LOCUS       NM_024529               5869 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens cell division cycle 73 (CDC73), mRNA.
ACCESSION   NM_024529
VERSION     NM_024529.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5869)
  AUTHORS   Yu,Z., Dong,X., Song,M., Xu,A., He,Q., Li,H., Ouyang,W.,
            Chouchane,L. and Ma,X.
  TITLE     Targeting UBR5 inhibits postsurgical breast cancer lung metastases
            by inducing CDC73 and p53 mediated apoptosis
  JOURNAL   Int J Cancer 154 (4), 723-737 (2024)
   PUBMED   37855385
  REMARK    GeneRIF: Targeting UBR5 inhibits postsurgical breast cancer lung
            metastases by inducing CDC73 and p53 mediated apoptosis.
REFERENCE   2  (bases 1 to 5869)
  AUTHORS   E,Y., Xue,H., Zhang,C.Y., Zhao,M.Z. and Zheng,H.C.
  TITLE     The clinicopathological and prognostic significances of CDC73
            expression in breast cancer: A pathological and bioinformatics
            analysis
  JOURNAL   Histol Histopathol 38 (4), 453-465 (2023)
   PUBMED   36255176
  REMARK    GeneRIF: The clinicopathological and prognostic significances of
            CDC73 expression in breast cancer: A pathological and
            bioinformatics analysis.
REFERENCE   3  (bases 1 to 5869)
  AUTHORS   Ababneh,E. and Nose,V.
  TITLE     Para This, Fibromin That: The Role of CDC73 in Parathyroid Tumors
            and Familial Tumor Syndromes
  JOURNAL   Surg Pathol Clin 16 (1), 97-105 (2023)
   PUBMED   36739170
  REMARK    GeneRIF: Para This, Fibromin That: The Role of CDC73 in Parathyroid
            Tumors and Familial Tumor Syndromes.
            Review article
REFERENCE   4  (bases 1 to 5869)
  AUTHORS   Woodard,G.E., Lin,L., Zhang,J.H., Agarwal,S.K., Marx,S.J. and
            Simonds,W.F.
  TITLE     Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome
            gene HRPT2, regulates cyclin D1/PRAD1 expression
  JOURNAL   Oncogene 24 (7), 1272-1276 (2005)
   PUBMED   15580289
  REMARK    GeneRIF: Human parafibromin is a nucleocytoplasmic tumor suppressor
            protein which regulates cyclin D1/PRAD1 expression.
REFERENCE   5  (bases 1 to 5869)
  AUTHORS   Rozenblatt-Rosen,O., Hughes,C.M., Nannepaga,S.J., Shanmugam,K.S.,
            Copeland,T.D., Guszczynski,T., Resau,J.H. and Meyerson,M.
  TITLE     The parafibromin tumor suppressor protein is part of a human Paf1
            complex
  JOURNAL   Mol Cell Biol 25 (2), 612-620 (2005)
   PUBMED   15632063
  REMARK    GeneRIF: By purifying cellular parafibromin and characterizing its
            associated proteins, a human counterpart to the yeast Paf1 complex
            including homologs of Leo1, Paf1, and Ctr9, has been described.
REFERENCE   6  (bases 1 to 5869)
  AUTHORS   Hobbs,M.R., Rosen,I.B. and Jackson,C.E.
  TITLE     Revised 14.7-cM locus for the hyperparathyroidism-jaw tumor
            syndrome gene, HRPT2
  JOURNAL   Am J Hum Genet 70 (5), 1376-1377 (2002)
   PUBMED   11951180
REFERENCE   7  (bases 1 to 5869)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
REFERENCE   8  (bases 1 to 5869)
  AUTHORS   Szabo,J., Heath,B., Hill,V.M., Jackson,C.E., Zarbo,R.J.,
            Mallette,L.E., Chew,S.L., Besser,G.M., Thakker,R.V., Huff,V. et al.
  TITLE     Hereditary hyperparathyroidism-jaw tumor syndrome: the endocrine
            tumor gene HRPT2 maps to chromosome 1q21-q31
  JOURNAL   Am J Hum Genet 56 (4), 944-950 (1995)
   PUBMED   7717405
REFERENCE   9  (bases 1 to 5869)
  AUTHORS   Skefos,C.M., Waguespack,S.G., Perrier,N.D. and Hu,M.I.
  TITLE     CDC73-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301744
REFERENCE   10 (bases 1 to 5869)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC298135.1, BC065037.1,
            AL139133.8 and AI638120.1.
