LOCUS       NM_017525               6161 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens CDC42 binding protein kinase gamma (CDC42BPG), mRNA.
ACCESSION   NM_017525 XM_290516
VERSION     NM_017525.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6161)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   2  (bases 1 to 6161)
  AUTHORS   Yasukochi,Y., Sakuma,J., Takeuchi,I., Kato,K., Oguri,M.,
            Fujimaki,T., Horibe,H. and Yamada,Y.
  TITLE     Identification of CDC42BPG as a novel susceptibility locus for
            hyperuricemia in a Japanese population
  JOURNAL   Mol Genet Genomics 293 (2), 371-379 (2018)
   PUBMED   29124443
  REMARK    GeneRIF: Findings indicate that CDC42BPG may be a susceptibility
            locus for hyperuricemia.
REFERENCE   3  (bases 1 to 6161)
  AUTHORS   Gagliardi,P.A., Somale,D., Puliafito,A., Chiaverina,G., di
            Blasio,L., Oneto,M., Bianchini,P., Bussolino,F. and Primo,L.
  TITLE     MRCKalpha is activated by caspase cleavage to assemble an apical
            actin ring for epithelial cell extrusion
  JOURNAL   J Cell Biol 217 (1), 231-249 (2018)
   PUBMED   29162624
REFERENCE   4  (bases 1 to 6161)
  AUTHORS   Tin,A., Woodward,O.M., Kao,W.H., Liu,C.T., Lu,X., Nalls,M.A.,
            Shriner,D., Semmo,M., Akylbekova,E.L., Wyatt,S.B., Hwang,S.J.,
            Yang,Q., Zonderman,A.B., Adeyemo,A.A., Palmer,C., Meng,Y.,
            Reilly,M., Shlipak,M.G., Siscovick,D., Evans,M.K., Rotimi,C.N.,
            Flessner,M.F., Kottgen,M., Cupples,L.A., Fox,C.S. and Kottgen,A.
  CONSRTM   CARe and CHARGE Consortia
  TITLE     Genome-wide association study for serum urate concentrations and
            gout among African Americans identifies genomic risk loci and a
            novel URAT1 loss-of-function allele
  JOURNAL   Hum Mol Genet 20 (20), 4056-4068 (2011)
   PUBMED   21768215
REFERENCE   5  (bases 1 to 6161)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   6  (bases 1 to 6161)
  AUTHORS   Ng,Y., Tan,I., Lim,L. and Leung,T.
  TITLE     Expression of the human myotonic dystrophy kinase-related
            Cdc42-binding kinase gamma is regulated by promoter DNA methylation
            and Sp1 binding
  JOURNAL   J Biol Chem 279 (33), 34156-34164 (2004)
   PUBMED   15194684
  REMARK    GeneRIF: CDC42BPG expression is regulated by promoter methylation
            and Sp1 binding.
REFERENCE   7  (bases 1 to 6161)
  AUTHORS   Kedra,D., Seroussi,E., Fransson,I., Trifunovic,J., Clark,M.,
            Lagercrantz,J., Blennow,E., Mehlin,H. and Dumanski,J.
  TITLE     The germinal center kinase gene and a novel CDC25-like gene are
            located in the vicinity of the PYGM gene on 11q13
  JOURNAL   Hum Genet 100 (5-6), 611-619 (1997)
   PUBMED   9341881
REFERENCE   8  (bases 1 to 6161)
  AUTHORS   Guru,S.C., Agarwal,S.K., Manickam,P., Olufemi,S.E., Crabtree,J.S.,
            Weisemann,J.M., Kester,M.B., Kim,Y.S., Wang,Y., Emmert-Buck,M.R.,
            Liotta,L.A., Spiegel,A.M., Boguski,M.S., Roe,B.A., Collins,F.S.,
            Marx,S.J., Burns,L. and Chandrasekharappa,S.C.
  TITLE     A transcript map for the 2.8-Mb region containing the multiple
            endocrine neoplasia type 1 locus
  JOURNAL   Genome Res 7 (7), 725-735 (1997)
   PUBMED   9253601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001187.5, AY648038.1 and BI793270.1.
