LOCUS       NM_152243               2148 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens CDC42 effector protein 1 (CDC42EP1), mRNA.
ACCESSION   NM_152243 NM_007061
VERSION     NM_152243.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   Bandyopadhyay,S., Zhang,X., Ascura,A., Edelblum,K.L., Bonder,E.M.
            and Gao,N.
  TITLE     Salmonella engages CDC42 effector protein 1 for intracellular
            invasion
  JOURNAL   J Cell Physiol 239 (1), 36-50 (2024)
   PUBMED   37877586
  REMARK    GeneRIF: Salmonella engages CDC42 effector protein 1 for
            intracellular invasion.
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Liu,X., Wu,J., Yang,B., Zhao,Y., Wang,Y., Pan,S., Miao,S. and Wu,X.
  TITLE     hsa_circ_0005991 promotes epithelial-mesenchymal transition by
            regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis
  JOURNAL   Genomics 115 (6), 110718 (2023)
   PUBMED   37757976
  REMARK    GeneRIF: hsa_circ_0005991 promotes epithelial-mesenchymal
            transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary
            endometriosis.
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2148)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2148)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   7  (bases 1 to 2148)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   8  (bases 1 to 2148)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
REFERENCE   9  (bases 1 to 2148)
  AUTHORS   Burbelo,P.D., Snow,D.M., Bahou,W. and Spiegel,S.
  TITLE     MSE55, a Cdc42 effector protein, induces long cellular extensions
            in fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 96 (16), 9083-9088 (1999)
   PUBMED   10430899
REFERENCE   10 (bases 1 to 2148)
  AUTHORS   Bahou,W.F., Campbell,A.D. and Wicha,M.S.
  TITLE     cDNA cloning and molecular characterization of MSE55, a novel human
            serum constituent protein that displays bone marrow
            stromal/endothelial cell-specific expression
  JOURNAL   J Biol Chem 267 (20), 13986-13992 (1992)
   PUBMED   1629197
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA047271.1, CR456524.1 and
            BC009356.2.
            
            On Nov 23, 2018 this sequence version replaced NM_152243.2.
            
            Summary: CDC42 is a member of the Rho GTPase family that regulates
            multiple cellular activities, including actin polymerization. The
            protein encoded by this gene is a CDC42 binding protein that
            mediates actin cytoskeleton reorganization at the plasma membrane.
            This protein is secreted and is primarily found in bone marrow.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.394995.1,
                                           SRR3476690.446293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249014.5/ ENSP00000249014.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               DA047271.1         17-566
            551-1663            CR456524.1         306-1418
            1664-2148           BC009356.2         1629-2113
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2148
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /note="CDC42 effector protein 1"
                     /db_xref="GeneID:11135"
                     /db_xref="HGNC:HGNC:17014"
                     /db_xref="MIM:606084"
     exon            1..109
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /inference="alignment:Splign:2.1.0"
     exon            110..850
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1563
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /note="serum constituent protein; 55 kDa bone marrow
                     stromal/endothelial cell protein; CDC42 effector protein
                     (Rho GTPase binding) 1; serum protein MSE55; binder of Rho
                     GTPases 5"
                     /codon_start=1
                     /product="cdc42 effector protein 1"
                     /protein_id="NP_689449.1"
