE     MYBL2 promotes proliferation and metastasis of bladder cancer
            through transactivation of CDCA3
  JOURNAL   Oncogene 41 (41), 4606-4617 (2022)
   PUBMED   36071275
  REMARK    GeneRIF: MYBL2 promotes proliferation and metastasis of bladder
            cancer through transactivation of CDCA3.
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Luo,J., Xia,L., Zhang,L., Zhao,K. and Li,C.
  TITLE     MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and
            apoptosis of lung adenocarcinoma cells
  JOURNAL   Mutat Res 825, 111798 (2022)
   PUBMED   36087462
  REMARK    GeneRIF: MiRNA-144-5p down-modulates CDCA3 to regulate
            proliferation and apoptosis of lung adenocarcinoma cells.
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Wang,Y., Liu,Y., Zhang,T., Guan,G., Mao,T., Liu,H., Zhang,J., Lu,F.
            and Chen,X.
  TITLE     LncCDCA3L inhibits cell proliferation via a novel RNA
            structure-based crosstalk with CDCA3 in hepatocellular carcinoma
  JOURNAL   Liver Int 42 (6), 1432-1446 (2022)
   PUBMED   35230745
  REMARK    GeneRIF: LncCDCA3L inhibits cell proliferation via a novel RNA
            structure-based crosstalk with CDCA3 in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Chen,J., Zhu,S., Jiang,N., Shang,Z., Quan,C. and Niu,Y.
  TITLE     HoxB3 promotes prostate cancer cell progression by transactivating
            CDCA3
  JOURNAL   Cancer Lett 330 (2), 217-224 (2013)
   PUBMED   23219899
  REMARK    GeneRIF: HoxB3 promote prostate cancer progression by upregulating
            CDCA3 expression.
REFERENCE   7  (bases 1 to 1144)
  AUTHORS   Uchida,F., Uzawa,K., Kasamatsu,A., Takatori,H., Sakamoto,Y.,
            Ogawara,K., Shiiba,M., Tanzawa,H. and Bukawa,H.
  TITLE     Overexpression of cell cycle regulator CDCA3 promotes oral cancer
            progression by enhancing cell proliferation with prevention of G1
            phase arrest
  JOURNAL   BMC Cancer 12, 321 (2012)
   PUBMED   22839099
  REMARK    GeneRIF: overexpression of CDCA3 occurs frequently during oral
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1144)
  AUTHORS   Yoshida,K.
  TITLE     Cell-cycle-dependent regulation of the human and mouse Tome-1
            promoters
  JOURNAL   FEBS Lett 579 (6), 1488-1492 (2005)
   PUBMED   15733861
  REMARK    GeneRIF: a repressor element (cell-cycle-dependent element/cell
            cycle gene homology region) in the vicinity of the transcription
            start site, and mutations within this element diminished the
            cell-cycle-dependent transcriptional regulation of Tome-1
REFERENCE   9  (bases 1 to 1144)
  AUTHORS   Ayad,N.G., Rankin,S., Murakami,M., Jebanathirajah,J., Gygi,S. and
            Kirschner,M.W.
  TITLE     Tome-1, a trigger of mitotic entry, is degraded during G1 via the
            APC
  JOURNAL   Cell 113 (1), 101-113 (2003)
   PUBMED   12679038
REFERENCE   10 (bases 1 to 1144)
  AUTHORS   Ansari-Lari,M.A., Muzny,D.M., Lu,J., Lu,F., Lilley,C.E., Spanos,S.,
            Malley,T. and Gibbs,R.A.
  TITLE     A gene-rich cluster between the CD4 and triosephosphate isomerase
            genes at human chromosome 12p13
  JOURNAL   Genome Res 6 (4), 314-326 (1996)
   PUBMED   8723724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U47924.1 and AK291421.1.
