LOCUS       NM_020239               3006 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CDC42 small effector 1 (CDC42SE1), transcript variant
            2, mRNA.
ACCESSION   NM_020239
VERSION     NM_020239.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3006)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3006)
  AUTHORS   Kalailingam,P., Tan,H.B., Pan,J.Y., Tan,S.H. and Thanabalu,T.
  TITLE     Overexpression of CDC42SE1 in A431 Cells Reduced Cell Proliferation
            by Inhibiting the Akt Pathway
  JOURNAL   Cells 8 (2), 117 (2019)
   PUBMED   30717410
  REMARK    GeneRIF: CDC42SE1 is downregulated in skin cancer to promote
            tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3006)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3006)
  AUTHORS   Bandyopadhyay,S., Chiang,C.Y., Srivastava,J., Gersten,M., White,S.,
            Bell,R., Kurschner,C., Martin,C., Smoot,M., Sahasrabudhe,S.,
            Barber,D.L., Chanda,S.K. and Ideker,T.
  TITLE     A human MAP kinase interactome
  JOURNAL   Nat Methods 7 (10), 801-805 (2010)
   PUBMED   20936779
REFERENCE   5  (bases 1 to 3006)
  AUTHORS   Ching,K.H., Kisailus,A.E. and Burbelo,P.D.
  TITLE     The role of SPECs, small Cdc42-binding proteins, in F-actin
            accumulation at the immunological synapse
  JOURNAL   J Biol Chem 280 (25), 23660-23667 (2005)
   PUBMED   15840583
  REMARK    GeneRIF: Overexpression studies of the related SPEC1 showed that it
            also was recruited to the activated TCR. Mutational analysis
            revealed that localization of SPEC1 to the TCR required two
            N-terminal cysteine residues
REFERENCE   6  (bases 1 to 3006)
  AUTHORS   Pirone,D.M., Fukuhara,S., Gutkind,J.S. and Burbelo,P.D.
  TITLE     SPECs, small binding proteins for Cdc42
  JOURNAL   J Biol Chem 275 (30), 22650-22656 (2000)
   PUBMED   10816584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP340339.1, AL590133.32 and BC012796.2.
            
            On Nov 22, 2018 this sequence version replaced NM_020239.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138517.992384.1, BC041604.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357235.6/ ENSP00000349773.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BP340339.1         28-38
            12-144              AL590133.32        145672-145804       c
            145-461             AL590133.32        141870-142186       c
            462-572             AL590133.32        141209-141319       c
            573-663             AL590133.32        140424-140514       c
            664-1286            AL590133.32        138898-139520       c
            1287-1778           BC012796.2         1058-1549
            1779-3006           AL590133.32        137178-138405       c
FEATURES             Location/Qualifiers
     source          1..3006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3006
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /note="CDC42 small effector 1"
                     /db_xref="GeneID:56882"
                     /db_xref="HGNC:HGNC:17719"
                     /db_xref="MIM:619456"
     exon            1..144
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..461
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..647
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /note="1300002M12Rik; small protein effector 1 of Cdc42;
                     signaling molecule SPEC1 beta; CDC42-binding protein
                     SCIP1; small effector of CDC42 protein 1"
                     /codon_start=1
                     /product="CDC42 small effector protein 1"
                     /protein_id="NP_064624.1"
                     /db_xref="CCDS:CCDS981.1"
                     /db_xref="GeneID:56882"
                     /db_xref="HGNC:HGNC:17719"
                     /db_xref="MIM:619456"
                     /translation="MSEFWHKLGCCVVEKPQPKKKRRRIDRTMIGEPMNFVHLTHIGS
                     GEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL"
     exon            462..572
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..663
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..3006
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1305..1310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1332
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /note="major polyA site"