            
            On Sep 13, 2018 this sequence version replaced NM_017525.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY648038.1, SRR7346977.2430426.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342711.6/ ENSP00000345133.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AP001187.5         50370-50453         c
            85-1853             AY648038.1         1-1769
            1854-1854           AP001187.5         41410-41410         c
            1855-1966           AY648038.1         1771-1882
            1967-1967           AP001187.5         41217-41217         c
            1968-4764           AY648038.1         1884-4680
            4765-5024           BI793270.1         294-553
            5025-6161           AP001187.5         28852-29988         c
FEATURES             Location/Qualifiers
     source          1..6161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..6161
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /note="CDC42 binding protein kinase gamma"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
     exon            1..244
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..4740
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /EC_number="2.7.11.1"
                     /note="myotonic dystrophy protein kinase like protein;
                     MRCK gamma; DMPK-like gamma; CDC42 binding protein kinase
                     gamma (DMPK-like); myotonic dystrophy protein kinase-like
                     alpha; myotonic dystrophy protein kinase-like gamma;
                     myotonic dystrophy kinase-related CDC42-binding kinase
                     gamma"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MRCK gamma"
                     /protein_id="NP_059995.2"
                     /db_xref="CCDS:CCDS31601.1"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
                     /translation="MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRE
                     RSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKML
                     HKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLL
                     SRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCL
                     RLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPF
                     YAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNH
                     PFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLP
                     FVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLR
                     KEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQ
                     EQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSR
                     QVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAH
                     SHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLA
                     DILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEAS
                     ARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL
                     RARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGA
                     VFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGY
                     FCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAA
                     LSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRV
                     TTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNG
                     LPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLV
                     VLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVL
                     CYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGA
                     GLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPM
                     GWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYL
                     RNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKL
                     ISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMG
                     SEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP"
     exon            245..336
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            337..420
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            421..516
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            517..665
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            666..759
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            760..960
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1209
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1289
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1387
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1468
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1572
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1752
