LOCUS       NM_033331               5602 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens cell division cycle 14B (CDC14B), transcript variant
            2, mRNA.
ACCESSION   NM_033331
VERSION     NM_033331.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5602)
  AUTHORS   Partscht,P. and Schiebel,E.
  TITLE     The diverging role of CDC14B: from mitotic exit in yeast to cell
            fate control in humans
  JOURNAL   EMBO J 42 (16), e114364 (2023)
   PUBMED   37493185
  REMARK    GeneRIF: The diverging role of CDC14B: from mitotic exit in yeast
            to cell fate control in humans.
            Review article
REFERENCE   2  (bases 1 to 5602)
  AUTHORS   Zhu,C., Zhao,Y. and Zheng,W.
  TITLE     CDC14B is a favorable biomarker for recurrence and prognosis of GBM
  JOURNAL   Clin Neurol Neurosurg 227, 107665 (2023)
   PUBMED   36898299
  REMARK    GeneRIF: CDC14B is a favorable biomarker for recurrence and
            prognosis of GBM.
REFERENCE   3  (bases 1 to 5602)
  AUTHORS   Partscht,P., Uddin,B. and Schiebel,E.
  TITLE     Human cells lacking CDC14A and CDC14B show differences in
            ciliogenesis but not in mitotic progression
  JOURNAL   J Cell Sci 134 (2), 224108 (2021)
   PUBMED   33328327
  REMARK    GeneRIF: Human cells lacking CDC14A and CDC14B show differences in
            ciliogenesis but not in mitotic progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5602)
  AUTHORS   Li,J.D., Chen,G., Wu,M., Huang,Y. and Tang,W.
  TITLE     Downregulation of CDC14B in 5218 breast cancer patients: A novel
            prognosticator for triple-negative breast cancer
  JOURNAL   Math Biosci Eng 17 (6), 8152-8181 (2020)
   PUBMED   33378938
  REMARK    GeneRIF: Downregulation of CDC14B in 5218 breast cancer patients: A
            novel prognosticator for triple-negative breast cancer.
REFERENCE   5  (bases 1 to 5602)
  AUTHORS   Liu,Q., Dong,Z. and Chen,T.
  TITLE     MiR-1247-5p Functions as a Tumor Suppressor in Human Astroglioma
            Cells by Targeting CDC14B
  JOURNAL   Ann Clin Lab Sci 50 (2), 182-189 (2020)
   PUBMED   32366555
  REMARK    GeneRIF: MiR-1247-5p Functions as a Tumor Suppressor in Human
            Astroglioma Cells by Targeting CDC14B.
REFERENCE   6  (bases 1 to 5602)
  AUTHORS   Dryden,S.C., Nahhas,F.A., Nowak,J.E., Goustin,A.S. and Tainsky,M.A.
  TITLE     Role for human SIRT2 NAD-dependent deacetylase activity in control
            of mitotic exit in the cell cycle
  JOURNAL   Mol Cell Biol 23 (9), 3173-3185 (2003)
   PUBMED   12697818
REFERENCE   7  (bases 1 to 5602)
  AUTHORS   Kaiser,B.K., Zimmerman,Z.A., Charbonneau,H. and Jackson,P.K.
  TITLE     Disruption of centrosome structure, chromosome segregation, and
            cytokinesis by misexpression of human Cdc14A phosphatase
  JOURNAL   Mol Biol Cell 13 (7), 2289-2300 (2002)
   PUBMED   12134069
REFERENCE   8  (bases 1 to 5602)
  AUTHORS   Mailand,N., Lukas,C., Kaiser,B.K., Jackson,P.K., Bartek,J. and
            Lukas,J.
  TITLE     Deregulated human Cdc14A phosphatase disrupts centrosome separation
            and chromosome segregation
  JOURNAL   Nat Cell Biol 4 (4), 317-322 (2002)
   PUBMED   11901424
  REMARK    Erratum:[Nat Cell Biol. 2006 Aug;8(8):897]
REFERENCE   9  (bases 1 to 5602)
  AUTHORS   Li,L., Ljungman,M. and Dixon,J.E.
  TITLE     The human Cdc14 phosphatases interact with and dephosphorylate the
            tumor suppressor protein p53
  JOURNAL   J Biol Chem 275 (4), 2410-2414 (2000)
   PUBMED   10644693
REFERENCE   10 (bases 1 to 5602)
  AUTHORS   Li,L., Ernsting,B.R., Wishart,M.J., Lohse,D.L. and Dixon,J.E.