     regulatory      2974..2979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /note="hexamer: AATACA"
     regulatory      2988..2993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /note="hexamer: AATAAA"
     polyA_site      2996
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
     polyA_site      3006
                     /gene="CDC42SE1"
                     /gene_synonym="SCIP1; SPEC1"
                     /note="major polyA site"
ORIGIN      
        1 agccggcccc acctctgccg gctcgtactc ggctccccca cctcgccgca gagctagccc
       61 gggaagccca cactggcggc cacggagcag agtccctcac ccccaccagc tgtagctgaa
      121 cgtctggatg gtggagaaga gcagggttcc gagtctgagg aagacataac cttgtgcctg
      181 cctgcccacc tctctctctg gtcctgttca tctctcaggc tctgagacac tgaccttcac
      241 tgctcagtta aaggttccag ggattccact ttgtctggac ccatccagct gagtgaaccc
      301 agggtggtgg tgtatctggg gagagtgagg agtgggttgt ccaaacacca gggaaagagc
      361 cctttggggc ctcagacagc ggagtgaagc tggaaccatc agggaacatg agtgaatttt
      421 ggcacaaact gggctgctgt gtggtagaga aaccccagcc gaagaagaag agaagacgga
      481 ttgaccggac catgattggg gaaccaatga attttgttca cctgactcac attggctcag
      541 gggagatggg ggccggagat ggacttgcca tgacaggtgc agttcaggag cagatgagat
      601 ccaagggaaa ccgagatagg ccatggagca attctagggg cttatagctc caataatgga
      661 atggttctgc catcttgaaa cccccattct gtttccagcc cagaagaaat gctgccccta
      721 ccagatccct ccttgaacca gtgatctaag gacccctctt ttccctatct gcctaacagt
      781 gcctcacaag gcttgggggc tggactccct ctactccctc tggccatagc ccctcctgga
      841 gatggggtca aggcagcagg actgatcaag tgactactgg ttagccagag gagctcagct
      901 gaagccctgg aaaccctcag gtctgagata ggagttctct aggaacctgg aatgagttcc
      961 tgtctcctga atgatggtct gggtgccacc tgtttttaaa ctcttaaacc tggaactcct
     1021 taaatggggt aggtgggtga gattatcaaa gctgaagctg gctttgctga gaagctccct
     1081 acctccctgc ccttctcctc cttcctgctg gaatgaacta aagcagatgt caagcagggg
     1141 ctggtggggg tgcctactcc cttttccact ctatctttag atttcaaacc ttaggcttac
     1201 agcccctcaa tatctctctg ctaacaccag tgtctctttc tagttaggcc tctaatcttc
     1261 tgtttctgtt taccagcttc ccagcaactt tcctttttta aaatattaaa aatttaattc
     1321 aggttctctt aattatcctc atcctgctgt tgcctccgcc cttaactcta tccctattag
     1381 gaaccttgtt tcccaccgaa taagagttaa ggtaagaggt agctcttcac ctgatgacat
     1441 tccatttaag ttttggggca tctttcctgc cctctgccaa cctccctgct ggcccaggtg
     1501 agaggaggaa gaggggtctg gaaagaaacc cagaatgcgg cagaactagg agtaagtcca
     1561 tctcaaggtg gacttctgat cattgaggat ggtgagataa ataggttgaa aacaatcatc
     1621 tgtgagttta ggagtcttaa gatcctcaca gcacgggagc agggagaggc tctagaacaa
     1681 ggtttcacaa ccgagatgcc tttgacattt tgggctgaag tgttctttgt aaggaaaacc
     1741 tgtttcctat tttgtgcatt acaggatatt tagcagcaac cctggcccac tctagttatg
     1801 acaaccaaaa atgtctctat acattgccag atttctccta gggggcaaaa tcgcctccat
     1861 ttgagaacca caactctaaa gtcaagatat ttttctctga agtgatttct gcttggcacg
     1921 ctaccctcat catcttactc atcttaagcc cgagccatgg atcaactagg agcccatata
     1981 aatgaggctc agtagggctg cacataatct ccaaacaatt ctttattcag tgttttgctt
     2041 gtgtttgcat gttgctatga tggacaggtc cccctcctcc attcttgccc tctggagaag
     2101 tggttcctgc agtgtagaga tatgaacagg gtatggtagg attggggaaa ggggagagag
     2161 aagcagtaga tacactcctt atcctcccca aattttaagc tctatttctg tgccctagtc
     2221 ctagacacac attagactca gggagttttg tctgaagacc aggtcccact gccccctggc
     2281 tgaagagtct gctttaaatg ggaaaacaac gtaggagcag gggtttttag gcactttcag
     2341 tattctcagg tgttcttcgt tctggccctt ccagggtaat taggaaggca gaacaagaca
     2401 gatgagctcc tgcctgctct gagacaagaa gggtggggtc tcattagctt tgcaacagga
     2461 aacatcctgt tttatggtag tggggtcagg aatgtaggaa ctggtatcca ttctgccaat
     2521 tccaccaccc attcagtttg cttatcccta cagaacagtg actgaggttc tttttttttt
     2581 tttttttttt tttttttcaa atttccatgt attttctgcc atttttcagg gtctaagatt
     2641 ggtcatacat tcccaattta ctctcagttc cagtcaagct ggttgctctg aaagtaaccc
     2701 agcttgttgc tctaaaatac ctcagtagcc tgagtgttat actagagatc taaagggtta
     2761 acaggatagg gtggaaaggt tagagactcc tagaaatctc tggtcaccgt gatcttcggc
     2821 ctcattctaa tacctgttct ttggacagtc tttttccttt ggtgctctct tgcctttagc
     2881 taccttctct aatatgtatg ctaccatcac taataaagtg atgggaatgg gtttgagagt
     2941 cgtaatttat attaaaaagt tgttggactt ttaaatacat tttttcaaat aaaaaattaa
     3001 gcaaaa
//
