LOCUS       NM_001253               6241 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens cell division cycle 5 like (CDC5L), mRNA.
ACCESSION   NM_001253
VERSION     NM_001253.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6241)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6241)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6241)
  AUTHORS   Wang,K., Li,B., Fan,P., Ren,X. and Jiang,H.
  TITLE     Downregulation of DEAD-box helicase 21 (DDX21) inhibits
            proliferation, cell cycle, and tumor growth in colorectal cancer
            via targeting cell division cycle 5-like (CDC5L)
  JOURNAL   Bioengineered 12 (2), 12647-12658 (2021)
   PUBMED   34903139
  REMARK    GeneRIF: Downregulation of DEAD-box helicase 21 (DDX21) inhibits
            proliferation, cell cycle, and tumor growth in colorectal cancer
            via targeting cell division cycle 5-like (CDC5L).
REFERENCE   4  (bases 1 to 6241)
  AUTHORS   Jokoji,G., Maeda,S., Oishi,K., Ijuin,T., Nakajima,M.,
            Tawaratsumida,H., Kawamura,I., Tominaga,H., Taketomi,E., Ikegawa,S.
            and Taniguchi,N.
  TITLE     CDC5L promotes early chondrocyte differentiation and proliferation
            by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1
  JOURNAL   J Biol Chem 297 (2), 100994 (2021)
   PUBMED   34298017
  REMARK    GeneRIF: CDC5L promotes early chondrocyte differentiation and
            proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and
            WEE1.
REFERENCE   5  (bases 1 to 6241)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6241)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   7  (bases 1 to 6241)
  AUTHORS   Ohi,R., Feoktistova,A., McCann,S., Valentine,V., Look,A.T.,
            Lipsick,J.S. and Gould,K.L.
  TITLE     Myb-related Schizosaccharomyces pombe cdc5p is structurally and
            functionally conserved in eukaryotes
  JOURNAL   Mol Cell Biol 18 (7), 4097-4108 (1998)
   PUBMED   9632794
  REMARK    Erratum:[Mol Cell Biol 1998 Oct;18(10):6164]
REFERENCE   8  (bases 1 to 6241)
  AUTHORS   Groenen,P.M., Vanderlinden,G., Devriendt,K., Fryns,J.P. and Van de
            Ven,W.J.
  TITLE     Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a
            patient with multicystic renal dysplasia
  JOURNAL   Genomics 49 (2), 218-229 (1998)
   PUBMED   9598309
REFERENCE   9  (bases 1 to 6241)
  AUTHORS   Bernstein,H.S. and Coughlin,S.R.
  TITLE     A mammalian homolog of fission yeast Cdc5 regulates G2 progression
            and mitotic entry
  JOURNAL   J Biol Chem 273 (8), 4666-4671 (1998)
   PUBMED   9468527
REFERENCE   10 (bases 1 to 6241)
  AUTHORS   Bernstein,H.S. and Coughlin,S.R.
  TITLE     Pombe Cdc5-related protein. A putative human transcription factor
            implicated in mitogen-activated signaling
  JOURNAL   J Biol Chem 272 (9), 5833-5837 (1997)
   PUBMED   9038199
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC422730.1, BC001568.1 and
            AL133262.8.
            
            On Nov 23, 2018 this sequence version replaced NM_001253.3.