  TITLE     A family of putative tumor suppressors is structurally and
            functionally conserved in humans and yeast
  JOURNAL   J Biol Chem 272 (47), 29403-29406 (1997)
   PUBMED   9367992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353578.18, AF064104.1,
            AL133477.16 and BQ004840.1.
            
            On May 17, 2019 this sequence version replaced NM_033331.3.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein tyrosine phosphatase family. This protein is
            highly similar to Saccharomyces cerevisiae Cdc14, a protein
            tyrosine phosphatase involved in the exit of cell mitosis and
            initiation of DNA replication, which suggests the role in cell
            cycle control. This protein has been shown to interact with and
            dephosphorylates tumor suppressor protein p53, and is thought to
            regulate the function of p53. Alternative splice of this gene
            results in 3 transcript variants encoding distinct isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF064104.1, DRR138522.1443689.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375241.6/ ENSP00000364389.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL353578.18        41994-42006
            14-1925             AF064104.1         1-1912
            1926-5207           AL133477.16        23283-26564
            5208-5602           BQ004840.1         24-418              c
FEATURES             Location/Qualifiers
     source          1..5602
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32-q22.33"
     gene            1..5602
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /note="cell division cycle 14B"
                     /db_xref="GeneID:8555"
                     /db_xref="HGNC:HGNC:1719"
                     /db_xref="MIM:603505"
     exon            1..625
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..1962
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2; dual
                     specificity protein phosphatase CDC14B; CDC14 cell
                     division cycle 14 homolog B"
                     /codon_start=1
                     /product="dual specificity protein phosphatase CDC14B
                     isoform 2"
                     /protein_id="NP_201588.1"
                     /db_xref="CCDS:CCDS6722.1"
                     /db_xref="GeneID:8555"
                     /db_xref="HGNC:HGNC:1719"
                     /db_xref="MIM:603505"
                     /translation="MKRKSERRSSWAAAPPCSRRCSSTSPGVKKIRSSTQQDPRRRDP
                     QDDVYLDITDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCC
                     KINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGET
                     SYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNW
                     IIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDA
                     GFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYR
                     MTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSK
                     LLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTVI
                     LQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLSISRTKTVLR"
     exon            626..716
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            717..792
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            793..885
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            886..962
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1029
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1092
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1180
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1411
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1550
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1710
