LOCUS       NM_006035               6844 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens CDC42 binding protein kinase beta (CDC42BPB),
            transcript variant 1, mRNA.
ACCESSION   NM_006035
VERSION     NM_006035.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6844)
  AUTHORS   Deshpande,R.P., Wu,K., Wu,S.Y., Tyagi,A., Smith,E.C., Hunting,J.,
            Ruiz,J., Li,W. and Watabe,K.
  TITLE     Tumor-intrinsic CDC42BPB confers resistance to anti-PD-1 immune
            checkpoint blockade in breast cancer
  JOURNAL   Mol Ther 32 (10), 3669-3682 (2024)
   PUBMED   39086134
  REMARK    GeneRIF: Tumor-intrinsic CDC42BPB confers resistance to anti-PD-1
            immune checkpoint blockade in breast cancer.
REFERENCE   2  (bases 1 to 6844)
  AUTHORS   Dixit,P., Kokate,S.B., Poirah,I., Chakraborty,D., Smoot,D.T.,
            Ashktorab,H., Rout,N., Singh,S.P. and Bhattacharyya,A.
  TITLE     Helicobacter pylori-induced gastric cancer is orchestrated by
            MRCKbeta-mediated Siah2 phosphorylation
  JOURNAL   J Biomed Sci 28 (1), 12 (2021)
   PUBMED   33536006
  REMARK    GeneRIF: Helicobacter pylori-induced gastric cancer is orchestrated
            by MRCKbeta-mediated Siah2 phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6844)
  AUTHORS   Unbekandt,M., Lilla,S., Zanivan,S. and Olson,M.F.
  TITLE     The CDC42 effector protein MRCKbeta autophosphorylates on Threonine
            1108
  JOURNAL   Small GTPases 11 (6), 451-460 (2020)
   PUBMED   30667325
  REMARK    GeneRIF: The CDC42 effector protein MRCKbeta autophosphorylates on
            Threonine 1108.
REFERENCE   4  (bases 1 to 6844)
  AUTHORS   Luo,L.J., Feng,F., Li,S.H., Lu,D., Li,L. and Zhou,Q.
  TITLE     Sequence variant in the CDC42BPB gene is potentially associated
            with Mullerian duct anomalies
  JOURNAL   J Obstet Gynaecol Res 46 (5), 684-693 (2020)
   PUBMED   32043305
  REMARK    GeneRIF: Sequence variant in the CDC42BPB gene is potentially
            associated with Mullerian duct anomalies.
REFERENCE   5  (bases 1 to 6844)
  AUTHORS   Chilton,I., Okur,V., Vitiello,G., Selicorni,A., Mariani,M.,
            Goldenberg,A., Husson,T., Campion,D., Lichtenbelt,K.D., van
            Gassen,K., Steinraths,M., Rice,J., Roeder,E.R., Littlejohn,R.O.,
            Srour,M., Sebire,G., Accogli,A., Heron,D., Heide,S., Nava,C.,
            Depienne,C., Larson,A., Niyazov,D., Azage,M., Hoganson,G.,
            Burton,J., Rush,E.T., Jenkins,J.L., Saunders,C.J., Thiffault,I.,
            Alaimo,J.T., Fleischer,J., Groepper,D., Gripp,K.W. and Chung,W.K.
  TITLE     De novo heterozygous missense and loss-of-function variants in
            CDC42BPB are associated with a neurodevelopmental phenotype
  JOURNAL   Am J Med Genet A 182 (5), 962-973 (2020)
   PUBMED   32031333
  REMARK    GeneRIF: De novo heterozygous missense and loss-of-function
            variants in CDC42BPB are associated with a neurodevelopmental
            phenotype.
REFERENCE   6  (bases 1 to 6844)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 6844)
  AUTHORS   Tan,I., Yong,J., Dong,J.M., Lim,L. and Leung,T.
  TITLE     A tripartite complex containing MRCK modulates lamellar actomyosin
            retrograde flow
  JOURNAL   Cell 135 (1), 123-136 (2008)
   PUBMED   18854160
REFERENCE   8  (bases 1 to 6844)
  AUTHORS   Choi,S.H., Czifra,G., Kedei,N., Lewin,N.E., Lazar,J., Pu,Y.,
            Marquez,V.E. and Blumberg,P.M.
