LOCUS       NM_015891               3859 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cell division cycle 40 (CDC40), mRNA.
ACCESSION   NM_015891
VERSION     NM_015891.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3859)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3859)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
REFERENCE   3  (bases 1 to 3859)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3859)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   5  (bases 1 to 3859)
  AUTHORS   Kong,X.X., Lv,Y.R., Shao,L.P., Nong,X.Y., Zhang,G.L., Zhang,Y.,
            Fan,H.X., Liu,M., Li,X. and Tang,H.
  TITLE     HBx-induced MiR-1269b in NF-kappaB dependent manner upregulates
            cell division cycle 40 homolog (CDC40) to promote proliferation and
            migration in hepatoma cells
  JOURNAL   J Transl Med 14 (1), 189 (2016)
   PUBMED   27349221
  REMARK    GeneRIF: HBx activates NF-kappaB to promote the expression of
            miR1269b, which augments CDC40 expression, contributing to
            malignancy in hepatocellular cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3859)
  AUTHORS   Lindsey,L.A. and Garcia-Blanco,M.A.
  TITLE     Functional conservation of the human homolog of the yeast pre-mRNA
            splicing factor Prp17p
  JOURNAL   J Biol Chem 273 (49), 32771-32775 (1998)
   PUBMED   9830021
REFERENCE   7  (bases 1 to 3859)
  AUTHORS   Ben Yehuda,S., Dix,I., Russell,C.S., Levy,S., Beggs,J.D. and
            Kupiec,M.
  TITLE     Identification and functional analysis of hPRP17, the human
            homologue of the PRP17/CDC40 yeast gene involved in splicing and
            cell cycle control
  JOURNAL   RNA 4 (10), 1304-1312 (1998)
   PUBMED   9769104
REFERENCE   8  (bases 1 to 3859)
  AUTHORS   Zhou,Z. and Reed,R.
  TITLE     Human homologs of yeast prp16 and prp17 reveal conservation of the
            mechanism for catalytic step II of pre-mRNA splicing
  JOURNAL   EMBO J 17 (7), 2095-2106 (1998)
   PUBMED   9524131
REFERENCE   9  (bases 1 to 3859)
  AUTHORS   Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
            Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Binding specificity and in vivo targets of the EH domain, a novel
            protein-protein interaction module
  JOURNAL   Genes Dev 11 (17), 2239-2249 (1997)
   PUBMED   9303539
REFERENCE   10 (bases 1 to 3859)
  AUTHORS   Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P.,
            Pelicci,P.G. and Di Fiore,P.P.
  TITLE     A protein-binding domain, EH, identified in the receptor tyrosine
            kinase substrate Eps15 and conserved in evolution
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9530-9534 (1995)
   PUBMED   7568168
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF038392.1, AK001426.1,
            CB242479.1 and AL671518.3.
            
            On Nov 23, 2018 this sequence version replaced NM_015891.2.
            
            Summary: Pre-mRNA splicing occurs in two sequential
            transesterification steps. The protein encoded by this gene is
            found to be essential for the catalytic step II in pre-mRNA
            splicing process. It is found in the spliceosome, and contains
            seven WD repeats, which function in protein-protein interactions.
