LOCUS       NM_003503               3215 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens cell division cycle 7 (CDC7), transcript variant 1,
            mRNA.
ACCESSION   NM_003503
VERSION     NM_003503.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3215)
  AUTHORS   Rojas-Prats,E., Martinez-Gonzalez,L., Gil,C., Ramirez,D. and
            Martinez,A.
  TITLE     Druggable cavities and allosteric modulators of the cell division
            cycle 7 (CDC7) kinase
  JOURNAL   J Enzyme Inhib Med Chem 39 (1), 2301767 (2024)
   PUBMED   38205514
  REMARK    GeneRIF: Druggable cavities and allosteric modulators of the cell
            division cycle 7 (CDC7) kinase.
REFERENCE   2  (bases 1 to 3215)
  AUTHORS   Goder,A., Maric,C.A., Rainey,M.D., O'Connor,A., Cazzaniga,C.,
            Shamavu,D., Cadoret,J.C. and Santocanale,C.
  TITLE     DBF4, not DRF1, is the crucial regulator of CDC7 kinase at
            replication forks
  JOURNAL   J Cell Biol 223 (8) (2024)
   PUBMED   38865090
  REMARK    GeneRIF: DBF4, not DRF1, is the crucial regulator of CDC7 kinase at
            replication forks.
REFERENCE   3  (bases 1 to 3215)
  AUTHORS   Zhang,L., Hong,J., Chen,W., Zhang,W., Liu,X., Lu,J., Tang,H.,
            Yang,Z., Zhou,K., Xie,H., Jia,C., Jiang,D. and Zheng,S.
  TITLE     DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular
            Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1
            Therapy
  JOURNAL   Int J Biol Sci 19 (11), 3412-3427 (2023)
   PUBMED   37497004
  REMARK    GeneRIF: DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular
            Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1
            Therapy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3215)
  AUTHORS   Gonzalez-Garrido,C. and Prado,F.
  TITLE     Novel insights into the roles of Cdc7 in response to replication
            stress
  JOURNAL   FEBS J 290 (12), 3076-3088 (2023)
   PUBMED   35398961
  REMARK    GeneRIF: Novel insights into the roles of Cdc7 in response to
            replication stress.
            Review article
REFERENCE   5  (bases 1 to 3215)
  AUTHORS   Guo,Y., Wang,J., Benedict,B., Yang,C., van Gemert,F., Ma,X.,
            Gao,D., Wang,H., Zhang,S., Lieftink,C., Beijersbergen,R.L., Te
            Riele,H., Qiao,X., Gao,Q., Sun,C., Qin,W., Bernards,R. and Wang,C.
  TITLE     Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through
            induction of DNA replication stress in liver cancer
  JOURNAL   Genome Med 13 (1), 166 (2021)
   PUBMED   34663432
  REMARK    GeneRIF: Targeting CDC7 potentiates ATR-CHK1 signaling inhibition
            through induction of DNA replication stress in liver cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3215)
  AUTHORS   Jiang,W., McDonald,D., Hope,T.J. and Hunter,T.
  TITLE     Mammalian Cdc7-Dbf4 protein kinase complex is essential for
            initiation of DNA replication
  JOURNAL   EMBO J 18 (20), 5703-5713 (1999)
   PUBMED   10523313
REFERENCE   7  (bases 1 to 3215)
  AUTHORS   Kumagai,H., Sato,N., Yamada,M., Mahony,D., Seghezzi,W., Lees,E.,
            Arai,K. and Masai,H.
  TITLE     A novel growth- and cell cycle-regulated protein, ASK, activates
            human Cdc7-related kinase and is essential for G1/S transition in
            mammalian cells
  JOURNAL   Mol Cell Biol 19 (7), 5083-5095 (1999)
   PUBMED   10373557
REFERENCE   8  (bases 1 to 3215)
  AUTHORS   Hess,G.F., Drong,R.F., Weiland,K.L., Slightom,J.L., Sclafani,R.A.
            and Hollingsworth,R.E.
  TITLE     A human homolog of the yeast CDC7 gene is overexpressed in some
            tumors and transformed cell lines
  JOURNAL   Gene 211 (1), 133-140 (1998)
   PUBMED   9573348
REFERENCE   9  (bases 1 to 3215)
  AUTHORS   Jiang,W. and Hunter,T.
