LOCUS       NM_001791              10503 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cell division cycle 42 (CDC42), transcript variant 1,
            mRNA.
ACCESSION   NM_001791
VERSION     NM_001791.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10503)
  AUTHORS   Shouib,R. and Eitzen,G.
  TITLE     Inflammatory gene regulation by Cdc42 in airway epithelial cells
  JOURNAL   Cell Signal 122, 111321 (2024)
   PUBMED   39067837
  REMARK    GeneRIF: Inflammatory gene regulation by Cdc42 in airway epithelial
            cells.
REFERENCE   2  (bases 1 to 10503)
  AUTHORS   Zhao,Z., Zhou,Y., Lv,P., Zhou,T., Liu,H., Xie,Y., Wu,Z., Wang,X.,
            Zhao,H., Zheng,J. and Jiang,X.
  TITLE     NSUN4 mediated RNA 5-methylcytosine promotes the malignant
            progression of glioma through improving the CDC42 mRNA
            stabilization
  JOURNAL   Cancer Lett 597, 217059 (2024)
   PUBMED   38876383
  REMARK    GeneRIF: NSUN4 mediated RNA 5-methylcytosine promotes the malignant
            progression of glioma through improving the CDC42 mRNA
            stabilization.
            Erratum:[Cancer Lett. 2025 Feb 1;610:217351. doi:
            10.1016/j.canlet.2024.217351.. PMID: 39616022]
REFERENCE   3  (bases 1 to 10503)
  AUTHORS   Yang,J., Feng,J., Lv,J., Chu,X., Wei,Y., Zhang,Y., Li,J., Sun,Y.,
            Li,G., Jiang,T., Huang,J. and Fan,X.
  TITLE     PTBP1-mediated repression of neuron-specific CDC42 splicing
            constitutes a genomic alteration-independent, developmentally
            conserved vulnerability in IDH-wildtype glioblastoma
  JOURNAL   Funct Integr Genomics 24 (4), 135 (2024)
   PUBMED   39117866
  REMARK    GeneRIF: PTBP1-mediated repression of neuron-specific CDC42
            splicing constitutes a genomic alteration-independent,
            developmentally conserved vulnerability in IDH-wildtype
            glioblastoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10503)
  AUTHORS   Chen,S., Zhao,Q., Zhang,R., Liu,J., Peng,W., Xu,H., Li,X., Wang,X.,
            Wu,S., Li,G. and Nan,A.
  TITLE     A transcribed ultraconserved noncoding RNA, uc.285+, promotes
            colorectal cancer proliferation through dual targeting of CDC42 by
            directly binding mRNA and protein
  JOURNAL   Transl Res 270, 52-65 (2024)
   PUBMED   38552953
  REMARK    GeneRIF: A transcribed ultraconserved noncoding RNA, uc.285+,
            promotes colorectal cancer proliferation through dual targeting of
            CDC42 by directly binding mRNA and protein.
REFERENCE   5  (bases 1 to 10503)
  AUTHORS   Chen,M., Gao,K., Guo,Z., Feng,L., Feng,Y., Fu,J., Li,H. and An,J.
  TITLE     The Circulating CDC42 Expression in Sepsis: Relation to Disease
            Susceptibility, Inflammation, Multiple Organ Dysfunctions and
            Mortality Risk
  JOURNAL   Ann Clin Lab Sci 54 (4), 525-532 (2024)
   PUBMED   39293840
  REMARK    GeneRIF: The Circulating CDC42 Expression in Sepsis: Relation to
            Disease Susceptibility, Inflammation, Multiple Organ Dysfunctions
            and Mortality Risk.
REFERENCE   6  (bases 1 to 10503)
  AUTHORS   Hart,M.J., Eva,A., Evans,T., Aaronson,S.A. and Cerione,R.A.
  TITLE     Catalysis of guanine nucleotide exchange on the CDC42Hs protein by
            the dbl oncogene product
  JOURNAL   Nature 354 (6351), 311-314 (1991)
   PUBMED   1956381
REFERENCE   7  (bases 1 to 10503)
  AUTHORS   Yamane,H.K., Farnsworth,C.C., Xie,H.Y., Evans,T., Howald,W.N.,
            Gelb,M.H., Glomset,J.A., Clarke,S. and Fung,B.K.
