LOCUS       NM_007065               1618 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cell division cycle 37, HSP90 cochaperone (CDC37),
            mRNA.
ACCESSION   NM_007065
VERSION     NM_007065.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Caveney,N.A., Tsutsumi,N. and Garcia,K.C.
  TITLE     Structural insight into guanylyl cyclase receptor hijacking of the
            kinase-Hsp90 regulatory mechanism
  JOURNAL   Elife 12, 86784 (2023)
   PUBMED   37535399
  REMARK    GeneRIF: Structural insight into guanylyl cyclase receptor
            hijacking of the kinase-Hsp90 regulatory mechanism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Iglesias-Martinez,L.F., Rauch,N., Wynne,K., McCann,B., Kolch,W. and
            Rauch,J.
  TITLE     Interactome dynamics of RAF1-BRAF kinase monomers and dimers
  JOURNAL   Sci Data 10 (1), 203 (2023)
   PUBMED   37045861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Oberoi,J., Guiu,X.A., Outwin,E.A., Schellenberger,P.,
            Roumeliotis,T.I., Choudhary,J.S. and Pearl,L.H.
  TITLE     HSP90-CDC37-PP5 forms a structural platform for kinase
            dephosphorylation
  JOURNAL   Nat Commun 13 (1), 7343 (2022)
   PUBMED   36446791
  REMARK    GeneRIF: HSP90-CDC37-PP5 forms a structural platform for kinase
            dephosphorylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Zhang,X., Li,S., Li,Z., Cheng,L., Liu,Z. and Wang,C.
  TITLE     The Therapeutic Potential of Targeting Hsp90-Cdc37 Interactions in
            Several Diseases
  JOURNAL   Curr Drug Targets 23 (10), 1023-1038 (2022)
   PUBMED   35400341
  REMARK    GeneRIF: The Therapeutic Potential of Targeting Hsp90-Cdc37
            Interactions in Several Diseases.
            Review article
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Kimura,Y., Rutherford,S.L., Miyata,Y., Yahara,I., Freeman,B.C.,
            Yue,L., Morimoto,R.I. and Lindquist,S.
  TITLE     Cdc37 is a molecular chaperone with specific functions in signal
            transduction
  JOURNAL   Genes Dev 11 (14), 1775-1785 (1997)
   PUBMED   9242486
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Lamphere,L., Fiore,F., Xu,X., Brizuela,L., Keezer,S., Sardet,C.,
            Draetta,G.F. and Gyuris,J.
  TITLE     Interaction between Cdc37 and Cdk4 in human cells
  JOURNAL   Oncogene 14 (16), 1999-2004 (1997)
   PUBMED   9150368
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Dai,K., Kobayashi,R. and Beach,D.
  TITLE     Physical interaction of mammalian CDC37 with CDK4
  JOURNAL   J Biol Chem 271 (36), 22030-22034 (1996)
   PUBMED   8703009
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Dey,B., Lightbody,J.J. and Boschelli,F.
  TITLE     CDC37 is required for p60v-src activity in yeast
  JOURNAL   Mol Biol Cell 7 (9), 1405-1417 (1996)
   PUBMED   8885235
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Stepanova,L., Leng,X., Parker,S.B. and Harper,J.W.
  TITLE     Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90
            that binds and stabilizes Cdk4
  JOURNAL   Genes Dev 10 (12), 1491-1502 (1996)
   PUBMED   8666233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE796008.1 and BC000083.2.
            
            On Nov 23, 2018 this sequence version replaced NM_007065.3.