            
            On Dec 4, 2019 this sequence version replaced NM_024529.4.
            
            Summary: This gene encodes a tumor suppressor that is involved in
            transcriptional and post-transcriptional control pathways. The
            protein is a component of the the PAF protein complex, which
            associates with the RNA polymerase II subunit POLR2A and with a
            histone methyltransferase complex. This protein appears to
            facilitate the association of 3' mRNA processing factors with
            actively-transcribed chromatin. Mutations in this gene have been
            linked to hyperparathyroidism-jaw tumor syndrome, familial isolated
            hyperparathyroidism, and parathyroid carcinoma. [provided by
            RefSeq, Jul 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226038.1, AF312865.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367435.5/ ENSP00000356405.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                DC298135.1         74-163
            91-2303             BC065037.1         1-2213
            2304-5702           AL139133.8         10768-14166
            5703-5869           AI638120.1         22-188              c
FEATURES             Location/Qualifiers
     source          1..5869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..5869
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /note="cell division cycle 73"
                     /db_xref="GeneID:79577"
                     /db_xref="HGNC:HGNC:16783"
                     /db_xref="MIM:607393"
     exon            1..301
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1766
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /note="hyperparathyroidism 2 protein; cell division cycle
                     protein 73 homolog; cell division cycle 73, Paf1/RNA
                     polymerase II complex component, homolog; cell division
                     cycle 73 Paf1/RNA polymerase II complex component-like
                     protein; Familial isolated hyperparathyroidism"
                     /codon_start=1
                     /product="parafibromin"
                     /protein_id="NP_078805.3"
                     /db_xref="CCDS:CCDS1382.1"
                     /db_xref="GeneID:79577"
                     /db_xref="HGNC:HGNC:16783"
                     /db_xref="MIM:607393"
                     /translation="MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWG
                     TGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEA
                     STSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGH
                     KEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEV
                     DVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPV
                     DPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQT
                     PAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEK
                     KKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGP
                     AWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDR
                     PVFLRFWETLDRYMVKHKSHLRF"
     exon            302..407
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            408..477
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            478..540
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            541..593
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            594..682
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            683..899
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            900..998
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1077
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1142
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1200
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1236
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1324
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1486
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1587