  TITLE     Membrane-binding domain of the small G protein G25K contains an
            S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl
            terminus
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 286-290 (1991)
   PUBMED   1898776
REFERENCE   8  (bases 1 to 10503)
  AUTHORS   Shinjo,K., Koland,J.G., Hart,M.J., Narasimhan,V., Johnson,D.I.,
            Evans,T. and Cerione,R.A.
  TITLE     Molecular cloning of the gene for the human placental GTP-binding
            protein Gp (G25K): identification of this GTP-binding protein as
            the human homolog of the yeast cell-division-cycle protein CDC42
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9853-9857 (1990)
   PUBMED   2124704
REFERENCE   9  (bases 1 to 10503)
  AUTHORS   Munemitsu,S., Innis,M.A., Clark,R., McCormick,F., Ullrich,A. and
            Polakis,P.
  TITLE     Molecular cloning and expression of a G25K cDNA, the human homolog
            of the yeast cell cycle gene CDC42
  JOURNAL   Mol Cell Biol 10 (11), 5977-5982 (1990)
   PUBMED   2122236
REFERENCE   10 (bases 1 to 10503)
  AUTHORS   Polakis,P.G., Snyderman,R. and Evans,T.
  TITLE     Characterization of G25K, a GTP-binding protein containing a novel
            putative nucleotide binding domain
  JOURNAL   Biochem Biophys Res Commun 160 (1), 25-32 (1989)
   PUBMED   2496687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121735.1, BC003682.1 and
            AL031281.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 6, 2018 this sequence version replaced NM_001791.3.
            
            Summary: The protein encoded by this gene is a small GTPase of the
            Rho-subfamily, which regulates signaling pathways that control
            diverse cellular functions including cell morphology, migration,
            endocytosis and cell cycle progression. This protein is highly
            similar to Saccharomyces cerevisiae Cdc 42, and is able to
            complement the yeast cdc42-1 mutant. The product of oncogene Dbl
            was reported to specifically catalyze the dissociation of GDP from
            this protein. This protein could regulate actin polymerization
            through its direct binding to Neural Wiskott-Aldrich syndrome
            protein (N-WASP), which subsequently activates Arp2/3 complex.
            Alternative splicing of this gene results in multiple transcript
            variants. Pseudogenes of this gene have been identified on
            chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) encodes isoform (1). Variants
            1 and 3 encode the same isoform. Variants 1 and 2 encode isoforms
            that are the same length, but have distinct protein sequences.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.377.1,
                                           SRR1803617.172982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000656825.1/ ENSP00000499457.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1193              AL121735.1         21-1213
            1194-2086           BC003682.1         1166-2058
            2087-10503          AL031281.6         40529-48945         c
FEATURES             Location/Qualifiers
