LOCUS       NM_021873               3119 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens cell division cycle 25B (CDC25B), transcript variant
            1, mRNA.
ACCESSION   NM_021873
VERSION     NM_021873.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Pan,X., Xu,C., Cheng,G., Chen,Z., Liu,M. and Mei,Y.
  TITLE     Transcription factor E2F3 activates CDC25B to regulate DNA damage
            and promote mitoxantrone resistance in stomach adenocarcinoma
  JOURNAL   Mol Biol Rep 51 (1), 90 (2024)
   PUBMED   38194158
  REMARK    GeneRIF: Transcription factor E2F3 activates CDC25B to regulate DNA
            damage and promote mitoxantrone resistance in stomach
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Li,L.P., Li,H.X., Zhou,H., Li,W.Y., Wang,R.L., Zhang,Y.C. and Ma,Y.
  TITLE     Exploring the mechanism of C473D mutation on CDC25B causing weak
            binding affinity with CDK2/CyclinA by molecular dynamics study
  JOURNAL   J Biomol Struct Dyn 41 (22), 12552-12564 (2023)
   PUBMED   36655391
  REMARK    GeneRIF: Exploring the mechanism of C473D mutation on CDC25B
            causing weak binding affinity with CDK2/CyclinA by molecular
            dynamics study.
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Xu,J., Li,D., Lu,Y. and Zheng,T.Y.
  TITLE     Abeta monomers protect lens epithelial cells against oxidative
            stress by upregulating CDC25B
  JOURNAL   Free Radic Biol Med 175, 161-170 (2021)
   PUBMED   34478836
  REMARK    GeneRIF: Abeta monomers protect lens epithelial cells against
            oxidative stress by upregulating CDC25B.
REFERENCE   6  (bases 1 to 3119)
  AUTHORS   Baldin,V., Cans,C., Superti-Furga,G. and Ducommun,B.
  TITLE     Alternative splicing of the human CDC25B tyrosine phosphatase.
            Possible implications for growth control?
  JOURNAL   Oncogene 14 (20), 2485-2495 (1997)
   PUBMED   9188863
REFERENCE   7  (bases 1 to 3119)
  AUTHORS   Conklin,D.S., Galaktionov,K. and Beach,D.
  TITLE     14-3-3 proteins associate with cdc25 phosphatases
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7892-7896 (1995)
   PUBMED   7644510
REFERENCE   8  (bases 1 to 3119)
  AUTHORS   Galaktionov,K. and Beach,D.
  TITLE     Specific activation of cdc25 tyrosine phosphatases by B-type
            cyclins: evidence for multiple roles of mitotic cyclins
  JOURNAL   Cell 67 (6), 1181-1194 (1991)
   PUBMED   1836978
REFERENCE   9  (bases 1 to 3119)
  AUTHORS   Nagata,A., Igarashi,M., Jinno,S., Suto,K. and Okayama,H.
  TITLE     An additional homolog of the fission yeast cdc25+ gene occurs in
            humans and is highly expressed in some cancer cells
  JOURNAL   New Biol 3 (10), 959-968 (1991)
   PUBMED   1662986
REFERENCE   10 (bases 1 to 3119)
  AUTHORS   Strausfeld,U., Labbe,J.C., Fesquet,D., Cavadore,J.C., Picard,A.,
            Sadhu,K., Russell,P. and Doree,M.
  TITLE     Dephosphorylation and activation of a p34cdc2/cyclin B complex in
            vitro by human CDC25 protein
  JOURNAL   Nature 351 (6323), 242-245 (1991)
   PUBMED   1828290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC051711.1, S78187.1 and
            BX640836.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_021873.3.
            
            Summary: CDC25B is a member of the CDC25 family of phosphatases.
