LOCUS       NP_001163873             519 aa            linear   PRI 20-SEP-2024
DEFINITION  cell division cycle protein 20 homolog B isoform 3 [Homo sapiens].
ACCESSION   NP_001163873
VERSION     NP_001163873.1
DBSOURCE    REFSEQ: accession NM_001170402.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Hou,X., Dai,H. and Zheng,Y.
  TITLE     Circular RNA hsa_circ_0008896 accelerates atherosclerosis by
            promoting the proliferation, migration and invasion of vascular
            smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle
            20B) axis
  JOURNAL   Bioengineered 13 (3), 5987-5998 (2022)
   PUBMED   35212610
  REMARK    GeneRIF: Circular RNA hsa_circ_0008896 accelerates atherosclerosis
            by promoting the proliferation, migration and invasion of vascular
            smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle
            20B) axis.
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Revinski,D.R., Zaragosi,L.E., Boutin,C., Ruiz-Garcia,S., Deprez,M.,
            Thome,V., Rosnet,O., Gay,A.S., Mercey,O., Paquet,A., Pons,N.,
            Ponzio,G., Marcet,B., Kodjabachian,L. and Barbry,P.
  TITLE     CDC20B is required for deuterosome-mediated centriole production in
            multiciliated cells
  JOURNAL   Nat Commun 9 (1), 4668 (2018)
   PUBMED   30405130
  REMARK    GeneRIF: CDC20B protein associates to deuterosomes and is required
            for centriole release and subsequent cilia production.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB237622.1, AK095246.1, AC091977.3 and BC136572.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.72279.1, BC136572.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267759 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381375.7/ ENSP00000370781.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     Protein         1..519
                     /product="cell division cycle protein 20 homolog B isoform
                     3"
                     /note="cell division cycle protein 20 homolog B;
                     CDC20-like protein; CDC20 cell division cycle 20 homolog
                     B"
                     /calculated_mol_wt=57204
     Region          79..133
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     Region          229..266
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     Region          235..271
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          271..310
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     Region          <274..517
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          276..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          311..341
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     Region          319..350
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          353..392
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     Region          358..399
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          399..441
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     Region          405..443
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          443..484
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     Region          448..486
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          487..519
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86Y33.3)"
     CDS             1..519
                     /gene="CDC20B"
                     /gene_synonym="G6VTS76519"
                     /coded_by="NM_001170402.1:178..1737"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS54852.1"
                     /db_xref="GeneID:166979"
                     /db_xref="HGNC:HGNC:24222"
                     /db_xref="MIM:620335"
ORIGIN      
        1 mewklertap rrvrteeeml wesimrvlsk dlkqkrsqds anvldsvnat ysdfksnfak
       61 rlsaevpvas spittrwqqs qtralssdsf geeqsttylp easgsvlktp peketltlgs
      121 rkeqlktpsk gisetsnsal hfckaphamd rdwkesvask gqkclkqlfv tqnvvqqang
      181 kmqlceqsec vwkgckdgvr desfhlkssg dindsilqpe vkihitglrn dyylnildws
      241 fqnlvaialg savyiwngen hngienidls ltcnyissvs wikegtclav gtsegevqlw
      301 dvvtkkrlrn mlghlsvvga lswnhfilss gsrlgrvyhh dvrvaqhhvg tlrhkqavca
      361 lkwspdgrll ssgcsdgllt iwphdpgasa qgqplkvitq stavkamdwc pwqsgvlaig
      421 ggmkdgrlhi ldinagksiq tpstnsqics liwlpktkei atgqgtpknd vtvwtcptvs
      481 rsggffghrg rvlhlslspd qtrvfsaaad gtasvwncy
//