            This protein has a sequence similarity to yeast Prp17 protein,
            which functions in two different cellular processes: pre-mRNA
            splicing and cell cycle progression. It suggests that this protein
            may play a role in cell cycle progression. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.242774.1,
                                           SRR1660809.250792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307731.2/ ENSP00000304370.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1956              AF038392.1         7-1962
            1957-3844           AK001426.1         625-2512
            3845-3847           CB242479.1         14-16               c
            3848-3859           AL671518.3         60048-60059
FEATURES             Location/Qualifiers
     source          1..3859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3859
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /note="cell division cycle 40"
                     /db_xref="GeneID:51362"
                     /db_xref="HGNC:HGNC:17350"
                     /db_xref="MIM:605585"
     exon            1..207
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1758
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /note="pre-mRNA splicing factor 17; EH-binding protein 3;
                     hPRP17; PRP17 homolog; cell division cycle 40 homolog"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 17"
                     /protein_id="NP_056975.1"
                     /db_xref="CCDS:CCDS5081.1"
                     /db_xref="GeneID:51362"
                     /db_xref="HGNC:HGNC:17350"
                     /db_xref="MIM:605585"
                     /translation="MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSP
                     SSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQ
                     QMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAE
                     KNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDE
                     ITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYL
                     PKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKA
                     VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFV
                     AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP
                     VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVA
                     GYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKV
                     ITCGWDGLIKLWD"
     exon            208..294
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            295..424
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            425..508
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            509..648
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            649..745
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            746..885
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            886..960
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1006
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1108
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1224
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1358
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1435
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1580
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..3859
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3826..3831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /note="hexamer: AATAAA"
     polyA_site      3859
                     /gene="CDC40"
                     /gene_synonym="EHB3; PCH15; PRP17; PRPF17"
                     /note="major polyA site"
ORIGIN      
        1 agaagatttg ttgccgtcat gtcggctgcg attgcagctc tggccgcttc ctatggttcg
       61 ggttcagggt ccgaatcgga ctcggacagt gagagcagtc ggtgtccgct gccagccgcc
      121 gactccctca tgcacttgac taaatcgcct tcatcaaagc cgtctctagc agtggcagtg
      181 gactcggctc cggaggtggc agttaaggaa gatttggaga ctggagttca ccttgaccct
      241 gccgtcaaag aagttcagta taatcctacc tatgagacca tgtttgctcc tgagtttgga
      301 ccagaaaatc cctttaggac acagcaaatg gctgccccta gaaatatgct ttctggatat
      361 gccgaaccag ctcatatcaa tgatttcatg tttgagcagc aaaggagaac ttttgcaaca
      421 tatggttatg cattagaccc ttcattagat aatcatcaag tgtctgctaa atatattggt
