LOCUS       NM_001789               3844 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cell division cycle 25A (CDC25A), transcript variant
            1, mRNA.
ACCESSION   NM_001789
VERSION     NM_001789.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3844)
  AUTHORS   Fu,L., Yang,M. and Ma,Y.
  TITLE     Regulatory mechanism of interaction between Y-box-binding protein 1
            and heterogenous nuclear ribonucleoprotein K in cell division cycle
            25a signal pathway and lung cancer metastasis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 62-68 (2023)
   PUBMED   38279484
  REMARK    GeneRIF: Regulatory mechanism of interaction between Y-box-binding
            protein 1 and heterogenous nuclear ribonucleoprotein K in cell
            division cycle 25a signal pathway and lung cancer metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3844)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3844)
  AUTHORS   Wang,C., Zeng,J., Li,L.J., Xue,M. and He,S.L.
  TITLE     Cdc25A inhibits autophagy-mediated ferroptosis by upregulating
            ErbB2 through PKM2 dephosphorylation in cervical cancer cells
  JOURNAL   Cell Death Dis 12 (11), 1055 (2021)
   PUBMED   34743185
  REMARK    GeneRIF: Cdc25A inhibits autophagy-mediated ferroptosis by
            upregulating ErbB2 through PKM2 dephosphorylation in cervical
            cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3844)
  AUTHORS   Liu,P., Xia,P., Fu,Q., Liu,C., Luo,Q., Cheng,L., Yu,P., Qin,T. and
            Zhang,H.
  TITLE     miR-199a-5p inhibits the proliferation of hepatocellular carcinoma
            cells by regulating CDC25A to induce cell cycle arrest
  JOURNAL   Biochem Biophys Res Commun 571, 96-103 (2021)
   PUBMED   34314996
  REMARK    GeneRIF: miR-199a-5p inhibits the proliferation of hepatocellular
            carcinoma cells by regulating CDC25A to induce cell cycle arrest.
REFERENCE   5  (bases 1 to 3844)
  AUTHORS   Ditano,J.P., Sakurikar,N. and Eastman,A.
  TITLE     Activation of CDC25A phosphatase is limited by CDK2/cyclin
            A-mediated feedback inhibition
  JOURNAL   Cell Cycle 20 (13), 1308-1319 (2021)
   PUBMED   34156324
  REMARK    GeneRIF: Activation of CDC25A phosphatase is limited by CDK2/cyclin
            A-mediated feedback inhibition.
REFERENCE   6  (bases 1 to 3844)
  AUTHORS   Galaktionov,K., Lee,A.K., Eckstein,J., Draetta,G., Meckler,J.,
            Loda,M. and Beach,D.
  TITLE     CDC25 phosphatases as potential human oncogenes
  JOURNAL   Science 269 (5230), 1575-1577 (1995)
   PUBMED   7667636
REFERENCE   7  (bases 1 to 3844)
  AUTHORS   Conklin,D.S., Galaktionov,K. and Beach,D.
  TITLE     14-3-3 proteins associate with cdc25 phosphatases
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7892-7896 (1995)
   PUBMED   7644510
REFERENCE   8  (bases 1 to 3844)
  AUTHORS   Galaktionov,K., Jessus,C. and Beach,D.
  TITLE     Raf1 interaction with Cdc25 phosphatase ties mitogenic signal
            transduction to cell cycle activation
  JOURNAL   Genes Dev 9 (9), 1046-1058 (1995)
   PUBMED   7744247
REFERENCE   9  (bases 1 to 3844)
  AUTHORS   Galaktionov,K. and Beach,D.
  TITLE     Specific activation of cdc25 tyrosine phosphatases by B-type
            cyclins: evidence for multiple roles of mitotic cyclins
  JOURNAL   Cell 67 (6), 1181-1194 (1991)
   PUBMED   1836978
REFERENCE   10 (bases 1 to 3844)
  AUTHORS   Strausfeld,U., Labbe,J.C., Fesquet,D., Cavadore,J.C., Picard,A.,
            Sadhu,K., Russell,P. and Doree,M.
  TITLE     Dephosphorylation and activation of a p34cdc2/cyclin B complex in
            vitro by human CDC25 protein
  JOURNAL   Nature 351 (6323), 242-245 (1991)
   PUBMED   1828290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104190.3, BC007401.2,
            BX392016.1, BQ065803.1, AI917350.1 and AC124916.3.
            
            On May 17, 2019 this sequence version replaced NM_001789.2.
            
            Summary: CDC25A is a member of the CDC25 family of phosphatases.