  TITLE     Characterization of the interaction of phorbol esters with the C1
            domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding
            kinase) alpha/beta
  JOURNAL   J Biol Chem 283 (16), 10543-10549 (2008)
   PUBMED   18263588
  REMARK    GeneRIF: analysis of the interaction of phorbol esters with the C1
            domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding
            kinase) alpha/beta
REFERENCE   9  (bases 1 to 6844)
  AUTHORS   Moncrieff,C.L., Bailey,M.E., Morrison,N. and Johnson,K.J.
  TITLE     Cloning and chromosomal localization of human Cdc42-binding protein
            kinase beta
  JOURNAL   Genomics 57 (2), 297-300 (1999)
   PUBMED   10198171
REFERENCE   10 (bases 1 to 6844)
  AUTHORS   Leung,T., Chen,X.Q., Tan,I., Manser,E. and Lim,L.
  TITLE     Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a
            Cdc42 effector in promoting cytoskeletal reorganization
  JOURNAL   Mol Cell Biol 18 (1), 130-140 (1998)
   PUBMED   9418861
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133455.4, AF128625.1,
            BC048261.1, AB032950.3 and AL117209.7.
            
            On Nov 22, 2018 this sequence version replaced NM_006035.3.
            
            Summary: This gene encodes a member of the serine/threonine protein
            kinase family. The encoded protein contains a Cdc42/Rac-binding p21
            binding domain resembling that of PAK kinase. The kinase domain of
            this protein is most closely related to that of myotonic dystrophy
            kinase-related ROK. Studies of the similar gene in rat suggested
            that this kinase may act as a downstream effector of Cdc42 in
            cytoskeletal reorganization. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF128625.1, BC155541.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361246.7/ ENSP00000355237.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL133455.4         135006-135149       c
            145-355             AF128625.1         58-268
            356-1842            BC048261.1         137-1623
            1843-3983           AB032950.3         1690-3830
            3984-6112           AF128625.1         3897-6025
            6113-6844           AL117209.7         148594-149325       c
FEATURES             Location/Qualifiers
     source          1..6844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.32"
     gene            1..6844
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /note="CDC42 binding protein kinase beta"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
     exon            1..551
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..5512
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase MRCK beta; myotonic
                     dystrophy protein kinase-like beta; DMPK-like beta;
                     myotonic dystrophy kinase-related CDC42-binding kinase
                     beta; CDC42BP-beta; CDC42 binding protein kinase beta
                     (DMPK-like)"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MRCK beta
                     isoform 1"
                     /protein_id="NP_006026.3"
                     /db_xref="CCDS:CCDS9978.1"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
                     /translation="MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHS
                     ALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIY
                     AMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGD
                     LLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLAD
                     FGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLY
                     GETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIE
                     DFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFS
                     GLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRL
                     EQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLE
                     RQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAKELKDA
                     HQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEK
                     LRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQE
                     ISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKL
                     EKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLE
                     DELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSSSLGS
                     RTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDS
                     EAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSAS
                     EQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSI
                     KSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKRPLGV
                     DVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQV
                     LDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENENEKRK
                     WVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEEGL
                     YVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDI
                     KLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQC
                     LAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEE
                     YLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEW
                     VQTIGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGAVLNVPDTSDNSKKQMLRTRS
                     KRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLS
                     AVPPSQEERPGPAPTNLARQPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKE
                     PDSDSTKHSTPSNSSNPSGPPSPNSPHRSQLPLEGLEQPACDT"
     exon            552..643
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            644..727
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            728..823
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            824..972
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1066
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1267
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1516
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1596
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1763
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1883
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2017
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2260
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2371
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2616
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2722
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2847
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2953
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3102
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3197
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3277
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3364
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3442
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3548
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3685
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3825
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3907
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4124
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4187
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4784
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            4785..4882
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..4967
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            4968..5085
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            5086..5203
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            5204..5309
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            5310..5380
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     exon            5381..6844
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6815..6820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /note="hexamer: AATAAA"
     polyA_site      6844
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /note="major polyA site"
ORIGIN      
        1 gggctcgggc gccggccggg cttgcgcagc gctaggctcc tcgccgctcc tagtctgcgg
       61 cggcggcggc ggggagggcg cggccgcggg cggggctgag ggcggcgggg gcgggccgcc
      121 cgagctggga gggcggcggc gccgagggga ggagagcggc ccatggaccc gcggggcccg
