LOCUS       NM_017913               3500 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cell division cycle 37 like 1, HSP90 cochaperone
            (CDC37L1), mRNA.
ACCESSION   NM_017913
VERSION     NM_017913.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3500)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3500)
  AUTHORS   Peak,S.L., Gracia,L., Lora,G. and Jinwal,U.K.
  TITLE     Hsp90-interacting Co-chaperones and their Family Proteins in Tau
            Regulation: Introducing a Novel Role for Cdc37L1
  JOURNAL   Neuroscience 453, 312-323 (2021)
   PUBMED   33246057
  REMARK    Review article
REFERENCE   3  (bases 1 to 3500)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3500)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 3500)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3500)
  AUTHORS   Cartledge,K., Elsegood,C., Roiniotis,J., Hamilton,J.A. and
            Scholz,G.M.
  TITLE     Importance of the C-terminal domain of Harc for binding to Hsp70
            and Hop as well as its response to heat shock
  JOURNAL   Biochemistry 46 (51), 15144-15152 (2007)
   PUBMED   18052042
  REMARK    GeneRIF: C-terminal domain of Harc is a key determinant of its
            cochaperone functions
REFERENCE   7  (bases 1 to 3500)
  AUTHORS   Roiniotis,J., Masendycz,P., Ho,S. and Scholz,G.M.
  TITLE     Domain-mediated dimerization of the Hsp90 cochaperones Harc and
            Cdc37
  JOURNAL   Biochemistry 44 (17), 6662-6669 (2005)
   PUBMED   15850399
  REMARK    GeneRIF: Harc forms dimers in vitro. The structural similarities
            between Harc and Cdc37 suggest that Harc may function to regulate
            the Hsp90-mediated folding of Cdc37-dependent protein kinases into
            functional conformations via dimerization with Cdc37.
REFERENCE   8  (bases 1 to 3500)
  AUTHORS   Scholz,G.M., Cartledge,K. and Hall,N.E.
  TITLE     Identification and characterization of Harc, a novel
            Hsp90-associating relative of Cdc37
  JOURNAL   J Biol Chem 276 (33), 30971-30979 (2001)
   PUBMED   11413142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA180237.1, BC014133.2 and AL136231.12.
            
            On Nov 23, 2018 this sequence version replaced NM_017913.3.
            
            Summary: CDC37L1 is a cytoplasmic phosphoprotein that exists in
            complex with HSP90 (HSPCA; MIM 140571) as well as several other
            proteins involved in HSP90-mediated protein folding (Scholz et al.,
            2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.420111.1,
                                           SRR1660803.3552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381854.4/ ENSP00000371278.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               DA180237.1         17-180
            165-1695            BC014133.2         1-1531
            1696-3500           AL136231.12        145525-147329
FEATURES             Location/Qualifiers
     source          1..3500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..3500
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /note="cell division cycle 37 like 1, HSP90 cochaperone"
                     /db_xref="GeneID:55664"
                     /db_xref="HGNC:HGNC:17179"
                     /db_xref="MIM:610346"
     exon            1..331
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1213
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /note="CDC37 cell division cycle 37 homolog-like 1;
                     Hsp90-associating relative of Cdc37; cell division cycle
                     37 like 1"
                     /codon_start=1
                     /product="hsp90 co-chaperone Cdc37-like 1"
                     /protein_id="NP_060383.2"
                     /db_xref="CCDS:CCDS6454.1"
                     /db_xref="GeneID:55664"
                     /db_xref="HGNC:HGNC:17179"
                     /db_xref="MIM:610346"
                     /translation="MEQPWPPPGPWSLPRAEGEAEEESDFDVFPSSPRCPQLPGGGAQ
                     MYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSE
                     LRQREEEWRQKEEALVQREKMCLWSTDAISKDVFNKSFINQDKRKDTEDEDKSESFMQ
                     KYEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAH
                     QAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQS
                     QSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMM
                     DTV"
     exon            332..613
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /inference="alignment:Splign:2.1.0"
     exon            614..707
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /inference="alignment:Splign:2.1.0"
     exon            708..823
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /inference="alignment:Splign:2.1.0"
     exon            824..946
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1111
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..3500
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /note="hexamer: ATTAAA"
