LOCUS       NM_001790               2093 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens cell division cycle 25C (CDC25C), transcript variant
            1, mRNA.
ACCESSION   NM_001790
VERSION     NM_001790.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Li,Y.F., Zheng,F.Y., Miao,X.Y., Liu,H.L., Zhang,Y.Y., Chao,N.X. and
            Mo,F.R.
  TITLE     Cell division cyclin 25C knockdown inhibits hepatocellular
            carcinoma development by inducing endoplasmic reticulum stress
  JOURNAL   World J Gastroenterol 30 (19), 2564-2574 (2024)
   PUBMED   38817663
  REMARK    GeneRIF: Cell division cyclin 25C knockdown inhibits hepatocellular
            carcinoma development by inducing endoplasmic reticulum stress.
REFERENCE   2  (bases 1 to 2093)
  AUTHORS   Zhai,M., Miao,J., Zhang,R., Liu,R., Li,F., Shen,Y., Wang,T., Xu,X.,
            Gao,G., Hu,J., He,A. and Bai,J.
  TITLE     KIF22 promotes multiple myeloma progression by regulating the
            CDC25C/CDK1/cyclinB1 pathway
  JOURNAL   J Cancer Res Clin Oncol 150 (5), 239 (2024)
   PUBMED   38713252
  REMARK    GeneRIF: KIF22 promotes multiple myeloma progression by regulating
            the CDC25C/CDK1/cyclinB1 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2093)
  AUTHORS   Xu,N., Ren,Y., Bao,Y., Shen,X., Kang,J., Wang,N., Wang,Z., Han,X.,
            Li,Z., Zuo,J., Wei,G.H., Wang,Z., Zong,W.X., Liu,W., Xie,G. and
            Wang,Y.
  TITLE     PUF60 promotes cell cycle and lung cancer progression by regulating
            alternative splicing of CDC25C
  JOURNAL   Cell Rep 42 (9), 113041 (2023)
   PUBMED   37682709
  REMARK    GeneRIF: PUF60 promotes cell cycle and lung cancer progression by
            regulating alternative splicing of CDC25C.
REFERENCE   4  (bases 1 to 2093)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 2093)
  AUTHORS   Bureik,M., Rief,N., Drescher,R., Jungbluth,A., Montenarh,M. and
            Wagner,P.
  TITLE     An additional transcript of the cdc25C gene from A431 cells encodes
            a functional protein
  JOURNAL   Int J Oncol 17 (6), 1251-1258 (2000)
   PUBMED   11078813
REFERENCE   6  (bases 1 to 2093)
  AUTHORS   Wegener,S., Hampe,W., Herrmann,D. and Schaller,H.C.
  TITLE     Alternative splicing in the regulatory region of the human
            phosphatases CDC25A and CDC25C
  JOURNAL   Eur J Cell Biol 79 (11), 810-815 (2000)
   PUBMED   11139144
REFERENCE   7  (bases 1 to 2093)
  AUTHORS   Sartor,H., Ehlert,F., Grzeschik,K.H., Muller,R. and Adolph,S.
  TITLE     Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31
            and 5q12, respectively
  JOURNAL   Genomics 13 (3), 911-912 (1992)
   PUBMED   1386342
REFERENCE   8  (bases 1 to 2093)
  AUTHORS   Galaktionov,K. and Beach,D.
  TITLE     Specific activation of cdc25 tyrosine phosphatases by B-type
            cyclins: evidence for multiple roles of mitotic cyclins
  JOURNAL   Cell 67 (6), 1181-1194 (1991)
   PUBMED   1836978
REFERENCE   9  (bases 1 to 2093)
  AUTHORS   Strausfeld,U., Labbe,J.C., Fesquet,D., Cavadore,J.C., Picard,A.,
            Sadhu,K., Russell,P. and Doree,M.
  TITLE     Dephosphorylation and activation of a p34cdc2/cyclin B complex in
            vitro by human CDC25 protein
  JOURNAL   Nature 351 (6323), 242-245 (1991)
   PUBMED   1828290
REFERENCE   10 (bases 1 to 2093)
  AUTHORS   Gould,K.L., Moreno,S., Tonks,N.K. and Nurse,P.
  TITLE     Complementation of the mitotic activator, p80cdc25, by a human
            protein-tyrosine phosphatase
  JOURNAL   Science 250 (4987), 1573-1576 (1990)
   PUBMED   1703321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104116.3, M34065.1,
            DB040755.1 and AW512559.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001790.4.
            
            Summary: This gene encodes a conserved protein that plays a key
            role in the regulation of cell division. The encoded protein
            directs dephosphorylation of cyclin B-bound CDC2 and triggers entry
            into mitosis. It also suppresses p53-induced growth arrest.
