LOCUS       NM_152562               3486 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens cell division cycle associated 2 (CDCA2), transcript
            variant 1, mRNA.
ACCESSION   NM_152562 XM_372034
VERSION     NM_152562.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3486)
  AUTHORS   Lin,X., Zou,Z., Zhong,J., Wang,T., Ma,W., Hu,T., Sun,W., Xu,Y.,
            Eggermont,A.M.M. and Chen,Y.
  TITLE     The Role of CDCA2 in tumor genesis, prognosis and future treatments
  JOURNAL   Eur J Cancer 211, 114308 (2024)
   PUBMED   39288736
  REMARK    GeneRIF: The Role of CDCA2 in tumor genesis, prognosis and future
            treatments.
            Review article
REFERENCE   2  (bases 1 to 3486)
  AUTHORS   Li,W., Lv,D., Yao,J., Chen,B., Liu,H., Li,W., Xu,C. and Li,Z.
  TITLE     A pan-cancer analysis reveals the diagnostic and prognostic role of
            CDCA2 in low-grade glioma
  JOURNAL   PLoS One 18 (9), e0291024 (2023)
   PUBMED   37733705
  REMARK    GeneRIF: A pan-cancer analysis reveals the diagnostic and
            prognostic role of CDCA2 in low-grade glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3486)
  AUTHORS   Sun,W., Jin,Y., Wei,C., Xu,Y., Liu,W., Zhong,J., Zou,Z., Lin,X.,
            Xiang,Y. and Chen,Y.
  TITLE     CDCA2 promotes melanoma progression by inhibiting
            ubiquitin-mediated degradation of Aurora kinase A
  JOURNAL   Eur J Cancer 188, 49-63 (2023)
   PUBMED   37196484
  REMARK    GeneRIF: CDCA2 promotes melanoma progression by inhibiting
            ubiquitin-mediated degradation of Aurora kinase A.
REFERENCE   4  (bases 1 to 3486)
  AUTHORS   Xiao,F., Jie,X., Zhou,X., Guo,Y., Sun,G.F., Lin,L., Hu,G.W.,
            Huang,K. and Guo,H.
  TITLE     PPP1R81 correlates with the survival and cell proliferation in
            lower-grade glioma
  JOURNAL   Biosci Rep 43 (5) (2023)
   PUBMED   37083601
  REMARK    GeneRIF: PPP1R81 correlates with the survival and cell
            proliferation in lower-grade glioma.
REFERENCE   5  (bases 1 to 3486)
  AUTHORS   Li,K., Fan,T., Shi,Z. and Jiang,H.
  TITLE     CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway
  JOURNAL   Anal Cell Pathol (Amst) 2022, 9912254 (2022)
   PUBMED   36588796
  REMARK    GeneRIF: CDCA2 Promotes HCC Cells Development via AKT-mTOR Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3486)
  AUTHORS   Vagnarelli,P.
  TITLE     Repo-man at the intersection of chromatin remodelling, DNA repair,
            nuclear envelope organization, and cancer progression
  JOURNAL   Adv Exp Med Biol 773, 401-414 (2014)
   PUBMED   24563358
  REMARK    Review article
REFERENCE   7  (bases 1 to 3486)
  AUTHORS   Qian,J., Lesage,B., Beullens,M., Van Eynde,A. and Bollen,M.
  TITLE     PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and
            regulates chromosomal aurora B targeting
  JOURNAL   Curr Biol 21 (9), 766-773 (2011)
   PUBMED   21514157
  REMARK    GeneRIF: Repo-Man promotes H3T11ph dephosphorylation by an indirect
            mechanism but directly and specifically targets H3T3ph for
            dephosphorylation by associated PP1gamma.
REFERENCE   8  (bases 1 to 3486)
  AUTHORS   Peng,A., Lewellyn,A.L., Schiemann,W.P. and Maller,J.L.
  TITLE     Repo-man controls a protein phosphatase 1-dependent threshold for
            DNA damage checkpoint activation
  JOURNAL   Curr Biol 20 (5), 387-396 (2010)
   PUBMED   20188555
  REMARK    GeneRIF: This study reports essential DNA damage response
            regulation mediated by Repo-Man-protein phosphatase 1 and further
            delineate underlying mechanisms.
REFERENCE   9  (bases 1 to 3486)
  AUTHORS   Trinkle-Mulcahy,L., Andersen,J., Lam,Y.W., Moorhead,G., Mann,M. and
            Lamond,A.I.