  TITLE     Identification and characterization of a human protein kinase
            related to budding yeast Cdc7p
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14320-14325 (1997)
   PUBMED   9405610
REFERENCE   10 (bases 1 to 3215)
  AUTHORS   Sato,N., Arai,K. and Masai,H.
  TITLE     Human and Xenopus cDNAs encoding budding yeast Cdc7-related
            kinases: in vitro phosphorylation of MCM subunits by a putative
            human homologue of Cdc7
  JOURNAL   EMBO J 16 (14), 4340-4351 (1997)
   PUBMED   9250678
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA791490.1, BC111044.1,
            AI672674.1 and N62245.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003503.3.
            
            Summary: This gene encodes a cell division cycle protein with
            kinase activity that is critical for the G1/S transition. The yeast
            homolog is also essential for initiation of DNA replication as cell
            division occurs. Overexpression of this gene product may be
            associated with neoplastic transformation for some tumors. Multiple
            alternatively spliced transcript variants that encode the same
            protein have been detected. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) represents the most commonly
            occurring transcript. Variants 1, 2, and 3 all encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.191048.1,
                                           SRR1803613.220864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234626.11/ ENSP00000234626.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA791490.1         5-20
            17-3156             BC111044.1         1-3140
            3157-3163           AI672674.1         51-57               c
            3164-3215           N62245.1           4-55                c
FEATURES             Location/Qualifiers
     source          1..3215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..3215
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /note="cell division cycle 7"
                     /db_xref="GeneID:8317"
                     /db_xref="HGNC:HGNC:1745"
                     /db_xref="MIM:603311"
     exon            1..98
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            99..276
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1886
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /EC_number="2.7.11.1"
                     /note="CDC7 (cell division cycle 7, S. cerevisiae,
                     homolog)-like 1; epididymis secretory sperm binding
                     protein; cell division cycle 7-like protein 1;
                     CDC7-related kinase; cell division cycle 7 homolog"
                     /codon_start=1
                     /product="cell division cycle 7-related protein kinase"
                     /protein_id="NP_003494.1"
                     /db_xref="CCDS:CCDS734.1"
                     /db_xref="GeneID:8317"
                     /db_xref="HGNC:HGNC:1745"
                     /db_xref="MIM:603311"
                     /translation="MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDI
                     EKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIA
                     AELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLN
                     LFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEA
                     QQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEG
                     SVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMN
                     SAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQT
                     TAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCS
                     KEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQY
                     SGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLH
                     PFFKDMSL"
     exon            277..360
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            361..496
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            497..590
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            591..733
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            734..983
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1079
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1258
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1341
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1491