            CDC25B activates the cyclin dependent kinase CDC2 by removing two
            phosphate groups and it is required for entry into mitosis. CDC25B
            shuttles between the nucleus and the cytoplasm due to nuclear
            localization and nuclear export signals. The protein is nuclear in
            the M and G1 phases of the cell cycle and moves to the cytoplasm
            during S and G2. CDC25B has oncogenic properties, although its role
            in tumor formation has not been determined. Multiple transcript
            variants for this gene exist. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as CDC25B3,
            represents the longest transcript and encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051711.1, SRR11853563.20164.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245960.10/ ENSP00000245960.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BC051711.1         476-486
            12-187              S78187.1           30-205
            188-2489            BC051711.1         664-2965
            2490-3110           BX640836.1         1984-2604
            3111-3119           S78187.1           3084-3092
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3119
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /note="cell division cycle 25B"
                     /db_xref="GeneID:994"
                     /db_xref="HGNC:HGNC:1726"
                     /db_xref="MIM:116949"
     exon            1..422
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1965
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     M-phase inducer phosphatase 2; dual specificity
                     phosphatase Cdc25B; CDC25 homolog B"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 2 isoform 1"
                     /protein_id="NP_068659.1"
                     /db_xref="CCDS:CCDS13067.1"
                     /db_xref="GeneID:994"
                     /db_xref="HGNC:HGNC:1726"
                     /db_xref="MIM:116949"
                     /translation="MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPV
                     RAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSE
                     SSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHS
                     PVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWA
                     SRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILE
                     SDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILK
                     RLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHREL
                     IGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGH
                     IKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAV
                     NDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAG
                     ERSRRELCSRLQDQ"
     exon            423..550
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..602
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..644
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..681
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..804
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..927
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1062
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1143
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1320
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1416
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1479
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1578
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1712
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1824
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..3119
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /note="hexamer: AATAAA"
     polyA_site      3119
                     /gene="CDC25B"
                     /gene_synonym="MPIP2"
                     /note="major polyA site"
ORIGIN      
