LOCUS       NM_001375635            4404 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens CDC42 small effector 2 (CDC42SE2), transcript variant
            5, mRNA.
ACCESSION   NM_001375635
VERSION     NM_001375635.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4404)
  AUTHORS   Pothula,S., Bazan,H.E. and Chandrasekher,G.
  TITLE     Regulation of Cdc42 expression and signaling is critical for
            promoting corneal epithelial wound healing
  JOURNAL   Invest Ophthalmol Vis Sci 54 (8), 5343-5352 (2013)
   PUBMED   23833064
  REMARK    GeneRIF: Cdc42 is an important regulator of corneal epithelial
            wound repair. To promote healing, Cdc42 may interact with receptor
            tyrosine kinase-activated signaling cascades that participate in
            cell migration and cell-cycle progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4404)
  AUTHORS   Edwards,T.L., Wang,X., Chen,Q., Wormly,B., Riley,B., O'Neill,F.A.,
            Walsh,D., Ritchie,M.D., Kendler,K.S. and Chen,X.
  TITLE     Interaction between interleukin 3 and dystrobrevin-binding protein
            1 in schizophrenia
  JOURNAL   Schizophr Res 106 (2-3), 208-217 (2008)
   PUBMED   18804346
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 4404)
  AUTHORS   Chen,X., Wang,X., Hossain,S., O'Neill,F.A., Walsh,D., Pless,L.,
            Chowdari,K.V., Nimgaonkar,V.L., Schwab,S.G., Wildenauer,D.B.,
            Sullivan,P.F., van den Oord,E. and Kendler,K.S.
  TITLE     Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated
            with schizophrenia
  JOURNAL   Hum Mol Genet 15 (22), 3329-3342 (2006)
   PUBMED   17030554
  REMARK    GeneRIF: haplotypes underlying the SPEC2/PDZ-GEF2/acyl-CoA
            synthetase long-chain family member 6 region are associated with
            schizophrenia
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4404)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 4404)
  AUTHORS   Ching,K.H., Kisailus,A.E. and Burbelo,P.D.
  TITLE     The role of SPECs, small Cdc42-binding proteins, in F-actin
            accumulation at the immunological synapse
  JOURNAL   J Biol Chem 280 (25), 23660-23667 (2005)
   PUBMED   15840583
  REMARK    GeneRIF: Recruitment of SPEC2 within Jurkat T cells to the
            antigen-presenting cell interface occurred following incubation
            with staphylococcal enterotoxin E superantigen-loaded B cells and
            colocalized there with F-actin and Cdc42. T cell receptor
REFERENCE   6  (bases 1 to 4404)
  AUTHORS   Pirone,D.M., Fukuhara,S., Gutkind,J.S. and Burbelo,P.D.
  TITLE     SPECs, small binding proteins for Cdc42
  JOURNAL   J Biol Chem 275 (30), 22650-22656 (2000)
   PUBMED   10816584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004777.1, AC114275.2 and AC008497.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058909.1, SRR14038193.3411347.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505065.2/ ENSP00000427421.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC004777.1         11053-11166
            115-283             AC114275.2         829-997             c
            284-622             AC008497.7         89533-89871         c
            623-724             AC008497.7         63436-63537         c
            725-4404            AC008497.7         54408-58087         c
FEATURES             Location/Qualifiers
     source          1..4404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..4404
