LOCUS       NM_003672               4231 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cell division cycle 14A (CDC14A), transcript variant
            1, mRNA.
ACCESSION   NM_003672
VERSION     NM_003672.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4231)
  AUTHORS   Partscht,P., Uddin,B. and Schiebel,E.
  TITLE     Human cells lacking CDC14A and CDC14B show differences in
            ciliogenesis but not in mitotic progression
  JOURNAL   J Cell Sci 134 (2), 224108 (2021)
   PUBMED   33328327
  REMARK    GeneRIF: Human cells lacking CDC14A and CDC14B show differences in
            ciliogenesis but not in mitotic progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4231)
  AUTHORS   Huang,Y., Zhu,Y., Zhang,Z., Li,Z. and Kong,C.
  TITLE     UNC5B mediates G2/M phase arrest of bladder cancer cells by binding
            to CDC14A and P53
  JOURNAL   Cancer Gene Ther 27 (12), 934-947 (2020)
   PUBMED   32372016
  REMARK    GeneRIF: UNC5B mediates G2/M phase arrest of bladder cancer cells
            by binding to CDC14A and P53.
            Erratum:[Cancer Gene Ther. 2022 Mar;29(3-4):398. doi:
            10.1038/s41417-021-00394-6.. PMID: 34671114]
REFERENCE   3  (bases 1 to 4231)
  AUTHORS   Hu,H., Yin,J.H., Shao,D.D., -L Wang,L., He,F., Huang,X.X.,
            Guo,H.L., Xiang,X.N., Zhu,S.S., Zhang,P.H. and Chen,J.S.
  TITLE     The phosphorylation of hCDC14A modulated by ZIPK regulates
            autophagy of murine pancreatic islet beta-TC3 cells upon glucose
            stimulation
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (19), 10028-10035 (2020)
   PUBMED   33090408
  REMARK    GeneRIF: The phosphorylation of hCDC14A modulated by ZIPK regulates
            autophagy of murine pancreatic islet beta-TC3 cells upon glucose
            stimulation.
REFERENCE   4  (bases 1 to 4231)
  AUTHORS   Mohseni,M., Akbari,M., Booth,K.T., Babanejad,M., Azaiez,H.,
            Ardalani,F., Arzhangi,S., Jalalvand,K., Nikzat,N., Ghodratpour,F.,
            Jamali,P., Adeli,O.A., Habibi,H., Kahrizi,K. and Najmabadi,H.
  TITLE     When transcripts matter: delineating between non-syndromic hearing
            loss DFNB32 and hearing impairment infertile male syndrome (HIIMS)
  JOURNAL   J Hum Genet 65 (7), 609-617 (2020)
   PUBMED   32231217
  REMARK    GeneRIF: When transcripts matter: delineating between non-syndromic
            hearing loss DFNB32 and hearing impairment infertile male syndrome
            (HIIMS).
REFERENCE   5  (bases 1 to 4231)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4231)
  AUTHORS   Mailand,N., Lukas,C., Kaiser,B.K., Jackson,P.K., Bartek,J. and
            Lukas,J.
  TITLE     Deregulated human Cdc14A phosphatase disrupts centrosome separation
            and chromosome segregation
  JOURNAL   Nat Cell Biol 4 (4), 317-322 (2002)
   PUBMED   11901424
  REMARK    GeneRIF: human Cdc14A phosphatase disrupts centrosome separation
            Erratum:[Nat Cell Biol. 2006 Aug;8(8):897]
REFERENCE   7  (bases 1 to 4231)
  AUTHORS   Bembenek,J. and Yu,H.
  TITLE     Regulation of the anaphase-promoting complex by the dual
            specificity phosphatase human Cdc14a
  JOURNAL   J Biol Chem 276 (51), 48237-48242 (2001)
   PUBMED   11598127
REFERENCE   8  (bases 1 to 4231)
  AUTHORS   Li,L., Ljungman,M. and Dixon,J.E.
  TITLE     The human Cdc14 phosphatases interact with and dephosphorylate the
            tumor suppressor protein p53
  JOURNAL   J Biol Chem 275 (4), 2410-2414 (2000)
   PUBMED   10644693
REFERENCE   9  (bases 1 to 4231)
  AUTHORS   Wong,A.K., Chen,Y., Lian,L., Ha,P.C., Petersen,K., Laity,K.,
            Carillo,A., Emerson,M., Heichman,K., Gupte,J., Tavtigian,S.V. and
            Teng,D.H.
  TITLE     Genomic structure, chromosomal location, and mutation analysis of
            the human CDC14A gene
  JOURNAL   Genomics 59 (2), 248-251 (1999)
   PUBMED   10409437
REFERENCE   10 (bases 1 to 4231)
  AUTHORS   Li,L., Ernsting,B.R., Wishart,M.J., Lohse,D.L. and Dixon,J.E.