                     /db_xref="CCDS:CCDS13949.1"
                     /db_xref="GeneID:11135"
                     /db_xref="HGNC:HGNC:17014"
                     /db_xref="MIM:606084"
                     /translation="MPGPQGGRGAATMSLGKLSPVGWVSSSQGKRRLTADMISHPLGD
                     FRHTMHVGRGGDVFGDTSFLSNHGGSSGSTHRSPRSFLAKKLQLVRRVGAPPRRMASP
                     PAPSPAPPAISPIIKNAISLPQLNQAAYDSLVVGKLSFDSSPTSSTDGHSSYGLDSGF
                     CTISRLPRSEKPHDRDRDGSFPSEPGLRRSDSLLSFRLDLDLGPSLLSELLGVMSLPE
                     APAAETPAPAANPPAPTANPTGPAANPPATTANPPAPAANPSAPAATPTGPAANPPAP
                     AASSTPHGHCPNGVTAGLGPVAEVKSSPVGGGPRGPAGPALGRHWGAGWDGGHHYPEM
                     DARQERVEVLPQARASWESLDEEWRAPQAGSRTPVPSTVQANTFEFADAEEDDEVKV"
     exon            851..2148
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2124..2129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /note="hexamer: ATTAAA"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /note="hexamer: AATAAG"
     polyA_site      2143
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
     polyA_site      2148
                     /gene="CDC42EP1"
                     /gene_synonym="BORG5; CEP1; MSE55"
                     /note="major polyA site"
ORIGIN      
        1 gcagaccggc ccagcgactc tcccgggctg ccagccggga cgcgcggccg ccgccgctgc
       61 agacgacgag tccgccctcg tcccgcgccc ccggggctcg cggagccagg tctccacctc
      121 tgggcaggag agttgccgac cacctcgggg gtgctttctc tgcgcttgaa catctatagc
      181 tgcttctgag gggctgggag ccgggcccct gggagagacg agccatgaac cccccacagc
      241 ctctgcattt ggggacctca ccttaggaga gtgccattta cagcttccgc cagggcaaag
      301 gagctgagca gccatcccaa gcccagccca cctccctccc ccggcccctg gtaggcatgg
      361 actagcagct gtgagcagcc agagctgatg cccggccccc aggggggcag aggcgccgcc
      421 accatgagcc tgggcaagct ctcgcctgtg ggctgggtgt ccagttcaca gggaaagagg
      481 cggctgactg cagacatgat cagccaccca ctcggggact tccgccacac catgcatgtg
      541 ggccgtggcg gggatgtctt cggggacacg tccttcctca gcaaccacgg tggcagctcc
      601 gggagcaccc atcgctcacc ccgcagcttc ctggccaaga agctgcagct ggtgcggagg
      661 gtgggggcgc ccccccggag gatggcatct ccccctgcac cctccccggc tccaccggcc
      721 atctccccca tcatcaagaa cgccatctcc ctgccccagc tcaaccaggc cgcctacgac
      781 agcctcgtgg ttggcaagct cagcttcgac agcagcccca ccagctccac ggacggccac
      841 tccagctacg gcctggactc tgggttctgc accatctccc gcctgccccg ctcggaaaag
      901 ccgcatgacc gagaccggga tggttccttc ccctctgagc ccgggcttcg ccgctctgac
      961 tctctcttgt ccttccgcct ggacctcgac cttgggccct cactcctcag cgagctgcta
     1021 ggggtcatga gcctcccaga agcccctgca gctgagactc cagcccccgc tgcaaacccc
     1081 ccagccccta ctgcaaaccc cacgggtcct gctgcaaacc ccccagccac tactgcaaac
     1141 cccccagcgc ctgctgcaaa cccctcagca cctgccgcaa cccccacggg tcctgctgca
     1201 aatcccccag cccctgccgc aagctccaca ccccatggac actgtcccaa tggggtaaca
     1261 gctgggttgg gcccagtggc tgaggtgaag tccagcccag tgggaggggg tccccgagga
     1321 cctgctggcc ctgccctcgg caggcactgg ggagcaggct gggatggcgg ccaccactac
     1381 ccagagatgg atgcgcggca ggagcgggtg gaggtgctgc cccaagcccg ggcctcctgg
     1441 gagagcctgg acgaagagtg gagggcgccc caggcaggca gcaggacccc agtgcccagc
     1501 acagtgcaag caaacacctt tgaatttgcg gatgctgagg aggatgatga ggtcaaggtg
     1561 tgaggggctg gggcacggtc ccagggcccc acctaggtgc agagccggcc cctcacctaa
     1621 cagctggttc ctaccagacc ggagagggga gaagtcatgt tgcccctaaa cccctcccca
     1681 cctctgcagg acagacatgg gagggaggac agggaaggcc aggcttgctc tgggactttt
     1741 atgctcccag aggccctgcc aaactgacca cctcccccga ctgccactct ggacctaata
     1801 gctgttcctt aggccccact ccatgccacc cccaccagct ggaggaccca gcctcacagt
     1861 gtgtcctttg tgccagacca agcggcccgt ggggggtggg gggcagggag tgtaccacac
     1921 agggccattg tctcacctcc caaagggacc gcctgccccc agctcatccc agagcgtccc
     1981 tgctgcaacc ctgacagccg tctcccaggc cgcttcccca acatccccgc cccagcctcc
     2041 ctcttacccc agaaaggtca ggtatgacct cccggggagg aatcccacct gcctgtatac
     2101 cccagacttg cctctggggc ctgattaaat aaggctgttt tgataaaa
//