      181 gcgccccaga ctctgcgccg tcgggacgga gcccaagatg tcggcctagg ccggggcgcg
      241 acgacgcgga cggggcggcg aggaggcgcc gctgctgccg gggctcgcag ccgccgagcc
      301 cccgagggcg cgccctgacg gactggccga gccggcggtg agaggccggc gcgtcgggag
      361 cgggccgcgc ggcaccatgt cggccaaggt gcggctcaag aagctggagc agctgctcct
      421 ggacgggccc tggcgcaacg agagcgccct gagcgtggaa acgctgctcg acgtgctcgt
      481 ctgcctgtac accgagtgca gccactcggc cctgcgccgc gacaagtacg tggccgagtt
      541 cctcgagtgg gctaaaccat ttacacagct ggtgaaagaa atgcagcttc atcgagaaga
      601 ctttgaaata attaaagtaa ttggaagagg tgcttttggt gaggttgctg ttgtcaaaat
      661 gaagaatact gaacgaattt atgcaatgaa aatcctcaac aagtgggaga tgctgaaaag
      721 agcagagacc gcgtgcttcc gagaggagcg cgatgtgctg gtgaacggcg actgccagtg
      781 gatcaccgcg ctgcactacg cctttcagga cgagaaccac ctgtacttag tcatggatta
      841 ctatgtgggt ggtgatttac tgaccctgct cagcaaattt gaagacaagc ttccggaaga
      901 tatggcgagg ttctacattg gtgaaatggt gctggccatt gactccatcc atcagcttca
      961 ttacgtgcac agagacatta aacctgacaa tgtccttttg gacgtgaatg gtcatatccg
     1021 cctggctgac tttggatcat gtttgaagat gaatgatgat ggcactgtgc agtcctccgt
     1081 ggccgtgggc acacctgact acatctcgcc ggagatcctg caggcgatgg aggacggcat
     1141 gggcaaatac gggcctgagt gtgactggtg gtctctgggt gtctgcatgt atgagatgct
     1201 ctatggagaa acgccgtttt atgcggagtc actcgtggag acctatggga agatcatgaa
     1261 ccatgaagag cgattccagt tcccatccca tgtcacggat gtatctgaag aagcgaagga
     1321 cctcatccag agactgatct gcagtagaga acgccggctg gggcagaatg gaatagagga
     1381 tttcaaaaag catgcgtttt ttgaaggtct aaattgggaa aatatacgaa acctagaagc
     1441 accttatatt cctgatgtga gcagtccctc tgacacatcc aacttcgacg tggatgacga
     1501 cgtgctgaga aacacggaaa tattacctcc tggttctcac acaggctttt ctggattaca
     1561 tttgccattc attggtttta cattcacaac ggaaagctgt ttttctgatc gaggctctct
     1621 gaagagcata atgcagtcca acacattaac caaagatgag gatgtgcagc gggacctgga
     1681 gcacagcctg cagatggaag cttacgagag gaggattcgg aggctggaac aggagaagct
     1741 ggagctgagc aggaagctgc aagagtccac ccagaccgtg cagtccctcc acggctcatc
     1801 tcgggccctc agcaattcaa accgagataa agaaatcaaa aagctaaatg aagaaatcga
     1861 acgcttgaag aataaaatag cagattcaaa caggctcgag cgacagcttg aggacacagt
     1921 ggcgcttcgc caagagcgtg aggactccac gcagcggctg cgggggctgg agaagcagca
     1981 ccgcgtggtc cggcaggaga aggaggagct gcacaagcaa ctggttgaag cctcagagcg
     2041 gttgaaatcc caggccaagg aactcaaaga tgcccatcag cagcgaaagc tggccctgca
     2101 ggagttctcg gagctgaacg agcgcatggc agagctccgt gcccagaagc agaaggtgtc
     2161 ccggcagctg cgagacaagg aggaggagat ggaggtggcc acgcagaagg tggacgccat
     2221 gcggcaggaa atgcggagag ctgagaagct caggaaagag ctggaagctc agcttgatga
     2281 tgctgttgct gaggcctcca aggagcgcaa gcttcgtgag cacagcgaga acttctgcaa
     2341 gcaaatggaa agcgagctgg aggccctcaa ggtgaagcaa ggaggccggg gagcgggtgc
     2401 caccttagag caccagcaag agatttccaa aatcaaatcc gagctggaga agaaagtctt
     2461 attttatgaa gaggaattgg tcagacgtga ggcctcccat gtgctagaag tgaaaaatgt
     2521 gaagaaggag gtgcatgatt cagaaagcca ccagctggcc ctgcagaaag aaatcttgat
     2581 gttaaaagat aagttagaaa agtcaaagcg agaacggcat aacgagatgg aggaggcagt
     2641 aggtacaata aaagataaat acgaacgaga aagagcgatg ctgtttgatg aaaacaagaa
     2701 gctaactgct gaaaatgaaa agctctgttc ctttgtggat aaactcacag ctcaaaatag
     2761 acagctggag gatgagctgc aggatctggc agccaagaag gagtcagtgg cccactggga
     2821 agctcagatt gcggaaatca ttcagtgggt cagtgacgag aaagatgccc ggggttacct
     2881 tcaagctctt gcttccaaga tgaccgaaga gctcgaggct ttgaggagtt ctagtctggg
     2941 gtcaagaaca ctggacccgc tgtggaaggt gcgccgcagc cagaagctgg acatgtccgc
     3001 gcggctggag ctgcagtcgg ccctggaggc ggagatccgg gccaagcagc ttgtccagga
     3061 ggagctcagg aaggtcaagg acgccaacct caccttggaa agcaaactaa aggattccga
     3121 agccaaaaac agagaattat tagaagaaat ggaaattttg aagaaaaaga tggaagaaaa
     3181 attcagagca gatactgggc tcaaacttcc agattttcag gattccattt ttgagtattt
     3241 caacactgct cctcttgcac atgacctgac atttagaacc agctcagcta gtgagcaaga
     3301 aacacaagct ccgaagccag aagcgtcccc gtcgatgtct gtggctgcat cagagcagca
     3361 ggaggacatg gctcggcccc cgcagaggcc atccgctgtg ccgttgccca ccacgcaggc
     3421 cctggctctg gctggaccga agccaaaagc tcaccagttc agcatcaagt ccttctccag
     3481 ccctactcag tgcagccact gcacctccct gatggttggg ctgatccggc agggctacgc
