LOCUS       NM_001293091            5682 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cell division cycle 27 (CDC27), transcript variant 4,
            mRNA.
ACCESSION   NM_001293091 XM_005257895
VERSION     NM_001293091.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5682)
  AUTHORS   Song,W., Xia,X., Fan,Y., Zhang,B. and Chen,X.
  TITLE     Functional and Genetic Analyses Unveil the Implication of CDC27 in
            Hemifacial Microsomia
  JOURNAL   Int J Mol Sci 25 (9), 4707 (2024)
   PUBMED   38731925
  REMARK    GeneRIF: Functional and Genetic Analyses Unveil the Implication of
            CDC27 in Hemifacial Microsomia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5682)
  AUTHORS   Zhao,C., Sun,J., Dang,Z., Su,Q. and Yang,J.
  TITLE     Circ_0000775 promotes the migration, invasion and EMT of hepatic
            carcinoma cells by recruiting IGF2BP2 to stabilize CDC27
  JOURNAL   Pathol Res Pract 235, 153908 (2022)
   PUBMED   35561648
  REMARK    GeneRIF: Circ_0000775 promotes the migration, invasion and EMT of
            hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27.
REFERENCE   3  (bases 1 to 5682)
  AUTHORS   Shang,S., Zhou,Y., Chen,K., Chen,L., Li,P., Li,D., Cui,S.,
            Zhang,M.J., Chen,X. and Li,Q.
  TITLE     A Novel Gene CDC27 Causes SLE and Is Associated With the Disease
            Activity
  JOURNAL   Front Immunol 13, 876963 (2022)
   PUBMED   35418986
  REMARK    GeneRIF: A Novel Gene CDC27 Causes SLE and Is Associated With the
            Disease Activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5682)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5682)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
REFERENCE   6  (bases 1 to 5682)
  AUTHORS   Ollendorff,V. and Donoghue,D.J.
  TITLE     The serine/threonine phosphatase PP5 interacts with CDC16 and
            CDC27, two tetratricopeptide repeat-containing subunits of the
            anaphase-promoting complex
  JOURNAL   J Biol Chem 272 (51), 32011-32018 (1997)
   PUBMED   9405394
REFERENCE   7  (bases 1 to 5682)
  AUTHORS   Ho,P.P., Couch,F.J., Brody,L.C., Abel,K.J., Boehnke,M.,
            Shearon,T.H., Chandrasekharappa,S.C., Collins,F.S. and Weber,B.L.
  TITLE     Localization of the human homolog of the yeast cell division
            control 27 gene (CDC27) proximal to ITGB3 on human chromosome
            17q21.3
  JOURNAL   Somat Cell Mol Genet 21 (5), 351-355 (1995)
   PUBMED   8619132
REFERENCE   8  (bases 1 to 5682)
  AUTHORS   Tugendreich,S., Tomkiel,J., Earnshaw,W. and Hieter,P.
  TITLE     CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic
            spindle and is essential for the metaphase to anaphase transition
  JOURNAL   Cell 81 (2), 261-268 (1995)
   PUBMED   7736578
REFERENCE   9  (bases 1 to 5682)
  AUTHORS   Chen,P.L., Ueng,Y.C., Durfee,T., Chen,K.C., Yang-Feng,T. and
            Lee,W.H.
  TITLE     Identification of a human homologue of yeast nuc2 which interacts
            with the retinoblastoma protein in a specific manner
  JOURNAL   Cell Growth Differ 6 (2), 199-210 (1995)
   PUBMED   7756179
REFERENCE   10 (bases 1 to 5682)
  AUTHORS   Tugendreich,S., Boguski,M.S., Seldin,M.S. and Hieter,P.
  TITLE     Linking yeast genetics to mammalian genomes: identification and
            mapping of the human homolog of CDC27 via the expressed sequence
            tag (EST) data base
  JOURNAL   Proc Natl Acad Sci U S A 90 (21), 10031-10035 (1993)
   PUBMED   8234252
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY023336.1, AK296881.1,
            AC002558.2 and AA927469.1.
            
            On May 31, 2019 this sequence version replaced NM_001293091.2.