            
            Summary: The protein encoded by this gene is highly similar to Cdc
            37, a cell division cycle control protein of Sacchromyces
            cerevisiae. This protein is a molecular chaperone with specific
            function in cell signal transduction. It has been shown to form
            complex with Hsp90 and a variety of protein kinases including CDK4,
            CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought
            to play a critical role in directing Hsp90 to its target kinases.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1159146.1,
                                           SRR3476690.452014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222005.7/ ENSP00000222005.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BE796008.1         58-80
            24-1618             BC000083.2         1-1595
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1618
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /note="cell division cycle 37, HSP90 cochaperone"
                     /db_xref="GeneID:11140"
                     /db_xref="HGNC:HGNC:1735"
                     /db_xref="MIM:605065"
     exon            1..165
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1200
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /note="CDC37 (cell division cycle 37, S. cerevisiae,
                     homolog); hsp90 chaperone protein kinase-targeting
                     subunit; CDC37 cell division cycle 37 homolog"
                     /codon_start=1
                     /product="hsp90 co-chaperone Cdc37"
                     /protein_id="NP_008996.1"
                     /db_xref="CCDS:CCDS12237.1"
                     /db_xref="GeneID:11140"
                     /db_xref="HGNC:HGNC:1735"
                     /db_xref="MIM:605065"
                     /translation="MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQ
                     KEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKL
                     EEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIK
                     HFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQF
                     ILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMK
                     EYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQ
                     RCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV"
     exon            166..441
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     exon            442..550
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     exon            551..666
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     exon            667..789
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     exon            790..972
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1044
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1618
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /note="hexamer: AATAAA"
     polyA_site      1618
                     /gene="CDC37"
                     /gene_synonym="P50CDC37"
                     /note="major polyA site"
ORIGIN      
        1 agtctccact gctgccgccg tcgccgccac ccgagccgga gcgggctggg ccgccaaggc
       61 aagatggtgg actacagcgt gtgggaccac attgaggtgt ctgatgatga agacgagacg
      121 caccccaaca tcgacacggc cagtctcttc cgctggcggc atcaggcccg ggtggaacgc
      181 atggagcagt tccagaagga gaaggaggaa ctggacaggg gctgccgcga gtgcaagcgc
      241 aaggtggccg agtgccagag gaaactgaag gagctggagg tggccgaggg cggcaaggca
      301 gagctggagc gcctgcaggc cgaggcacag cagctgcgca aggaggagcg gagctgggag
      361 cagaagctgg aggagatgcg caagaaggag aagagcatgc cctggaacgt ggacacgctc
      421 agcaaagacg gcttcagcaa gagcatggta aataccaagc ccgagaagac ggaggaggac
      481 tcagaggagg tgagggagca gaaacacaag accttcgtgg aaaaatacga gaaacagatc
      541 aagcactttg gcatgcttcg ccgctgggat gacagccaaa agtacctgtc agacaacgtc
      601 cacctggtgt gcgaggagac agccaattac ctggtcattt ggtgcattga cctagaggtg
      661 gaggagaaat gtgcactcat ggagcaggtg gcccaccaga caatcgtcat gcaatttatc
      721 ctggagctgg ccaagagcct aaaggtggac ccccgggcct gcttccggca gttcttcact
      781 aagattaaga cagccgatcg ccagtacatg gagggcttca acgacgagct ggaagccttc
      841 aaggagcgtg tgcggggccg tgccaagctg cgcatcgaga aggccatgaa ggagtacgag
      901 gaggaggagc gcaagaagcg gctcggcccc ggcggcctgg accccgtcga ggtctacgag
      961 tccctccctg aggaactcca gaagtgcttc gatgtgaagg acgtgcagat gctgcaggac
     1021 gccatcagca agatggaccc caccgacgca aagtaccaca tgcagcgctg cattgactct
     1081 ggcctctggg tccccaactc taaggccagc gaggccaagg agggagagga ggcaggtcct
     1141 ggggacccat tactggaagc tgttcccaag acgggcgatg agaaggatgt cagtgtgtga
     1201 cctgccccag ctaccaccgc cacctgcttc caggccccta tgtgcccctt ttcagaaaac
     1261 agatagatgc catctcgccc gctcctgact tcctctactt gcgctgctcg gcccagcctg
     1321 gggggcccgc ccagccctcc ctggcctctc cactgtctcc actctccagc gcccattcaa
     1381 gtctctgctt tgagtcaagg ggcttcactg cctgcagccc cccatcagca ttatgccaaa
     1441 ggcccggggg tccggggaag ggcagaggtc accaggctgg tctaccaggt agttggggag
     1501 ggtccccagc caaggggccg gctctcgtca ctgggctctg ttttcactgt tcgtctgctg
     1561 tctgtgtctt ctatttggca aacagcaatg atcttccaat aaaagatttc agatgctc
//