     source          1..10503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..10503
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /note="cell division cycle 42"
                     /db_xref="GeneID:998"
                     /db_xref="HGNC:HGNC:1736"
                     /db_xref="MIM:116952"
     exon            1..34
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /inference="alignment:Splign:2.1.0"
     exon            35..189
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..660
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; GTP binding protein, 25kDa; cell division
                     control protein 42 homolog; dJ224A6.1.1 (cell division
                     cycle 42 (GTP-binding protein, 25kD)); small GTP binding
                     protein CDC42; growth-regulating protein; dJ224A6.1.2
                     (cell division cycle 42 (GTP-binding protein, 25kD)); G25K
                     GTP-binding protein"
                     /codon_start=1
                     /product="cell division control protein 42 homolog isoform
                     1 precursor"
                     /protein_id="NP_001782.1"
                     /db_xref="CCDS:CCDS221.1"
                     /db_xref="GeneID:998"
                     /db_xref="HGNC:HGNC:1736"
                     /db_xref="MIM:116952"
                     /translation="MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTV
                     MIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEIT
                     HHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL
                     TQKGLKNVFDEAILAALEPPEPKKSRRCVLL"
     exon            190..262
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /inference="alignment:Splign:2.1.0"
     exon            263..372
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /inference="alignment:Splign:2.1.0"
     exon            373..570
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /inference="alignment:Splign:2.1.0"
     exon            571..10503
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2064..2069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /note="hexamer: ATTAAA"
     regulatory      2072..2077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /note="hexamer: AACAAA"
     polyA_site      2086
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /note="major polyA site"
     polyA_site      2089
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /note="major polyA site"
     regulatory      10484..10489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
                     /note="hexamer: AATAAA"
     polyA_site      10503
                     /gene="CDC42"
                     /gene_synonym="CDC42Hs; G25K; TKS"
ORIGIN      
        1 gcagtgctgc caacgccccg gtggagaagc tgaggtcatc atcagatttg aaatatttaa
       61 agtggataca aaactatttc agcaatgcag acaattaagt gtgttgttgt gggcgatggt
      121 gctgttggta aaacatgtct cctgatatcc tacacaacaa acaaatttcc atcggaatat
      181 gtaccgactg tttttgacaa ctatgcagtc acagttatga ttggtggaga accatatact
      241 cttggacttt ttgatactgc agggcaagag gattatgaca gattacgacc gctgagttat
      301 ccacaaacag atgtatttct agtctgtttt tcagtggtct ctccatcttc atttgaaaac
