LOCUS       NM_006449               5096 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CDC42 effector protein 3 (CDC42EP3), transcript
            variant 1, mRNA.
ACCESSION   NM_006449
VERSION     NM_006449.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5096)
  AUTHORS   Yang,Z., Xu,T., Xie,T., Yang,L., Wang,G., Gao,Y., Xi,G. and
            Zhang,X.
  TITLE     CDC42EP3 promotes glioma progression via regulation of CCND1
  JOURNAL   Cell Death Dis 13 (4), 290 (2022)
   PUBMED   35365622
  REMARK    GeneRIF: CDC42EP3 promotes glioma progression via regulation of
            CCND1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5096)
  AUTHORS   Xu,P., Li,X., Tang,C., Wang,T. and Xu,J.
  TITLE     Deduction of CDC42EP3 suppress development and progression of
            osteosarcoma
  JOURNAL   Exp Cell Res 412 (1), 113018 (2022)
   PUBMED   34998812
  REMARK    GeneRIF: Deduction of CDC42EP3 suppress development and progression
            of osteosarcoma.
REFERENCE   3  (bases 1 to 5096)
  AUTHORS   Chen,W., Zhu,Y., Zhang,W., Zhang,H., Zhou,Y., Sun,P. and Wu,G.
  TITLE     CDC42EP3 is a key promoter involved in the development and
            progression of gastric cancer
  JOURNAL   Carcinogenesis 42 (9), 1179-1188 (2021)
   PUBMED   34111280
  REMARK    GeneRIF: CDC42EP3 is a key promoter involved in the development and
            progression of gastric cancer.
REFERENCE   4  (bases 1 to 5096)
  AUTHORS   Eduardo da Silva,L., Russo,L.C. and Forti,F.L.
  TITLE     Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger
            DNA damage response signaling and sensitize cells to DNA-damaging
            agents
  JOURNAL   Exp Cell Res 395 (2), 112206 (2020)
   PUBMED   32739212
  REMARK    GeneRIF: Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to
            trigger DNA damage response signaling and sensitize cells to
            DNA-damaging agents.
REFERENCE   5  (bases 1 to 5096)
  AUTHORS   Gomis,R.R., Alarcon,C., He,W., Wang,Q., Seoane,J., Lash,A. and
            Massague,J.
  TITLE     A FoxO-Smad synexpression group in human keratinocytes
  JOURNAL   Proc Natl Acad Sci U S A 103 (34), 12747-12752 (2006)
   PUBMED   16908841
REFERENCE   6  (bases 1 to 5096)
  AUTHORS   Spik,A., Oczkowski,S., Olszak,A., Formanowicz,P., Blazewicz,J. and
            Jaruzelska,J.
  TITLE     Human fertility protein PUMILIO2 interacts in vitro with testis
            mRNA encoding Cdc42 effector 3 (CEP3)
  JOURNAL   Reprod Biol 6 (2), 103-113 (2006)
   PUBMED   17173092
REFERENCE   7  (bases 1 to 5096)
  AUTHORS   Lim,W.C. and Chow,V.T.
  TITLE     Gene expression profiles of U937 human macrophages exposed to
            Chlamydophila pneumoniae and/or low density lipoprotein in five
            study models using differential display and real-time RT-PCR
  JOURNAL   Biochimie 88 (3-4), 367-377 (2006)
   PUBMED   16466844
REFERENCE   8  (bases 1 to 5096)
  AUTHORS   Joberty,G., Perlungher,R.R., Sheffield,P.J., Kinoshita,M., Noda,M.,
            Haystead,T. and Macara,I.G.
  TITLE     Borg proteins control septin organization and are negatively
            regulated by Cdc42
  JOURNAL   Nat Cell Biol 3 (10), 861-866 (2001)
   PUBMED   11584266
REFERENCE   9  (bases 1 to 5096)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   10 (bases 1 to 5096)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006369.3.
            
            On Jul 19, 2019 this sequence version replaced NM_006449.4.