            
            Summary: The protein encoded by this gene shares strong similarity
            with Saccharomyces cerevisiae protein Cdc27, and the gene product
            of Schizosaccharomyces pombe nuc 2. This protein is a component of
            the anaphase-promoting complex (APC), which is composed of eight
            protein subunits and is highly conserved in eukaryotic cells. This
            complex catalyzes the formation of cyclin B-ubiquitin conjugate,
            which is responsible for the ubiquitin-mediated proteolysis of
            B-type cyclins. The protein encoded by this gene and three other
            members of the APC complex contain tetratricopeptide (TPR) repeats,
            which are important for protein-protein interactions. This protein
            was shown to interact with mitotic checkpoint proteins including
            Mad2, p55CDC and BUBR1, and it may thus be involved in controlling
            the timing of mitosis. Alternative splicing of this gene results in
            multiple transcript variants. Related pseudogenes have been
            identified on chromosomes 2, 22 and Y. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (4) lacks an alternate exon in the
            5' region and it thus differs in its 5' UTR and initiates
            translation at an alternate start codon, and it also uses an
            alternate in-frame splice site in the central coding region,
            compared to variant 1. The encoded isoform (4) has a distinct
            N-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296881.1, SRR18074969.1162834.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                HY023336.1         19-62
            45-1798             AK296881.1         2-1755
            1799-1799           AC002558.2         61660-61660
            1800-2614           AK296881.1         1757-2571
            2615-5650           AC002558.2         78131-81166
            5651-5682           AA927469.1         11-42               c
FEATURES             Location/Qualifiers
     source          1..5682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..5682
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="cell division cycle 27"
                     /db_xref="GeneID:996"
                     /db_xref="HGNC:HGNC:1728"
                     /db_xref="MIM:116946"
     exon            1..150
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            151..226
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2450
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     anaphase promoting complex subunit 3; nuc2 homolog;
                     anaphase-promoting complex, protein 3; cell division cycle
                     27 homolog; D0S1430E, D17S978E"
                     /codon_start=1
                     /product="cell division cycle protein 27 homolog isoform
                     4"
                     /protein_id="NP_001280020.1"
                     /db_xref="GeneID:996"
                     /db_xref="HGNC:HGNC:1728"
                     /db_xref="MIM:116946"
                     /translation="MASTKPLCLPRCGFPRRTPLCRRLAEGEQILSGGVFNKQKSHDD
                     IVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPD
                     PDQTFKFTSLQNFSNCLPNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSN
                     SKYSLNTDSSVSYIDSAVISPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLT
                     PSFGILPLETPSPGDGSYLQNYTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSG
                     NSREVTPILAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKK
                     LKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFN
                     LQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFE
                     LSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEA
                     WCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA
                     IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS
                     EKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLI
                     GKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTD
                     ESQESSMTDADDTQLHAAESDEF"
     exon            227..352
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..450
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..605
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..817
