LOCUS       NM_145057                896 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CDC42 effector protein 5 (CDC42EP5), mRNA.
ACCESSION   NM_145057
VERSION     NM_145057.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 896)
  AUTHORS   Farrugia,A.J., Rodriguez,J., Orgaz,J.L., Lucas,M., Sanz-Moreno,V.
            and Calvo,F.
  TITLE     CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function,
            migration, and invasion
  JOURNAL   J Cell Biol 219 (9) (2020)
   PUBMED   32798219
REFERENCE   2  (bases 1 to 896)
  AUTHORS   Farrugia,A.J. and Calvo,F.
  TITLE     The Borg family of Cdc42 effector proteins Cdc42EP1-5
  JOURNAL   Biochem Soc Trans 44 (6), 1709-1716 (2016)
   PUBMED   27913681
  REMARK    GeneRIF: Studies indicate some of the functional and mechanistic
            roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5),
            including cytoskeletal remodelling and signalling.
            Review article
REFERENCE   3  (bases 1 to 896)
  AUTHORS   Joberty,G., Perlungher,R.R., Sheffield,P.J., Kinoshita,M., Noda,M.,
            Haystead,T. and Macara,I.G.
  TITLE     Borg proteins control septin organization and are negatively
            regulated by Cdc42
  JOURNAL   Nat Cell Biol 3 (10), 861-866 (2001)
   PUBMED   11584266
REFERENCE   4  (bases 1 to 896)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   5  (bases 1 to 896)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245884.3, DA867588.1,
            BC024327.1, BC065910.1 and AI379873.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145057.3.
            
            Summary: Cell division control protein 42 (CDC42), a small Rho
            GTPase, regulates the formation of F-actin-containing structures
            through its interaction with the downstream effector proteins. The
            protein encoded by this gene is a member of the Borg (binder of Rho
            GTPases) family of CDC42 effector proteins. Borg family proteins
            contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to
            CDC42 and regulate its function negatively. The encoded protein may
            inhibit c-Jun N-terminal kinase (JNK) independently of CDC42
            binding. The protein may also play a role in septin organization
            and inducing pseudopodia formation in fibroblasts [provided by
            RefSeq, Jul 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024327.1, ERR279841.5696.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301200.3/ ENSP00000301200.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC245884.3         190827-190832       c
            7-35                DA867588.1         1-29
            36-548              BC024327.1         1-513
            549-890             BC065910.1         448-789
            891-896             AI379873.1         15-20               c
FEATURES             Location/Qualifiers
     source          1..896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..896
                     /gene="CDC42EP5"
                     /gene_synonym="Borg3; CEP5"
                     /note="CDC42 effector protein 5"
                     /db_xref="GeneID:148170"
                     /db_xref="HGNC:HGNC:17408"
                     /db_xref="MIM:609171"
     exon            1..233
                     /gene="CDC42EP5"
                     /gene_synonym="Borg3; CEP5"
                     /inference="alignment:Splign:2.1.0"
     exon            234..374
                     /gene="CDC42EP5"
                     /gene_synonym="Borg3; CEP5"
                     /inference="alignment:Splign:2.1.0"
     exon            375..896
                     /gene="CDC42EP5"
                     /gene_synonym="Borg3; CEP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..821
                     /gene="CDC42EP5"
                     /gene_synonym="Borg3; CEP5"
                     /note="binder of Rho GTPases 3; CDC42 effector protein
                     (Rho GTPase binding) 5"
                     /codon_start=1
                     /product="cdc42 effector protein 5"
                     /protein_id="NP_659494.2"
                     /db_xref="CCDS:CCDS12896.1"
                     /db_xref="GeneID:148170"
                     /db_xref="HGNC:HGNC:17408"
                     /db_xref="MIM:609171"
                     /translation="MPVLKQLGPAQPKKRPDRGALSISAPLGDFRHTLHVGRGGDAFG
                     DTSFLSRHGGGPPPEPRAPPAGAPRSPPPPAVPQSAAPSPADPLLSFHLDLGPSMLDA
                     VLGVMDAARPEAAAAKPDAEPRPGTQPPQARCRPNADLELNDVIGL"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP5"
                     /gene_synonym="Borg3; CEP5"
                     /note="hexamer: CATAAA"
     polyA_site      896
                     /gene="CDC42EP5"
                     /gene_synonym="Borg3; CEP5"
                     /note="major polyA site"
ORIGIN      
        1 acacttagtc ctggcctcct cccgccccca cactccgccc agaggggcct cagcttttcc
       61 accactgctt tctagtcctt taactcctag aggcaaactt ttgggggata agaaagcctg
      121 ggaggggcct gtgccaaaac cctctctgcc tggggactgg gcggtgattc cgcttctgcc
      181 tgggctcctg ccatggcccc cgagaggggc tgacacttta gctcccggtg caggtgagaa
      241 cccgcccgga ggaagaagga aggcgcgggc cggggattag gagacggagg cggactcgga
      301 gccagggaac caggggtccg ggctagagct ggagtcgtga gcgcgcgccc gccccgctct
      361 gggaggaccg cgagatgccc gtgctgaagc agctgggccc cgcgcagccc aagaagcggc
      421 ctgatcgcgg cgccctgtcc atctccgcgc cgctcggcga cttccggcac acgctgcacg
      481 tggggcgcgg cggcgacgcc ttcggggaca cctcgttcct gagccgccac ggcggcgggc
      541 cgccccccga gccccgggcg ccccccgcgg gggccccgcg ctccccgccg ccgcccgccg
      601 tcccgcagtc cgcagcgccc tcgcctgccg acccgctgct gtccttccac ctggatctgg
      661 ggccctccat gctggacgcg gtgctgggcg tcatggacgc ggcgcgcccg gaggcggctg
      721 ccgccaagcc cgacgcggaa ccccgccccg ggacgcagcc cccccaggcc cgctgccgcc
      781 ccaacgcgga cctcgagctg aacgacgtca tcggcctcta ggttccctca ttccccgcgc
      841 ccttcccgcc cggcacccca cttctgtata cataaacggc caaggtgtgt gcccgg
//
