LOCUS       NM_001255               1649 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens cell division cycle 20 (CDC20), mRNA.
ACCESSION   NM_001255
VERSION     NM_001255.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1649)
  AUTHORS   Sitry-Shevah,D., Miniowitz-Shemtov,S., Liburkin Dan,T. and
            Hershko,A.
  TITLE     The Mitotic Checkpoint Complex controls the association of Cdc20
            regulatory protein with the ubiquitin ligase APC/C in mitosis
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2413089121 (2024)
   PUBMED   39231204
  REMARK    GeneRIF: The Mitotic Checkpoint Complex controls the association of
            Cdc20 regulatory protein with the ubiquitin ligase APC/C in
            mitosis.
REFERENCE   2  (bases 1 to 1649)
  AUTHORS   Li,Q., Chen,Q., Zheng,T., Wang,F., Teng,J., Zhou,H. and Chen,J.
  TITLE     CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20
            Integration into the MCC
  JOURNAL   Adv Sci (Weinh) 11 (35), e2406009 (2024)
   PUBMED   39018254
  REMARK    GeneRIF: CCDC68 Maintains Mitotic Checkpoint Activation by
            Promoting CDC20 Integration into the MCC.
REFERENCE   3  (bases 1 to 1649)
  AUTHORS   Zhang,Y., Young,R., Garvanska,D.H., Song,C., Zhai,Y., Wang,Y.,
            Jiang,H., Fang,J., Nilsson,J., Alfieri,C. and Zhang,G.
  TITLE     Functional analysis of Cdc20 reveals a critical role of CRY box in
            mitotic checkpoint signaling
  JOURNAL   Commun Biol 7 (1), 164 (2024)
   PUBMED   38337031
  REMARK    GeneRIF: Functional analysis of Cdc20 reveals a critical role of
            CRY box in mitotic checkpoint signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1649)
  AUTHORS   Park,S.E., Chung,K.S., Heo,S.W., Kim,S.Y., Lee,J.H., Hassan,A.H.E.,
            Lee,Y.S., Lee,J.Y. and Lee,K.T.
  TITLE     Therapeutic role of 2-stearoxyphenethyl phosphocholine targeting
            microtubule dynamics and Wnt/beta-catenin/EMT signaling in human
            colorectal cancer cells
  JOURNAL   Life Sci 334, 122227 (2023)
   PUBMED   37926298
REFERENCE   5  (bases 1 to 1649)
  AUTHORS   Godoy,P.M., Oyedeji,A., Mudd,J.L., Morikis,V.A., Zarov,A.P.,
            Longmore,G.D., Fields,R.C. and Kaufman,C.K.
  TITLE     Functional analysis of recurrent CDC20 promoter variants in human
            melanoma
  JOURNAL   Commun Biol 6 (1), 1216 (2023)
   PUBMED   38030698
  REMARK    GeneRIF: Functional analysis of recurrent CDC20 promoter variants
            in human melanoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1649)
  AUTHORS   Fang,G., Yu,H. and Kirschner,M.W.
  TITLE     The checkpoint protein MAD2 and the mitotic regulator CDC20 form a
            ternary complex with the anaphase-promoting complex to control
            anaphase initiation
  JOURNAL   Genes Dev 12 (12), 1871-1883 (1998)
   PUBMED   9637688
REFERENCE   7  (bases 1 to 1649)
  AUTHORS   Kallio,M., Weinstein,J., Daum,J.R., Burke,D.J. and Gorbsky,G.J.
  TITLE     Mammalian p55CDC mediates association of the spindle checkpoint
            protein Mad2 with the cyclosome/anaphase-promoting complex, and is
            involved in regulating anaphase onset and late mitotic events
  JOURNAL   J Cell Biol 141 (6), 1393-1406 (1998)
   PUBMED   9628895
REFERENCE   8  (bases 1 to 1649)
  AUTHORS   Weinstein,J., Karim,J., Geschwind,D.H., Nelson,S.F., Krumm,J. and
            Sakamoto,K.M.
  TITLE     Genomic organization, 5' flanking enhancer region, and chromosomal
            assignment of the cell cycle gene, p55Cdc
  JOURNAL   Mol Genet Metab 64 (1), 52-57 (1998)
   PUBMED   9682218
  REMARK    Erratum:[Mol Genet Metab 2001 Apr;72(4):364]
REFERENCE   9  (bases 1 to 1649)
  AUTHORS   Weinstein,J.
  TITLE     Cell cycle-regulated expression, phosphorylation, and degradation
            of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1
  JOURNAL   J Biol Chem 272 (45), 28501-28511 (1997)
   PUBMED   9353311
REFERENCE   10 (bases 1 to 1649)
  AUTHORS   Weinstein,J., Jacobsen,F.W., Hsu-Chen,J., Wu,T. and Baum,L.G.
