LOCUS       NM_139286                871 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cell division cycle 26 (CDC26), mRNA.
ACCESSION   NM_139286
VERSION     NM_139286.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 871)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 871)
  AUTHORS   Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
            Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
  TITLE     A homozygous loss-of-function mutation in FBXO43 causes human
            non-obstructive azoospermia
  JOURNAL   Clin Genet 101 (1), 55-64 (2022)
   PUBMED   34595750
REFERENCE   3  (bases 1 to 871)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 871)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 871)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 871)
  AUTHORS   Geley,S., Kramer,E., Gieffers,C., Gannon,J., Peters,J.M. and
            Hunt,T.
  TITLE     Anaphase-promoting complex/cyclosome-dependent proteolysis of human
            cyclin A starts at the beginning of mitosis and is not subject to
            the spindle assembly checkpoint
  JOURNAL   J Cell Biol 153 (1), 137-148 (2001)
   PUBMED   11285280
REFERENCE   7  (bases 1 to 871)
  AUTHORS   Gmachl,M., Gieffers,C., Podtelejnikov,A.V., Mann,M. and Peters,J.M.
  TITLE     The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are
            sufficient to ubiquitinate substrates of the anaphase-promoting
            complex
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8973-8978 (2000)
   PUBMED   10922056
REFERENCE   8  (bases 1 to 871)
  AUTHORS   Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
            Peters,J.M.
  TITLE     Mitotic regulation of the APC activator proteins CDC20 and CDH1
  JOURNAL   Mol Biol Cell 11 (5), 1555-1569 (2000)
   PUBMED   10793135
REFERENCE   9  (bases 1 to 871)
  AUTHORS   Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
            Peters,J.M., Bartek,J. and Lukas,J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   10 (bases 1 to 871)
  AUTHORS   Zachariae,W., Shin,T.H., Galova,M., Obermaier,B. and Nasmyth,K.
  TITLE     Identification of subunits of the anaphase-promoting complex of
            Saccharomyces cerevisiae
  JOURNAL   Science 274 (5290), 1201-1204 (1996)
   PUBMED   8895471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF244254.1, BC042534.1,
            CA446805.1 and AL449305.4.
            
            On Nov 23, 2018 this sequence version replaced NM_139286.3.
            
            Summary: The protein encoded by this gene is highly similar to
            Saccharomyces cerevisiae Cdc26, a component of cell cycle
            anaphase-promoting complex (APC). APC is composed of a group of
            highly conserved proteins and functions as a cell cycle-regulated
            ubiquitin-protein ligase. APC thus is responsible for the cell
            cycle regulated proteolysis of various proteins. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066300.1, BU661772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142348,
                                           SAMEA2142363 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374206.4/ ENSP00000363322.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BF244254.1         18-138
            122-839             BC042534.1         94-811
            840-855             CA446805.1         14-29               c
            856-871             AL449305.4         98318-98333         c
FEATURES             Location/Qualifiers
     source          1..871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..871
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /note="cell division cycle 26"
                     /db_xref="GeneID:246184"
                     /db_xref="HGNC:HGNC:17839"
                     /db_xref="MIM:614533"
     exon            1..191
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            192..301
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            302..423
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..600
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /note="CDC26 subunit of anaphase promoting complex; cell
                     division cycle protein 26 homolog; anaphase-promoting
                     complex subunit 12; cell division cycle 26 homolog"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit CDC26"
                     /protein_id="NP_644815.1"
                     /db_xref="CCDS:CCDS6790.1"
                     /db_xref="GeneID:246184"
                     /db_xref="HGNC:HGNC:17839"
                     /db_xref="MIM:614533"
                     /translation="MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDG
                     EGAIGLSSDPKSREQMINDRIGYKPQPKPNNRSSQFGSLEF"
     exon            424..871
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      838..843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /note="hexamer: AATATA"
     polyA_site      871
                     /gene="CDC26"
                     /gene_synonym="ANAPC12; APC12; C9orf17"
                     /note="major polyA site"
ORIGIN      
        1 gtagtaggaa atggcgtcgt ggcattgagg ggcatccctc ctagaacctc caggaaaagc
       61 tcgcggaaga cgaggttctg cggagagaga ggctccaagc agtctgggaa gtgtagtcca
      121 gttggcttag cagtagtttc gttggggggg agccgaggtt ccgggaaggg gctaggccgg
      181 cttgaaaaga gattatgact gtacctttta actttgtagc tggaacacaa gaagtgtttg
      241 tttaatgaat gacgtacaca tttaagatct gtttggacgc ggaggataat cctgtgaatt
      301 gctaatagtt cactgggttt ggcccttagt gttgacttca gtatgctgag acggaaacca
      361 acacgcctag agctaaagct tgatgacatt gaagagtttg agaacattcg aaaggacctg
      421 gagacccgta agaaacagaa ggaagatgtg gaagttgtag gaggcagtga tggagaagga
      481 gccattgggc ttagcagtga tcccaagagc cgggaacaaa tgatcaatga tcggattggt
      541 tataaacccc aacccaagcc caataatcgt tcatctcaat ttggaagtct tgaattttag
      601 agatggatta tcttgcatgc cagagcgctg gaatggaata aaatgatggc agaagtacaa
      661 accagattta gagaattgag tgcttgcagt caagcagaat gtacctcctg cagagacaaa
      721 tcttctgcat gagattactg atgcttcact tgcactctaa gctggaatcc aaactctggt
      781 ttgtctcttg aaaatttgac tctataaaac tgatctgatt ttctgttttt aaaaataaat
      841 atatttttgg aaaaatgtga ggcatcctta a
//