            
            Summary: The protein encoded by this gene shares a significant
            similarity with Schizosaccharomyces pombe cdc5 gene product, which
            is a cell cycle regulator important for G2/M transition. This
            protein has been demonstrated to act as a positive regulator of
            cell cycle G2/M progression. It was also found to be an essential
            component of a non-snRNA spliceosome, which contains at least five
            additional protein factors and is required for the second catalytic
            step of pre-mRNA splicing. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128737.1, SRR1803611.250437.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371477.4/ ENSP00000360532.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC422730.1         192-210
            20-2855             BC001568.1         1-2836
            2856-6241           AL133262.8         24544-27929
FEATURES             Location/Qualifiers
     source          1..6241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..6241
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /note="cell division cycle 5 like"
                     /db_xref="GeneID:988"
                     /db_xref="HGNC:HGNC:1743"
                     /db_xref="MIM:602868"
     exon            1..163
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2527
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /note="Cdc5-related protein; dJ319D22.1 (CDC5-like
                     protein); pombe cdc5-related protein; CDC5 cell division
                     cycle 5-like"
                     /codon_start=1
                     /product="cell division cycle 5-like protein"
                     /protein_id="NP_001244.1"
                     /db_xref="CCDS:CCDS4912.1"
                     /db_xref="GeneID:988"
                     /db_xref="HGNC:HGNC:1743"
                     /db_xref="MIM:602868"
                     /translation="MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAK
                     QCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEF
                     LLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLA
                     NTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEK
                     KPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLP
                     SAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSAS
                     STLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDF
                     SGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNI
                     NPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREID
                     DTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLT
                     DLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKF
                     SKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANL
                     ASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWD
                     QIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETL
                     KSKF"
     exon            164..267
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            268..429
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            430..557
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            558..657
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            658..876
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1021
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1210
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1359
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1522
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1687
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1768
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2011
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2209
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2422
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..6241
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /note="hexamer: AATAAA"
     polyA_site      2846
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /note="major polyA site"
     polyA_site      2855