      481 tctgtagaag aagctgaaaa aaatcaaggt ttaactgtat ttgaaactgg tcagaagaaa
      541 acagaaaaga ggaaaaagtt taaagaaaat gatgcatcca atattgatgg ttttttggga
      601 ccatgggcaa aatatgtgga tgaaaaagat gtagccaaac cttcagaaga agagcaaaaa
      661 gaattggatg aaatcacagc aaagaggcag aaaaaaggaa aacaggaaga agagaaacct
      721 ggggaggaga agacaatctt acatgttaaa gaaatgtatg actatcaagg caggtcctat
      781 cttcacatac ctcaggatgt tggtgttaat ctacggtcaa ctatgccacc tgagaagtgt
      841 tatcttccca aaaaacaaat tcatgtgtgg tctggacaca caaagggcgt cagtgcagtc
      901 agattgtttc ctctctctgg ccatttattg ctgtcttgtt ccatggactg taaaattaag
      961 ctatgggagg tttatggaga acggcgctgt ctgagaacat ttattggtca cagtaaggct
     1021 gttagggata tctgcttcaa tactgcagga acacagttcc tcagtgcagc ctatgacagg
     1081 tatcttaagc tctgggacac tgagacagga cagtgtatat caagatttac aaaccgaaaa
     1141 gtaccttatt gtgtcaaatt caatcctgat gaagataagc aaaatctctt tgtggctggg
     1201 atgtctgata agaagattgt gcaatgggac attcgaagtg gagaaattgt gcaggaatat
     1261 gatcggcatt tgggagctgt caacaccatt gtttttgtgg atgagaatag gagatttgtg
     1321 agcacatctg atgataaaag cctaagagtt tgggaatggg atatccctgt ggatttcaag
     1381 tacatagcag aacccagtat gcactcaatg cctgcagtga ctttgtctcc aaatggaaaa
     1441 tggctagcat gccaatcaat ggacaaccaa atcttaattt ttggagcaca gaacagattt
     1501 agattaaata agaaaaaaat ttttaagggc catatggtag caggctatgc ttgtcaggtg
     1561 gacttttcac cagacatgag ttatgtgatt tcaggagatg gaaatggaaa attaaacatt
     1621 tgggactgga agaccacaaa actctacagt cgatttaaag ctcatgataa agtgtgtata
     1681 ggtgcagtgt ggcatcctca tgaaacttct aaggtcataa catgtggttg ggatggtctc
     1741 attaaattgt gggattaatg agattaatcc ttaaactagc tgggatcatt tttgatccat
     1801 tgtcatattt atatttaatt attaaatgta tctgatgata acttgattta cagataatgt
     1861 tgatgacatt gaccctttgt ttaaaaaaag aaactgtaaa tttgacataa tttcatttgc
     1921 aacttcattt tgttttttat aaatgttatt tatacagaaa gtggctattg actttctatt
     1981 tgacaagtag ttataattgg caagcagttt gagtttatac tcatgacata ctgaaagcat
     2041 ctctttgggg tcaagaaaga atccctagtg gatttgggat tctagaggag gtgttataat
     2101 taattattca gaaaaatgca tgtatttacc tcttcaacca aaagggcagt aaagaatagg
     2161 gataatatat tttaatgtaa atttggaaga aggataaaat cacccacagt tactctccct
     2221 attattttca ctgggtcaag ttttaatctt ttggcttcat gagttccact ccctttgatg
     2281 atatatgttg tatattttta gttgtaaagc agtaatcttt aactgtagca ttcctctaat
     2341 tataaacagt gaaaaatcaa aatcagtcca gagttctttt gttgacttaa ttcctgatca
     2401 gtatagacag gactatatat atttaatcag agaattacat tatatctgaa gatggagctc
     2461 aggagaatgc accaagactt tgaattgtat ttacattcac tgtcagtaaa gacctggcta
     2521 cgctttgaga aatcaggatc tcctaggtca ttgcttcgca gctgtgatta ctgaaatcct
     2581 cctcatagga gataaagtac gaggggtaga gtccaagatg tcaacttgta atttctttga
     2641 agtcatatgt tttatcttta aaattattct tattttacct gtgaatatat acaacagaac
     2701 tttttaagat taaaaaattt ttaaacctct atgtctgaaa aaaaaaatga cactcctgga
     2761 agatggctag ggttccccag tttgagaagc agtggccatg gtgaaaaata gtttttgaaa
     2821 acatcagatt ataaaatcaa gatagtccgg acgcggtggc acatgcctgt aatcccagca
     2881 ctttgggagg ctgaggcagg tgaatcacct gaggtcagga gttcaagacc agcctggcca
     2941 acatagtgaa accccgtctc tactaaaaac acaaaaatta gccaggcttg gtggctggcg
     3001 cctgtaattc cagctactca gaaggctgag gcagggagaa ttgcttgaac ccaggagtgg
     3061 aggttgcagt gagctgagat catgccactg cactccagcc tgggcgacag agcgagactc
     3121 cacctcaaaa aataaaatca agataacctc ttgaatgtaa tagctcatag cactttaatt
     3181 tggcaagcca tttttcctgt tttattataa atctatatta gatgtttgaa tatggtttga
     3241 aatatttcac taccgtgctg aaaaaggttg gttgatagca gcttggagtg ctaactggaa
     3301 gatcaaaatc atgtctcttg ctgataacct aagagcatta agctctgagt ccagtgaggt
     3361 catagcagtg tatgctcctt gcccttacgg agtgtctgtt tttagaaatt tagattttaa
     3421 aaggcgtggg acatacgacc aggccctata gccacataaa tataaatttc atagaaaaag
     3481 aataaaagcg gagatatatt ttttgacaca gaggcaccca aagaaataca aacattgcct
     3541 agctgctgcc atttctgtaa ctgcccagaa gggtgacaga tttctgaagg ggaaaggatt
     3601 cagatatgac cttttcttta gtcccaacca ctagttttaa caaatgtgaa ttattgaaat
     3661 gtgaagggac aaaaagaatc atacatttaa actgtcttgt tcagcatacc aatattgtat
     3721 gttacaaatc atcatttcta aatctggatt gattctgttg tgtttttgac tgtttctaaa
     3781 gtaagtgtgt ataaaagtct cctttttaaa aagatcatat ttttaaataa agcatttttt
     3841 gtagaaagtg ctatcaaaa
//