      361 gtgaaagaaa agtgggtgcc tgagataact caccactgtc caaagactcc tttcttgctt
      421 gttgggactc aaattgatct cagagatgac ccctctacta ttgagaaact tgccaagaac
      481 aaacagaagc ctatcactcc agagactgct gaaaagctgg cccgtgacct gaaggctgtc
      541 aagtatgtgg agtgttctgc acttacacag aaaggcctaa agaatgtatt tgacgaagca
      601 atattggctg ccctggagcc tccagaaccg aagaagagcc gcaggtgtgt gctgctatga
      661 acatctctcc agagcccttt ctgcacagct ggtgtcggca tcatactaaa agcaatgttt
      721 aaatcaaact aaagattaaa aattaaaatt cgtttttgca ataatgacaa atgccctgca
      781 cctacccaca tgcactcgtg tgagacaagg cccataggta tggccccccc cttccccctc
      841 ccagtactag ttaattttga gtaattgtat tgtcagaaaa gtgattagta ctattttttt
      901 ttgttgtttc aaaaaaaaaa tttttgtgtg tgtgtgtttt tttttttttt ttttttgttg
      961 tttaaaagca aggcatgctt gtggatgact ctgtaacaga ctaattggaa ttgttgaagc
     1021 tgctccctgg ttccactctg gagagtaatc tgggacatct tagtgttttg ttttgttttt
     1081 ttccctcctc ttttttttgg gggggagtgt gtgtggggtt tgttttttag tcttgttttt
     1141 ttaattcatt aaccagtggt tagcccttaa ggggaggagg acggattgat tccacattcc
     1201 acttcctaga tctagtttag aaaacatgtt ccccatctgg tgctcttagg aaggagtata
     1261 gtaaatgcct catttaataa catactcctt tttgaaagtt gccttttctc tccacccttg
     1321 agtagatcca gtatttgatg aaactcatga aagtgggtgg agcccatctt gcccctcctc
     1381 ttttctagga cgcactatat gtgactgtga ctttcaagga catttgtttg ccatttgctg
     1441 atttttttgg gaagttaatt tctaacttct ttcactgata aatgaagaaa agtattgcac
     1501 ctttgaaatg caccaaatga attgagtttg taattaaaaa aatttttttc cctttcagtc
     1561 attgtcttat atgcttagca tagatttgca gctcagtagt atatggtgtt cctagaatgc
     1621 agctgaagac ctgttatgta gaggaaatac gaggggtggt gctagaagac agacatctgt
     1681 ggaatgattc acatcctctc aagttaggag gatggaggcc tgcttcatta agaagctggg
     1741 ggtagggtgg gggtggggag aacacttaac aacatgggga ccagtcaggg gaatcccctt
     1801 atttctgttt tgcatatgag gaaccctaga gcagccaggt gaggctctct agtttaataa
     1861 aaatcatgga aagactctta atgcagactc ttcttaagtg ttaataggga ttttttcagc
     1921 ttattttggt tgcagtttcc aatttttaaa aatgttgagg taatctttcc caccttccca
     1981 aacctaattc ttgtagatgc attagtgttg aaccaatgct ttctcatgtc tcaattcttt
     2041 gtatatgcat tcttttcaga tgtattaaac aaacaaaaac ccttcacaag ccagcctgag
     2101 ggttgttatt ttccctccgt ctcttacttt tcagatattg aggagtggga atttgactct
     2161 tgataacatc aatttctaac aaactttggg ataaaatttt aaagctttat tatttttatt
     2221 ttctggcatt ttagtttgag ataatattta gccctctata tgttcaggtt tgtgctttct
     2281 cctctaagtt tgacccttcc cttaaatacc aagtaggtcc ataataattc ttagtgaagc
     2341 agtgttcagg aagctcactg ctcatggtgg aaggaaatgt cagtgtacct ttaatccata
     2401 gatcattgaa aagcagctca ttttccccca agttttctgc atcagtggtt ctccaactgg
     2461 agtgcagctt gaacaatgtg atttttaagt tttccaggca tttctaaaat gtagccaagt
     2521 ttgggaatca ccacacctag ttggttatct caaactacta ctatcagaat acaggttctg
     2581 tgctgcgaat ctgaatatgg gatacatttt ctttaggtag caagaaaggt ttatttacct
     2641 ttaggacatt atactgatct gcatgagaat cttagaaact aagaaccctt aaaatcagtt
     2701 aaggttggta cactgtggcc tcattttgat agttctctgc atggagtcat gtttggcatg
     2761 atttgcatac tgtgctagaa ttaagctggg ttggttgaga aggggttagg aagaggcaga
     2821 tgtaagcttt aacagttcta accaagaaat gcatcttatt tattccttgt tgactatact
     2881 agggagagat acctggatca tgtgataccc tggaaagcag ggacatatgt atccttagtg
