LOCUS       NM_004661               3133 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cell division cycle 23 (CDC23), mRNA.
ACCESSION   NM_004661
VERSION     NM_004661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3133)
  AUTHORS   Fan,H., Zhou,Z., Zheng,W., Guan,Y., Meng,Q., Wang,W., Dong,J.,
            Wan,L., Zhu,J., Zeng,Y., Liu,R., Gu,H., Lin,G., Chen,B., Sang,Q.
            and Wang,L.
  TITLE     Homozygous variants in CDC23 cause female infertility characterized
            by oocyte maturation defects
  JOURNAL   Hum Genet 142 (11), 1621-1631 (2023)
   PUBMED   37768355
  REMARK    GeneRIF: Homozygous variants in CDC23 cause female infertility
            characterized by oocyte maturation defects.
REFERENCE   2  (bases 1 to 3133)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3133)
  AUTHORS   Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
            Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
  TITLE     A homozygous loss-of-function mutation in FBXO43 causes human
            non-obstructive azoospermia
  JOURNAL   Clin Genet 101 (1), 55-64 (2022)
   PUBMED   34595750
REFERENCE   4  (bases 1 to 3133)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3133)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3133)
  AUTHORS   Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
            Peters,J.M., Bartek,J. and Lukas,J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   7  (bases 1 to 3133)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   8  (bases 1 to 3133)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   9  (bases 1 to 3133)
  AUTHORS   Zhao,N., Lai,F., Fernald,A.A., Eisenbart,J.D., Espinosa,R.,
            Wang,P.W. and Le Beau,M.M.
  TITLE     Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and
            evaluation as a candidate tumor suppressor gene in myeloid
            leukemias
  JOURNAL   Genomics 53 (2), 184-190 (1998)
   PUBMED   9790767
REFERENCE   10 (bases 1 to 3133)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106752.3 and BC017713.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004661.3.
            
            Summary: The protein encoded by this gene shares strong similarity
            with Saccharomyces cerevisiae Cdc23, a protein essential for cell
            cycle progression through the G2/M transition. This protein is a
            component of anaphase-promoting complex (APC), which is composed of
            eight protein subunits and highly conserved in eukaryotic cells.
            APC catalyzes the formation of cyclin B-ubiquitin conjugate that is
            responsible for the ubiquitin-mediated proteolysis of B-type
            cyclins. This protein and 3 other members of the APC complex
            contain the TPR (tetratricopeptide repeat), a protein domain
            important for protein-protein interaction. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017713.1, AF053977.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394886.7/ ENSP00000378350.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC106752.3         34481-34652         c
            173-245             AC106752.3         34320-34392         c
            246-383             AC106752.3         27876-28013         c
            384-426             AC106752.3         23442-23484         c
            427-532             AC106752.3         22672-22777         c
            533-665             AC106752.3         22436-22568         c
            666-843             AC106752.3         19934-20111         c
            844-941             AC106752.3         19755-19852         c
            942-1023            AC106752.3         19528-19609         c
            1024-1177           AC106752.3         13833-13986         c
            1178-1297           AC106752.3         13598-13717         c
            1298-1373           AC106752.3         13191-13266         c
            1374-1435           AC106752.3         12803-12864         c
            1436-1514           AC106752.3         11157-11235         c
            1515-1634           AC106752.3         10962-11081         c
            1635-3132           AC106752.3         8980-10477          c
            3133-3133           BC017713.1         3112-3112
FEATURES             Location/Qualifiers
     source          1..3133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..3133
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /note="cell division cycle 23"
                     /db_xref="GeneID:8697"
                     /db_xref="HGNC:HGNC:1724"
                     /db_xref="MIM:603462"
     exon            1..172
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1805
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /note="anaphase-promoting complex subunit 8; cyclosome
                     subunit 8; cell division cycle 23 homolog"
                     /codon_start=1
                     /product="cell division cycle protein 23 homolog"
                     /protein_id="NP_004652.2"
                     /db_xref="CCDS:CCDS4200.2"
                     /db_xref="GeneID:8697"
                     /db_xref="HGNC:HGNC:1724"
                     /db_xref="MIM:603462"
                     /translation="MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTR
                     ERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRA
                     AHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSK
                     KHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEM
                     LKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNI
                     RDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETC
                     CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAI
                     EVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLV
                     EAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLE
                     ESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTE
                     VPAPFFLPASLSANNTPTRRVSPLNLSSVTP"
     exon            173..245
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            246..383
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            384..426
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            427..532
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            533..665
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            666..843
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            844..941
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1023
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1177
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1297
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1373
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1435
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1514
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1634
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..3133
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3113..3118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /note="hexamer: AATAAA"
     polyA_site      3133
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /note="major polyA site"
ORIGIN      
        1 gagtcgggaa aatggctgcg agtacctcca tggtcccggt ggctgtgacg gcggcagtgg
       61 cgcctgtcct gtccataaac agcgatttct cagatttgcg ggaaattaaa aagcaactgc
      121 tgcttattgc gggccttacc cgggagcggg gcctactaca cagtagcaaa tggtcggcgg
      181 agttggcttt ctctctccct gcattgcctc tggccgagct gcaaccgcct ccgcctatta
      241 cagaggaaga tgcccaggat atggatgcct ataccctggc caaggcctac tttgacgtta
      301 aagagtatga tcgggcagca catttcctgc atggctgcaa tagcaagaaa gcctattttc
      361 tgtatatgta ttccagatat ctgtctggag aaaaaaagaa ggacgatgaa acagttgata
      421 gcttaggccc cctggaaaaa ggacaagtga aaaatgaggc gcttagagaa ttgagagtgg
      481 agctcagcaa aaaacaccaa gctcgagaac ttgatggatt tggactttat ctgtatggtg
      541 tggtgcttcg aaaactggac ttggttaaag aggccattga tgtgtttgtg gaagctactc
      601 atgttttgcc cttgcattgg ggagcctggt tagaactctg taacctgatc acagacaaag
      661 agatgctgaa gttcctgtct ttgccagaca cctggatgaa agagtttttt ctggctcata
      721 tatacacaga gttgcagttg atagaggagg ccctgcaaaa gtatcagaat ctcattgatg
      781 tgggcttctc taagagctcg tatattgttt cccaaattgc agttgcctat cacaatatca
      841 gagatattga caaagccctc tccattttta atgagctaag gaaacaagac ccttacagga
      901 ttgaaaatat ggacacattc tccaaccttc tttatgtcag gagcatgaaa tcggagttga
      961 gttatctggc tcataacctc tgtgagattg ataaatatcg tgtagaaacg tgctgtgtaa
     1021 ttggcaatta ttacagttta cgttctcagc atgagaaagc agccttatat ttccagagag
     1081 ccctgaaatt aaatcctcgg tatcttggtg cctggacact aatgggacat gagtacatgg
     1141 agatgaagaa cacgtctgct gctatccagg cttatagaca tgccattgag gtcaacaaac
     1201 gggactacag agcttggtat ggcctcgggc agacctatga aatccttaag atgccatttt
     1261 actgccttta ttattataga cgggcccacc agcttcgacc caatgattct cgcatgctgg
     1321 ttgctttagg agaatgttac gagaaactca atcaactagt ggaagccaaa aagtgttatt
     1381 ggagagctta cgccgtggga gatgtggaga aaatggctct ggtgaaactg gcaaagcttc
     1441 atgaacagtt gactgagtca gaacaggctg cccagtgtta catcaaatat atccaagata
     1501 tctattcctg tggggaaata gtagaacact tggaggaaag cactgccttt cgctatctgg
     1561 cccagtacta ttttaagtgc aaactgtggg atgaagcttc aacttgtgca caaaagtgtt
     1621 gtgcatttaa tgatacccgg gaagaaggta aggccttact ccggcaaatc ctacagcttc
     1681 ggaaccaagg cgagactcct accaccgagg tgcctgctcc ctttttccta cctgcttcac
     1741 tctctgctaa caataccccc acacgcagag tttctccact caacttgtct tctgtcacgc
     1801 catagttggc tactctcaag ccagcacatt gttagaccca tcttaattaa gccttacctc
     1861 catgtaaaga acagcacgtc tgttccaagg acctcagctc ttcttgtttc tacagatggc
     1921 aacagctcca tagggacagc ttgtataatt accttcagag gccaactgac agaatcctgg
     1981 caggaacaga cattatcttg ccagttagaa gtacttctgt ctcacttatg tccaaagagt
     2041 ggctatagat cttggccttc ttccctgaat gctttttttt tttggccccc aagaaagtcc
     2101 cttttatagc actttagcac aggcaatgct acaggaacaa agtttcaatg ctgctgagag
     2161 tgaaagaaag gaggaaagtc tgccactcta ccctgagctg gcagtagggc actgagtacc
     2221 ctaggaagaa gtcagagcaa tggatacaaa tgaccttgct cttggatttg ctgagcatga
     2281 tccctattct gatgtcagag attaggttta aatggaatag agctatccat ttgttcttac
     2341 tctctaggga gacaatcttc caaaacagtt ttgggggggt cttctaaagc tttcaaattg
     2401 gaagtaactt tattcaacta gagttgaata aaagaagggc aaaaataatc tcacagagct
     2461 tggaactgct gatagccctt actgagggca aaagatggct atattgttag ctatactcct
     2521 accaaagcaa gcaaggagat aggattatag ataatttcac ggacatttgg aaataacatt
     2581 ggtgattata cagacaagaa taaactcact tcaagctggt ctgttttaat aaattttcaa
     2641 cgtaattgtc tatttttttc cctcccatct gcaacagaat acattttttt cagcctttat
     2701 ctagatgagg taaagggaat cattcttatg gtgctcttgg agagtttcag gcctgtgcat
     2761 gtgtgtacag caggaggtaa tatgctataa tgtctgctgt aatatatttg cacagtagat
     2821 gctatggatc attctgagct cagggtccag actttattct tattcccaga attttgtgtt
     2881 acgtttttac ctcctaacat atgacacttc atcttatatt aaggaaggtt tagaatatct
     2941 aatacgactt gaattcattt gttactaagc cttctcaggc aagctgtata ctagttactg
     3001 gtctccactg ccatgccttt tcaaggttcc catggtccag aatgatgttt gattcttaat
     3061 ttttctgtcc cttttataat ttgttttaat gattttgcta catttggaat tcaataaaaa
     3121 atgtgaacaa taa
//