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1808
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1925
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..5602
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5584..5589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /note="hexamer: ATTAAA"
     polyA_site      5602
                     /gene="CDC14B"
                     /gene_synonym="Cdc14B1; Cdc14B2; CDC14B3; hCDC14B"
                     /note="major polyA site"
ORIGIN      
        1 gtgaatgaag cgccacggaa cagccctcct ggggtcccca cgagccgcgt cctgctgtgc
       61 cccggcgcct acgcagcagc ggccgcggcc gcggtgggca cgcacggtta ccccgggcag
      121 ctccggccgc cagctgcagc cccgtcgcct cggccgcgcc agccggctgc gggcacctgg
      181 gggcgggctg ggggcgccgg ccgcggcagg aggcgctgta gcgagggctg cggcgccggt
      241 cctgcggcgg ccgcgggagg cagcggggca ggcgctgtgg gccgggctcc tcctccggct
      301 cctgcgcgac cgcctcccgc cgggctctgc cggcgcccgc cgtccccgca gcgccgctct
      361 gcgcccgccg ccccgagcgc ccgcgcgggg ctggcgggag cctcggcggg cgcgcgggcg
      421 cgcggggcca tggtcgtggc cccctgacgg gccgcggccg cctccatgaa gcggaaaagc
      481 gagcggcggt cgagctgggc cgccgcgccc ccctgctcgc ggcgctgctc gtcgacctcg
      541 ccgggtgtga agaagatccg cagctccacg cagcaagacc cgcgccgccg ggacccccag
      601 gacgacgtgt acctggacat caccgatcgc ctttgttttg ccattctcta cagcagacca
      661 aagagtgcat caaatgtaca ttatttcagc atagataatg aacttgaata tgagaacttc
      721 tacgcagatt ttggaccact caatctggca atggtttaca gatattgttg caagatcaat
      781 aagaaattaa agtccattac aatgttaagg aagaaaattg ttcattttac tggctctgat
      841 cagagaaaac aagcaaatgc tgccttcctt gttggatgct acatggttat atatttgggg
      901 agaaccccag aagaagcata tagaatatta atctttggag agacatccta tattcctttc
      961 agagatgctg cctatggaag ttgcaatttc tacattacac ttcttgactg ttttcatgca
     1021 gtaaagaagg caatgcagta tggcttcctt aatttcaact catttaacct tgatgaatat
     1081 gaacactatg aaaaagcaga aaatggagat ttaaattgga taataccaga ccgatttatt
     1141 gccttctgtg gacctcattc aagagccaga cttgaaagtg gttaccacca acattctcct
     1201 gagacttata ttcaatattt taagaatcac aatgttacta ccattattcg tctgaataaa
     1261 aggatgtatg atgccaaacg ctttacggat gctggcttcg atcaccatga tcttttcttt
     1321 gcggatggca gcacccctac tgatgccatt gtcaaagaat tcctagatat ctgtgaaaat
     1381 gctgagggtg ccattgcagt acattgcaaa gctggccttg gtcgcacggg cactctgata
     1441 gcctgctaca tcatgaagca ttacaggatg acagcagccg agaccattgc gtgggtcagg
     1501 atctgcagac ctggctcggt gattgggcct cagcagcagt ttttggtgat gaagcaaacc
     1561 aacctctggc tggaagggga ctattttcgt cagaagttaa aggggcagga gaatggacaa
     1621 cacagagcag ccttctccaa acttctctct ggcgttgatg acatttccat aaatggggtc
     1681 gagaatcaag atcagcaaga acccgaaccg tacagtgatg atgacgaaat caatggagtg
     1741 acacaaggtg atagacttcg ggccttgaaa agcagaagac aatccaaaac aaacgctatt
     1801 cctctcacag taattcttca atccagtgtt cagagctgta aaacatctga acctaacatt
     1861 tctggcagtg caggcattac taaaagaacc accagatctg cttcaaggaa aagcagtgtt
     1921 aaaagtctct ccatttcaag gactaaaaca gtcttgcgtt aagtaaaaac ctgtgaccag
     1981 agctgaagga agactctagg actgaaaact gcaacagaaa ttagcacaat ttgaaaacaa
     2041 aacaaaattg caaaagcctt agttgctttt tccacctaag aagttgatca atggagaaaa
     2101 tgtccactgg agtttgaata atgaactttg agtttgggtg caagcaaatg actcagagaa
     2161 gggtccagct ctcaagctga atgacaaaca tgctgttgta aatttagtct caggtgtaaa
     2221 tacccaagcc ctctggtacc cagggagctg gctggtctgt ggtgcatgtg tgtccctgtg
     2281 atggcaatca ttgtagttgc tggccttcag aagaattgag gatctgatgg aggtttttta
     2341 tgtatttatt ttctgttcac cttgtgaccc tgtgtcaaaa tttataaaga tacaaaaggc
     2401 attactgaaa tggtactttc tgtaatttga tactatttgg cttaatcatc ttcacttgac
     2461 tatttgtaat actgttgtaa tgttaactct gttaagtacc caagctgctt gtcttccacc
     2521 aaagagtgct ttattaacaa gaatctgtga aaatcacatt taaacactgt tgcatgttgt