     2941 tagtcagggg cgtataggtc cttgactatt gctatatctt tgtcctaaag caatgcttga
     3001 catgatatgg ctctagaagt agtcattgga tgggtatatt attttataaa tgagtaagtg
     3061 aaataaagca ggtcatacag ttgtgtcaac gaattatccg tgtatcagaa gaacaaggat
     3121 gatggggatt gattgaagct aatgttttct taaatatttt cagattgatt tctgcatgtc
     3181 agaagaactt gggtagcaag tggatgcagc ttaggttttc catttaaata ttgttttcta
     3241 tttgacgtaa caaacttgct tatagtcgtg gcttagaagg tgagtgatat tctccaggga
     3301 gtatgattta gaggctggaa agggttattg aaaatagtcc ttacaggctt agtttgtgtc
     3361 agaatttata gtatttaata cgatgttaat atattattgc tatttataag tgttttactg
     3421 aacatcctag aaatagattt tttttttttt ttttttttga gacggagtct cgctctgtcg
     3481 cccaggctgg agtgcagtgg cgcgatctcg gctcactgca agctccgcct cccgggttca
     3541 cgccattctc ctgcctcagc ctcccgagta gctgggacta ccggcgcccg ctaccacgcc
     3601 cggctaattt tttgtatttt tagtagagac ggggtttcac cgtgttagcc agaatggtct
     3661 cgatctcctg acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg
     3721 tgagccaccg cgcccggcca gaaatagatt ttatagttaa agcgatgttc ttcaagctgg
     3781 actttatgcc acaaggggag tgtattctaa aggggaagaa aaggattgtg gtttaaaaga
     3841 acaattgtaa tatttccttc attctgaggt gtatttttct cacattttca tattgtaatt
     3901 aggatacctg ttaacattgg tgtacattta atgtagtagt actttttctc cttttgccct
     3961 gcaagttgtc actaaatttg tgctatcata attgttacct tcatagaatg cttaaatagt
     4021 ggtacttctt tgacttgtta ggtttggact attttccttt tcttcttcca tttgtgaggt
     4081 aaattagtgg ttattttggt gctgggtgct aagaaactcg caaaacaagg gccctgctca
     4141 agaaggattg aaacttagtc cttgctgggt acaaatttag aaatttgtta tataactgtg
     4201 gggcaaggga caacatttca ccaggaagta gcaactccat catctttcag gaagggctga
     4261 tggttagggc atctctgaat gattattgga gggaagtggc tttatgtcac acttgttttc
     4321 tgtaagtctt actctgtatc tacccgactt cagatcatgg tgatttaatt acatggccca
     4381 atcatgtttt ctttccaggg ctgcttgaat gcttgaatac tttttttttt gagatggagt
     4441 ctcgttctgt cgcccaggct ggagtgcagt ggtgcaatct cggctcattg caagctccgc
     4501 ctcccgggtt cacaccattc tcctgcctca gcctcccgag tagccaggac tacaggcatg
     4561 tgccaccatg cctggctaat gttttgtatt tttagtagag atagggtttc accatgttag
     4621 ccaggatggt ctcgatctcc tgacctcgtg atccgcccgc cttggcctcc caaagtgcta
     4681 ggattacagg cgtgagccac cgcgcctggc cagaatgaat acttttaatt actactatga
     4741 gtcttttttc aaagtgcctc caccttaaaa aaaattcctt attttattca cttgccagaa
     4801 taatgttgca tttgaaccat gccaacggta gcttattaaa acagcattta tttttctcat
     4861 tcatgggtca gctgaacttg tctctagcct tcagattggg ctcaggtggg ctttgtgttt
     4921 gtcattctgg agcctagttc cagagagcag tggctgcttg agtgtggact tgcttatggt
     4981 gggccaaaga ggggcaaggg aaagcgcatt tacactttct cgtattccat tgcccagaga
     5041 tggcatatag ccgatcccaa gtcagtgcta ttcattcatt tttttaaaaa aatttattta
     5101 tttatttatt tatttatttt cagacggggt cttgcactgt tgcccgggct ggagtgcagt
     5161 ggtggcatct ccgctcactg caacctccac ctcccaggtt cacatgattc tcctgcctca
     5221 gcctcctgag tagctgggat tacaggtgtc tgccactgcg cccggctaat tttttgtatt
     5281 tttaagggag actgggtgtc actatgttgg ccagacagat ctcaaactcc tgacctcctg
     5341 atccgccctc ctcagcctcc caaagtgctg ggattatagg catgagtcac tgcgcccggc
     5401 ctattcattc attcttacag tgaattagta aattcaacaa ataggttttt ttaaagcaat
