LOCUS       NM_152627               2908 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens cell division cycle 14C (CDC14C), mRNA.
ACCESSION   NM_152627 NR_003595 XM_001125780 XM_001126948 XM_001131355
            XM_498195
VERSION     NM_152627.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2908)
  AUTHORS   Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums
            JG, Bailey K, Gong Y, Turner ST, Johnson JA and Boerwinkle E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
REFERENCE   2  (bases 1 to 2908)
  AUTHORS   Mocciaro A and Schiebel E.
  TITLE     Cdc14: a highly conserved family of phosphatases with non-conserved
            functions?
  JOURNAL   J Cell Sci 123 (Pt 17), 2867-2876 (2010)
   PUBMED   20720150
  REMARK    Review article
REFERENCE   3  (bases 1 to 2908)
  AUTHORS   Rosso L, Marques AC, Weier M, Lambert N, Lambot MA, Vanderhaeghen P
            and Kaessmann H.
  TITLE     Birth and rapid subcellular adaptation of a hominoid-specific CDC14
            protein
  JOURNAL   PLoS Biol 6 (6), e140 (2008)
   PUBMED   18547142
REFERENCE   4  (bases 1 to 2908)
  AUTHORS   Marques AC, Dupanloup I, Vinckenbosch N, Reymond A and Kaessmann H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006024.1, BC068452.1 and BC028690.2.
            
            On Jun 2, 2019 this sequence version replaced NM_152627.2.
            
            Summary: This gene represents a retrogene of cell division cycle
            14B (CDC14B), which is located on chromosome 9. The introns in the
            coding sequence have been processed out relative to the CDC14B
            locus, but there is an intact open reading frame that is missing
            only some sequence at the N-terminus, including the nuclear
            localiztion signal, relative to proteins encoded by the CDC14B
            gene. There is a difference in the subcellular localization of the
            protein encoded by this gene, relative to its parental gene
            product. While the parental gene product displays microtubular
            localization, GFP chimeras of the protein encoded by this gene
            localize to the endoplasmic reticulum, indicating a possible new
            functional role for this gene. [provided by RefSeq, Nov 2017].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC028690.2, SRR5189667.195273.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650262.2/ ENSP00000497792.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC006024.1         67847-67860         c
            15-18               BC068452.1         1-4
            19-19               AC006024.1         67842-67842         c
            20-26               BC068452.1         6-12
            27-183              BC028690.2         1-157
            184-184             BC068452.1         169-169
            185-2688            BC028690.2         159-2662
            2689-2689           BC068452.1         2674-2674
            2690-2908           BC028690.2         2664-2882
FEATURES             Location/Qualifiers
     source          1..2908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.3"
     gene            1..2908
                     /gene="CDC14C"
                     /gene_synonym="CDC14B2; CDC14Bretro"
                     /note="cell division cycle 14C"
                     /db_xref="GeneID:168448"
                     /db_xref="HGNC:HGNC:22427"
     exon            1..2908
                     /gene="CDC14C"
                     /gene_synonym="CDC14B2; CDC14Bretro"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1470
                     /gene="CDC14C"
                     /gene_synonym="CDC14B2; CDC14Bretro"
                     /note="CDC14 cell division cycle 14 homolog C"
                     /codon_start=1
                     /product="dual specificity protein phosphatase CDC14C"
                     /protein_id="NP_689840.2"
                     /db_xref="CCDS:CCDS94101.1"
                     /db_xref="GeneID:168448"
                     /db_xref="HGNC:HGNC:22427"
                     /translation="MRSSTLQDPRRRDPQDDVYVDITDRLRFAILYSRPKSASNVHYF
                     SIDNELEYENFSEDFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANA
                     AFLVGCYMVIYLGRTPEAAYRILIFGDTPYIPFRDAAYGSCNFYITLLDCFHAVKKAM
                     QYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETY
                     IQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKRFLDICENA
                     EGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGLVIGPQQQFLVMKQ
                     TSLWLEGDYFRQRLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPKPYSDDDEI
                     NGVTQGDRSRALKRRRQSKTNDILLPSPLAVLTFTLCSVVIWWIVCDYILPILLF"
ORIGIN      
        1 gtggtcgttg ctccctgact ggccgcggcg gcctccagga agcggaaaag caaggggcgg
       61 tcgagctggg ccgccgcgcc ccactgctcg ccgcgctgct ctttgacctc gcagggtgtg
      121 aagaagatgc gcagctccac gctgcaggac ccgcgccgcc gggaccccca ggacgacgtg
      181 tacgtggaca tcaccgatcg ccttcgtttt gccattctct acagcagacc aaagagtgca
      241 tcaaatgtac attatttcag catagataat gaactcgaat atgagaactt ctccgaagac
      301 tttggaccac tcaatctggc aatggtttac agatattgtt gcaagataaa taagaaatta
      361 aagtccatta caatgttaag gaagaaaatt gttcatttta ctggctctga tcagagaaaa
      421 caagcaaatg ctgccttcct tgttggatgc tacatggtta tatacttggg gagaacccca
      481 gaagcagcat atagaatatt aatctttgga gatacaccct atattccttt cagagatgct
      541 gcctatggaa gctgcaattt ctacattaca cttcttgact gttttcatgc agtaaagaag
      601 gcaatgcagt atggcttcct taatttcaac tcatttaacc ttgatgaata tgaacactat
      661 gaaaaagcag aaaacggaga tttaaattgg ataataccag accgatttat tgccttctgt
      721 ggacctcatt caagagccag acttgaaagt ggttaccacc aacattctcc cgagacttat
      781 attcaatatt ttaagaatca caatgttact accattattc gtctgaataa aaggatgtat
      841 gatgccaaac gctttacgga tgctggcttc gatcaccatg atcttttctt tgcggatggc
      901 agcaccccta ctgatgccat tgtcaaaaga tttctggata tctgtgaaaa tgctgagggt
      961 gccattgcag tacattgtaa agctggcctt ggtcgcacag gcactctgat agcctgctac
     1021 atcatgaagc attacaggat gacagcagcc gagaccattg cgtgggtaag gatctgcaga
     1081 cctggcttgg tgatcgggcc tcagcagcag tttttggtga tgaagcaaac aagcctctgg
     1141 ctggaagggg actattttcg tcagaggtta aaggggcagg agaatggaca acacagagca
     1201 gccttctcca aacttctctc tggtgttgat gacatttcca taaatggggt cgagaatcaa
     1261 gaccagcaag aacccaaacc ttacagtgat gacgacgaaa tcaatggagt gacacaaggt
     1321 gatagaagtc gggccctgaa aaggcgaaga caatcaaaaa caaacgatat tcttctccca
     1381 tctcccctgg ctgtgctgac ctttacactg tgtagtgttg tcatctggtg gattgtttgt
     1441 gactacattc ttcccatcct gctattctga ctcaaagatt tcagaacata gtagccatca
     1501 ggaccccctg acagatagct gcttctctcc atttcaagga ctaaaatggt tttgcattaa
     1561 gtaaaaacct gtgaccagaa ctgaaggaag actctaggaa ctgaaaactg caacagaaat
     1621 tagcacaatt tgaaaacaaa acaaaattgc aaaagactta gttgctttcc acctaagaag
     1681 ctaatcaatg gggaaaatgt ccacggggtt tcagtaatga acttttgagt ttgggtgcaa
     1741 gcaaatgtac caagaccagc tcagtcaggg agaccctacc ccagtggtgc tagaggaatt
     1801 aaagacacac acacagaaat acagaggtgt aaagtgggaa atcaggggtc tcacagcctt
     1861 cagagctgag agccccgaac agagatttac ccacatattg attaacagca aacaagtcat
     1921 tagcattgtt tctatagata ttaaattaac taaaagtatc ccttatggga aacgaaggga
     1981 tgggcctaat taaaggcata ggttgggcta gttaactgcg gcaggagcac gtccttaagg
     2041 cacagatggc tcatgctatt gtttgtggct taagaatgcc tttaagcagt tttccactct
     2101 gggctgggtg ggccaggtgt tccttgccct cattccggta aacccacacc cttccagcgt
     2161 gggcattagg gccattatga acatgttaca gtgctgcaga gattttattt atggccagtt
     2221 ttggggccag tttatggctg gattttgggg ggcttgctcc caaaaagaat gactcaaaga
     2281 aaggcccagc tctcaagctg aatgacaaaa atgctgttgt aaatttagtc tcaggtgtaa
     2341 atacccaagc cctctggtac tcagggagct ggctggtctg tggtgcatgt gtgtccttgt
     2401 gatggcaagc attgtagttg atggccttca gaagaattga ggatctgatg gaggtttttt
     2461 aatgtattta ttttctgttc agcttgtgac cctgtgtcaa aatttgtaaa gatacaaaag
     2521 gcattactga aatggtactt tctgtaattt gatactattt ggctttacca tcttcacttg
     2581 actgtttgta atactgtagt aatattaact ctgataagta cccaagctgc ttgtcttcta
     2641 ccaaagagtg ctttattaac aagaatctgt gaaaaccaca ttttaaacac tgttgcatgt
     2701 tgtaatacca ggtgatacct tggtaaccta aaacttgcaa gagaatatta gtggtagctt
     2761 tagaagactc aggaggagaa actgacttca gagctggaag atgttgcaag tcattccttt
     2821 ttctgtcctt tagggactga agaactggga ggttgcccat tgtttggttg ccagtcatac
     2881 aaattaaaat catatttcct tccatgca
//
