LOCUS       NP_004652                597 aa            linear   PRI 19-SEP-2024
DEFINITION  cell division cycle protein 23 homolog [Homo sapiens].
ACCESSION   NP_004652
VERSION     NP_004652.2
DBSOURCE    REFSEQ: accession NM_004661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 597)
  AUTHORS   Fan,H., Zhou,Z., Zheng,W., Guan,Y., Meng,Q., Wang,W., Dong,J.,
            Wan,L., Zhu,J., Zeng,Y., Liu,R., Gu,H., Lin,G., Chen,B., Sang,Q.
            and Wang,L.
  TITLE     Homozygous variants in CDC23 cause female infertility characterized
            by oocyte maturation defects
  JOURNAL   Hum Genet 142 (11), 1621-1631 (2023)
   PUBMED   37768355
  REMARK    GeneRIF: Homozygous variants in CDC23 cause female infertility
            characterized by oocyte maturation defects.
REFERENCE   2  (residues 1 to 597)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 597)
  AUTHORS   Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
            Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
  TITLE     A homozygous loss-of-function mutation in FBXO43 causes human
            non-obstructive azoospermia
  JOURNAL   Clin Genet 101 (1), 55-64 (2022)
   PUBMED   34595750
REFERENCE   4  (residues 1 to 597)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 597)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (residues 1 to 597)
  AUTHORS   Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
            Peters,J.M., Bartek,J. and Lukas,J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   7  (residues 1 to 597)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   8  (residues 1 to 597)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   9  (residues 1 to 597)
  AUTHORS   Zhao,N., Lai,F., Fernald,A.A., Eisenbart,J.D., Espinosa,R.,
            Wang,P.W. and Le Beau,M.M.
  TITLE     Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and
            evaluation as a candidate tumor suppressor gene in myeloid
            leukemias
  JOURNAL   Genomics 53 (2), 184-190 (1998)
   PUBMED   9790767
REFERENCE   10 (residues 1 to 597)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106752.3 and BC017713.1.
            
            On Nov 24, 2006 this sequence version replaced NP_004652.1.
            
            Summary: The protein encoded by this gene shares strong similarity
            with Saccharomyces cerevisiae Cdc23, a protein essential for cell
            cycle progression through the G2/M transition. This protein is a
            component of anaphase-promoting complex (APC), which is composed of
            eight protein subunits and highly conserved in eukaryotic cells.
            APC catalyzes the formation of cyclin B-ubiquitin conjugate that is
            responsible for the ubiquitin-mediated proteolysis of B-type
            cyclins. This protein and 3 other members of the APC complex
            contain the TPR (tetratricopeptide repeat), a protein domain
            important for protein-protein interaction. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017713.1, AF053977.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394886.7/ ENSP00000378350.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     Protein         1..597
                     /product="cell division cycle protein 23 homolog"
                     /note="anaphase-promoting complex subunit 8; cyclosome
                     subunit 8; cell division cycle 23 homolog"
                     /calculated_mol_wt=68703
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          27..63
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          45..148
                     /region_name="ANAPC8"
                     /note="Anaphase promoting complex subunit 8 / Cdc23;
                     pfam04049"
                     /db_xref="CDD:427675"
     Region          73..112
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          114..144
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          169..200
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          172..>401
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          229..259
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          263..293
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            273
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:14657031; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          297..327
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          325..>495
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          331..361
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          331..359
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..395
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          367..393
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(369..370,373..374,376,400,403..404,407..408,
                     410..411,434,437..438,441..442,445)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          398..428
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          400..432
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          433..466
                     /region_name="TPR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          433..461
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          467..495
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            467
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          468..500
                     /region_name="TPR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Region          501..536
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          504..540
                     /region_name="TPR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            562
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:14657031,
                     ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            565
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:14657031; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            578
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            582
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            588
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16964243,
                     ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            593
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UJX2.3)"
     Site            596
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16964243,
                     ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (Q9UJX2.3)"
     CDS             1..597
                     /gene="CDC23"
                     /gene_synonym="ANAPC8; APC8; CUT23"
                     /coded_by="NM_004661.4:12..1805"
                     /db_xref="CCDS:CCDS4200.2"
                     /db_xref="GeneID:8697"
                     /db_xref="HGNC:HGNC:1724"
                     /db_xref="MIM:603462"
ORIGIN      
        1 maastsmvpv avtaavapvl sinsdfsdlr eikkqlllia gltrergllh sskwsaelaf
       61 slpalplael qppppiteed aqdmdaytla kayfdvkeyd raahflhgcn skkayflymy
      121 srylsgekkk ddetvdslgp lekgqvknea lrelrvelsk khqareldgf glylygvvlr
      181 kldlvkeaid vfveathvlp lhwgawlelc nlitdkemlk flslpdtwmk efflahiyte
      241 lqlieealqk yqnlidvgfs kssyivsqia vayhnirdid kalsifnelr kqdpyrienm
      301 dtfsnllyvr smkselsyla hnlceidkyr vetccvigny yslrsqheka alyfqralkl
      361 nprylgawtl mgheymemkn tsaaiqayrh aievnkrdyr awyglgqtye ilkmpfycly
      421 yyrrahqlrp ndsrmlvalg ecyeklnqlv eakkcywray avgdvekmal vklaklheql
      481 teseqaaqcy ikyiqdiysc geivehlees tafrylaqyy fkcklwdeas tcaqkccafn
      541 dtreegkall rqilqlrnqg etpttevpap fflpaslsan ntptrrvspl nlssvtp
//
