LOCUS       NM_006779               1963 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens CDC42 effector protein 2 (CDC42EP2), mRNA.
ACCESSION   NM_006779
VERSION     NM_006779.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1963)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1963)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1963)
  AUTHORS   Farrugia,A.J. and Calvo,F.
  TITLE     The Borg family of Cdc42 effector proteins Cdc42EP1-5
  JOURNAL   Biochem Soc Trans 44 (6), 1709-1716 (2016)
   PUBMED   27913681
  REMARK    GeneRIF: Studies indicate some of the functional and mechanistic
            roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5),
            including cytoskeletal remodelling and signalling.
            Review article
REFERENCE   4  (bases 1 to 1963)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 1963)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1963)
  AUTHORS   Xue,Y., Bi,F., Zhang,X., Zhang,S., Pan,Y., Liu,N., Shi,Y., Yao,X.,
            Zheng,Y. and Fan,D.
  TITLE     Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau
            suppression and HIF1alpha activation
  JOURNAL   Int J Cancer 118 (12), 2965-2972 (2006)
   PUBMED   16395716
  REMARK    GeneRIF: activations of Rac1 and Cdc42 are involved in the
            hypoxia-induced production of angiogenesis-promoting factors and
            tumor suppressors, and suggest that the Rho family GTPases Rac1 and
            Cdc42 may contribute to the hypoxia-mediated angiogenesis.
REFERENCE   7  (bases 1 to 1963)
  AUTHORS   Joberty,G., Perlungher,R.R., Sheffield,P.J., Kinoshita,M., Noda,M.,
            Haystead,T. and Macara,I.G.
  TITLE     Borg proteins control septin organization and are negatively
            regulated by Cdc42
  JOURNAL   Nat Cell Biol 3 (10), 861-866 (2001)
   PUBMED   11584266
REFERENCE   8  (bases 1 to 1963)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   9  (bases 1 to 1963)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
REFERENCE   10 (bases 1 to 1963)
  AUTHORS   Burbelo,P.D., Snow,D.M., Bahou,W. and Spiegel,S.
  TITLE     MSE55, a Cdc42 effector protein, induces long cellular extensions
            in fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 96 (16), 9083-9088 (1999)
   PUBMED   10430899
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315444.1 and BC022337.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006779.3.
            
            Summary: CDC42, a small Rho GTPase, regulates the formation of
            F-actin-containing structures through its interaction with the
            downstream effector proteins. The protein encoded by this gene is a
            member of the Borg family of CDC42 effector proteins. Borg family
            proteins contain a CRIB (Cdc42/Rac interactive-binding) domain.
            They bind to, and negatively regulate the function of CDC42.
            Coexpression of this protein with CDC42 suggested a role of this
            protein in actin filament assembly and cell shape control.
            [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.486747.1, AF001436.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279249.3/ ENSP00000279249.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              AK315444.1         1-1077
            1078-1963           BC022337.1         721-1606
FEATURES             Location/Qualifiers
     source          1..1963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1963
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /note="CDC42 effector protein 2"
                     /db_xref="GeneID:10435"
                     /db_xref="HGNC:HGNC:16263"
                     /db_xref="MIM:606132"
     exon            1..89
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /inference="alignment:Splign:2.1.0"
     exon            90..1963