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1729
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..5869
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4926..4931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /note="hexamer: AATAAA"
     polyA_site      4955
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /note="major polyA site"
     regulatory      5837..5842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
                     /note="hexamer: AATAAA"
     polyA_site      5869
                     /gene="CDC73"
                     /gene_synonym="C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX"
ORIGIN      
        1 gctactgccc ctgctgctgt cgtaggcgag gacggctgtt agtgctgctg ctgttggttc
       61 gtcgcggcgg cgaaggagga ggaggaagag ggcgaggcga caagagaaga aggaggcagg
      121 cgcggcggca gcggcggcgc cccgagccgg cggaggcgag gggggggaag atggcggacg
      181 tgcttagcgt cctgcgacag tacaacatcc agaagaagga gattgtggtg aagggagacg
      241 aagtgatctt cggggagttc tcctggccca agaatgtgaa gaccaactat gttgtttggg
      301 ggactggaaa ggaaggccaa cccagagagt actacacatt ggattccatt ttatttctac
      361 ttaataacgt gcacctttct catcctgttt atgtccgacg tgcagctact gaaaatattc
      421 ctgtggttag aagacctgat cgaaaagatc tacttggata tctcaatggt gaagcgtcaa
      481 catcggcaag tatagacaga agcgctccct tagaaatagg tcttcagcga tctactcaag
      541 tcaaacgagc tgcagatgaa gttttagcag aagcaaagaa accacgaatt gaggatgaag
      601 agtgtgtgcg ccttgataaa gagagattgg ctgcccgttt ggagggtcac aaagaaggga
      661 ttgtacagac tgaacagatt aggtctttgt ctgaagctat gtcagtggaa aaaattgctg
      721 caatcaaagc caaaattatg gctaagaaaa gatctactat caagactgat ctagatgatg
      781 acataactgc ccttaaacag aggagttttg tggatgctga ggtagatgtg acccgagata
      841 ttgtcagcag agagagagta tggaggacac gaacaactat cttacaaagc acaggaaaga
      901 atttttccaa gaacattttt gcaattcttc aatctgtaaa agccagagaa gaagggcgtg
      961 cacctgaaca gcgacctgcc ccaaatgcag cacctgtgga tcccactttg cgcaccaaac
     1021 agcctatccc agctgcctat aacagatacg atcaggaaag attcaaagga aaagaagaaa
     1081 cggaaggctt caaaattgac actatgggaa cctaccatgg tatgacactg aaatctgtaa
     1141 cggagggtgc atctgcccgg aagactcaga ctcctgcagc ccagccagta ccaagaccag
     1201 tttctcaagc aagacctccc ccaaatcaga agaaaggatc tcgaacaccc attatcataa
     1261 ttcctgcagc taccacctct ttaataacca tgcttaatgc aaaagacctt ctacaggacc
     1321 tgaaatttgt cccatcagat gaaaagaaga aacaaggttg tcaacgagaa aatgaaactc
     1381 taatacaaag aagaaaagac cagatgcaac cagggggcac tgcaattagt gttacagtac
     1441 cttatagagt agtagaccag ccccttaaac ttatgcctca agactgggac cgcgttgtag
     1501 ccgtttttgt gcagggtcct gcatggcagt tcaaaggttg gccatggctt ttgcctgatg
     1561 gatcaccagt tgatatattt gctaaaatta aagccttcca tctgaagtat gatgaagttc
     1621 gtctggatcc aaatgttcag aaatgggatg taacagtatt agaactcagc tatcacaaac
     1681 gtcatttgga tagaccagtg ttcttacggt tttgggaaac attggacagg tacatggtaa
     1741 agcataaatc gcacttgaga ttctgaatta tttggctcct ccatttctgg aaattgagac
     1801 tcaagcttta tgaatttatc aagaacttaa aaatgaagaa ggtcacagat tgatctttta
     1861 taagacctta tttgatgctt tgtgcttcaa ggagatgata cctgtcatcc atataagcaa
     1921 actttttggc ttacaactat ttttttaata ttagccttct agtctgtaat ggaaattgta
     1981 tattttgata gaagtttttt ctccattggt taaattagca ttacttaaaa tttgtttctt
     2041 tagaaaataa atgcaggtta taaatgtgtg tatatttaga gattataagg ctctctgagc
     2101 catcttctga tttttcattg ctctataatt ctttttactg aaaatactat gttatgaatg
     2161 gtattaaatt ttagtctctg gaacatccaa aaccaagcaa agggatgtga ctattttgaa
     2221 tgaatcagaa tgtcaacttg tatgtacact atatctacac ttactcatta tttaaaaaga
     2281 ataatgaaaa atctagatca attcttcaat ttgattgaac tgttcagcct tttcaagatt
     2341 tctttattta caaatgatta catttaaatg aatgtacatt cttctcactg actttggtga
     2401 ttttgaaacc tagaatgatg tgtttctatc tgtaatatct ttccatttga aaaaaatctc
     2461 aaaacacaga ttaaaaccac aataggctgt agtatttttt attttgggag ccagagtatg
     2521 atttggggga agaatatgta tcagccctat tgcagtataa ctttaagctc cttttctctt
     2581 tagtccactt ttgattgtaa tttttatggt ataggatttt gaatcttcta ttttaggctt
     2641 gtcagtcttg gagttcttat cttccattat ccctaaatat tgataaactc ccaggcacca