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..932
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1045
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1145
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1353
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1526
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1679
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1888
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2006
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2135
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2210
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2367
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..5682
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2924..2929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="hexamer: AATAAA"
     polyA_site      2950
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="major polyA site"
     regulatory      5161..5166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="hexamer: ATTAAA"
     polyA_site      5188
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
     regulatory      5418..5423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="hexamer: ATTAAA"
     polyA_site      5441
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="major polyA site"
     regulatory      5660..5665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
                     /note="hexamer: AATAAA"
     polyA_site      5682
                     /gene="CDC27"
                     /gene_synonym="ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E;
                     H-NUC; HNUC; NUC2"
ORIGIN      
        1 gctcggcctc ccccatcccc cggtaacggt cgctggtgag tttaaatgag caggggctgg
       61 ccgggccgga gccgctacag ggggggcctg aggcactgca gaaagtgggc ctgagcctcg
      121 aggatgacgg tgctgcagga acccgtccag gctgctatat ggcaagcact aaaccactat
      181 gcttaccgag atgcggtttt cctcgcagaa cgcctttatg cagaaggctt gcagaagggg
      241 aacaaatctt atctggtgga gtgtttaata agcagaaaag ccatgatgat attgttactg
      301 agtttggtga ttcagcttgc tttactcttt cattgttggg acatgtatat tgcaagacag
      361 atcggcttgc caaaggatca gaatgttacc aaaagagcct tagtttaaat cctttcctct
      421 ggtctccctt tgaatcatta tgtgaaatag gtgaaaagcc agatcctgac caaacattta
      481 aattcacatc tttacagaac tttagcaact gtctgcccaa ctcttgcaca acacaagtac
      541 ctaatcatag tttatctcac agacagcctg agacagttct tacggaaaca ccccaggaca
      601 caattgaatt aaacagattg aatttagaat cttccaattc aaagtactcc ttgaatacag
      661 attcctcagt gtcttatatt gattcagctg taatttcacc tgatactgtc ccactgggaa
      721 caggaacttc catattatct aaacaggttc aaaataaacc aaaaactggt cgaagtttat
      781 taggaggacc agcagctctt agtccattaa ccccaagttt tgggattttg ccattagaaa
      841 ccccaagtcc tggagatgga tcctatttac aaaactacac taatacacct cctgtaattg
      901 atgtgccatc caccggagcc ccttcaaaaa agtctgttgc cagaatcggc caaactggaa
      961 caaagtctgt cttctcacag agtggaaata gccgagaggt aactccaatt cttgcacaaa
     1021 cacaaagttc tggtccacaa acaagtacaa cacctcaggt attgagcccc actattacat
     1081 ctcccccaaa cgcactgcct cgaagaagtt cacgactctt tactagtgac agctccacaa
     1141 ccaaggagaa tagcaaaaaa ttaaaaatga agtttccacc taaaatccca aacagaaaaa
     1201 caaaaagtaa aactaataaa ggaggaataa ctcaacctaa cataaatgat agcctggaaa
     1261 ttacaaaatt ggactcttcc atcatttcag aagggaaaat atccacaatc acacctcaga
     1321 ttcaggcctt taatctacaa aaagcagcag cagaaggttt gatgagcctt cttcgtgaaa
     1381 tggggaaagg ttatttagct ttgtgttcat acaactgcaa agaagctata aatattttga
     1441 gccatctacc ttctcaccac tacaatactg gttgggtact gtgccaaatt ggaagggcct
     1501 attttgaact ttcagagtac atgcaagctg aaagaatatt ctcagaggtt agaaggattg
     1561 agaattatag agttgaaggc atggagatct actctacaac actttggcat cttcaaaaag
     1621 atgttgctct ttcagttctg tcaaaagact taacagacat ggataaaaat tcgccagagg
     1681 cctggtgtgc tgcagggaac tgtttcagtc tgcaacggga acatgatatt gcaattaaat
     1741 tcttccagag agctatccaa gttgatccaa attacgctta tgcctatact ctattagggc
     1801 atgagtttgt cttaactgaa gaattggaca aagcattagc ttgttttcga aatgctatca
     1861 gagtcaatcc tagacattat aatgcatggt atggtttagg aatgatttat tacaagcaag
     1921 aaaaattcag ccttgcagaa atgcatttcc aaaaagcgct tgatatcaac cctcaaagtt
     1981 cagttttact ttgccacatt ggagtagttc aacatgcact gaaaaaatca gagaaggctt
     2041 tggataccct aaacaaagcc attgtcattg atcccaagaa ccctctatgc aaatttcaca
     2101 gagcctcagt tttatttgca aatgaaaaat ataagtctgc tttacaagaa cttgaagaat