  TITLE     Repo-Man recruits PP1 gamma to chromatin and is essential for cell
            viability
  JOURNAL   J Cell Biol 172 (5), 679-692 (2006)
   PUBMED   16492807
  REMARK    GeneRIF: Repo-Man forms an essential complex with protein
            phosphatase 1 (PP1) gamma and is required for the recruitment of
            PP1 to chromatin
REFERENCE   10 (bases 1 to 3486)
  AUTHORS   Walker,M.G.
  TITLE     Drug target discovery by gene expression analysis: cell cycle genes
  JOURNAL   Curr Cancer Drug Targets 1 (1), 73-83 (2001)
   PUBMED   12188893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299278.1, BC015691.2,
            AL833396.1, AA678348.1 and AI022757.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152562.3.
            
            Summary: This gene encodes a targeting subunit of the cell-cycle
            associated protein, protein phosphatase 1, with a role in targeting
            this protein to chromatin during anaphase. These two proteins
            comprise a phosphatase complex that is involved in nuclear envelope
            reformation and regulation of the DNA damage response. The encoded
            protein may also play a role in cancer progression. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.60662.1, BC015691.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330560.8/ ENSP00000328228.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AK299278.1         9-398
            391-2320            BC015691.2         376-2305
            2321-3449           AL833396.1         1728-2856
            3450-3477           AA678348.1         15-42               c
            3478-3486           AI022757.1         7-15                c
FEATURES             Location/Qualifiers
     source          1..3486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..3486
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /note="cell division cycle associated 2"
                     /db_xref="GeneID:157313"
                     /db_xref="HGNC:HGNC:14623"
                     /db_xref="MIM:618785"
     exon            1..241
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..3313
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle-associated protein 2; recruits PP1 onto
                     mitotic chromatin at anaphase protein; protein phosphatase
                     1, regulatory subunit 81"
                     /codon_start=1
                     /product="cell division cycle-associated protein 2 isoform
                     1"
                     /protein_id="NP_689775.2"
                     /db_xref="CCDS:CCDS6049.1"
                     /db_xref="GeneID:157313"
                     /db_xref="HGNC:HGNC:14623"
                     /db_xref="MIM:618785"
                     /translation="MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPN
                     PCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETN
                     HLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEK
                     MTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAE
                     GKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALK
                     VADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKP
                     SVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKR
                     VTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDD
                     KGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSN
                     RRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKK
                     GKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLE
                     EVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNI
                     MNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFS
                     AGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLI
                     ENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSV
                     GSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPS
                     TSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPG
                     KRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ"
     exon            242..302
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            303..473
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            474..628
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            629..779
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            780..976
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1061
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1273
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1361
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1606
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1685
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1774