        1 agaggcttcc ctggctggtg cctgagcccg gcgtccctcg ccccccgccc tccccgcatc
       61 cctctcctcc ctcgcgcctg gccctgtggc tcttcctccc tccctccttc cccccccccc
      121 cacccctcgc ccgctgcctc cctcggccca gccagctgtg ccggcgtttg ttggctgccc
      181 tgcgcccggc cctccagcca gccttctgcc ggccccgccg cgatggaggt gccccagccg
      241 gagcccgcgc caggctcggc tctcagtcca gcaggcgtgt gcggtggcgc ccagcgtccg
      301 ggccacctcc cgggcctcct gctgggatct catggcctcc tggggtcccc ggtgcgggcg
      361 gccgcttcct cgccggtcac caccctcacc cagaccatgc acgacctcgc cgggctcggc
      421 agcgaaaccc caaagagtca ggtagggacc ctgctcttcc gcagccgcag ccgcctgacg
      481 cacctatccc tgtctcgacg ggcatccgaa tcctccctgt cgtctgaatc ctccgaatct
      541 tctgatgcag gtctctgcat ggattccccc agccctatgg acccccacat ggcggagcag
      601 acgtttgaac aggccatcca ggcagccagc cggatcattc gaaacgagca gtttgccatc
      661 agacgcttcc agtctatgcc ggtgaggctg ctgggccaca gccccgtgct tcggaacatc
      721 accaactccc aggcgcccga cggccggagg aagagcgagg cgggcagtgg agctgccagc
      781 agctctgggg aagacaagga gaatgatgga tttgtcttca agatgccatg gaagcccaca
      841 catcccagct ccacccatgc tctggcagag tgggccagcc gcagggaagc ctttgcccag
      901 agacccagct cggcccccga cctgatgtgt ctcagtcctg accggaagat ggaagtggag
      961 gagctcagcc ccctggccct aggtcgcttc tctctgaccc ctgcagaggg ggatactgag
     1021 gaagatgatg gatttgtgga catcctagag agtgacttaa aggatgatga tgcagttccc
     1081 ccaggcatgg agagtctcat tagtgcccca ctggtcaaga ccttggaaaa ggaagaggaa
     1141 aaggacctcg tcatgtacag caagtgccag cggctcttcc gctctccgtc catgccctgc
     1201 agcgtgatcc ggcccatcct caagaggctg gagcggcccc aggacaggga cacgcccgtg
     1261 cagaataagc ggaggcggag cgtgacccct cctgaggagc agcaggaggc tgaggaacct
     1321 aaagcccgcg tcctccgctc aaaatcactg tgtcacgatg agatcgagaa cctcctggac
     1381 agtgaccacc gagagctgat tggagattac tctaaggcct tcctcctaca gacagtagac
     1441 ggaaagcacc aagacctcaa gtacatctca ccagaaacga tggtggccct attgacgggc
     1501 aagttcagca acatcgtgga taagtttgtg attgtagact gcagataccc ctatgaatat
     1561 gaaggcgggc acatcaagac tgcggtgaac ttgcccctgg aacgcgacgc cgagagcttc
     1621 ctactgaaga gccccatcgc gccctgtagc ctggacaaga gagtcatcct cattttccac
     1681 tgtgaattct catctgagcg tgggccccgc atgtgccgtt tcatcaggga acgagaccgt
     1741 gctgtcaacg actaccccag cctctactac cctgagatgt atatcctgaa aggcggctac
     1801 aaggagttct tccctcagca cccgaacttc tgtgaacccc aggactaccg gcccatgaac
     1861 cacgaggcct tcaaggatga gctaaagacc ttccgcctca agactcgcag ctgggctggg
     1921 gagcggagcc ggcgggagct ctgtagccgg ctgcaggacc agtgaggggc ctgcgccagt
     1981 cctgctacct cccttgcctt tcgaggcctg aagccagctg ccctatgggc ctgccgggct
     2041 gagggcctgc tggaggcctc aggtgctgtc catgggaaag atggtgtggg tgtcctgcct
     2101 gtctgcccca gcccagattc ccctgtgtca tcccatcatt ttccatatcc tggtgccccc
     2161 cacccctgga agagcccagt ctgttgagtt agttaagttg ggttaatacc agcttaaagg
     2221 cagtattttg tgtcctccag gagcttcttg tttccttgtt agggttaacc cttcatcttc
     2281 ctgtgtcctg aaacgctcct ttgtgtgtgt gtcagctgag gctgggggag agccgtggtc
     2341 cctgaggatg ggtcagagct aaactccttc ctggcctgag agtcagctct ctgccctgtg
     2401 tacttcccgg gccagggctg cccctaatct ctgtaggaac cgtggtatgt ctgccatgtt
     2461 gcccctttct cttttcccct ttcctgtccc accatacgag cacctccagc ctgaacagaa
     2521 gctcttactc tttcctattt cagtgttacc tgtgtgcttg gtctgtttga ctttacgccc
     2581 atctcaggac acttccgtag actgtttagg ttcccctgtc aaatatcagt tacccactcg
     2641 gtcccagttt tgttgcccca gaaagggatg ttattatcct tgggggctcc cagggcaagg
     2701 gttaaggcct gaatcatgag cctgctggaa gcccagcccc tactgctgtg aaccctgggg
     2761 cctgactgct cagaacttgc tgctgtcttg ttgcggatgg atggaaggtt ggatggatgg
     2821 gtggatggcc gtggatggcc gtggatgcgc agtgccttgc atacccaaac caggtgggag
     2881 cgttttgttg agcatgacag cctgcagcag gaatatatgt gtgcctattt gtgtggacaa
     2941 aaatatttac acttagggtt tggagctatt caagaggaaa tgtcacagaa gcagctaaac
     3001 caaggactga gcaccctctg gattctgaat ctcaagatgg gggcagggct gtgcttgaag
     3061 gccctgctga gtcatctgtt agggccttgg ttcaataaag cactgagcaa gttgagaaa
//
