LOCUS       NM_001170402            2984 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cell division cycle 20B (CDC20B), transcript variant
            3, mRNA.
ACCESSION   NM_001170402
VERSION     NM_001170402.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Hou,X., Dai,H. and Zheng,Y.
  TITLE     Circular RNA hsa_circ_0008896 accelerates atherosclerosis by
            promoting the proliferation, migration and invasion of vascular
            smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle
            20B) axis
  JOURNAL   Bioengineered 13 (3), 5987-5998 (2022)
   PUBMED   35212610
  REMARK    GeneRIF: Circular RNA hsa_circ_0008896 accelerates atherosclerosis
            by promoting the proliferation, migration and invasion of vascular
            smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle
            20B) axis.
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Revinski,D.R., Zaragosi,L.E., Boutin,C., Ruiz-Garcia,S., Deprez,M.,
            Thome,V., Rosnet,O., Gay,A.S., Mercey,O., Paquet,A., Pons,N.,
            Ponzio,G., Marcet,B., Kodjabachian,L. and Barbry,P.
  TITLE     CDC20B is required for deuterosome-mediated centriole production in
            multiciliated cells
  JOURNAL   Nat Commun 9 (1), 4668 (2018)
   PUBMED   30405130
  REMARK    GeneRIF: CDC20B protein associates to deuterosomes and is required
            for centriole release and subsequent cilia production.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB237622.1, AK095246.1, AC091977.3 and BC136572.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.72279.1, BC136572.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267759 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381375.7/ ENSP00000370781.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB237622.1         1-2
            3-84                AK095246.1         1-82
            85-85               AC091977.3         123690-123690       c
            86-130              AK095246.1         84-128
            131-537             BC136572.1         1-407
            538-538             AC091977.3         94235-94235         c
            539-1196            BC136572.1         409-1066
            1197-1224           AK095246.1         1195-1222
            1225-1662           BC136572.1         1095-1532
            1663-2984           AC091977.3         63568-64889         c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..2984
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /note="cell division cycle 20B"
                     /db_xref="GeneID:166979"
                     /db_xref="HGNC:HGNC:24222"
                     /db_xref="MIM:620335"
     exon            1..240
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1737
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /note="isoform 3 is encoded by transcript variant 3; cell
                     division cycle protein 20 homolog B; CDC20-like protein;
                     CDC20 cell division cycle 20 homolog B"
                     /codon_start=1
                     /product="cell division cycle protein 20 homolog B isoform
                     3"
                     /protein_id="NP_001163873.1"
                     /db_xref="CCDS:CCDS54852.1"
                     /db_xref="GeneID:166979"
                     /db_xref="HGNC:HGNC:24222"
                     /db_xref="MIM:620335"
                     /translation="MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVL
                     DSVNATYSDFKSNFAKRLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEA
                     SGSVLKTPPEKETLTLGSRKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASK
                     GQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQ
                     PEVKIHITGLRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYI
                     SSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRL
                     GRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQG
                     QPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICS
                     LIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAA
                     ADGTASVWNCY"
     exon            241..303
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            304..532
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            533..663