  TITLE     A family of putative tumor suppressors is structurally and
            functionally conserved in humans and yeast
  JOURNAL   J Biol Chem 272 (47), 29403-29406 (1997)
   PUBMED   9367992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104457.2 and AL589990.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003672.3.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein tyrosine phosphatase family. It is highly
            similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine
            phosphatase involved in the exit of cell mitosis and initiation of
            DNA replication, suggesting a role in cell cycle control. This
            protein has been shown to interact with, and dephosphorylate tumor
            suppressor protein p53, and is thought to regulate the function of
            p53. Alternative splicing of this gene results in several
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 3' UTR and
            coding sequence compared to variant 2. The resulting isoform (1)
            has a shorter and distinct C-terminus compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071578.1, SRR1660805.219968.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336454.5/ ENSP00000336739.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               AC104457.2         116149-116646       c
            499-589             AC104457.2         115300-115390       c
            590-665             AC104457.2         91531-91606         c
            666-758             AC104457.2         78328-78420         c
            759-838             AC104457.2         44851-44930         c
            839-905             AC104457.2         29154-29220         c
            906-968             AC104457.2         26156-26218         c
            969-1056            AC104457.2         13660-13747         c
            1057-1287           AC104457.2         6271-6501           c
            1288-1426           AL589990.9         804-942
            1427-1586           AL589990.9         17140-17299
            1587-1699           AL589990.9         27666-27778
            1700-1747           AL589990.9         28850-28897
            1748-1870           AL589990.9         30933-31055
            1871-2204           AL589990.9         31777-32110
            2205-4231           AL589990.9         51099-53125
FEATURES             Location/Qualifiers
     source          1..4231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..4231
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /note="cell division cycle 14A"
                     /db_xref="GeneID:8556"
                     /db_xref="HGNC:HGNC:1718"
                     /db_xref="MIM:603504"
     exon            1..498
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..2234
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1; CDC10
                     (cell division cycle 10, S. cerevisiae, homolog); dual
                     specificity protein phosphatase CDC14A; CDC14 cell
                     division cycle 14 homolog A"
                     /codon_start=1
                     /product="dual specificity protein phosphatase CDC14A
                     isoform 1"
                     /protein_id="NP_003663.2"
                     /db_xref="CCDS:CCDS769.1"
                     /db_xref="GeneID:8556"
                     /db_xref="HGNC:HGNC:1718"
                     /db_xref="MIM:603504"
                     /translation="MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELV
                     YENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAY
                     AVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFD
                     FETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKK
                     HNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAV
                     HCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQ
                     GDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNG
                     ITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKM
                     ALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGF
                     TASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILR
                     PSYTGLSSSSARFLSRSIPSLQSEYVHY"
     exon            499..589
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            590..665
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            666..758
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            759..838
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            839..905
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            906..968
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1056
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1287
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1426