            CDC25A is required for progression from G1 to the S phase of the
            cell cycle. It activates the cyclin-dependent kinase CDC2 by
            removing two phosphate groups. CDC25A is specifically degraded in
            response to DNA damage, which prevents cells with chromosomal
            abnormalities from progressing through cell division. CDC25A is an
            oncogene, although its exact role in oncogenesis has not been
            demonstrated. Two transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.4108045.1, BC007401.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302506.8/ ENSP00000303706.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC104190.3         77361-77466         c
            107-2627            BC007401.2         1-2521
            2628-3168           BX392016.1         28-568              c
            3169-3648           BQ065803.1         151-630
            3649-3812           AI917350.1         12-175              c
            3813-3844           AC124916.3         181942-181973       c
FEATURES             Location/Qualifiers
     source          1..3844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3844
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /note="cell division cycle 25A"
                     /db_xref="GeneID:993"
                     /db_xref="HGNC:HGNC:1725"
                     /db_xref="MIM:116947"
     exon            1..640
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..2045
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1;
                     M-phase inducer phosphatase 1; dual specificity
                     phosphatase CDC25A; CDC25 homolog A"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 1 isoform a"
                     /protein_id="NP_001780.2"
                     /db_xref="CCDS:CCDS2760.1"
                     /db_xref="GeneID:993"
                     /db_xref="HGNC:HGNC:1725"
                     /db_xref="MIM:116947"
                     /translation="MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTN
                     LTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPM
                     RRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCL
                     HSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGF
                     VDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRP
                     ERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDP
                     RDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYE
                     GGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDR
                     LGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTW
                     AGEKSKREMYSRLKKL"
     exon            641..717
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..760
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..797
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..899
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1019
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1154
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1226
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1400
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1499
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1562
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1661
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1792
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1904
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..3844
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3792..3797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /note="hexamer: AATAAA"
     polyA_site      3811
                     /gene="CDC25A"
                     /gene_synonym="CDC25A2"
                     /note="major polyA site"
ORIGIN      
        1 actgagccgc tattaccgcg aaaggccggc ctggctgcga cagcctgggt aagaggtgta
       61 ggtcggcttg gttttctgct acccggagct gggcaagcgg gtgggagaac agcgaagaca
      121 gcgtgagcct gggccgttgc ctcgaggctc tcgcccggct tctcttgccg acccgccacg
      181 tttgtttgga tttaatcttc aggttgccgg cgcccgcccg cccgctggcc tcgcggtgtg
      241 agagggaagc acccgtgcct gtggctggtg gctggcgcct ggagggtccg cacacccgcc
      301 cggccgcgcc gcttgcccgc ggcagccgcg tccctgaacc gcggagtcgt gtttgtgttt
      361 gacccgcggg cgccggtggc gcgcggccga ggccggtgtc ggcggggcgg ggcggtcgcg
