LOCUS       NM_012121               3098 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens CDC42 effector protein 4 (CDC42EP4), mRNA.
ACCESSION   NM_012121
VERSION     NM_012121.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3098)
  AUTHORS   Zhang,X., Yu,T., Gao,G., Xu,J., Lin,R., Pan,Z., Liu,J. and Feng,W.
  TITLE     Cell division cycle 42 effector protein 4 inhibits prostate cancer
            progression by suppressing ERK signaling pathway
  JOURNAL   Biomol Biomed 24 (4), 840-847 (2023)
   PUBMED   38153517
  REMARK    GeneRIF: Cell division cycle 42 effector protein 4 inhibits
            prostate cancer progression by suppressing ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3098)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3098)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3098)
  AUTHORS   Farrugia,A.J. and Calvo,F.
  TITLE     The Borg family of Cdc42 effector proteins Cdc42EP1-5
  JOURNAL   Biochem Soc Trans 44 (6), 1709-1716 (2016)
   PUBMED   27913681
  REMARK    GeneRIF: Studies indicate some of the functional and mechanistic
            roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5),
            including cytoskeletal remodelling and signalling.
            Review article
REFERENCE   5  (bases 1 to 3098)
  AUTHORS   Datta,D., Arion,D., Corradi,J.P. and Lewis,D.A.
  TITLE     Altered expression of CDC42 signaling pathway components in
            cortical layer 3 pyramidal cells in schizophrenia
  JOURNAL   Biol Psychiatry 78 (11), 775-785 (2015)
   PUBMED   25981171
  REMARK    GeneRIF: This study showed that CDC42EP4 messenger RNA levels was
            significantly upregulated in subjects with schizophrenia in laminar
            and cellular samples.
REFERENCE   6  (bases 1 to 3098)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 3098)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3098)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   9  (bases 1 to 3098)
  AUTHORS   Osada,N., Kusuda,J., Suzuki,Y., Sugano,S. and Hashimoto,K.
  TITLE     Sequence analysis, gene expression, and chromosomal assignment of
            mouse Borg4 gene and its human orthologue
  JOURNAL   J Hum Genet 45 (6), 374-377 (2000)
   PUBMED   11185749
REFERENCE   10 (bases 1 to 3098)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI560730.1, BC010451.1 and
            BC002774.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012121.4.
            
            Summary: The product of this gene is a member of the CDC42-binding
            protein family. Members of this family interact with Rho family
            GTPases and regulate the organization of the actin cytoskeleton.
            This protein has been shown to bind both CDC42 and TC10 GTPases in
            a GTP-dependent manner. When overexpressed in fibroblasts, this
            protein was able to induce pseudopodia formation, which suggested a
            role in inducing actin filament assembly and cell shape control.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002774.1, SRR3476690.753948.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335793.4/ ENSP00000338258.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               BI560730.1         27-550
            525-2834            BC010451.1         504-2813
            2835-3087           BC002774.1         2838-3090
            3088-3098           BC002774.1         3092-3102
FEATURES             Location/Qualifiers
     source          1..3098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3098
                     /gene="CDC42EP4"
                     /gene_synonym="BORG4; CEP4; KAIA1777"
                     /note="CDC42 effector protein 4"
                     /db_xref="GeneID:23580"
                     /db_xref="HGNC:HGNC:17147"
                     /db_xref="MIM:605468"
     exon            1..109
                     /gene="CDC42EP4"
                     /gene_synonym="BORG4; CEP4; KAIA1777"
                     /inference="alignment:Splign:2.1.0"
     exon            110..3098
                     /gene="CDC42EP4"
                     /gene_synonym="BORG4; CEP4; KAIA1777"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1292
                     /gene="CDC42EP4"
                     /gene_synonym="BORG4; CEP4; KAIA1777"
                     /note="binder of Rho GTPases 4; CDC42 effector protein
                     (Rho GTPase binding) 4"
                     /codon_start=1
                     /product="cdc42 effector protein 4"
                     /protein_id="NP_036253.2"
                     /db_xref="CCDS:CCDS11695.1"
                     /db_xref="GeneID:23580"
                     /db_xref="HGNC:HGNC:17147"
                     /db_xref="MIM:605468"