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /note="CDC42 small effector 2"
                     /db_xref="GeneID:56990"
                     /db_xref="HGNC:HGNC:18547"
                     /db_xref="MIM:619457"
     exon            1..114
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            115..283
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..622
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..823
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /note="non-kinase Cdc42 effector protein SPEC2; small
                     effector of CDC42 protein 2"
                     /codon_start=1
                     /product="CDC42 small effector protein 2"
                     /protein_id="NP_001362564.1"
                     /db_xref="CCDS:CCDS34224.1"
                     /db_xref="GeneID:56990"
                     /db_xref="HGNC:HGNC:18547"
                     /db_xref="MIM:619457"
                     /translation="MSEFWLCFNCCIAEQPQPKRRRRIDRSMIGEPTNFVHTAHVGSG
                     DLFSGMNSVSSIQNQMQSKGGYGGGMPANVQMQLVDTKAG"
     exon            623..724
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..4404
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /note="hexamer: AATAAA"
     polyA_site      4404
                     /gene="CDC42SE2"
                     /gene_synonym="SPEC2"
                     /note="major polyA site"
ORIGIN      
        1 aggaagctgc gagcgcgctg gggagcgcag ctgcaggcgt tggggcggca ggagccgcgg
       61 agccggcgct gagaggggct gcggccggag cgggcggctg agacaaaggc gacgataggg
      121 ccagatttga gtgtgtgaat ttttgagtga aacctggaac ccaaatgaga agaaatctgc
      181 aaggaataac tactgacagt gaatctgcgg tcatctgtat gcataatatg gaatgttctt
      241 aacccagaag tagctgaatg tgttactcca ttgctgagga gtgactatct gttatagtcc
      301 ctgggtcaag acaacaattt ttataccttc gtcgtggttc agaaaggagt ctctgtagaa
      361 ccagaagcaa agaaaggaaa caatccaaat ttttctttat taaatcgact gtgtaagata
      421 cttgacttcc aggaacaaaa acacggtgaa ataataaaat ttcatcttgg catcactgga
      481 catcatcgta ttgaggagcg tatttttgga acttcccgag ttgagatttg gaaccttcat
      541 tggtgctcat ttactgtgga ctgtaagcat gagtgaattc tggttgtgtt tcaactgctg
      601 tattgcagaa cagcctcagc ctaaaaggcg acggcggatt gacagaagta tgattggaga
      661 gcccacaaac tttgtgcata cagctcatgt tggatcagga gacctgttca gtggaatgaa
      721 ttcagttagc tccattcaga accaaatgca gtccaaggga ggttatggag gtggaatgcc
      781 tgccaatgtc cagatgcagc tcgtggatac gaaggcggga tagccctggt cctttctcca
      841 gtgagtactc agagctgggg tctggacctg acggccagac atggccaggc caataatagt
      901 aaatatatgt atatatatat aattttttaa tggtgaactt attgggaaag gcaaaattac
      961 tcagctaagt gtagtttctg cacttggaat gtaagtttta ggttcttttc cttattaaga
     1021 actttaaata ctttaaaaca tctggttggg gaggattctg atgacaagat gcttcttatg
     1081 tgtcctttaa acaagagtga aatcattatt ttgagtattg aggccgagca tggtggctca
     1141 cacctgtaat cccagcactt tgggaggcct aggtgggctg atcacctgag gccaggaatt
     1201 ggagactagc ctggccaaca tggtgaaacc ccatctctac taaaaataca aaaattagct
     1261 gggcatggtg gcgcatgcct gtaatcgcag ctactcagga ggctgaggca cgagaattgc
     1321 ttgaacctgg gaggcagggg ttgcagtcag ctgagaatgc gccactgcgc tccagcctgg
     1381 gtgacagagc aagaccctgt ctcaaaaaag tactgatact aaagataatc tcttgggtag
     1441 taattttaca gttaagactt cattgtttat aaacttttca aattaattaa aaagactact
     1501 ttgaaaaagg ataaaccctg aaaatgtaga aataatttca agtttttttt tgttttatag
     1561 ggttattgtg aatttctata ttttctctgt ccactattct gtaatttttt tttgtcctgt
     1621 gattgctttt attttgaatt acaaaaaaga agtgtgatgg caccttgtcc accctgtcgt