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1842
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1964
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2037
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2144
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2259
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2408
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2497
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2550
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2649
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2709
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2815
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2949
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3089
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3171
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3388
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3451
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..4051
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4052..4149
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4234
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4235..4355
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4356..4473
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4597
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4683
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..6161
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5711..5716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /note="hexamer: ATTAAA"
     polyA_site      5749
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /note="major polyA site"
ORIGIN      
        1 agacggttgg gcggacggac ggcccgacag gcgggcatgc gggcggccag actgtagccg
       61 agcagcgagg ctccggccgc agccatggag cggcggctgc gcgcgctgga gcagctggcg
      121 cggggcgagg ccggcggctg cccggggctc gacggcctcc tagatctgct gctggcgctg
      181 caccacgagc tcagcagcgg ccccctacgg cgggagcgca gcgtggcgca gttcctgagc
      241 tgggccagcc ccttcgtatc aaaggtgaaa gaactgcgtc tgcagagaga tgactttgag
      301 atcttgaagg tgatcggccg aggagccttt ggggaggtca ccgtggtgag gcagagggac
      361 actgggcaga tttttgccat gaaaatgctg cacaagtggg agatgctgaa gagggctgag
      421 acagcctgtt tccgggagga gcgggatgtg ctcgtgaaag gggacagccg ttgggtgacc
      481 actctgcact atgccttcca agacgaggag tacctgtacc ttgtgatgga ctactatgct
      541 ggtggggacc tcctgacgct gctgagccgc ttcgaggacc gtctcccgcc cgagctggcc
      601 cagttctacc tggctgagat ggtgctggcc atccactcgc tgcaccagct gggttatgtc
      661 cacagggatg tcaagccaga caacgtcctg ctggatgtga acgggcacat tcgcctggct
      721 gacttcggct cctgcctgcg tctcaacacc aacggcatgg tggattcatc agtggcagta
      781 gggacgccgg actatatctc ccctgagatc ctgcaggcca tggaggaggg caagggccac
      841 tacggcccac agtgtgactg gtggtcgctt ggagtctgcg cctatgagct gctctttggg
      901 gagacgccct tctatgctga gtccttggtg gaaacctacg gcaagatcat gaaccacgag
      961 gaccacctgc agttcccccc ggacgtgcct gacgtgccag ccagcgccca agacctgatc
     1021 cgccagctgc tgtgtcgcca ggaagagcgg ctaggccgtg gtgggctgga tgacttccgg
     1081 aaccatcctt tcttcgaagg cgtggactgg gagcggctgg cgagcagcac ggccccctat
     1141 attcctgagc tgcgggggcc catggacacc tccaactttg atgtggatga cgacaccctc
     1201 aaccatccag ggaccctgcc accgccctcc cacggggcct tctccggcca tcacctgcca
     1261 ttcgtgggct tcacctacac ctcaggcagt cacagtcctg agagcagctc tgaggcttgg
     1321 gctgccctgg agcggaagct ccagtgtctg gagcaggaga aggtggagct gagcaggaag
     1381 caccaagagg ccctgcacgc ccccacagac catcgggagc tggagcagct acggaaggaa
     1441 gtgcagactc tgcgggacag gctgccagag atgctgaggg acaaggcctc attgtcccag
     1501 acggatgggc ccccagctgg tagcccaggt caggacagtg acctacggca ggagcttgac
     1561 cgacttcacc gggagctggc cgagggtcgg gcagggctgc aggctcagga gcaggagctc
     1621 tgcagggccc aggggcagca ggaggagctg cttcagaggc tacaggaggc ccaggagaga
     1681 gaggcggcca cagctagcca gacccgggcc ctgagctccc agctggagga agcccgggct
     1741 gcccagaggg agctggaggc ccaggtgtcc tccctgagcc ggcaggtgac gcagctgcag
     1801 ggacagtggg agcaacgcct tgaggagtcg tcccaggcca agaccatcca cacagcctct
     1861 gagaccaacg ggatgggacc ccctgagggt gggcctcagg aggcccaact gaggaaggag
     1921 gtggccgccc tgcgagagca gctggagcag gcccacagcc acaggccgag tggtaaggag
     1981 gaggctctgt gccagctgca ggaggaaaac cggaggctga gccgggagca ggagcggcta
     2041 gaagcagagc tggcccagga gcaggagagc aagcagcggc tggagggtga gcggcgggag
     2101 acggagagca actgggaggc ccagctcgcc gacatcctca gctgggtgaa tgatgagaag
     2161 gtctcaagag gctacctgca ggccctggcc accaagatgg cagaggagct ggagtccttg
     2221 aggaacgtag gcacccagac gctccctgcc cggccactgg accaccagtg gaaggcgcgg
     2281 cgactgcaga agatggaggc ctcggccagg ctggagctgc agtcagcgct ggaggccgag
     2341 atccgcgcca agcagggcct gcaggagcgg ctgacacagg tgcaggaggc ccagctgcag
