LOCUS       NM_001078645            2331 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cell division cycle 16 (CDC16), transcript variant 2,
            mRNA.
ACCESSION   NM_001078645
VERSION     NM_001078645.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Hu,F., Fong,K.O., Cheung,M.P.L., Liu,J.A., Liang,R., Li,T.W.,
            Sharma,R., Ip,P.P., Yang,X. and Cheung,M.
  TITLE     DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through
            Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted
            SCUBE3
  JOURNAL   Adv Sci (Weinh) 9 (10), e2105226 (2022)
   PUBMED   35088579
  REMARK    GeneRIF: DEPDC1B Promotes Melanoma Angiogenesis and Metastasis
            through Sequestration of Ubiquitin Ligase CDC16 to Stabilize
            Secreted SCUBE3.
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
            Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
  TITLE     A homozygous loss-of-function mutation in FBXO43 causes human
            non-obstructive azoospermia
  JOURNAL   Clin Genet 101 (1), 55-64 (2022)
   PUBMED   34595750
REFERENCE   4  (bases 1 to 2331)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2331)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2331)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   7  (bases 1 to 2331)
  AUTHORS   Kallio,M., Weinstein,J., Daum,J.R., Burke,D.J. and Gorbsky,G.J.
  TITLE     Mammalian p55CDC mediates association of the spindle checkpoint
            protein Mad2 with the cyclosome/anaphase-promoting complex, and is
            involved in regulating anaphase onset and late mitotic events
  JOURNAL   J Cell Biol 141 (6), 1393-1406 (1998)
   PUBMED   9628895
REFERENCE   8  (bases 1 to 2331)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
REFERENCE   9  (bases 1 to 2331)
  AUTHORS   Ollendorff,V. and Donoghue,D.J.
  TITLE     The serine/threonine phosphatase PP5 interacts with CDC16 and
            CDC27, two tetratricopeptide repeat-containing subunits of the
            anaphase-promoting complex
  JOURNAL   J Biol Chem 272 (51), 32011-32018 (1997)
   PUBMED   9405394
REFERENCE   10 (bases 1 to 2331)
  AUTHORS   Tugendreich,S., Tomkiel,J., Earnshaw,W. and Hieter,P.
  TITLE     CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic
            spindle and is essential for the metaphase to anaphase transition
  JOURNAL   Cell 81 (2), 261-268 (1995)
   PUBMED   7736578
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC391369.1, BQ051608.1,
            AW953481.1, BQ424567.1, AW662777.1 and BM663581.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001078645.2.
            
            Summary: The protein encoded by this gene functions as a protein
            ubiquitin ligase and is a component of the multiprotein APC
            complex. The APC complex is a cyclin degradation system that
            governs exit from mitosis by targeting cell cycle proteins for
            degredation by the 26S proteasome. Each component protein of the
            APC complex is highly conserved among eukaryotic organisms. This
            protein, and other APC complex proteins, contain a
            tetratricopeptide repeat (TPR) domain; a protein domain that is
            often involved in protein-protein interactions and the assembly of
            multiprotein complexes. Multiple alternatively spliced transcript
            variants, encoding distinct proteins, have been identified.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.264295.1,
                                           SRR1803616.84521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356221.8/ ENSP00000348554.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               DC391369.1         53-569
            518-539             BQ051608.1         122-143
            540-1163            AW953481.1         80-703
            1164-1803           BQ424567.1         35-674
            1804-2283           AW662777.1         11-490              c
            2284-2331           BM663581.1         16-63               c
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..2331
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /note="cell division cycle 16"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
     exon            1..236
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2051
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /note="isoform 1 is encoded by transcript variant 2; cell
                     division cycle protein 16 homolog; cell division cycle 16
                     homolog; anaphase-promoting complex, subunit 6; cyclosome
                     subunit 6"
                     /codon_start=1
                     /product="cell division cycle protein 16 homolog isoform
                     1"
                     /protein_id="NP_001072113.1"
                     /db_xref="CCDS:CCDS9542.2"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
                     /translation="MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLA
                     QCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKR
                     LFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLD
                     VYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSET
                     VIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLV
                     ELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYG
                     PAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFS
                     QALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNN
                     LGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL
                     RRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFR
                     EFEVEKQTAEETGLTPLETSRKTPDSRPSLEETFEIEMNESDMMLETSMSDHST"
     exon            237..291
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            292..389
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            390..428
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            429..569
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            570..729
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            730..821
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            822..955
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1035
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1085
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1159
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1285
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1438
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1502
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1564
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1700
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1791
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2331
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2264..2269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /note="hexamer: AATAAA"
     polyA_site      2283
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /note="major polyA site"
     regulatory      2309..2314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /note="hexamer: AATAAA"
     polyA_site      2331
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
ORIGIN      
        1 agtgcacggg gcctgggtgg ggggtgcggg tgtgggtggg gacctgcggc cttcgagtcc
       61 gcggccttcg agtcctgggg cggcggcggc ggctgcaggc acgggcacgg gcacggggcg
      121 gggtgcttag ggtgcaggag gcgcgcgcct agcggcggag tgtggcgtga ggccgggccc
      181 gcgccgccat gaacctagag cggctgcgga agcgcgtccg gcagtacctc gaccagcaac
      241 agtatcaaag tgctctattt tgggcagata aagtagcttc actctctcgt gaagaacccc
      301 aggacatcta ttggttggct cagtgtcttt acctgacagc acaatatcac agagccgccc
      361 atgcacttcg gtcacgaaaa ctggacaaat tgtatgaagc atgtcgttac cttgcagcta
      421 ggtgccatta tgctgcaaaa gagcaccagc aggcccttga tgttcttgac atggaagagc
      481 ccatcaataa aagattattt gaaaaatact tgaaggacga aagtggcttc aaagatcctt
      541 ccagcgactg ggaaatgtca cagtcttcaa taaagagttc tatctgtctt ctacgcggga
      601 aaatctatga tgctctagat aaccgaaccc tggctaccta cagctacaaa gaagctttga
      661 agcttgatgt ctactgtttt gaagcgttcg atcttttaac atcacatcac atgctgacag
      721 cacaagaaga aaaagaactt cttgaatcac taccccttag caagctgtgt aatgaagaac
      781 aggaattgct gcgttttcta tttgagaaca aattgaaaaa atataataag cctagtgaaa
      841 cggtcatccc tgaatctgta gatggcttgc aagagaatct ggatgtggta gtgtctttag
      901 ctgagagaca ttattataac tgtgatttta aaatgtgcta caagcttact tctgtagtaa
      961 tggagaaaga tcctttccat gcaagttgtt tacctgtaca tatagggacg cttgtagagc
     1021 tgaataaagc caatgaactt ttctatcttt ctcataaact ggtggattta tatcctagta
     1081 atcctgtgtc ttggtttgca gtgggatgtt actatctcat ggtcggtcat aaaaatgaac
     1141 atgccagaag atatctcagc aaagccacaa cacttgagaa aacctatgga cctgcatgga
     1201 tagcctatgg acattcattt gcggtggaga gtgagcacga ccaagcgatg gctgcttact
     1261 tcacagcagc acagctgatg aaagggtgtc atttgcctat gctgtatatt ggattagaat
     1321 atggtttgac caataactca aaactagctg aaaggttctt cagccaagct ctgagcattg
     1381 caccggaaga cccttttgtt atgcatgagg tcggcgtggt tgcatttcag aatggagaat
     1441 ggaaaacagc cgaaaaatgg tttcttgatg ctttggaaaa aattaaagca attgggaacg
     1501 aggtaacagt tgacaaatgg gaacctttgt tgaacaactt ggggcatgtc tgcagaaaac
     1561 ttaaaaagta tgctgaggcc ttggattacc accgtcaggc actggtgttg attcctcaga
     1621 acgcatccac ctactctgct attggatata tccacagtct gatgggcaac tttgaaaatg
     1681 ctgtggacta cttccacaca gcccttggtc ttaggcgaga tgatacattt tctgttacaa
     1741 tgcttggtca ttgcatcgaa atgtacattg gtgattctga agcttatatt ggagcagaca
     1801 ttaaagacaa attaaaatgt tatgactttg atgtgcatac aatgaagaca ctaaaaaaca
     1861 ttatttcacc tccgtgggat ttcagggaat ttgaagtaga aaaacagact gcagaagaaa
     1921 cggggcttac gccattggaa acctcaagga aaactccaga ttccagacct tccttggaag
     1981 aaacctttga aattgaaatg aatgaaagtg acatgatgtt agagacatct atgtcagacc
     2041 acagcacgtg actccagtca gtggtcctgg tcccactgtc ccagtgtagg ttagtattcc
     2101 ttcacatcct ctccatggct taagaatgtc ccacttccta acgtgactcc aaactgcatc
     2161 tctacattta ggaacagaga cccgccttaa gagactggat cgcacacctt tgcaacagat
     2221 gtgttctgat tctctgaacc tacaaaatag ttatacatag tggaataaag aaggtaaacc
     2281 atctgttatg tctttttttt tcttttccaa taaactttta ttttggacta a
//