            
            On May 21, 2020 this sequence version replaced NM_031299.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002551.2, AK312843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538862.7/ ENSP00000442068.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                U47924.1           63280-63296         c
            18-1144             AK291421.1         1-1127
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1144
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /note="cell division cycle associated 3"
                     /db_xref="GeneID:83461"
                     /db_xref="HGNC:HGNC:14624"
                     /db_xref="MIM:607749"
     exon            1..65
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..242
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..929
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle-associated protein 3; gene-rich cluster
                     protein C8; trigger of mitotic entry protein 1"
                     /codon_start=1
                     /product="cell division cycle-associated protein 3 isoform
                     1"
                     /protein_id="NP_112589.1"
                     /db_xref="CCDS:CCDS8565.1"
                     /db_xref="GeneID:83461"
                     /db_xref="HGNC:HGNC:14624"
                     /db_xref="MIM:607749"
                     /translation="MGSAKSVPVTPARPPPHNKHLARVADPRSPSAGILRTPIQVESS
                     PQPGLPAGEQLEGLKHAQDSDPRSPTLGIARTPMKTSSGDPPSPLVKQLSEVFETEDS
                     KSNLPPEPVLPPEAPLSSELDLPLGTQLSVEEQMPPWNQTEFPSKQVFSKEEARQPTE
                     TPVASQSSDKPSRDPETPRSSGSMRNRWKPNSSKVLGRSPLTILQDDNSPGTLTLRQG
                     KRPSPLSENVSELKEGAILGTGRLLKTGGRAWEQGQDHDKENQHFPLVES"
     exon            243..372
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..666
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..773
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..1144
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1106..1111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /note="hexamer: ATTAAA"
     polyA_site      1144
                     /gene="CDCA3"
                     /gene_synonym="GRCC8; TOME-1; TOME1"
                     /note="major polyA site"
ORIGIN      
        1 gaaactggta acttcgggag ttgagccacg agctgttgtg catccagagg tggaattggg
       61 gcccggcatt ccctcctcgt cccgggctgg cccttgcccc caccctgcaa ctcctggttg
      121 agatgggctc agccaagagc gtcccagtca caccagcgcg gcctccgccg cacaacaagc
      181 atctggctcg agtggcggac ccccgttcac ctagtgctgg catcctgcgc actcccatcc
      241 aggtggagag ctctccacag ccaggcctac cagcagggga gcaactggag ggtcttaaac
      301 atgcccagga ctcagatccc cgctctccta ctcttggtat tgcacggaca cctatgaaga
      361 ccagcagtgg agacccccca agcccactgg tgaaacagct gagtgaagta tttgaaactg
      421 aagactctaa atcaaatctt cccccagagc ctgttctgcc cccagaggca cctttatctt
      481 ctgaattgga cttgcctctg ggtacccagt tatctgttga ggaacagatg ccaccttgga
      541 accagactga gttcccctcc aaacaggtgt tttccaagga ggaagcaaga cagcccacag
      601 aaacccctgt ggccagccag agctccgaca agccctcaag ggaccctgag actcccagat
      661 cttcaggttc tatgcgcaat agatggaaac caaacagcag caaggtacta gggagatccc
      721 ccctcaccat cctgcaggat gacaactccc ctggcaccct gacactacga cagggtaagc
      781 ggccttcacc cctaagtgaa aatgttagtg aactaaagga aggagccatt cttggaactg
      841 gacgacttct gaaaactgga ggacgagcat gggagcaagg ccaggaccat gacaaggaaa
      901 atcagcactt tcccttggtg gagagctagg ccctgcatgg ccccagcaat gcagtcaccc
      961 agggcctggt gatatctgtg tcctctcacc ccttctttcc cagggatact gaggaatggc
     1021 ttgttttctt agactcctcc tcagctacca aactgggact cacagcttta ttgggctttc
     1081 tttgtgtctt gtgtgtttct tttatattaa aggaagtaat tttaaatgtt actttaaaaa
     1141 ggta
//