     3541 ctgcgaggtg tgttcctttg cttgccacgt gtcctgcaaa gacggtgccc cccaggtgtg
     3601 cccaatacct cccgagcagt ccaagaggcc tctgggcgtg gacgtgcagc gaggcatcgg
     3661 aacagcctac aaaggccatg tcaaggtccc aaagcccacg ggggtgaaga agggatggca
     3721 gcgcgcatat gcagtcgtct gtgactgcaa gctcttcctg tatgatctgc ctgaaggaaa
     3781 atccacccag cctggtgtca ttgcgagcca agtcttggat ctcagagatg acgagttttc
     3841 cgtgagctca gtcctggcct cagatgtcat tcatgctaca cgccgagata ttccatgtat
     3901 attcagggtg acggcctctc tcttaggtgc accttctaag accagctcgc tgctcattct
     3961 gacagaaaat gagaatgaaa agaggaagtg ggttgggatt ctagaaggac tccagtccat
     4021 ccttcataaa aaccggctga ggaatcaggt cgtgcatgtt cccttggaag cctacgacag
     4081 ctcgctgcct ctcatcaagg ccatcctgac agctgccatc gtggatgcag acaggattgc
     4141 agtcggccta gaagaagggc tctatgtcat agaggtcacc cgagatgtga tcgtccgtgc
     4201 cgctgactgt aagaaggtac accagatcga gcttgctccc agggagaaga tcgtaatcct
     4261 cctctgtggc cggaaccacc atgtgcacct ctatccgtgg tcgtcccttg atggagcgga
     4321 aggcagcttt gacatcaagc ttccggaaac caaaggctgc cagctcatgg ccacggccac
     4381 actcaagagg aactctggca cctgcctgtt tgtggccgtg aaacggctga tcctttgcta
     4441 tgagatccag agaacgaagc cattccacag aaagttcaat gagattgtgg ctcccggcag
     4501 cgtgcagtgc ctggcggtgc tcagggacag gctctgtgtg ggctaccctt ctgggttctg
     4561 cctgctgagc atccaggggg acgggcagcc tctaaacctg gtaaatccca atgacccctc
     4621 gcttgcgttc ctctcacaac agtcttttga tgccctttgt gctgtggagc tcgaaagcga
     4681 ggagtacctg ctttgcttca gccacatggg actgtacgtg gacccgcaag gccggagggc
     4741 acgcgcgcag gagctcatgt ggcctgcggc tcctgtcgcc tgtagttgca gccccaccca
     4801 cgtcacggtg tacagcgagt atggcgtgga cgtctttgat gtgcgcacca tggagtgggt
     4861 gcagaccatc ggcctgcgga ggataaggcc cctgaactct gaaggcaccc tcaacctcct
     4921 caactgcgag cctccacgct tgatctactt caagagcaag ttctcgggag cggttctcaa
     4981 cgtgccggac acctccgaca acagcaagaa gcagatgctg cgcaccagga gcaaaaggcg
     5041 gttcgtcttc aaggtcccag aggaagagag actgcagcag aggcgagaga tgcttagaga
     5101 cccagaattg agatccaaaa tgatatccaa cccaaccaac ttcaaccacg tggcccacat
     5161 gggcccaggc gacggcatgc aggtgctcat ggacctgcct ctgagtgctg tgcccccctc
     5221 ccaggaggaa aggccgggcc ccgctcccac caacctggct cgccagcctc catccaggaa
     5281 caagccctac atctcgtggc cctcatcagg tggatcggag cctagcgtga ctgtgcctct
     5341 gagaagtatg tctgatccag accaggactt tgacaaagag cctgattcgg actccaccaa
     5401 acactcaact ccatcgaata gctccaaccc cagcggccca ccgagcccca actcccccca
     5461 caggagccag ctccccctcg aaggcctgga gcagccggcc tgtgacacct gaagccgcca
     5521 gctcgccaca ggggccaggg agctggagat ggcctccagc gtcagtgcca agactgagcg
     5581 ggccctccag tgttgtccaa ggaaatgtag aatcactttg tagatatgga gatgaagaag
     5641 acaaatcttt attataatat tgatcagttt tatgccgcat tgttcgtggc agtagaccac
     5701 atctgttcgt ctgcacagct gtgaggcgat gctgttccat ctgcacatga aggaccccca
     5761 tacagcctgt ctcccacccc tgacaacccg agagggcata tggggccctg ccaacaccac
     5821 ttcctcagca gaaacccgtc atgacgcggc tgcttcggaa gcagacatct ggggacacag
     5881 cctcagtacc cagtcttttc cctagttcct gaaactttcc taggacctta agagaatagt
     5941 aggaggtcct atagcattcc cagtgtcact agaattttga agacaggaaa gtggaggtta
     6001 gtctgtggcc tttttttcat ttagccattg cacagtcagc tgcagaagtc ctgctgacca
     6061 cctagtcatg gacaaaggcc caggaccagt gacaccctgc gtccctgtgt gcattaagtt
     6121 cattctgggt cgcagccatg aagtgtcacc agtatctact actgtgaagt cagctgtgct
     6181 gttttccatt cgcttccacg gcttctgcct cctgccataa aaccagcgag tgtcgtggtg
     6241 caggcaggcc ctgtggcctg ctgggctgag ggaagtcaga gccccagggc gccacgaagc
     6301 agccactggg ataccccacc ccgccccgcc ctgcccgccc ccccccccac cagtcctgcc
     6361 cccgcatgga gcccccgtga ttagtagccc gtatgatcac gtagacccac ccaacacact
     6421 cctgcacact ggccccggcc cacggcacag caatcccctg cgcgtggatt tcacctcacc
     6481 ctttgtacca gatgttgagt gaccagctct gtggccctgt gtcgtcagag gcttgtgatt
     6541 aactgtggcg gcagacacag cttgtccaca gcttgggcca ggcttcccct gtcctcccac
     6601 cggtcggctg cttggcaagg ctgttcagga cgtgcacttc cccaagtcgg cactgagtgg
     6661 cccagcaccg cctagccctg ccaccccact gccctcctgg gccttctgct ggatgggcac
     6721 ctggggggtt ctggttttta cttttttaat gtaagtctca gtctttgtaa ttaattattg
     6781 aattgtgaga acatttttga acaatttacc tgtcaataaa gcagaagacg gcagttttaa
     6841 agtt
//