            
            Summary: This gene encodes a member of a small family of guanosine
            triphosphate (GTP) metabolizing proteins that contain a CRIB
            (Cdc42, Rac interactive binding) domain. Members of this family of
            proteins act as effectors of CDC42 function. The encoded protein is
            involved in actin cytoskeleton re-organization during cell shape
            changes, including pseudopodia formation. A pseudogene of this gene
            is found on chromosome 19. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2250327.1,
                                           SRR14038194.3908681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295324.4/ ENSP00000295324.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC006369.3         86240-86456
            218-5096            AC006369.3         111060-115938
FEATURES             Location/Qualifiers
     source          1..5096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..5096
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
                     /note="CDC42 effector protein 3"
                     /db_xref="GeneID:10602"
                     /db_xref="HGNC:HGNC:16943"
                     /db_xref="MIM:606133"
     exon            1..217
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..5096
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1217
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
                     /note="MSE55-related protein; CRIB-containing BORG2
                     protein; binder of Rho GTPases 2; MSE55-related
                     Cdc42-binding protein; CDC42 effector protein (Rho GTPase
                     binding) 3"
                     /codon_start=1
                     /product="cdc42 effector protein 3"
                     /protein_id="NP_006440.2"
                     /db_xref="CCDS:CCDS1791.1"
                     /db_xref="GeneID:10602"
                     /db_xref="HGNC:HGNC:16943"
                     /db_xref="MIM:606133"
                     /translation="MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHI
                     GKEGQHDVFGDISFLQGNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPV
                     LKNAISLPTIGGSQALMLPLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLL
                     ENGTVHQGDTSWGSSGSASQSSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKT
                     KSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
                     /note="hexamer: AATATA"
     polyA_site      1886
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
     regulatory      5074..5079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
                     /note="hexamer: AATGAA"
     polyA_site      5096
                     /gene="CDC42EP3"
                     /gene_synonym="BORG2; CEP3; UB1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcgc accttctctc gcggccgggg gaccgcagcg cggggctagc ccggagaccc
       61 ggccaccggc ctggggcgcc ttcacgccgt ctcggagcgg ataatgcggt gagcaggcac
      121 cacgccggca gactcggctg gatctgcgca cagcggcagg gattgcgtgc gcccgcggga
      181 ggcccggggc agcggctggg atcctcagcg gcggccggtt tgtcctggtt gtggtcaaga
      241 ctggatgatg taactggctc tctaggaagc ctcacttggc cgtaacctca ggaaggttct
      301 ctttgacccc atctcatttc gaagccactt ctgaagccac ttgagaaaaa tgatgtgaca
      361 gttcctatca aaaaggattc agaaacatat accatctgtg aagaaagtgg ccctttctcc
      421 cgcttgcaaa atagacattc tcaaattcca aaatgccagc caagacccca atttacctga
      481 aagcagccaa taacaagaaa ggaaagaaat ttaaactgag ggacattctg tctcctgata
      541 tgatcagtcc cccgcttgga gactttcgcc acaccatcca cattggcaaa gagggccagc
      601 acgatgtctt tggagatatt tcctttcttc aagggaacta cgagctttta cctggaaacc
      661 aggagaaagc acacctgggc cagttccctg ggcataatga gttcttccgg gccaacagca
      721 cctcggactc tgtgttcaca gaaacgccct ccccggtgct caaaaatgcc atctccctcc
      781 cgaccattgg aggatcccaa gctctcatgt tgcccttatt gtcaccagtg acatttaatt
      841 ccaaacagga gtccttcggg ccagcaaagc tgcccaggct tagctgcgag cccgtcatgg
      901 aggaaaaagc tcaggagaaa agcagtctgt tggagaatgg gacagtccac cagggagaca
      961 cctcgtgggg ctccagcggt tctgcatctc agtccagcca aggcagagac agccactcct
     1021 ccagcctgtc cgaacagtac cccgactggc cagccgagga catgtttgac catcccaccc
     1081 catgcgagct catcaaggga aagactaagt cagaggagtc cctctctgac cttacaggtt
     1141 ccctcctctc cctgcagctt gatcttgggc cctcactttt ggatgaggtg ctgaatgtaa
     1201 tggataaaaa taagtaacaa gatgccaact tttttccttt ggggtaaaag gtacaaaaac
     1261 aaactaacca cagttgaaga gaagggcttc cggagctgta tttgcagttt tgtgttgggt
     1321 tttctaaaat aatattctta caaagtattt ttttacctgt tatgccctgt ttgcaaaaac