  TITLE     A novel mammalian protein, p55CDC, present in dividing cells is
            associated with protein kinase activity and has homology to the
            Saccharomyces cerevisiae cell division cycle proteins Cdc20 and
            Cdc4
  JOURNAL   Mol Cell Biol 14 (5), 3350-3363 (1994)
   PUBMED   7513050
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001088.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001255.2.
            
            Summary: CDC20 appears to act as a regulatory protein interacting
            with several other proteins at multiple points in the cell cycle.
            It is required for two microtubule-dependent processes, nuclear
            movement prior to anaphase and chromosome separation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001088.2, U05340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310955.11/ ENSP00000308450.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1649              BC001088.2         27-1675
FEATURES             Location/Qualifiers
     source          1..1649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1649
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /note="cell division cycle 20"
                     /db_xref="GeneID:991"
                     /db_xref="HGNC:HGNC:1723"
                     /db_xref="MIM:603618"
     exon            1..26
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            27..256
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1575
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /note="CDC20 cell division cycle 20 homolog; fizzy
                     homolog"
                     /codon_start=1
                     /product="cell division cycle protein 20 homolog"
                     /protein_id="NP_001246.2"
                     /db_xref="CCDS:CCDS484.1"
                     /db_xref="GeneID:991"
                     /db_xref="HGNC:HGNC:1723"
                     /db_xref="MIM:603618"
                     /translation="MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMR
                     AANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPE
                     NSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGS
                     SRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQ
                     LLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW
                     NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVN
                     VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGAC
                     LSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT
                     MSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR"
     exon            257..405
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            406..502
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            503..631
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            632..828
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            829..923
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1152
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1278
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1396
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1649
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /note="hexamer: AATAAA"
     polyA_site      1649
                     /gene="CDC20"
                     /gene_synonym="bA276H19.3; CDC20A; OOMD14; OZEMA14;
                     p55CDC"
                     /note="major polyA site"
ORIGIN      
        1 cggtcggaac tgctccggag ggcacgggct ccgtaggcac caactgcaag gacccctccc
       61 cctgcgggcg ctcccatggc acagttcgcg ttcgagagtg acctgcactc gctgcttcag
      121 ctggatgcac ccatccccaa tgcaccccct gcgcgctggc agcgcaaagc caaggaagcc
      181 gcaggcccgg ccccctcacc catgcgggcc gccaaccgat cccacagcgc cggcaggact
      241 ccgggccgaa ctcctggcaa atccagttcc aaggttcaga ccactcctag caaacctggc
      301 ggtgaccgct atatccccca tcgcagtgct gcccagatgg aggtggccag cttcctcctg
      361 agcaaggaga accagcctga aaacagccag acgcccacca agaaggaaca tcagaaagcc
      421 tgggctttga acctgaacgg ttttgatgta gaggaagcca agatccttcg gctcagtgga
      481 aaaccacaaa atgcgccaga gggttatcag aacagactga aagtactcta cagccaaaag
      541 gccactcctg gctccagccg gaagacctgc cgttacattc cttccctgcc agaccgtatc
      601 ctggatgcgc ctgaaatccg aaatgactat tacctgaacc ttgtggattg gagttctggg
      661 aatgtactgg ccgtggcact ggacaacagt gtgtacctgt ggagtgcaag ctctggtgac
      721 atcctgcagc ttttgcaaat ggagcagcct ggggaatata tatcctctgt ggcctggatc
      781 aaagagggca actacttggc tgtgggcacc agcagtgctg aggtgcagct atgggatgtg
      841 cagcagcaga aacggcttcg aaatatgacc agtcactctg cccgagtggg ctccctaagc
      901 tggaacagct atatcctgtc cagtggttca cgttctggcc acatccacca ccatgatgtt
      961 cgggtagcag aacaccatgt ggccacactg agtggccaca gccaggaagt gtgtgggctg
     1021 cgctgggccc cagatggacg acatttggcc agtggtggta atgataactt ggtcaatgtg
     1081 tggcctagtg ctcctggaga gggtggctgg gttcctctgc agacattcac ccagcatcaa
     1141 ggggctgtca aggccgtagc atggtgtccc tggcagtcca atgtcctggc aacaggaggg
     1201 ggcaccagtg atcgacacat tcgcatctgg aatgtgtgct ctggggcctg tctgagtgcc
     1261 gtggatgccc attcccaggt gtgctccatc ctctggtctc cccattacaa ggagctcatc
     1321 tcaggccatg gctttgcaca gaaccagcta gttatttgga agtacccaac catggccaag
     1381 gtggctgaac tcaaaggtca cacatcccgg gtcctgagtc tgaccatgag cccagatggg
     1441 gccacagtgg catccgcagc agcagatgag accctgaggc tatggcgctg ttttgagttg
     1501 gaccctgcgc ggcggcggga gcgggagaag gccagtgcag ccaaaagcag cctcatccac
     1561 caaggcatcc gctgaagacc aacccatcac ctcagttgtt ttttattttt ctaataaagt
     1621 catgtctccc ttcatgtttt ttttttaaa
//