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /note="major polyA site"
     regulatory      4944..4949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /note="hexamer: AATAAA"
     polyA_site      4969
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
     regulatory      6218..6223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
                     /note="hexamer: ATTAAA"
     polyA_site      6241
                     /gene="CDC5L"
                     /gene_synonym="CDC5; CDC5-LIKE; CEF1; dJ319D22.1; PCDC5RP"
ORIGIN      
        1 cttcaaagca gaaggtcgcg cttggaggaa gtggcggctt tgagtccggt ggcccaatcg
       61 ctgttactac ttctctgaag ctcctctcgg ctgcttgccg agacaccctg ccgccaagat
      121 gcctcgaatt atgatcaagg ggggcgtatg gaggaatacc gaggatgaaa ttctgaaagc
      181 agcggtaatg aaatatggga aaaatcagtg gtctaggatt gcctcattgc tgcatagaaa
      241 atcagcaaag cagtgcaaag ccagatggta tgaatggctg gatccaagca ttaagaagac
      301 agaatggtcc agagaagaag aggaaaaact cttgcacttg gccaagttga tgccaactca
      361 gtggaggacc attgctccaa tcattggaag aacagcggcc cagtgcttag aacactatga
      421 atttcttctg gataaagctg cccaaagaga caatgaagag gaaacaacag atgatccacg
      481 aaaacttaaa cctggagaaa tagatccaaa tccagaaaca aaaccagcgc ggcctgatcc
      541 aattgatatg gatgaggatg aacttgagat gctttctgaa gccagagccc gcttggctaa
      601 tactcaggga aagaaggcca agaggaaagc aagagagaaa caattggaag aagcaagacg
      661 tcttgctgcc ctccaaaaaa gaagagaact tcgagcagct ggcatagaaa ttcagaagaa
      721 aagaaaaagg aagagaggag ttgattataa tgccgaaatc ccatttgaaa aaaagcctgc
      781 ccttggtttt tatgatactt ctgaggaaaa ctaccaagct cttgacgcag atttcaggaa
      841 attaagacaa caggatcttg atggggagct aagatctgaa aaagaaggaa gagatagaaa
      901 aaaagacaaa cagcatttga aaaggaaaaa agaatctgat ttaccatcag ctattcttca
      961 aactagtggt gtttctgaat ttactaaaaa gagaagcaaa ctagtacttc ctgcccctca
     1021 gatttcagat gcagaactcc aggaagttgt aaaagtaggc caagcgagtg aaattgcacg
     1081 tcaaactgcc gaggaatctg gcataacaaa ttctgcttcc agtacacttt tgtctgagta
     1141 caatgtcacc aacaacagcg ttgctcttag aacaccacga acaccagctt cccaggacag
     1201 aattctgcag gaagcccaga acctcatggc cctcaccaat gtggacaccc cattgaaagg
     1261 tggacttaat accccattgc atgagagtga cttctcaggt gtaactccac agcgacaagt
     1321 tgtacagact ccaaacacag ttctctctac tccattcagg actccttcta atggagctga
     1381 agggctgact ccccggagtg gaacaactcc caaaccagtt attaactcta ctccgggtag
     1441 aactcctctt cgagacaagt taaacattaa tcccgaggat ggaatggcag actatagtga
     1501 tccctcttac gtgaagcaga tggaaagaga atcccgagaa catctccgtt tagggttgtt
     1561 gggccttcct gcccctaaga atgattttga aattgttcta ccagaaaatg ccgagaagga
     1621 gctggaagaa cgtgaaatag atgatactta cattgaagat gctgctgatg tggatgctcg
     1681 aaagcaggcc atacgagatg cagagcgtgt aaaggaaatg aaacgaatgc ataaagctgt
     1741 ccagaaagat ctgccaagac catcagaagt aaatgaaact attctaagac ccttaaatgt
     1801 agaaccgcct ttaacagatt tacagaaaag tgaagaacta atcaaaaaag aaatgatcac
     1861 aatgcttcat tatgaccttc tacatcaccc ttatgaacca tctggaaata aaaaaggcaa
     1921 aactgtaggg tttggtacca ataattcaga gcacattacc tatctggaac ataatcctta
     1981 tgaaaagttc tccaaagaag agctgaaaaa ggcccaggat gttttggtgc aggagatgga
     2041 agtggttaaa caaggaatga gccatggaga gctctcaagt gaagcttata accaggtgtg
     2101 ggaagaatgc tacagtcaag ttttatatct tcctgggcag agccgctaca cacgggccaa
     2161 tctggctagt aaaaaggaca gaattgaatc acttgaaaag aggctcgaga taaacagggg
     2221 tcacatgacg acagaagcca agagggctgc aaagatggaa aagaagatga aaattttgct
     2281 tgggggttac cagtctcgtg ctatggggct catgaaacag ttgaatgact tatgggacca
     2341 aattgaacag gctcacttgg agttacgcac ttttgaagaa ctcaagaaac atgaagattc
     2401 tgctattccc cggaggctag agtgtctaaa agaagacgtt cagcgacaac aagaaagaga
     2461 aaaggaactt caacatagat atgctgattt gctgctggag aaagagactt taaagtcaaa
     2521 attctgaagt acagtttata ttctgtcaca ggattaatta attgccggtt ttcatactct
     2581 agaaggctga aactgatgtt tatcttcatt gacaaattta cccaccatct gtggtttttc
     2641 agttgtttat tttaaatgat atcgatctta cacattctgt gtataaagac cttaactcca
     2701 caggacggac attttagagt ttaaattatt aaggctatca ttcttttagt aatgtcatat
     2761 ttgcaaactt ttttagtttt ggcctttaat ttaaaaagcc taattttaaa gtgctgcctg
     2821 tgagtaactc ttgaataaaa acaaaatata aaaaattgag aatgtagcct tttgtttgaa
     2881 gtaattagat acttaagagt gcctgcaaac cagcagctat gtactctgtg tcatatttaa