     2401 gctgagcgcc gtctgcagga ggccgagaag cagagccagg ccctgcaaca ggagctcgcc
     2461 atgctgcggg aggagctgcg ggcccgaggg ccagtggaca ccaagccctc aaactccctg
     2521 attcccttcc tgtccttccg gagctcagag aaggattctg ccaaggaccc tggcatctca
     2581 ggagaggcca caaggcatgg aggagagcca gatctgaggc cggagggccg acgcagcctg
     2641 cgcatggggg ctgtgttccc cagagcaccc actgccaaca cagcctctac agaaggtctt
     2701 cctgctaagc ccggctcaca cacgctgcgc ccccggagct tcccatcccc gaccaagtgt
     2761 ctccgctgca cctcgctgat gctgggcctg ggccgccagg gcctgggttg tgatgcctgc
     2821 ggctactttt gtcacacaac ctgtgcccca caggccccac cctgccccgt gccccctgac
     2881 ctcctccgca cagccctggg agtacacccc gaaacaggca caggcactgc ctatgagggc
     2941 tttctgtcgg tgccgcggcc ctcaggtgtc cggcggggct ggcagcgcgt gtttgctgcc
     3001 ctgagtgact cacgcctgct gctgtttgac gcccctgacc tgaggctcag cccgcccagt
     3061 ggggccctcc tgcaggtcct agatctgagg gacccccagt tctcggctac ccctgtcctg
     3121 gcctctgatg ttatccatgc ccaatccagg gacctgccac gcatctttag ggtgacaacc
     3181 tcccagctgg cagtgccgcc caccacgtgc actgtgctgc tgctggcaga gagcgagggg
     3241 gagcgggaac gctggctgca ggtgctgggt gagctgcagc ggctgctgct ggacgcgcgg
     3301 ccaagacccc ggcccgtgta cacactcaag gaggcttacg acaacgggct gccgctgctg
     3361 cctcacacgc tctgcgctgc catcctcgac caggatcgac ttgcgcttgg caccgaggag
     3421 gggctctttg tcatccatct gcgcagcaac gacatcttcc aggtggggga gtgccggcgc
     3481 gtgcagcagc tgaccttgag ccccagtgca ggcctgctgg tcgtgctgtg tggccgcggc
     3541 cccagcgtgc gtctctttgc cctggcggag ctggagaaca tagaggtagc aggtgccaag
     3601 atccccgagt ctcgaggctg ccaggtgctg gcagctggaa gcatcctgca ggcccgcacc
     3661 ccggtgctct gtgtagccgt caagcgccag gtgctctgct accagctggg cccgggccct
     3721 gggccctggc agcgccgcat ccgtgagctg caggcacctg ccactgtgca gagcctgggg
     3781 ctgctgggcg accggctatg tgtgggcgcc gccggtggct ttgcactcta cccgctgctc
     3841 aacgaggctg cgccgttggc gctgggggcc ggtttggtgc ctgaggagct gccaccatcc
     3901 cgcgggggcc tgggtgaggc actgggtgcc gtggagctta gcctcagcga gttcctgcta
     3961 ctcttcacca ctgctggcat ctacgtggat ggcgcaggcc gcaagtctcg tggccacgag
     4021 ctgttgtggc cagcagcgcc catgggctgg gggtatgcgg ccccctacct gacagtgttc
     4081 agcgagaact ccatcgatgt gtttgacgtg aggagggcag aatgggtgca gaccgtgccg
     4141 ctcaagaagg tgcggcccct caatccagag ggctccctgt tcctctacgg caccgagaag
     4201 gtccgcctga cctacctcag gaaccagctg gcagagaagg acgagttcga catcccggac
     4261 ctcaccgaca acagccggcg ccagctgttc cgcaccaaga gcaagcgccg cttctttttc
     4321 cgcgtgtcgg aggagcagca gaagcagcag cgcagggaga tgctgaagga cccttttgtg
     4381 cgctccaagc tcatctcgcc gcctaccaac ttcaaccacc tagtacacgt gggccctgcc
     4441 aacgggcggc ccggcgccag ggacaagtcc ccggctcccg aagagaaggg ccgagttgcc
     4501 cgcggctccg gcccacagcg gccccacagc ttctccgagg cgttgcggcg cccagcctcc
     4561 atgggcagcg aaggcctcgg tggagacgca gaccccatga agaggaaacc ctggacatcc
     4621 ctgtccagcg agtctgtgtc ctgcccccag ggatcgctga gccctgcaac ctccctaatg
     4681 caggtctcag aacggccccg aagcctcccc ctatcccctg aattggagag ctctccttga
     4741 tgccctctgt tagggcccac cccaatccca gggcagaagg acatgaggga gcaaagagct
     4801 tgaggaatgc catactccgg ctggtccggg acatggaaat tcggactcag ggaggacccg
     4861 ggctgggcaa tgactgggag acttgcctgg gttcccagga cttgggggtc ctgactccca
     4921 gccctcatcc tgccttaccc ctctgttccc agccccagcc tttctaagcc attgggaata
     4981 gaatggcccc ttttgttctg gtgtccaggg gtgattgtgc caaagctctt atttccagtg
     5041 ccaagccccc agaggcttgt aagagttggg atgagggatg gagagggact gggtctctgg
     5101 gaacaggttg gaggtcttat ctgtggactg tctgactccc agctgaggcc aagatggggc
     5161 atgtccccgt ctctgcttag cgtctgggtg agaaaaacag gctgtgatcc agaagaaggg
     5221 aagatagaga aggagggaaa ggatgtaggc gaaggaggtg agagacagga taggaggaag
     5281 gaagtggagg aggaggtgat aggaattgga aggaggtaga agccgtgcag aggaagaggg
     5341 gagagggacg aaggaggagc gatgaagaag aggagggaga caaaaagagg gatggaggag
     5401 agagggagtc tggagaacaa agggtccttt ctctggggag gggtgcagtg ggcggggctg
     5461 acactgtcag ccaatcctcc catcggggaa gagaatcctg gacagggaca ggatggggag
     5521 ggtatttata agggcttttt ggtgggagat gggtacccag tgggggccac tggagggtct
     5581 ccgggcacac tctggccctt cccagaaagg gggtcgtttt tctcgaatct tcaaccagtt
     5641 gtgtattgga aactagggcg cattttacta ttgatcacag tcattatatt gttattatat
     5701 tactattttt attaaacctc cccccactga agtgtggggg gcaaaataag tatttatctc
     5761 ctcaaatgcc acattcccag gagggacaga ccctgatgct ctgtgaggcg caagaaacca
     5821 ataaagatgc cgggcgcggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc
     5881 gggcagatcc cgaggtcagg agattgagac catcctggct aacacggtga aaccccatct
     5941 ctactaaaaa tacaaaaaat tagccgggcg tggtgacggg tgcctgtagt ccctgctact
     6001 cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagccgag
     6061 atcgcgccac tgcactccag cctgggtgac agagtgagac tccgtctcaa aaaaaaaaaa
     6121 aaagaaaaga aaaggaaacc aataaagaca gctttgtaag c
//