     2701 aagaaaacat ttgcttaatt gtctgaaaag aaacaagaga aaaacactgg tatttttatg
     2761 tctgtattca atatggtata aaatataaaa actatatttt aacttagtga aatattttac
     2821 tatttctcta cttcagacaa aatgttgcat ccaaggtaca tcaagtgacc atttgccttg
     2881 aaccttgatt tcactttgtt tttttttttt ccttaaaggc aactaggaag ctttactttc
     2941 ctaaagtgtt tttgccattg gaatttttgc tgatcacagt cttatgtcat ttttttctct
     3001 gtttttattc ccagcaattt tctcctaggt taacatattt ttggtgaacg tttaggcctt
     3061 tcataggtat taagctgaca ttatctagct tcttaatgaa atttaacact gtcacaaaaa
     3121 tgagaagtta ttatttttta agtgatcaca tagttcatac cactagtaac tagaaaagat
     3181 atttattcac atgatattta caaggctctt cagaagggaa cagtcagcat tttaaattac
     3241 tagattttag catacttaac aaggtttgaa cagattctac ccctattttc ctcccttttt
     3301 agcgtcttct ttccttaaag ataaaagaaa actcaaattt gtttacatta ggctttctta
     3361 gcatataaat atatttccaa aataaattac atgttgtgta aactttctcc atgatgaaat
     3421 agtcaaggac cagaatctgt aatattttta tgtaagatta cttgtcaaga ctactacaag
     3481 tcagtatgaa ctaccttccc ataaagattt ttggtatttg tacttattta tgaactttac
     3541 ttgagacaga atatggttaa aattaggaac atctactttg aatgaggttt atttttctat
     3601 tttgaatttg ccttatgtat attcaaaggc ttatggaaat actgtaaagg aacattagga
     3661 aaaggacaaa taggctataa ccatctatct taaaatcaga cccttagtat aagcacctct
     3721 ttttcttttc ctctttgaca atttagtctc ttatttaggt ccatgtaatt aatttcattc
     3781 cattattttt tagctgttta ttctaaaaaa caaaaatttt cagccactcc catttattct
     3841 cccatgacat ggtcctatat agcagtactt aacacagtgc cttgcacata gtaggcattc
     3901 agtaaatact tacatgcatg aatgaataat gtattttcag tgtaacaaat ttattataaa
     3961 agtgtagttc gactcttctt ggtcttggag tttgagagta cagaattaca gggaatgaag
     4021 agaggtataa gtagatattt taatggaaat gaagtataaa ttaataactt gacttacccc
     4081 tccataagtt actgctaact ggagataccc ttgtatgccc aacctgtaaa ggaaaaagtt
     4141 ctatttctat atttatagga cattcttctc agtcaaggaa cagtaagaaa tatgtaggtt
     4201 tcaatcagtt gctctcaacc ctgactgcat tttagaatca tttggagagt ttttaaaaat
     4261 atccatgcct gaatcttgat tcccattttc atgtaatttg agacaagacc tggtcatcag
     4321 tatttttttt aaagttctcc aggtaatttg aatgtgcagg aaggattcag aatcactggt
     4381 ttaatttgtt attgaaaaca gtaccagtat taaatgtgtt tcctcttcct tcttttctgt
     4441 atgtatgtgt ggtttttgat tttttgttgt tgttgttgtt ttgtggccac cctttgcact
     4501 agaccatccc ttttattggt ggtattggcc tatattccca ttgacaaatg caatttttaa
     4561 ttatttattt aatataggag tattttactg tttaatattt aaacaatgtt taatgtattt
     4621 cattattaac tagtattata gtttgttttt ttcccatgtc tccataactt ttactaacat
     4681 ttgtttttag cagcacaaca gtaatccata taaaaacaac taattcataa tgaggaaaat
     4741 ctcataattt ttaaggcaga aagaagtatt aatttttgat ctgccatgta gaatgagaca
     4801 aatacagttt gcttatgaaa ggaaagtggc atacttttaa attggtctac acagaaaagt
     4861 aaaagtaaac tattcattta aataagattc attatctaat aaatattgag ggaatatttt
     4921 tcctaaataa aaatttttct gactgctaac aaaaattaaa gtgattacat tgttcttttt
     4981 tggaggggtg gggaggaata tttgttgaac taaagtatat aaaatttttt gagactagca
     5041 gtatatttta taatattaca aatacaacaa ttatttataa aagctagtca aattaatggc
     5101 ttagaaagta gctgtaaact ttgtgttttg aaattgcttg tttaaatgca aaattatgag
     5161 taagataagt ctttttaaat tttttatttt taattttttt ggaagtttat taaagccctt
     5221 catatacaca tactttttaa aaaaagattc ttaataaaga aattattggt ttgtctggtt
     5281 aaagtccata tagaatgctg agaaataatt tataaaataa gaactataga aatttgttct
     5341 cagctgaaaa gttggcagct gctctgtttc tttaaaaaag tacaacatga aaatttaatt
     5401 acattagcct taatattact tgactgaatt tctactattt attcacttgt gtttgagatt
     5461 cacccagcta ttctaatgat agaaataaaa agtggagaaa tgactaaagt tgacttaagt
     5521 taagaattgg agtgggaatt ttgaaatgcc atgtcctata tattctggca tatttgttgg
     5581 cacatttgca agtatgttga tcccagcatt gtttatatct gttggaataa taactaagga
     5641 aaaattgaaa atgtataata gatgtataaa gatttatatt tagttagtat ataatagata
     5701 atacttgcag gttttttatg tgttttgggt ttctgtgtat tattttaggt aatctttata
     5761 agggcatctt ggaagttata aatatgtgcc atttactgaa aagtgggaag catttttata
     5821 tgagtaaagc taatgaaata aaactagttt tattgccaaa attcaaaaa
//