      421 gcggaggcag aggaagaggg agcgggagct ctgcgaggcc gggcgccgcc atggaactgg
      481 gcccggagcc cccgcaccgc cgccgcctgc tcttcgcctg cagcccccct cccgcgtcgc
      541 agcccgtcgt gaaggcgcta tttggcgctt cagccgccgg gggactgtcg cctgtcacca
      601 acctgaccgt cactatggac cagctgcagg gtctgggcag tgattatgag caaccactgg
      661 aggtgaagaa caacagtaat ctgcagagaa tgggctcctc cgagtcaaca gattcaggtt
      721 tctgtctaga ttctcctggg ccattggaca gtaaagaaaa ccttgaaaat cctatgagaa
      781 gaatacattc cctacctcag aagctgttgg gatgtagtcc agctctgaag aggagccatt
      841 ctgattctct tgaccatgac atctttcagc tcatcgaccc agatgagaac aaggaaaatg
      901 aagcctttga gtttaagaag ccagtaagac ctgtatctcg tggctgcctg cactctcatg
      961 gactccagga gggtaaagat ctcttcacac agaggcagaa ctctgcccca gctcggatgc
     1021 tttcctcaaa tgaaagagat agcagtgaac cagggaattt cattcctctt tttacacccc
     1081 agtcacctgt gacagccact ttgtctgatg aggatgatgg cttcgtggac cttctcgatg
     1141 gagagaatct gaagaatgag gaggagaccc cctcgtgcat ggcaagcctc tggacagctc
     1201 ctctcgtcat gagaactaca aaccttgaca accgatgcaa gctgtttgac tccccttccc
     1261 tgtgtagctc cagcactcgg tcagtgttga agagaccaga acgatctcaa gaggagtctc
     1321 cacctggaag tacaaagagg aggaagagca tgtctggggc cagccccaaa gagtcaacta
     1381 atccagagaa ggcccatgag actcttcatc agtctttatc cctggcatct tcccccaaag
     1441 gaaccattga gaacattttg gacaatgacc caagggacct tataggagac ttctccaagg
     1501 gttatctctt tcatacagtt gctgggaaac atcaggattt aaaatacatc tctccagaaa
     1561 ttatggcatc tgttttgaat ggcaagtttg ccaacctcat taaagagttt gttatcatcg
     1621 actgtcgata cccatatgaa tacgagggag gccacatcaa gggtgcagtg aacttgcaca
     1681 tggaagaaga ggttgaagac ttcttattga agaagcccat tgtacctact gatggcaagc
     1741 gtgtcattgt tgtgtttcac tgcgagtttt cttctgagag aggtccccgc atgtgccggt
     1801 atgtgagaga gagagatcgc ctgggtaatg aataccccaa actccactac cctgagctgt
     1861 atgtcctgaa ggggggatac aaggagttct ttatgaaatg ccagtcttac tgtgagcccc
     1921 ctagctaccg gcccatgcac cacgaggact ttaaagaaga cctgaagaag ttccgcacca
     1981 agagccggac ctgggcaggg gagaagagca agagggagat gtacagtcgt ctgaagaagc
     2041 tctgagggcg gcaggaccag ccagcagcag cccaagcttc cctccatccc cctttaccct
     2101 ctttgctgca gagaaactta agcaaagggg acagctgtgt gacatttgga gagggggcct
     2161 gggacttcca tgccttaaac ctacctccca cactcccaag gttggagccc agggcatctt
     2221 gctggctacg cctcttctgt ccctgttaga cgtcctccgt ccatatcaga actgtgccac
     2281 aatgcagttc tgagcaccgt gtcaagctgc tctgagccac agtgggatga accagccggg
     2341 gccttatcgg gctccagcca tctcatgagg ggagaggaga cggaggggag tagagaagtt
     2401 acacagaaat gctgctggcc aaatagcaaa gacaacctgg gaaggaaagg tctttgtggg
     2461 ataatccata tgtttaattt attcaacttc atcaatcact ttattttatt tttttttcta
     2521 actcctggag acttatttta ctgcttcatt aggttgaaat actgccattc taggtagggt
     2581 tttattatcc cagggactac ctcggctttt aatttaaaaa aaaaaaagaa gtgggtaaga
     2641 aaatgcaaac ctgttataag ttatcggaca gaaagctagg tgctctgtca cccccaggag
     2701 gcgctgtggt actggggctg ctgctattta agccaagaac tgaggtcctg gtgagagcgt
     2761 tggacccagg cttggctgcc tgacataagc taaatctccc agacccacca ctggctaccg
     2821 atatctattt ggtgggaggt gtggccctgt tcttcctcac cccagttcca tgacattggc
     2881 tggtatagga gccacagtca ggaaagcact tgaggcagca tctgttgggc cacccccggc
     2941 tcagtgctgg aatgttgcag tgtaggtttc ccagggaagg ggggtggggg taggtgggct
     3001 ccacaggatg ggggaggagc atgtccactg agtatcttcc ttatgttgct gtgatattga
     3061 tagcttttat tttctaattt ttaaaaaatg gtcatattat gagtcaaaga gtatcaaatc
     3121 agtgttggat ggaccaccca agggtgagga gaggggctgg aagccctggg cattaggaga
     3181 agggagtggg tgctggcatg gacatgactg gatagaattt tctcaggagg gagcttggtg
     3241 gattttgaag gtaaaacttt ctgggtttat catgttttaa ttttagagac agggagtgat
     3301 gaatcatcac cggttgtccc cttatctaac tccataaaag tgggaatttc aaaagaacac
     3361 ctcatccaag gagctggggc agacttcatt gattctagag agacctgttt cagtgcctac
     3421 tcatccctgc cctctggtgc cagcctcctt accatcacgg cttcactgag gtgtaggtgg
     3481 gtttttctta aacaggagac agtctctccc ctcttacctc aacttcttgg ggtgggaatc
     3541 agtgatactg gagatggcta gttgctgtgt tacgggtttg agttacattt ggctataaaa
     3601 caatcttgtt gggaaaaatg tgggggagag gacttcttcc tacacgcgca ttgagacaga
     3661 ttccaactgg ttaatgatat tgtttgtaag aaagagattc tgttggttga ctgcctaaag
     3721 agaaaggtgg gatggccttc agattatacc agcttagcta gcattactaa ccaactgttg
     3781 gaagctctga aaataaaaga tcttgaaccc atgctctctg cctagttctt gatggattta
     3841 agga
//