     5461 taaggcactg aggatataca gagagtaaaa tagatgtctc ctgacttcta cttggaattt
     5521 tctttccctt acagttttga tagctgcttt ctcttgaata actatgtcat ctctttccac
     5581 tttgcattgc tcccaagaga gtaatgtaaa agttttatct gtgcatgcat attcatgaca
     5641 cattcatttg tcattattta tcaaaaacct gttcccttcc ctggcactgg agacattgga
     5701 gaatgacagt ctcaagcagt gcagagatgt aagcaggcag aggtaaggac tttggtctca
     5761 atagcctaca gggtgcttca tccactcact gtattctgtg tgcctgtgcc gcggtgcagg
     5821 tggtcagttg gaacccctga tgggtatctg ggccactgcc caggccacac agagcctttg
     5881 tgcaaattag aaaaggccct tccaaagata ctttatgaac gacttgtaat aatttagtga
     5941 ttttattttc caaagcaagg catttggttg ctacctgcta gaactgttac agtaaataca
     6001 cagatctatt ttgtgagcaa atagtactgc cttggatgtg gtacccttgt gcagtgcaca
     6061 acttggacag ttcatacaca atgttgtatt gagatgattg ttattctaca ttgtatttat
     6121 ttagatagtg ggattgaaaa taggctaaga tggagaactg ggtggggaac aatttgtaat
     6181 cctttttagt tcatatgtca caatcacaga attgagacta gctagtttaa atccctgcat
     6241 cttgcacatg gtgaggaaag gtgaggacat ttagatgacc tttgcctgtc accacacagc
     6301 tgtatggtag cagagctggg cgtgaaacct gcattcctgg cctctccttt tgtggtgctt
     6361 acagtgctgt gttaggtcca gttttacctc ttaaatctgt attattactt ttttttcgag
     6421 accagatctt actctgtcgc ccaggctgga gtgcagtggc gtgatctcgg cttgctgcaa
     6481 tctctgcaat tctcatgcct cagcctccca agtagctggg actacaggcg tgagccaccg
     6541 tgcctggcta atttttgtat ttttagtaga gatggggttt caccatgttg gccaggctgg
     6601 tcttgaactc ctgacctcag gtgatccgcc cgttgcggcc tccctaagtg ctgggattat
     6661 aggcgtgagc cactgcgccc ggcctgaaat gtgtattctt aagtccgcct ttcaaagttg
     6721 agtactgcat tcttgcggct ctacctaagt ttctcctaga atctccctgc acttcttgtt
     6781 ttgctgccat caggtaattt gtgcattaga actagcttgg aacagaatgg gtaaacttct
     6841 gtgaagttag acacttgcct cttagaggca tatccagtga gtctttaaag ccctacgtta
     6901 tagaaaaatg tgaagtatgt ctaataaagg agtacagtgg aaggtttaaa agcacattgc
     6961 tgattagtgg ggtcaggatg ggaggagagc cctgatttta atgcagtgtc atagtctcat
     7021 aggtgatttc cccaaaagca aataaatgct cgatggattt tgggtccacc atgcatctct
     7081 gaagtagaag tgacagattt tcaaggctaa ggtaagtata gcattttctc aaccctatta
     7141 caatagagca caggatcata actgttctgt ttgctctgat gcgtcccgca gagcagtgct
     7201 ttttctcggt gtgaactgtg gatcacttgt ctcagtcatc aggattcctg gaccctgtag
     7261 gatttactct caatctttag gggtagagac taggagccta cattttgaac aagcatcttt
     7321 ttattttgat gaagtttgca ttattactcc taacaacgtg ccctttggca ggtagcttcc
     7381 acttttctgg cctcattatc tgtaaaattg catacttagt tatcattgag gtctcaaatg
     7441 cagttcgggt tcctggttgg tgaacaatta gatgggaagg ctgaaaaaaa aaatactcct
     7501 gagattctga atctgtaagt atgcaatggg acctgagaat caatctaatt tctaaaagat
     7561 tcccagatag aactttgttg agctatgttt agggaccagt gcacaccttg gtgatagaac
     7621 ctttttgaaa ctttgaaaaa gttaaaaggg ttctgtgtaa tgttacctaa gaagcttatt
     7681 tttaaaaaag gaaagcagtg cttagggcca tattgttttg aaataggatc tgagcaccat
     7741 ttaaattttt ataaattatt ttttagaggc atcacttctt taaagcccat cagattaatg
     7801 tgccattggt ttgaaaacca tgacatgaga tgatttctta aggttttatt tgtgtcagac
     7861 atgaatttta gagtatttct gggctatagg tcattacagc tttacttatt tattttttgg
     7921 agacagggtc tcactctgtc acccaggctg gagtgcagtg tcgtggtctt gggtcactgc