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1912
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2084
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..3486
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3425..3430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /note="hexamer: AATAAA"
     polyA_site      3449
                     /gene="CDCA2"
                     /gene_synonym="PPP1R81; Repo-Man"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggct gccgggcaga gcgcaggcca ggatcagcgc aggctgtgag tccaggtcag
       61 ccgtcgggac ctcgggctcc gggttcgaag agcggctccc ggctgcgggt gctttgccag
      121 gagagccctt ccggacagag gagccggggt ctggaaggag cggccgacgc gacgctcgcc
      181 tgccacgggg ctctgggagt aagcctgtct gcctggcggg ccttcaggtg cggcgtgaga
      241 gatggatgcc aattcaaaag acaagccccc tgaaaccaag gagtctgcaa tgaataatgc
      301 tggaaatgcc tctttcattt tgggaactgg gaagattgtg actcctcaga agcatgccga
      361 attacctcct aatccttgca caccagatac ttttaaatca cctttgaact tttccacagt
      421 aaccgtagag caattgggaa ttacacctga aagctttgtt aggaactctg caggaaagtc
      481 atcatcctac cttaaaaaat gtagacgacg ttctgcagtc ggtgctcggg gctctcctga
      541 aacaaaccat ctgattcgtt tcattgctcg gcagcaaaat ataaagaatg ctaggaaatc
      601 tcctttggca caagattctc cttcccaggg cagccctgca ctgtatcgaa atgttaacac
      661 tttaagagaa cgaatatcag ccttccagtc agcttttcac tccataaagg aaaacgagaa
      721 aatgaccggc tgtctggaat tctcagaggc aggaaaagag tccgagatga cagacttgac
      781 cagaaaggaa ggtctcagcg cttgccagca gtctgggttc cctgcagtgt tgtcctccaa
      841 acgtcggaga atatcctatc agagagactc tgatgaaaat ctgacggatg ctgaaggaaa
      901 agtaattggt ctccagatat tcaatattga tacagacaga gcatgtgcag ttgaaacttc
      961 tgtagatctt tctgagatat catctaaact tggttcaaca cagtctggat ttttagttga
     1021 agagtctctt cccctttcag agctcacaga gacttcaaat gcactaaagg ttgctgactg
     1081 tgtagtgggc aaaggatcaa gtgatgccgt ttcgcctgac acgttcacag cagaagtgag
     1141 ctcagacgca gtccctgatg tcaggtcacc agctactcca gcctgcagga gggaccttcc
     1201 cacccccaag acctttgtac ttcgttctgt actgaagaaa ccctctgtta agatgtgtct
     1261 agagagctta caggaacact gtaacaacct ctatgatgat gatgggactc atccgagctt
     1321 aatctcaaat ctcccaaact gttgcaaaga gaaagaagca gaagatgaag aaaattttga
     1381 agcacctgcc tttctaaata tgaggaagag gaagagagtt acttttggag aggacttaag
     1441 cccggaagtg tttgatgaat ctttgccagc aaatactcca ttgcgtaaag gaggaacacc
     1501 tgtttgtaaa aaagacttca gtggtctcag ttccctgctg cttgagcagt cacctgttcc
     1561 tgagccatta cctcaaccag attttgatga caagggggag aatcttgaaa acatagaacc
     1621 acttcaagta tcatttgccg ttctcagttc tcctaataaa tcatcaatct ctgagaccct
     1681 ttcaggcact gataccttta gttcttcaaa taaccatgag aaaatatcct ctcctaaagt
     1741 tggtagaata acaaggactt ctaacagaag aaatcaattg gtcagtgttg tagaagagag
     1801 tgtttgcaac ttattgaata cagaagttca gccttgtaaa gaaaagaaaa ttaataggag
     1861 gaagtctcaa gaaacaaagt gtacaaagag agcacttcct aagaagagtc aggttttaaa
     1921 aagttgcaga aagaagaaag gaaagggaaa gaaaagtgtt cagaaatctt tatatgggga
     1981 aagagacatt gcttctaaga agcccctcct cagtcctatt cccgagctgc ctgaagtccc
     2041 tgagatgaca ccttccattc cgagcatccg aagactgggt tcaggttatt tcagttcaaa
     2101 tggcaaactg gaagaagtga agactcctaa aaatccagtg aaaagaaagg atcttttgcg
     2161 tcatgaccca gatttgcata tgcatcaagg ctatgataaa tatgatgtct ctgaattctg
     2221 ctcttatata aaaagttcct catcgcttgg caatgctact tctgatgaag atccaaatac
     2281 aaatataatg aacattaatg aaaataaaaa tattccaaaa gcaaaaaata agtcagaaag
     2341 tgaaaatgaa ccaaaagctg gaactgacag tcctgtttct tgtgcttctg taactgaaga
     2401 acgtgtggca tcagatagtc ccaaacctgc tctgaccctg cagcagggtc aagaattttc
     2461 tgctggtggt caaaatgcag aaaacctttg tcagttcttt aaaatttcac cagatttaaa
     2521 cataaagtgt gaaagaaagg atgacttctt aggagctgca gaaggaaaac tgcaatgcaa
     2581 tcgtttaatg cctaattcac aaaaagactg tcattgttta ggagatgtct taattgaaaa
     2641 tacgaaagaa tctaaaagcc agagtgagga tttgggaaga aaacccatgg aaagtagcag
     2701 tgttgtgagt tgcagagaca ggaaagatag aagacgttcc atgtgttatt ctgatggtcg
     2761 aagtttacat ttggaaaaaa atggaaatca cacaccatcc tccagtgtgg gcagctctgt
     2821 agaaattagt ttagaaaatt ctgaactgtt taaagatttg tctgatgcca ttgagcaaac
     2881 ctttcagagg agaaatagtg aaaccaaagt gcgacgtagc acgaggctac agaaggattt
     2941 agaaaacgaa ggtcttgtat ggatttcact tccacttcct tccacttccc aaaaagccaa
     3001 aagaagaaca atatgtacat ttgacagcag tggatttgaa agtatgtctc ccataaaaga
     3061 aactgtgtcc tccagacaaa aaccgcagat ggcacctccc gtctcagatc cagaaaacag
     3121 ccagggccct gctgctggtt cttccgatga acctggtaag aggaggaaga gcttttgtat
     3181 atctacactt gcaaatacta aagccacttc ccagttcaaa ggctaccgga gaagatcctc
     3241 tcttaatggg aagggagaga gctctctgac tgccttggaa aggattgaac ataatggaga
     3301 aagaaagcag taattgacat ttcctgcaga gtctgtggca agagggaaag taaccatcta
     3361 tgctgaaatg atctgtctag ttcccattct ctgttcaacc tcagtgtttc aaaagttcct
     3421 aataaataaa ctcatttgag ttgaacctac ttttatgtag aaataaataa gtttcttcat
     3481 cattca
//