                     /translation="MPILKQLVSSSVHSKRRSRADLTAEMISAPLGDFRHTMHVGRAG
                     DAFGDTSFLNSKAGEPDGESLDEQPSSSSSKRSLLSRKFRGSKRSQSVTRGEREQRDM
                     LGSLRDSALFVKNAMSLPQLNEKEAAEKGTSKLPKSLSSSPVKKANDGEGGDEEAGTE
                     EAVPRRNGAAGPHSPDPLLDEQAFGDLTDLPVVPKATYGLKHAESIMSFHIDLGPSML
                     GDVLSIMDKEEWDPEEGEGGYHGDEGAAGTITQAPPYAVAAPPLARQEGKAGPDLPSL
                     PSHALEDEGWAAAAPSPGSARSMGSHTTRDSSSLSSCTSGILEERSPAFRGPDRARAA
                     VSRQPDKEFSFMDEEEEDEIRV"
     regulatory      3076..3081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP4"
                     /gene_synonym="BORG4; CEP4; KAIA1777"
                     /note="hexamer: ATTAAA"
     polyA_site      3098
                     /gene="CDC42EP4"
                     /gene_synonym="BORG4; CEP4; KAIA1777"
                     /note="major polyA site"
ORIGIN      
        1 agagggaaac aaacgccggc gctgacaggg gccgccagcc cctccgccgc gcggagccca
       61 cgaaggggac agcgcagccg gcccagagct cgggtctccg gggaccgagc cttatgatct
      121 cctcattgcg tccccctctg cccactggac ttggacttca gatctgaccc cagacctgcc
      181 ggctacctcg ggagggccca cctccccgcc catccagcaa gatgccaatc ctcaagcaac
      241 tggtgtccag ctcggtgcac tccaagcgcc gttcccgagc ggacctcacg gccgagatga
      301 tcagcgcccc gctgggcgac ttccgccaca ccatgcacgt tggccgggcc ggagacgcct
      361 ttggggacac ctccttcctc aatagcaagg ctggcgagcc cgacggcgag tccttggacg
      421 aacagccctc ttcttcatct tccaaacgca gtctcctgtc caggaagttc cggggcagca
      481 agcggtcaca gtcggtgacc aggggggagc gggagcagcg tgacatgctg ggctccctgc
      541 gggactcggc cctgtttgtc aagaatgcca tgtccctgcc ccagctcaat gagaaggagg
      601 ccgcggagaa gggcaccagt aagctgccca agagcctgtc atccagcccc gtgaagaagg
      661 ccaatgacgg ggagggcggc gatgaggagg cgggcacgga ggaggcagtg ccccgtcgga
      721 atggggccgc gggtccacat tcccctgacc ccctcctcga tgagcaggcc tttggggatc
      781 tgacagatct gcctgtcgtg cccaaggcca cgtacgggct gaagcatgcg gagtccatca
      841 tgtccttcca catcgacctg gggccctcca tgctgggtga cgtcctcagc atcatggaca
      901 aggaggagtg ggaccccgag gagggggagg gtggttacca tggcgatgag ggcgccgctg
      961 gcaccatcac ccaggctccc ccgtacgccg tggcggcccc tcccctggca aggcaggaag
     1021 gcaaggctgg cccagacttg ccctccctcc cctcccatgc tctggaggat gaggggtggg
     1081 cagcagcggc ccccagcccc ggctcagccc gcagcatggg cagccacacc acacgggaca
     1141 gcagctccct ctccagctgc acctcaggca tcctggagga gcgcagccct gccttccggg
     1201 ggccggacag ggcccgggct gctgtctcaa gacagccaga caaggagttc tccttcatgg
     1261 atgaggagga ggaggatgaa atccgtgtgt gaggcggaca gtgggtggcc accgggagct
     1321 cttggctgca tcttctccct gcccccaccc cactatgacc tttgacccta cggcgcaggg
     1381 gcagccagga cccttgattc agaccatgga ccctggacct tgtagatgag ggacactggc
     1441 ctggccctcg ggtcttcgga ggacgtaggg ggctggcatg ggtgccgact ggctgcctga
     1501 cttcatcatg ctccctgcac ttaggctgcg tgggacaagg gctgtgttgt cacagcagga
     1561 ataggttttc ctctgttggc ctccctttcc tccaccctgg cctcaaatgg atgccagatg
     1621 ccaaccccag ttctggccac gtacagccag cgggtcagcc cagaggcagc ctcagctcca
     1681 gggctaagga ctctcggctc ccattttctc tgctggcgtt tctgctgtgc ccagcagtgg
     1741 ctgctgggga agcagctgca gcaggaggga gacggtcttg cctctcagcc cctccctgcc
     1801 ccaccccagc tcctgccctg gaaatctgga gccccttgga gctgagctgg acggggggcc
     1861 agctgcgagc atgtgcacta aacgcagccc tttccagggg aagagaacag gatggagaat
     1921 ggaaggaaag ccccccaggc ttcgtgaatt gcaagaaggg acccttccag gatgacacta
     1981 ggaacagggc tagggcactc gctcagtccc taggggcttg tttgttcttt attattgtgt
     2041 ttaaatcctt atagagcaat atcaggatgg tgttaatagg tctgcctcag aatgagaatc
     2101 aatcctttta gaaaaccttt atactaagcc tcctcttcaa aattcacagt ggcgattagc
     2161 ggactggagt ctggtggcga ttagcggact ggagtctggg gacatccgtg gcaaagacac
     2221 cagctcaact ttagtgcttc ccaactttat ttagaatgac atggggtggg tgtctggtgt
     2281 gtgtgttttc cctacgcacc tcccatagct attaacaact gaggaaggcc agtgcagaat
     2341 atttttggag aacgattttt tttttaaata atatatcatt cctatggggg gaaagccttt
     2401 tttttctttt tggctgagtt attccctccc tcccctcaat accctcagta ctgactactt
     2461 ccctttcttt tctcaggcct ccccccaccg acttttgagg ccagggttgg ccagatttag
     2521 caaaaccaaa acagagtgct gagttaaacg caaatttcag gtaaacaaaa gataattttc
     2581 tagcattaat atgccccacg caatatttgg aacacttatg tgaaaaatga tttgtttttc
     2641 tgaaattcac gtttctctct gagtcctgta actgtccccg aggggattga gcagaagctc
     2701 gggtatgagc cctgaggttg actgccggtt atttttctgt cctgggaaca gcctgaccca
     2761 cctccctgtc tccatgtagc cagtgagggg agggggagac acagaaccaa ccacagccag
     2821 gggcgtcccc atggcgactg tggcccggcc cctcctctct tgcctgactc tcctctcttg
     2881 cctgactcta gacactaact tagttccagg ttcggtgccc tgttggtgct cctgtttcca
     2941 atagcttagg tcccatggtg ggggaggaac ctcaggggct atgcagcccc cgccagctgc
     3001 cctcgaatcc cgtccaggcc aattccagat tctaaactga tttttttcat gatattgtca
     3061 aaacagtgag gaaacattaa aaaaaaagcc ctaaagca
//