     7981 atccttgacc tccccagctc aagcgatcct cccgcctcag cctcccgagt agaaggtact
     8041 acaggtgtgt gacaccacgc ctggctcatt tttgcatttt gtgtagagag ggggttttgc
     8101 cattttaccc aggctggtct cgaactcctg agctgatcct cccacctcgg cctcccaacg
     8161 tgctgggatt acaggcatta gccactgtgc ccagctgggt atggatttct gagtggaggg
     8221 aatgtgaaca aaggagggcc caggcatgtt tgcagagtgg ctgggggccc tgcttcacca
     8281 cggcataggg acgggtgcag taggaagaaa ggtagcctca aggcccccat aaataaattg
     8341 gtgcattaag gaaggaatat taatcacatc caggagggct ctgccctaac tgctgagaat
     8401 cataaaagaa atggggacat attctggcga aataacagct ttgttaattg agctcttact
     8461 gtgtgccttt gcactgtgtt aagcacatgg tgttatcaca cttgctactc acaacagctc
     8521 tgaggttgat agtacaggta tcttcttttt atggagcagg actctgagac atcataattg
     8581 cttggtatat gcagccagag ttggaaatcc tatctgtctg attttggaaa ctgtgtgctt
     8641 accattacat atcttatgtg gaaataaaat gtatatgatt aattacaaag ctgaaaatcg
     8701 tagttgaagc atcatatagt gcacagggca agcaaagcag cataaaaggc ttcatctgta
     8761 agggtaggtt tgttgggtag gagctttttg ggggaggtga ctttaggatc agttgtagca
     8821 tgagagaata tgacaccttc ttcctttaga ggatctaaag gtgtagcttt agaggattgt
     8881 agggtgcctt tgcccattgt gtcatttggt ccttcttaaa atttgagtgt ttattctcta
     8941 catggcactc ttttaagcct ttgtgtgaat taactcagtc ttctcagcaa tcccccattt
     9001 tttcatatgt ggaaactgag gcatgttatg atacaaagct tgtccaagaa ttcagagcta
     9061 gcttgtccaa gaattcagag ctagtaagtg agggaactgg gatttgaatt taagcagtct
     9121 gtctctagag tctgctcagc tggccttttt ttctttcttc ttcttcttct tctttttttt
     9181 tttttttgta taataggcct gtgagttggg aagagcaggg tttgtttggt gagaaagttg
     9241 caccttagtg aatacccaag gtctgaggga ggcttggagc cagctctgca acctggctcc
     9301 cttctttcat tagcttgacc caagcacagg gagatgactg gggctctgcc ttcatcttct
     9361 ctgcaaacgg tcagggatac tcatgcagtt tttgagttta agtagtaaac tcctaaactt
     9421 caagtcatgt ttgtattagt gatttcactt gacctcagta caactctgta aaagaggcag
     9481 ggatggatga tgtcatttgt caaatggtaa aactgaggcg aaacaacttg gcattgttgg
     9541 tgttgtgcga agtacatgca taggctttgg atttgagttt ggctctgcca ctaacttgat
     9601 ctatgtcttc aggcaagtaa cttaaatgct ctgagtgttg cattctctgt gaagtggaaa
     9661 tagctgtact ttgcccaaga gttgtgagag tgacatgaat tgctatatgt gaggttctta
     9721 gcatagtgcc tggcaagtag aaggtactca tctgtgaatg gggtagatag cagctgtctt
     9781 catcactgtc atcattgttg gctcacatca aatcaggacc agaaaaccct gttgacttct
     9841 gggtcttaaa ctgctgtatc agtgaggggc ttcctcctca tactcattgc caggagtaga
     9901 gtaaggcttt taatttcatc tctaaccaac tctgataggg ctggaaatgt gtatggagtt
     9961 ccagacccac catggggccc cagtgctagc ttcttagccc tcctttgtaa ggtttgcact
    10021 agtttgatgg gagagggatt ttttttgtct tgattctgaa gctcttaaag aaatgctcct
    10081 ttttctccat aacttgagga tttcacaatt gtattggaat tattggtgtt aaggagttag
    10141 gtccatctct tggcagcttg tgaagggtgg gcaggcacct gtgaattctt cactggcttc
    10201 ttgtaagaat gactttactg gagggtgctg agtttgtgat tatctcctct gctgctagaa
    10261 aactccgtga accctggtac atatagcgtg ataaatcaag tcctgttttt gctcctaact
    10321 tgcattatgg tgtttgatac tatatcttca tttctcccat ggtagtaata acactgttgg
    10381 aaagagctct cagttggaag ttgaagatcc aggttctagt tgaggcacca gagtttcctt
    10441 gggcaagttg ccataccttt ttgggccttg gtttcctcat ctcaataaaa tgagtttctg
    10501 ttc
//