     2161 tgaaacaaat tgttcccaaa gaatccctcg tttacttctt aataggaaag gtttacaaga
     2221 agttaggtca aacgcacctc gccctgatga atttctcttg ggctatggat ttagatccta
     2281 aaggagccaa taaccagatt aaagaggcaa ttgataagcg ttatcttcca gatgatgagg
     2341 agccaataac ccaagaagaa cagatcatgg gaacagatga atcccaggag agcagcatga
     2401 cagatgcgga tgacacacaa cttcatgcag ctgaaagtga tgaattttaa cttctggaaa
     2461 tcagactttt acaactggat gtgtgactag tgctgacgtg tttcttgtcc ctctgtatac
     2521 tgagtcttta ctcttgagct ggcggtgtca tcgtccgtca cttataccat gagtgtgcca
     2581 ctttcattgg accctgactg tatacagaat gaaaggcagt gcaatattta gctgctaaca
     2641 agactggctc ttttaccagt atgaatgaca atttatgggg ggtagggtgg ggaactttct
     2701 tttctgtttt tctttaatct ccctttgttg gaaagtatca tgaaaggaag agttatgctt
     2761 tatcttgaag gaaccattag atatggaaaa tagtgatgaa ccagagtttc ttggttgctt
     2821 tttcaaaaat ttgtttttat ttggttctgt tcctgataaa cagagtaact gaccttcatt
     2881 tctaggttct tcaagaatgg tgtttgcaag tgccagatgg aacaataaaa gacgttgcct
     2941 ataacagtga cttgattgcc aaggaatgta aattacctta aacttgcagt atctcccata
     3001 aacaaatgta atgggcatat tgggactcgt atgtaggaat caaatatccc tccatacagt
     3061 gtactcttat tcttggcaag aatgctttaa tgtctaacca agaattttaa tttattcatc
     3121 ttgcttcaaa gtgttgatca ttgttgtctt ggtattgcaa actttaaaat tgtttcttac
     3181 catattgcct cttctctttg agctctgtgg gatcaccttt aacattcaga gatgatagag
     3241 tggttcccca ctgagaagcc aaaacaaggc ccttaataac cccttaagtt caccatatga
     3301 atcagaagga gaacactaaa gtggagagac ttttaagaga tcatgatagt gaaagcctta
     3361 atataatcag aattgtacca taaccttgaa tctatatttg ttcaaaacat ccctttgact
     3421 tttctaagtg tttgcttaag cagagtgtaa gaatgtgtgg ttacctttgg ttgagatcct
     3481 ttccattctt tttgactctc tgcttcagat tttttcagta gtgtgagtca ccaaaacatt
     3541 tactaagagt aattgggttt aggatgttgg aaatttttag cttgggggaa aaaacattct
     3601 tatgaaggag ataggttctc ttctgagttt gtcataatat agattggtgt ctttggaaaa
     3661 tggccacaat tttaagaatt caattatgca tataaaatga taattattgg aattccacag
     3721 taacagattt aaacagtctt aaattgttta tctcctttac tgtaatgtat tgaaattttt
     3781 agagaaattt tagttgttaa cattttatta agtgccagtg tcagaatata acaaattata
     3841 gtttcttatg aatgacaggc ctacagttat tattctggat tatttgatgg aggacaaact
     3901 tacctgtatt tgttagtcaa gctgtgaaaa taaggtggat tacaaaagat gtgaaaaaaa
     3961 ttttagtctg tagactcagt aattttctat aatttactgt taatctcatt tgaacatgga
     4021 ttaggtacaa tttataaatt aattcaagtc agggtcttta ggtatcaggt gccagagaga
     4081 tatttaacag atttccctac ctaaatttat gtatatgtac tgtctaaaac aatacttttt
     4141 taaaaaaaag gaacagttgg gagaaaataa atataatgaa aaattcccag aggctagcac
     4201 ttggattcta acacgtatgc tattgtatta tccattagtt ctgtaatatt taattttaga
     4261 ttcttttatt tttttaattg gcaaagcaca aggtgctgta taacagtgtc atttagagtt
     4321 ttatagaaag cttcaacctg agttctgcgt tataaagcct ggagaaagct aagcttagaa
     4381 cataacttgc tgaagtataa ttatcttttt gtagcaggaa tttatgtgcc agaggtgaga
     4441 gtctttctgg tactgatttt ttgagaccaa ggataaaagg atcgttttgt aagacatgcc
     4501 atggcaatgg ctggttgggg gacagtttcc gcccaagctt ggcctatttt atttttcctc
     4561 atacctactt tcaaagtcat ttaggtattt gaagccttat ttcccacgta gtaacacttt
     4621 ctggcttttg cagtttcttt ttttgtttgg ttttgttttt tgcatggaat ggggatcaaa
     4681 caacccgaag aagaacacat tttgatcaag caaaatgttt gcttcaaatt tcagaagttt
     4741 attttacaga aattaaatta agtagtttga catccttttc tctgtttcac acatatatta
     4801 ggttggtgca taagtaattg tggtttttgc catgactttt atggcaaaac ctgcaattac
     4861 ttttgcacca acttaataca tctatataca tatatatata cgcgcacaca cttgttcaga
     4921 agttatgttg tggccttgga tttgtttttc cccttggaaa tggttcttaa ctctgggatt
     4981 ttagaaggtt agaatatttt ttcaagagaa cagtggtact caaaagaatg aaaggtggtc
     5041 cctacatttt ctgtattcat cacttaaaat ttttaatttt tccgagaact acaagtaaca
     5101 tttgaaccat gctgctgttg taccttaaac aaaaactcag tgataaccag tatttagtct
     5161 attaaaaatg ctctttttga agaaaaaagt ttggaagtct ctgattagcc agagtatagt
     5221 atgagtcttc actgagaaat atggtgaccc attttctttg tgaaaacctg ggaaaatgca
     5281 agtgtgggta tgaagtgtgt gttctgtttg cattgaaaca atgtaatttt gtgtcttctt
     5341 tttgctttaa ctgacttatt tcagaaattg tacagtgttg agggggaaag tcttttctgt
     5401 taatatattt gcaattcatt aaaggatatg gaaaatccaa ataagttact tttgaaagca
     5461 atttataatc aagttgttaa agctatatga aagctgtgcc atctgtattt taataagaag
     5521 gcacagaaaa acagagatac agttttatgt ttcacaaaaa actagagcaa tgtttatcta
     5581 attttttaaa acttacactc ttaatatatt tatattttta aacggtcata ctctttttta
     5641 gtattatttg gaatatcaaa ataaatacta tgacaaaaac aa
//