            Multiple alternatively spliced transcript variants of this gene
            have been described. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1
            and 3 encode the same protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34065.1, SRR1163657.23.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267752 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323760.11/ ENSP00000321656.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC104116.3         59926-60135         c
            211-455             M34065.1           173-417
            456-572             DB040755.1         450-566
            573-1708            M34065.1           535-1670
            1709-2055           AC104116.3         13638-13984         c
            2056-2093           AW512559.1         26-63               c
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..2093
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /note="cell division cycle 25C"
                     /db_xref="GeneID:995"
                     /db_xref="HGNC:HGNC:1727"
                     /db_xref="MIM:157680"
     exon            1..210
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            211..442
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1670
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1; dual
                     specificity phosphatase CDC25C; mitosis inducer CDC25;
                     phosphotyrosine phosphatase; protein phosphatase 1,
                     regulatory subunit 60; CDC25 homolog C; M-phase inducer
                     phosphatase 3"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 3 isoform a"
                     /protein_id="NP_001781.2"
                     /db_xref="CCDS:CCDS4202.1"
                     /db_xref="GeneID:995"
                     /db_xref="HGNC:HGNC:1727"
                     /db_xref="MIM:157680"
                     /translation="MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPD
                     VPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSS
                     GLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVD
                     SEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMP
                     ENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEED
                     SNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPY
                     EYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLR
                     EEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQ
                     SKVQEGERQLREQIALLVKDMSP"
     exon            443..537
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            538..583
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            584..617
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            618..707
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            708..863
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1010
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1112
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1175
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1274
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1408
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1520
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2093
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /note="hexamer: ATTAAA"
     polyA_site      1789
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /note="hexamer: AATAAA"
     polyA_site      2093
                     /gene="CDC25C"
                     /gene_synonym="CDC25; PPP1R60"
                     /note="major polyA site"
ORIGIN      
        1 attcttgctc agaggccgta actttggcct tctgctcagg gaagactctg agtccgacgt
       61 tggcctaccc agtcggaagg cagagctgca atctagttaa ctacctcctt tcccctagat
      121 ttcctttcat tctgctcaag tcttcgcctg tgtccgatcc ctatctactt tctctcctct
      181 tgtaggcaag cctcagactc caggcttgag ctaggttttg tttttctcct ggtgagaatt
      241 cgaagaccat gtctacggaa ctcttctcat ccacaagaga ggaaggaagc tctggctcag
      301 gacccagttt taggtctaat caaaggaaaa tgttaaacct gctcctggag agagacactt
      361 cctttaccgt ctgtccagat gtccctagaa ctccagtggg caaatttctt ggtgattctg
      421 caaacctaag cattttgtct ggaggaaccc caaaacgttg cctcgatctt tcgaatctta
      481 gcagtgggga gataactgcc actcagctta ccacttctgc agaccttgat gaaactggtc
      541 acctggattc ttcaggactt caggaagtgc atttagctgg gatgaatcat gaccagcacc
      601 taatgaaatg tagcccagca cagcttcttt gtagcactcc gaatggtttg gaccgtggcc
      661 atagaaagag agatgcaatg tgtagttcat ctgcaaataa agaaaatgac aatggaaact
      721 tggtggacag tgaaatgaaa tatttgggca gtcccattac tactgttcca aaattggata
      781 aaaatccaaa cctaggagaa gaccaggcag aagagatttc agatgaatta atggagtttt
      841 ccctgaaaga tcaagaagca aaggtgagca gaagtggcct atatcgctcc ccgtcgatgc
      901 cagagaactt gaacaggcca agactgaagc aggtggaaaa attcaaggac aacacaatac
      961 cagataaagt taaaaaaaag tatttttctg gccaaggaaa gctcaggaag ggcttatgtt
     1021 taaagaagac agtctctctg tgtgacatta ctatcactca gatgctggag gaagattcta
     1081 accaggggca cctgattggt gatttttcca aggtatgtgc gctgccaacc gtgtcaggga
     1141 aacaccaaga tctgaagtat gtcaacccag aaacagtggc tgccttactg tcggggaagt
     1201 tccagggtct gattgagaag ttttatgtca ttgattgtcg ctatccatat gagtatctgg
     1261 gaggacacat ccagggagcc ttaaacttat atagtcagga agaactgttt aacttctttc
     1321 tgaagaagcc catcgtccct ttggacaccc agaagagaat aatcatcgtg ttccactgtg
     1381 aattctcctc agagaggggc ccccgaatgt gccgctgtct gcgtgaagag gacaggtctc
     1441 tgaaccagta tcctgcattg tactacccag agctatatat ccttaaaggc ggctacagag
     1501 acttctttcc agaatatatg gaactgtgtg aaccacagag ctactgccct atgcatcatc
     1561 aggaccacaa gactgagttg ctgaggtgtc gaagccagag caaagtgcag gaaggggagc
     1621 ggcagctgcg ggagcagatt gcccttctgg tgaaggacat gagcccatga taacattcca
     1681 gccactggct gctaacaagt caccaaaaga cactgcagaa accctgagca gaaagaggcc
     1741 ttctggatgg ccaaacccaa gattattaaa agatgtctct gcaaaccaac aggctaccaa
     1801 cttgtatcca ggcctgggaa tggattaggt ttcagcagag ctgaaagctg gtggcagagt
     1861 cctggagctg gctctataag gcagccttga gttgcataga gatttgtatt ggttcaggga
     1921 actctggcat tccttttccc aactcctcat gtcttctcac aagccagcca actctttctc
     1981 tctgggcttc gggctatgca agagcgttgt ctaccttctt tctttgtatt ttccttcttt
     2041 gtttccccct ctttcttttt taaaaatgga aaaataaaca ctacagaatg aga
//