     1381 aatttagaaa aaaacaacaa agcaaaacct atcttggcaa aaaaaggaag tgagtcagag
     1441 cccattttca ggaggcattg gtgatgttcg gctcacatat tgtttgcaga cacacaagaa
     1501 atctggcttg gccaggattg gcactagcta tgaagggctg agcgagtcac attaaggaac
     1561 ttcacggaac tttatagcac tccgacattt tctgagcaag aggaagtcaa aatttattta
     1621 acacctaagc ctttttgtag actcttttct atatattgct taggctcacc atagcgaatt
     1681 ctccagtgtt aaaacttttc tgttttcaca tttgaacttt atgggttttg gggattttct
     1741 tgtagttctt atatatccct atatattata tctatattgc aaaattttga ctgtcagcta
     1801 catgttggta agacacaggc aaagtattac tgtaactaag ttatttttaa agttaaaata
     1861 tatttttacg tgcctttggc tttttattgc agagtctaca ttttatagat tctacatcag
     1921 atgttgtcac ttatttccat tgggattcca ttgtaagctg tgtatgtgcg tgtttggaaa
     1981 agtgtattca tacttagttt ttttttcttc atctgttatc atacttttaa cagcaaccaa
     2041 taacggattg taaagtgtaa aggcacaggt tactcatgat gcttctgcag agactgtggg
     2101 ctacaccaca tatgttattt ggaaatatag gtattttagt acagtacata cttgcattac
     2161 ataggtactt caagcaacac aataaaaagt aaatgataaa gtgaacttgc ttgtttatag
     2221 taataaacaa gaccataaga gaataagtat agctagagaa attgcttctc tgaaatgtac
     2281 atgagccctt aaggtaagag atgatttcca tctactctca ttttgattac ttccttatgg
     2341 tttgagaggc tagaaactga gcctctctac ttttggaaaa atgaacatgt gaggtcagat
     2401 tttttttttt ttttttaagt cagcactgat gccaccctct cagtggtcat ttctgagcat
     2461 cttcctgact tgaacacctt ctacagcaaa ctcttgcaag tccagtttca tccctgtaag
     2521 gcaaatgtct tttcacgcag aaagtgccat atagacgaga taaaggcagc taaaacgagg
     2581 gcagtagaga gcacttaccc gaccccaagg tgccagagat gccctgagga tggtggttaa
     2641 ggaaacagga gcaggaaatg tacacacaga ttcctgtccc tttgccaact actccttccc
     2701 catcaaagaa aaacacttgc acacagtaac taccagctcc ttctctcaaa cttgtatttc
     2761 tcctggaaat gtatctcaga aatgacctcc tctcccaacc acttcaacga ttctttcttt
     2821 gggtttgggg ttcttgcagt tctatcatct aaaataacct ttggactgca ggtaaaatgc
     2881 aattaggaca actaaccaag tagacgaaac aagttcccct aggcaggggt gtccaatatt
     2941 ttagcttccc tggaccgcat tggaagaatt ttcttgggcc acatgtaaaa cacactaaca
     3001 ctaaccatag ttgatgagct taaaaaaata aaaatagaaa attgcaaaaa aaaaaaaaaa
     3061 aaaaaatctc agactgtttt aagaaagttt aaaaatttgt gttggacttc atgcgggcca
     3121 caggttggac aagcttgccc tagggcattg tgtgctttcc gtaacttctc agttgtattt
     3181 cgttatccat gactctccag tgttttttct gttggaccac acccgtcaca gttcacagtt
     3241 ccaaagagaa atttcccagc ctattctaaa tcttgttaat gacgaagagt ccaatgtatc
     3301 tcattatttg tagccaattt tagactcttt tcaatacctc ccccccattt taattagtat
     3361 tgatcatatt cagtctttca ttttactctt catctgtagc gtgacctcaa ggtaaagatg
     3421 aaactatttc atgaaaaggg gaggagtatg gctgtgcatt agctctactc cctctctggt
     3481 aagtactggg gagagaacag ccctgccagt actgggtttg atagattcta aatattaatc
     3541 acacatcctg cctacagtta gccattttag tttctgggag ttctttcatg tacattttct
     3601 tccattaatt gaattaggta taattgagat ggcaataaat atgcccgtat tagaaagagg
     3661 aaacaaagct acatgcggct tatgattttg ttgagtcact tctcccgagg cagcctttcc
     3721 aatgcctggt cccttcccct gagagcaggt ggactgctgg tggtggcttt ctttcctgca
     3781 gagaggcact ttagacccat acctgctgtg agctgaattg atgttctcat cctgtgaacc
     3841 ttctcccact ttaacctaat ttatctttac ttgtttaaag ataaggaaac ccaagatgta
     3901 ctttatttgc aaactcaaag caaatggcga gccacctgtg acccagtaac cagaaaagaa
     3961 accatgccat ttgtataagt agagacactt cttgttgagg taggcaaggc tcttgtgagc
     4021 gatttttttc ccctagtgag acctaacaaa agacaagcta tatcatttct gcctgaaatt
     4081 atctgcttga aaagatcaaa atatcaggat acttagctct tcacaaatat gaagtcatta
     4141 tcacatttca ctgagccaga aatcactgtt aacagcacac acaaaagact acactggttg
     4201 aacagcaaag agaaacccgg gtctccagaa tcacagttta gtccttctat attactgcaa
     4261 gtgacctgtt ttttctgaag gctccccgca aatgaagtcc tggaatggaa aaaatccata
     4321 agtccataaa ttaacttgat aaatatttta gaacagacaa aagaaaatat tgagtgatgt
     4381 agttctaatc ctcctaatat ggaacctggc aagactgaat cattttactg tgaaatatat
     4441 aaacacaata gaatgagcca acatgatggt ttctctccag taagagtttt tcttttggaa
     4501 atgaggttaa cctagcccca aatctagcaa ttctcataaa atccgatttt agaattagcc
     4561 tcccagatta atctgaatga ttgacttatt ttttcttagg caagtcagta agccacccac
     4621 tagacagcca tatccagcaa aataagagaa gtttccagat gccaaatgat aagccaccat
     4681 caacccagcg gggaagcctt ctggttggtt tggctgtatg agattcagga aggccagaat
     4741 acccaaaatt attcacacga cgttaactta ttggtactgg ctaagcaata catgtatttc
     4801 ctaaaggagg agatggtctt ttggttgatt tatggacaca cttgtttcat ctgactgtaa
     4861 atatattgca tgctttattc tgatggtgca ctatttcatc cagcaagctt ttcatctgag
     4921 aatgtttaat gttgacctta ttcttagagc aagtagatct aaatattttt cagctgagtt
     4981 attagggagt cattattctg tggtacaatg ctgcaaaaag catcatgtgg aagaatggga
     5041 actatgctta ctttatgaag tgatgtataa cacaatgaaa tctgttttac aactac
//