     1681 gattattcca gtgagatgtt actgttctgc tctgaagaag atactgtcag acgaatcctg
     1741 catttccttc agctggcatg catgcctttg gactcatgga cagagttctt tggattgtca
     1801 ctgaattttc aatgtttaat cagtatggat ctgatcttcg catgatcttt tttgtgaatg
     1861 ctaacaccat tttgcagttt tttttttcta ttttaaacat ttttcttttc actgccgacc
     1921 ccctgcctta cgattttatt ggaaagcaag gacctgctat tatttgttaa tttgccatca
     1981 tttatgtata ttttggaagg tatgagaccc acaagcacaa tgatcatttt tatttgtttg
     2041 tttgtttgaa acttcagcag aatagatatc tgcatgcttt atgaagttgt tgcttcggta
     2101 agagcccatg ggatgccaga aattaacatt tctttgctgc catgggctga tgatgctgct
     2161 attagataaa gtttagctgt ggcaccaagt cacatcattt tcatagaaaa agattacttg
     2221 tagcttattt tagaagtatg accttttggt ctgtttgatt gattgattag aattgcaata
     2281 aaagaaaagc ttgcattcat aaggcattca ttctgttgta aatgttcaat atatttattt
     2341 tgagagcaag gacctgtggt tgtaaacagg tgtggttaca ggtgtggtta tgtatctgag
     2401 tgttgcggtc atactctcct ccagtccaat cctgagcatc ttcatcttat taattagctg
     2461 ttcgtttctt tgtgcactca ttcttttatt tttacttctt tttaatgtta tggtatccag
     2521 ttgtttccag tagcagtttc ttgaacttct ggcctgtact actaactgca gacctccaga
     2581 gtcactggcc tttctgtgct ctacatatta ttttaggggc cacatcagtt gccaagagca
     2641 acatacatac cgacctggct gaattattgc cagtgaaaac aacctgtacg aagcctttgc
     2701 tcaggttcta aaatatgttt gtccttgcac gaattttgta tatttcaaat atttctgtaa
     2761 aggtttcttc ttttctgtta gagtgtggtg ttaagccaga gtcagtggtt tgtgttctca
     2821 ttaaaatgtt tgtttaaatc ctatgtccaa ttcaagccta tctaactaca tttggtagga
     2881 ttaacatttc atataacaaa tggggcttaa ttaaaaactt taacttggaa taaaggaaca
     2941 gggatcactt tatcttctgc cttcatttac cttagtccaa gattcttgca aaacaggcaa
     3001 ctgaacaaac attaggttta tgtaggtaaa atgtgaaagc atttctcctc cactttttaa
     3061 aatttaattt acccagtaca gcggggcacc agattacttg atctttgtat tttgcagttt
     3121 tgagcctttg tgtcaatccc aagcacagag aggatctgcc aaggaaaaac atttgcatct
     3181 tcggagtaga cattttgcag tttgtttaat aacaacttct aaagtaagtt gaattcatcc
     3241 attgtcactg attcaccaag tggatgttgc attgtggaat ttgcctgagt actgttgtca
     3301 ttctgctcag ccaggcacgg tcagtttctt ggccagggac attgctatgt gctgtgtgca
     3361 agctctttag aagagagatt ggattttctt ggcattatca gcactcatgc tatttagtct
     3421 acttctattt tgactgactc tttaaattag tacaattttt ctacttgtca tataactcct
     3481 ggaacaatag tacgggaagc cgtgatcctt ttccctgact catgatttta gtctttttcc
     3541 aaatcgctgt tttttttttt tttttttttt tttttgctgc tccaacgacc agcatgtgtt
     3601 ggagcagatc tccatggtaa gccaaaagtg gacttgtcag cctataacta ctctgcagct
     3661 gccactaact ctacaggcac agtaactaca ctttatacag gagcacatgc caaagtgcct
     3721 gggaggtgcc aataaaatca agaaataaga aaactacaaa aaaagatacg gtattaacct
     3781 tggacataat tttttttagg gaggcagctt tcccactttt ataaaggggg ttgtaaatct
     3841 caagaggtca tttgttcccc atagcagcat atctcatttt taaattgaag cgaattaaat
     3901 aggattttac tactcaacat tcattatact gttaatcttt gctgaaatat atgctaacaa
     3961 atgttaagca agggaaactg aagacttagt catgtggatt gttagcagtg atctgcattc
     4021 tgtaaaagag gtactttccc atgatgtagg catgaagtgg tgccagtaag cgtagagcgg
     4081 aaatgttgac tttagttaac attgggttta gcatttccag tgcagcatta tcagtgggcc
     4141 tttaaaaata cttcgtaagt acattagctt tcactttgtt gttaaattat agcagactca
     4201 ttatagagaa caagtttgcc ttgattttgt ttaaaatgac ttctgctaag cacccagaag
     4261 ataaaattga catattttta taatataagc atactttttt tgtacattgt gttcattctt
     4321 gaataaaatg agttctgtgt tggcttgtag atactaaaaa gaaagtattg attttgattc
     4381 aataaatgtt ttctttcaat cctg
//