     2941 tgagtaactc ttgggtaatc aaaatggtga tgcagtatct taaacactta agaggcagtt
     3001 ctttgtggct ttgttagttt cagcaaagag tggtcatttc tgtatacact gacaagttag
     3061 attaactttt tagtacctca aatttttttt ttgttaatat cactttaaag aaggtctctt
     3121 gtctgccagc tacttaaata atttatgggt cagggcttaa aagatttaac ttccttgccc
     3181 cattattttc ttataagtat tttttgacaa aggcatttta aaagttaatt tcaagaaggc
     3241 catcaaactt aaagctctat gtttagccta agaagtcagt tacatcagtg tagaatttgg
     3301 ggaatggata gaggtggaga tatttaattt tatataattc atataaattg atttagttac
     3361 agtatcagtt ggctacaagc tcattataga ctagcaatgt tttgacatca ccaaaaacgt
     3421 ttgcccagtc ttagaatact agggactata ggaagggaag ggattcattc attcattcga
     3481 tattgaatgt ataccctgtg ccagagtctt agagagagaa caacaaacaa aataggccta
     3541 gttcttgttt agtagagctt atagtctttt gagaatgaca gacaattaaa atccaaatgt
     3601 ttatttggtg attcttatgt gtcagacact taagtgttgg gagataagca gttattaaga
     3661 cagagttctt gctctcatgg aggtgacatt agtggggagg agatactaag tatgtccagg
     3721 gaaagtatca gaccatgagt tttagattct gtggaggaaa ttaaagtagg gtgattatga
     3781 gatagtgaat gagtggctat tttagactgg acgatcaaag agacctcttg gaaggcagct
     3841 atgctcacca ctataccact gcactgtgcc gcaccgtacc actataagct gcacggccaa
     3901 agagacctct taaagaagta acatttaaga taacatgtga ttgacatttt agaatgggct
     3961 atccttgtga gattcaagga aagaacatcc taggtggagt gaatagcaaa cataaagcct
     4021 cttttgtatg tttgaggaac aaaaaggaca atgcagctag agtgtcaaga atggcatttc
     4081 tgtatataag acctcgttgt atagagccac ataaataagg ctataataag gaatttggat
     4141 cttactttaa atatgataag aatcgatgag aagatctaag caaaggaatg acatgatcag
     4201 atttggtttt agaaacatca ctatctcctt agtgtgtaaa atctcaccag gctggagata
     4261 gggaagccag tccaattagg agcctgatgc agtgatccag acaaaaaaat aatagtgatt
     4321 ctaactagag tccaggtaat agtagtggag atatgtggag agacatgata ggtatatact
     4381 taatagtctt atcagacgat aaattgatat tttcctggtg tgtagtcact taattcaaat
     4441 acttttttca gtaagttctg ggttttctag gaaaaacttc agtatcatca gtgaataatg
     4501 atagtgtttc ttctgatagt tttatttcac ttttattgca tgttttgtta tctgaaatgt
     4561 ttaggacaat gttaacaata atgatgttag acattttttt ttcttatttt aatgggaatg
     4621 tccatagttt taagtttgct gttgggagtt agatagtctt tatctgaaag acagtgtctc
     4681 tcttttagtt tttaaagagt ttgaattaga aatggctctg gaactttaaa cagtatacca
     4741 tttgggcatc tattaaagca ttcatataat tgttctcatt tgatgttttg atgaggtata
     4801 ttaatagatt ttcccacatt aaatcatctt tgcactcctg gaatcaggta gattaatttt
     4861 taaaagaaat tttaaaggat ttatagttta tttgcacttt ttgtagactt gaattatatg
     4921 gatttaaaag ttgatctaat attaataaag gctcactttg ttttcaaaat ttgaagtaat
     4981 tcacatactt atagcctaaa aaaatcggca ggaattacaa aatttcaaaa ctggcacatt
     5041 gtaaactgca tatgcatttg ccaggtagtg gtgccacttg aaatggtgaa cagacacact
     5101 gttatccttt gtcagtatcc tgtaaagccc aggattcttt accagcacca tacagcgatt
     5161 ttggtgacta ttttaacatt cacactgagg ccaggggtgg tgagtcatgc ctgtaatcct
     5221 agcactttgg gaggccaagg tgggaggatc atttgagctc aggagttcaa gattagcctg
     5281 ggtaacatag tgagaccctg tctctattaa aaaataataa taaaaataac attcacattg
     5341 gtattgttca ctaaggtatt ggttgttaag gcattcatta aggtattgtt aaaacttgtg
     5401 ttaagcatgt taaagtctca gtaactttgg gatagaaata aaatgtgata aaaagctgaa
     5461 agaaaccacc acaagggaga gtcctttttg aaatattaga gacataatgc tgtctaataa
     5521 aaaacgacat caaagaaaaa ctacactaca gtgactgcag acttaatgtt ggccaaccat
     5581 gcatcctccc tagaaatgca tttgaatttg atttactaat cttttattta ggaaatttac
     5641 atttttacat tagtgagatt ggtcttttgg gctattgtac tttttttttt ttttttttga
     5701 gatggagtct tgctctctca cccaggctgg agtgcagtag tgcaatcttg gcccactgca
     5761 acctctgcct cctgggctcg agtgattctc tgcctcagcc ttccaagtag ctgggactac
     5821 aggcatgtgc caccgcacct ggctaatttt tgtgttttta gtagagatgg ggttttgcta
     5881 tgttggccag gctggtcttg aattcctgac ctcaggtgat ccacctacct cggcctccca
     5941 aagtgctaga attacaggtg tgagccacca tgcccagcct ggttattgta ttttgatatt
     6001 gggattttgc tagctctcta aagtaaatag gataactgta tatctttttc tgtgcattaa
     6061 gcagttataa catgggaatg atttgttcat gaaaggttga aagtctgtac ttacagaact
     6121 tttgagttca cagtgctttc tggaaataat ttctttataa ctgtcagttt cttttgtgac
     6181 tattatgtta cctattttta aatttaagca actttaaatt aaaaaaattg tttttaaaat
     6241 a
//