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..3215
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /note="hexamer: AATAAA"
     polyA_site      3215
                     /gene="CDC7"
                     /gene_synonym="CDC7L1; HsCDC7; Hsk1; huCDC7"
                     /note="major polyA site"
ORIGIN      
        1 gttgcgcagg cgcatccgat cgactcggta ggtggggatc tcttggagac ggcgacccag
       61 gcatctgggg agccacagaa gtcgtactcc cttaaaccct gctttgctcc ccctgtggat
      121 gtaacccctt agctggcatt ttgcatctca attggcttgt gatggaggcg tctttgggga
      181 ttcagatgga tgagccaatg gctttttctc cccagcgtga ccggtttcag gctgaaggct
      241 ctttaaaaaa aaacgagcag aattttaaac ttgcaggtgt taaaaaagat attgagaagc
      301 tttatgaagc tgtaccacag cttagtaatg tgtttaagat tgaggacaaa attggagaag
      361 gcactttcag ctctgtttat ttggccacag cacagttaca agtaggacct gaagagaaaa
      421 ttgctctaaa acacttgatt ccaacaagtc atcctataag aattgcagct gaacttcagt
      481 gcctaacagt ggctgggggg caagataatg tcatgggagt taaatactgc tttaggaaga
      541 atgatcatgt agttattgct atgccatatc tggagcatga gtcgtttttg gacattctga
      601 attctctttc ctttcaagaa gtacgggaat atatgcttaa tctgttcaaa gctttgaaac
      661 gcattcatca gtttggtatt gttcaccgtg atgttaagcc cagcaatttt ttatataata
      721 ggcgcctgaa aaagtatgcc ttggtagact ttggtttggc ccaaggaacc catgatacga
      781 aaatagagct tcttaaattt gtccagtctg aagctcagca ggaaaggtgt tcacaaaaca
      841 aatcccacat aatcacagga aacaagattc cactgagtgg cccagtacct aaggagctgg
      901 atcagcagtc caccacaaaa gcttctgtta aaagacccta cacaaatgca caaattcaga
      961 ttaaacaagg aaaagacgga aaggagggat ctgtaggcct ttctgtccag cgctctgttt
     1021 ttggagaaag aaatttcaat atacacagct ccatttcaca tgagagccct gcagtgaaac
     1081 tcatgaagca gtcaaagact gtggatgtac tgtctagaaa gttagcaaca aaaaagaagg
     1141 ctatttctac aaaagttatg aatagtgctg tgatgaggaa aactgccagt tcttgcccag
     1201 ctagcctgac ctgtgactgc tatgcaacag ataaagtttg tagtatttgc ctttcaaggc
     1261 gtcagcaggt tgcccctagg gcaggtacac caggattcag agcaccagag gtcttgacaa
     1321 agtgccccaa tcaaactaca gcaattgaca tgtggtctgc aggtgtcata tttctttctt
     1381 tgcttagtgg acgatatcca ttttataaag caagtgatga tttaactgct ttggcccaaa
     1441 ttatgacaat taggggatcc agagaaacta tccaagctgc taaaactttt gggaaatcaa
     1501 tattatgtag caaagaagtt ccagcacaag acttgagaaa actctgtgag agactcaggg
     1561 gtatggattc tagcactccc aagttaacaa gtgatataca agggcatgct tctcatcaac
     1621 cagctatttc agagaagact gaccataaag cttcttgcct cgttcaaaca cctccaggac
     1681 aatactcagg gaattcattt aaaaaggggg atagtaatag ctgtgagcat tgttttgatg
     1741 agtataatac caatttagaa ggctggaatg aggtacctga tgaagcttat gacctgcttg
     1801 ataaacttct agatctaaat ccagcttcaa gaataacagc agaagaagct ttgttgcatc
     1861 cattttttaa agatatgagc ttgtgataat ggatcttcat ttaatgttta ctgttatgag
     1921 gtagaataaa aaagaatact ttgtaatagc cacaagttct tgtttagaga ccagagcagg
     1981 attaataatt tattttaaca ttttagtgtt tggtggcaca ttctaaaata tagattaaga
     2041 atacttaaaa tgcctgggat agttcttggg actaacaaca tgatcttctt tgagttaaac
     2101 ctacctaagt agattttagg tgggttccta ttaggtcaga tttttagctt ccctaattac
     2161 ctttcactga catatacaga aaaaggagca gttttagttt taattaatta aaattaacag
     2221 atgtgatgag gattaaatga atcaaaagac ttaatttgta gattctttta gagttatgag
     2281 ctaggtatag tttggggaaa ctcaacctgg tgctggtgct cttaacaatt ttgtaaataa
     2341 agaagataat ttccttttct agaggtacat attaggcctt ttatgaacac taaaacaatg
     2401 aggaaatgtt ggtcatgggg caaagtatca cttaaaattg aattcatcca tttttaaaaa
     2461 acacttcatg aaagcattct ggtgtgaatt gccatttttt tcttactggc ttctcaattt
     2521 tcttccttct ctgcccctac ctaaaacatt ctcctcggaa attacatggt gctgaccaca
     2581 aagtttctgg atgttttatt aaatattgta cgtgtttaca gttgggaatt taaaataata
     2641 catacactgg ttgataaagg gaagctgcag gaccaaggtg aagattgata gtccaaatgc
     2701 ttttcttttt tgagttgtat attttttcac accatcttag atataattag gtagctgctg
     2761 aaaggaaaag tgaatacaga attgacggta ttattggaga tttttcctct gcgtagagcc
     2821 atccagatct ctgtatcctg ttttgactaa gtcttaggtg ggttgggaag acagataatg
     2881 aagtaggcaa agagaaaagg acccaagata gaggtttata ttcagaaatg gtatatatca
     2941 atgacagcat atcaaacttc ctatgggaaa aagtctggtg ggtggtcagc tgacagattt
     3001 cccatttagt agtcatagaa tacagaaata gtttagggac atgtattcat tttgttattt
     3061 tgagcattga taggtcagta tatctaccta atctgtttgg taagtatagg atatataaac
     3121 cattaccatt gatctgtctt atgccataat cttaaaaaaa atttgaatgc tcttgaattt
     3181 gtatattcaa taaagttatc cttttatatt tttta
//