     polyA_site      1695
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /note="major polyA site"
     regulatory      2744..2749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /note="hexamer: AATAAA"
     polyA_site      2765
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /note="major polyA site"
     regulatory      3478..3483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
                     /note="hexamer: AATAAA"
     polyA_site      3500
                     /gene="CDC37L1"
                     /gene_synonym="CDC37B; HARC"
ORIGIN      
        1 cttccgccgt ccgccggtgg cgaggcccag gctgtcgccg ggtgtgcagc ggcgtcgcgg
       61 ccagtagagg gattctgggt aacggcccgg acccccggct gggcttctgg ctcggcgcag
      121 caggttccat tcacgccaag tctgttggca gtggcagttg tagggccaag ggcggttgta
      181 ggacccggag cagccggaca tggaacaacc gtggccgcct ccgggaccct ggagcctccc
      241 tcgggccgag ggtgaggctg aggaagagag tgacttcgac gtgttcccca gttctccccg
      301 ctgcccgcag ctgccaggcg gcggcgccca gatgtatagc catggaattg aattggcttg
      361 ccaaaagcag aaagagtttg tgaagagctc tgtggcgtgc aaatggaatc ttgctgaagc
      421 tcaacagaaa cttggtagct tagcactgca taattctgag tccttggatc aggagcatgc
      481 caaagcacaa acagcagtat cagaactgag gcaacgggaa gaagagtggc gacagaaaga
      541 agaagctcta gtacaaagag agaagatgtg tctgtggagc acggatgcca ttagcaagga
      601 tgtttttaat aagagtttta ttaatcaaga taaaagaaaa gacacagaag atgaagataa
      661 atcagaatca tttatgcaaa aatatgagca aaaaatcaga cattttggta tgttgagtcg
      721 atgggatgat agccagagat ttttgtctga ccatccatac cttgtatgtg aagaaactgc
      781 taaatatctt attttatggt gttttcacct ggaagctgag aagaaagggg ctttaatgga
      841 acaaatagca catcaagctg ttgtaatgca gtttattatg gaaatggcca aaaactgtaa
      901 tgtggatcca agagggtgtt ttcgtttatt tttccagaaa gccaaagcag aggaagaagg
      961 ttattttgaa gcattcaaaa atgaacttga agctttcaag tcaagagtaa gactttattc
     1021 tcaatcacaa agttttcaac ctatgacagt tcagaatcat gttccccatt ctggtgttgg
     1081 atctataggt ttattagaat ccttaccaca gaatccagat tatcttcagt attctatcag
     1141 tacagctctc tgcagcttaa actcggtggt acataaagaa gatgatgaac ccaaaatgat
     1201 ggacactgta taatttggtt aagactgctg aggccaagtg ctattttgtt acaagaaagg
     1261 aagaacttgg ctattttctt gacactttta tgggtgctgc actttatttt tgttcggttt
     1321 ttgatgggag ggaaagagta ctgaaatgtt ttgtaaattt tttttaatgt gctgctaggt
     1381 tttttgtttt gttttgttct gaagagaaga gtggtaccat atgttgcagg aagtcaaact
     1441 ggactttttg tggctactaa atttgctttt aatcttattg ttctcaattt tggaatcaag
     1501 tatgaaaatc tgcacaaatg caatgtttac aagaactggt tgattctggg aggcatctgc
     1561 tacagtctct ttttatatgg atatgtacat gtcctattct acaaaaatga ttaaagataa
     1621 aaacatactt gtatcccact gctactttag ctgtcaaatt tggtgtttca tcacattaaa
     1681 agcaataaat cagtagttgg taatgtactt tactaaataa gttggggggt acaattttta
     1741 aaagtcttaa ctcttaaata cttgactttc ggcaccatca gttaaatcct tgactataat
     1801 acaaatttga tatatacatt acatttaccc tcaaattatt ctcaaaacta tattccttag
     1861 aatttgattt taccctgctg actttaagag ttataataat atcaaatgtg atgagctaat
     1921 atagattttc tttttaaata agaataactt caagctcact ctttcttaac atagtctggg
     1981 atctctcagg gagtaagttt taaaagaata ctaatggctt gtaagaacaa acaggaataa
     2041 taatctgatt tttaaatttg tagttatttt actcatgttg ccttttaatt tttgttattt
     2101 tggtttattt tttgatgtag ccttttaaaa aaggagtctt aaaaatgatt ttttttttaa
     2161 aggcaagaga aatcttgtag tgctaactgc cttgagctgc caattaccta tttctgagaa
     2221 tttggtgact cttattggta atgatggcat ttacaacatt tggcatttcc cctttttcag
     2281 ctcagttacc atagaatact tccaagcttt actacttcct ctgtaagtca tttcagttat
     2341 gccaggatat ttgatgattt tgtttatgta gaattaggta acaaagccaa ttatgctatc
     2401 cttattattg aaggattaat cttatgactt aacataagct ttggttatat ttgggtgtag
     2461 tctttggcta agtacccatt aaggctagta gcaaacactt ggaaggtggc taactgggac
     2521 tgggaatacg tgtctcaact tgagaaacca aatagtgcga agggactcag ggtggccaga
     2581 cctgtgacct tggcctcatt tgtatcttgt tttcgctgag gtgatcagac acttagtacc
     2641 ctagaaatgg actggaatta ttgaatcttc ttctgtaaca tcacaatctt cctggttttc
     2701 agaataaacg tttttgtgct tttgatataa atatatactc tataataaaa tgtttgacta
     2761 atttatatag tagtgtttgt cagcctgtac tttttttttt tttaaaccca tgacctagtc
     2821 gtagacattt ttttcttttt gttctgttct gaagcaagct cttatttttc cctttctacc
     2881 aaattgagag aatgggcaga cacaggagcc atattcctag tttcacagaa atgttacttg
     2941 aattattatt ttcccttctt tcccaggatt tgcctgtaag cattcaaatt gttttgaatt
     3001 tcattttgcc ttctctaagt tagaggtatt taatgactga agactggcag gagagaaagt
     3061 atcaacaaac tgagtaaact attcttgagg ggcactgaaa agatgttctt tgaaacttga
     3121 tttatatatt tttacttgca aaagaatata ctgtgttttg agtatgaaag tgtgattggg
     3181 tctgttgtgg gaaccactga ctgatgccat aatttgcact taaaggctat aaattacata
     3241 gttagccgta ctttagtact agaaacagta aattgacatc cttgaactaa ttcctacctt
     3301 ttttttgttt ctgaagaaat aaagagtata ttaagcaaag ggataattta tatttcaggt
     3361 tggacaattt accctaaaca aattaaacca tggaaagtgc aaacacatga atgaaacatt
     3421 tttttacatc aaagtatcat caaagattct tgtttcattt gataaaatta atatttgaat
     3481 aaaaaaattt ttaaatcaaa
//