     2581 aagaccaggt ggtaccttag taacctaaaa cttgcaagag aatattaatg gtagctttag
     2641 aagactcagg aggagaaact gacttcagag ttggaagatg ttgcaagtcg ttcctttttc
     2701 tgtccttcag ggactgaaga actgggaggc tgcccattgt ttggttgcca gtcatacaaa
     2761 ttaaaatcat atttccttcc atgaatggaa gaaacacact attggttttt ccccttggaa
     2821 acagcaatcc caaataatgt cggcttacaa aaaaaaaaag ttaccacttt tttagagtcc
     2881 ttccctgtaa cattggattt tttttttccc ttatgagatc cacctaaggc cattgacgtg
     2941 gcctgcgatc tcagtgacaa tgatctgctt ctggatctca ctgttgcctt tggttaggga
     3001 acacaactag taactctgca gagtgccttc tcccgcagcc ctactggaac acagcagagt
     3061 ctgtgccatg aagcagttac agaaacagaa ttgatgtgct gctaaaaaaa aaaaaaaaaa
     3121 tggggcccga aataaaagaa tatatagtac tcacctcagt tccttccata agaagtgggt
     3181 ggtttaatga ttgttaagcc atttttgcct gtgccgggag catggagggc tgagatgtcg
     3241 acaggcagtg ggaaacaaat gccctcctaa gccacaaggc gtgcgccaga ttagtaggca
     3301 actccatttt aagaagctgc ctttttcaca aaactggaag aaataaaagc ggttggaata
     3361 aacaagttaa aagtctttaa tgcaaaaagt aattgaaagg cagtgcctcc attttggtgt
     3421 actttcttgg aagaaagtat aaaattgacc ggcatcatga gagacggaag atgccgtgtt
     3481 ctcagccaaa caagcaactc tttccccgcc aggcactgtc gggtggggtc aggccagctt
     3541 ttaaacactg gggactggat cacagaaaaa cagtggtttt ctgtccctgg aaatgaatag
     3601 gcacaaagac ccacttggct gtgggcagac tactcttcaa taagatttgg gtgggaggag
     3661 gaacattcct tttgctattt tgagctgaga caatataaat attcaaactg tgccatgcat
     3721 aaagcattga attctcaggg cacctcttct tccccttacc ccttttaagg ccatcccctc
     3781 cattaataat aatccaggta gttgtgaaaa tcgtgcttct atctgatccc ttcttagttt
     3841 ggcttttcat cccatcagaa caagtaaacg taggcgccac agctcttgtg agtactgtct
     3901 ccctcacggt gaatgagcct cctggtgttt cgtccaagaa aagaaagggt gtcactggaa
     3961 ccacagccct ttttcatttt ataaactgcc tcttcatgtt gcctgctcaa gtttccacct
     4021 agaattgcta tcactgtggc tctttctaaa aatctttcta tttaactggt tcactgaaat
     4081 tagtcataga aaacttgtga tttggtgaag aggcattcct tgtaataacc aaatgacttg
     4141 ggatggtgtg catagcaagg gcagtgttac acttatgagg actgtctcta gcatccagga
     4201 agtctctggg tctgagggat ggaaagttct tcctgctatg aatgagagtg gactcttccc
     4261 ctcaccccca actgaaacca caaacaacca gaatcttctg gaattctgac ttagagtcgt
     4321 tgttatagaa gaccttgttg ctatggaaca tgaaactgtg tgtcagatgg agagatcccc
     4381 ttaacctaag agccttaaat agccctgaaa gtacactggg acggtttgcg atggaattaa
     4441 aattggaagt gaatattttt aggtgctctt gaagctttct ggggactcaa aattatcaaa
     4501 agtcagggac agtccggagg aagagcgtct gcaaaactgg gttcctagaa gtatagacgg
     4561 acttagcttt ttgtagaatt tggtgaggag cagcgcctcg tgagagcaga atggcctggc
     4621 gtggccagtg cttcccggca gcacgcagct ctgcggcctc cagaattccc ctgttctgag
     4681 cttgatgccc ctagcctgtc ccctacctac ttcctcccct cctctctagc cctctcacag
     4741 gggtgattgc tacctctctg ttttcttggg cctaggcaag ttttagagga gttcccaagc
     4801 attgttatga ggccagtgtg ctcgctgggc tgggcgggat ggcctgggct tgtgtgtggc
     4861 ctgagggctc tcctggggcc ttctcttttc ccagtcacct ttggagccac agaagcagtg
     4921 cactcattgg atgtctgttc ttaacacagc ttctctttct acattaaaaa aaatcattat
     4981 tgcattttgg aaagcagtgc tcatcaaaag caacttttaa aacctatttt attgttcctt
     5041 taaatgttct ctcccgctga aactgccctg gagaggctat ctgctgctct tccatttacc
     5101 cacatcaggt tattctccat gtcactcagt ggagatgact ccagatgtgt ttaaagactg
     5161 gacaattcac ctatactgtg taggaaatta cctccttaat tacctggtag aattgtcagc
     5221 agacatgttc atccgatgat agtactgcag ttttctatta ataatttgca gacttttatc
     5281 taacctgcac tcatgtacag attattaaaa gttttaaaat gtaactgatc agtattgatc
     5341 aatcattgtc ttgatttttt tttacagcgt atatttctaa tcatattttt taaagccaag
     5401 agaactggtt gaatgaatgt ttattttcct gaaggtattt ttaagataaa gcttcctaat
     5461 ggcgtgtaaa ctttgcatat gtatgtagtt tgatacatat tgtcacattt gaaaatcttg
     5521 tgggttgtaa ctggttttat acaaaatatc gaatagtgga aattgtataa ttacaatcat
     5581 gtaattaaaa gtattaaccc aa
//