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            664..757
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            758..874
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1071
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1166
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1392
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1518
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1636
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..2984
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcggcgg tgggaggagt gggggacctg gagggaggtg gtgaaataga atggtcctgg
       61 gggacgggac tccaggggtt tgacgattag gcgtcaagac tgacttagac ctgggaagaa
      121 aaccagaggc agtcgagcag agaggccaaa cgccaggcag ggcgaagtca gccggagatg
      181 gagtggaaac tggagcgcac cgcgcctcgg agggtccgca cggaagagga gatgctgtgg
      241 gaaagtatca tgcgtgtgct ctccaaagac ttgaagcaga agagaagtca agattccgcc
      301 aacgtactcg attcagttaa tgctacgtat tctgacttta agagcaactt tgcgaagagg
      361 ctgtccgcag aggttcctgt tgcgagtagc cccattacca caaggtggca gcaaagtcaa
      421 actagggctc tgtcctctga ttcctttggg gaagagcagt caaccaccta cctcccagaa
      481 gcttccggat cagtgctgaa gacaccgcct gagaaagaga ccttgactct aggatcccgc
      541 aaagaacaac tgaagacccc cagcaaagga atttctgaaa caagtaactc tgctctccat
      601 ttttgcaagg cacctcatgc aatggacaga gactggaaag aaagtgttgc ctcaaaaggg
      661 cagaaatgcc taaaacaact ctttgtaacc cagaacgtgg ttcagcaggc taatggaaaa
      721 atgcagctct gtgagcaatc cgaatgtgtt tggaaaggct gcaaagatgg agtcagagat
      781 gaatccttcc atcttaaaag ttctggtgat ataaacgatt ccatactcca accagaggtg
      841 aagattcata ttactggtct tcgaaatgac tactatctga atatcctaga ttggagtttt
      901 cagaatcttg ttgccatagc cctgggctct gctgtataca tctggaatgg ggagaaccac
      961 aatgggattg aaaacataga cttaagtctc acttgtaact atatctcttc tgtgtcctgg
     1021 ataaaagagg gaacttgcct ggcagttggc accagcgagg gagaagtgca attatgggat
     1081 gtggtaacta aaaagcggct gagaaatatg cttggtcatt tgtcagtagt tggggctctg
     1141 agctggaatc actttatcct cagcagtggg tcaagactgg ggcgtgttta tcatcacgat
     1201 gttcgggtag cccagcatca tgttggaaca cttcgccaca agcaagctgt gtgtgctctg
     1261 aagtggtcac cggatggcag gctgctttcc agcggctgca gtgatggact gctgacaata
     1321 tggccccacg atccaggtgc cagtgcacag ggccaaccgc tgaaagtcat aacccagtct
     1381 acggcagtca aggccatgga ttggtgtccc tggcagtctg gggtccttgc cattggagga
     1441 ggaatgaagg atggacgctt acacatcttg gatataaatg ctgggaagag catccagacc
     1501 ccaagcacaa actcacagat ttgttcctta atctggctac ctaagacaaa ggagattgca
     1561 actggtcaag gtactcccaa gaatgatgtg actgtgtgga cctgtcccac tgtgtccagg
     1621 tcaggtgggt tttttggcca caggggcaga gtgctgcacc tgtctttgag tccagaccag
     1681 acccgggtgt tttctgctgc agctgatggg acggcctctg tatggaattg ctactagcac
     1741 ccagcccctc taggtttcag tttccttatt tctgagtgaa gatgatgatg ttggctatgt
     1801 cttctccatg gggtttttat gagtatcaaa caagttgaaa tactcttctt gatgtgaatg
     1861 cctgttctcc tgttcttctt ttgcagattg ctttacttgc tctgcttccc agagatccgc
     1921 ttcttttctt ctctgctttc ttctttctgc ccctcttcct ccccctcctc ttcttcctcc
     1981 cattcttacc cctttctaga gattcatttt cactacttta ttcagaataa catctatagc
     2041 aaagatttct acttctttcc cgtatgactt ttctccccag ctccaaacct catatttctg
     2101 attgcctcag gatagttccc ttttgagata ctttcctgtc tttagctcaa tctcaacaca
     2161 ttgaaaacac aactcattca cttgaaaaac acttactaaa atctcactat atgctaggca
     2221 gtatgttaag catgcatatt gctctctcta aaaatcagtt ctgtaggaat ccctttcccc
     2281 tcctgatggt ctcatcctta tcctggtctc ccactcaggg aacctcctga ttattctgct
     2341 ctgtgcttcc tcagttcacc ctttgctctc ttttcttttg cttcacctag tcacatcctg
     2401 tgtgcctgac agccagtctg ctgtaattgt cttagaactg atcctcttga ctccacacca
     2461 ctgctaggtt gaacatctaa aagtcctgtg ctgatcctct cagtcccctg ctcatcaact
     2521 ctcaaggaca acctattacc aaacaccttt gacctcaacc tctggagtcc tcagcccagg
     2581 acttgaagtt aggagatctt tttttgcctt ggctctgcca taaatacacc ctgtaacctt
     2641 ggatgtgttg caacatctgc aaggatagga atttgatcac tgctaaggtt ccttcaaact
     2701 tgatcagttc gctgttctgt cttttgaatg ttaattcaca ttcatctcct atattaagac
     2761 tttggctaag tcttgtgatt tcttgcctta ttggagcttt tcttctaatc tgaattcttg
     2821 cttctctctc cttttccttt acacacccac acaagtccta acctctccag gaagtgtttt
     2881 gaaatgatgt tacctgggtt tgagttcttg gcattagcct gtatcatcta tttggtatta
     2941 ttatactatt atagctgttt aaaaaaatct tttattactg tttg
//