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..1077
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /note="CRIB-containing BOGR1 protein; binder of Rho
                     GTPases 1; CDC42 effector protein (Rho GTPase binding) 2"
                     /codon_start=1
                     /product="cdc42 effector protein 2"
                     /protein_id="NP_006770.1"
                     /db_xref="CCDS:CCDS8099.1"
                     /db_xref="GeneID:10435"
                     /db_xref="HGNC:HGNC:16263"
                     /db_xref="MIM:606132"
                     /translation="MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIG
                     SGGGSDMFGDISFLQGKFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSP
                     LLKNAISLPVIGGPQALTLPTAQAPPKPPRLHLETPQPSPQEGGSVDIWRIPETGSPN
                     SGLTPESGAEEPFLSNASSLLSLHVDLGPSILDDVLQIMDQDLDSMQIPT"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /note="hexamer: AATAAA"
     polyA_site      1638
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /note="major polyA site"
     regulatory      1944..1949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /note="hexamer: AATAAA"
     polyA_site      1963
                     /gene="CDC42EP2"
                     /gene_synonym="BORG1; CEP2"
                     /note="major polyA site"
ORIGIN      
        1 gtaagttcac cgccggtcgg gtccggccgc cgcgctgtcc agctcctgag accttgctgt
       61 ccgccggtct gccgtctgcg cgcctcacgc tcctcagccc tggaccgggg acaagtaacc
      121 ctcggtgaca agaccaaagt gcactgctgc ccacacagtt cctacctttc tggcttcaat
      181 tcttcagaag agtttgccgt cctttgggga gaacgtgatt tttgttatct cagcccactg
      241 acttcattga tctctaatct tttttaattc cttgggccaa ctttgttcgt gcccccacac
      301 tgtagccaga agcccgttgg cgagctctgg cacctgcaaa ccaccccgtg gaacgagtgt
      361 ttcctctggc tgagggttgg agaggaggtg tggtctcagc aggcggcccg tagcctcaca
      421 gccaggcctg gtggtgaggt caccatgtcc accaaggtgc ccatctatct gaagcgtggc
      481 agtcgcaagg gcaagaagga gaagcttcgg gacctgctgt cctcggacat gatcagccca
      541 ccgctggggg acttccgcca caccattcat attggcagtg gcggcggcag tgacatgttt
      601 ggcgacatct ccttcctgca gggcaagttc cacctcctgc cggggaccat ggtggagggg
      661 cctgaagaag atggcacctt cgacctcccc ttccagttca cccgcaccgc caccgtgtgt
      721 gggcgggagc tcccggacgg cccatcccct ctgctcaaga acgccatctc cctcccggtt
      781 atcggtggac cccaggctct caccctgccc acagcccagg ctccacccaa gccccctcgc
      841 ctgcacctgg agacccctca gccttcccca caggagggag ggagtgtgga catctggagg
      901 attccagaga ctggctcccc caacagtgga ctgaccccgg agtcaggggc cgaggagccc
      961 ttcctgtcca atgccagctc cctgctgtcc ctgcacgtgg acctggggcc ttccatcctg
     1021 gatgatgtcc tgcagatcat ggatcaggac ctggacagca tgcagatccc cacataggac
     1081 acgaggctgc ctaggctggg gtcccaggtg gggcccagcc aggaggtggg gtgtggaccc
     1141 ggccctggcg gcggagtcag ggtcccaaga tcccacctgt atggtcgctg gccagtgatt
     1201 ctccttctga gccgtgtttc ccctctccct ccctctccac gtgggcaggg caggccccat
     1261 cgctttcctc tgataaccac atggacacat cctgaagtca gcccaggcgc cctgagcatc
     1321 ttggggcacc tggaccccat cacaatactc cttcttcctt caggtccctg ggtgaaggct
     1381 ttgctgaaac cgacccccct tttcacgtcc cttctgcctc tgccccgttg gatgccctga
     1441 ctgggggcag gggaagagac agggcacagc tggccacagg gctcagccac tgagcaggct
     1501 gttccgggcc tttggctttg catcctggac ggggagtgtc ctgtcaggga ccagatgtgt
     1561 cctgcctcat ccctagctcc aatcccttcc ccacgtgacc ggggattctg gttgcaataa
     1621 aacatgctgc tgctggtggc ggagctccct gtccctttgc cccaggtttc ctcccggagg
     1681 cagacagtct cccagagctg agggcttgcc tctggagacc ccagccccag agggctttgt
     1741 ggaggacagg ccttgccctc aagaacgtcg tacctgacgc tgagcctgtc atgagaatgc
     1801 aacaggagca aaccaagtgt tgctgtgaca ttgattcaga tgtttggcaa gaggtggctg
     1861 agcactgggg tgggcttggc actgtgccaa gcctggggcc aatccctgcc cagtcagctg
     1921 gggtctggtg ggggacaccc aagaataaaa gaataaccac aaa
//