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1586
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1699
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1747
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1870
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2204
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..4231
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4111..4116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /note="hexamer: AATAAA"
     polyA_site      4132
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
     regulatory      4210..4215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /note="hexamer: AATAAA"
     polyA_site      4231
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /note="major polyA site"
ORIGIN      
        1 agcagctgct gccagcccgc gggcactgaa gtcctcccgg ctgccgctcg agtagccacg
       61 ggcgcgatcg ggaccagaag tctcctcctc catgatcact ttggaagccg ggggaagact
      121 ttgccctgcc ctgagagctg gtctgcgttt cccaggcgcg gcggcggcgg agcagcagct
      181 gcagcagccg agtccaaata ggagcggcca cagccagggg cgtgagcgcc ccgcgcggag
      241 cgagctcggg ttcccctcgg aatgtccccg gggcgcccgg cgcgctgacc ccgaagccgc
      301 ctccgccttc ggcgcctgct gcctccctcg gccaggcttg ttgttcggga ctgtgagctt
      361 cctggctcct gggcagtggg gaagcccccg ggggcgagtg acttcagctg gccacgaccc
      421 agccctcccc cgtgcgtatc tcgcttaaga tggcagcgga gtcaggggaa ctaatcgggg
      481 cttgtgagtt catgaaagat cggttatatt ttgctacttt aaggaataga ccaaaaagca
      541 cagtaaatac ccactatttc tccatcgatg aggagctggt ctatgaaaat ttctatgcag
      601 attttggacc gctgaacttg gcaatggtgt acagatattg ctgcaaacta aacaagaaac
      661 taaaatcata cagtttgtca agaaagaaaa tagtgcacta cacctgtttt gaccaacgga
      721 aaagagcaaa tgcagcattt ttgataggtg cctatgcagt aatctattta aagaagacac
      781 cagaagaagc ctacagagca ctcctgtctg gctcaaaccc cccctatctt ccattcaggg
      841 atgcttcctt tggaaattgc acttacaatc tcaccattct cgactgtttg cagggaatca
      901 gaaagggatt acaacatgga ttttttgact ttgagacatt tgatgtggat gaatatgaac
      961 attatgagcg agttgaaaat ggtgacttca actggattgt tccaggaaaa tttttagcat
     1021 ttagtggacc acatcctaaa agcaaaattg agaatggtta tcctcttcac gcccctgaag
     1081 cctactttcc ttatttcaaa aagcataatg tgactgcagt tgtgaggcta aacaaaaaga
     1141 tttatgaggc aaagcgcttc acagacgctg gcttcgagca ctatgacctc ttcttcatag
     1201 atggcagcac acccagtgac aacatcgtgc gaaggttcct gaacatctgt gagaacaccg
     1261 aaggggccat cgccgttcac tgcaaagctg gtcttggaag aacagggaca ttgatagcct
     1321 gttatgtaat gaaacactac aggtttacac atgctgaaat aattgcttgg attagaatat
     1381 gccggccagg ctctattata ggaccccagc agcacttcct ggaagaaaaa caagcatcgt
     1441 tgtgggtcca aggagacatt ttccgatcca aactgaaaaa tcgaccatcc agtgaaggaa
     1501 gtattaataa aattctttct ggcctagatg atatgtctat tggtggaaat ctttcaaaaa
     1561 cacaaaacat ggaacgattt ggagaggata acttagaaga tgatgatgtg gaaatgaaaa
     1621 atggtataac ccagggagac aaactacgtg ccttaaaaag tcagagacag ccacgtacct
     1681 caccatcctg tgcatttagg tcagatgata caaaaggaca tccaagagca gtgtcccagc
     1741 ctttcagatt aagttcatcc ctgcaaggat ctgcagttac tttgaagaca tcaaaaatgg
     1801 cactgtcccc ttcagcaacg gccaagagga tcaacagaac ttctttgtct tcgggtgcca
     1861 ctgtaagaag cttttccata aactcccggc tagccagttc tctagggaac ttgaatgctg
     1921 caacagatga tccagagaac aaaaagacct cctcatcctc taaggcaggc ttcacagcca
     1981 gcccgtttac caacctcttg aatggcagct cccagccaac taccagaaat taccctgagc
     2041 tcaacaataa tcagtacaac agaagcagca acagcaacgg gggcaacctg aacagccccc
     2101 caggccccca cagcgccaag acagaggagc acaccaccat cctccgaccc tcctacaccg
     2161 ggctttcttc ttcttcagcg agattcctga gccgttctat cccttccctt cagtctgaat
     2221 atgttcatta ctaaggcctt gccactccag tgaaagctgt tcttctctta gacacaattt
     2281 cttcatctgg acgagcagtg gagagggaaa gcaacttctt gctggaagaa tatctctgcc
     2341 ttcttacctt aaattaaaaa gagcactaag ataacacctt caagagactt gaaaacagaa
     2401 aactggttaa tgactactat aaatgcactg aaactatgtt tatggagatt tccatacttt
     2461 taaagacagt tttaatgttg aatttggtat tttgaagggt tatttttaat gtattttggt
     2521 aatacattta ttattatatt tacatgtaca gtgttacatt atatatgtat tgtgaacttt
     2581 aaaagactat tttgataaat ttataaatat ataaaattat gtaaaaacta cactatattt
     2641 tgatttagat tttcctgctg tttgctacca aaaatttgta ttttaaatct gtttagtttt
     2701 agtatggttt tgtctctaat gaataaataa ttccttctta ttaagaagaa gtaagggaga
     2761 aagtttttag aaagtgattt ttatgctcgc actataaata tggcaggtca gttcattctt
     2821 ttgggaagtc agtttagtta cactgagttt atccaagttt atctctacca agagtataat
     2881 ggcatgggat ggcttattta ggacaattcc ctttcctatt gtttttgttg ctgagccaat
     2941 ttgagttagt tttgcatcct ggggggcttt aaaatacagc atgcagtgaa agatcagaat
     3001 tcactgaata tttcttctga gagcatggtt tcatggtttt tctctatgaa atgactcaat
     3061 attccaaatg tttttttttc cttcctcctt tcaaaagagt tcttaaccca attaggatat
     3121 cctgctttgg gtatgaggtt gttgttgcct gtaatcacac atggtttgac atcagtttta
     3181 aatcaatgga gagaaaaaac tgaaaaagat gctgctaagt agttctctgt attaaaggag
     3241 atatttttaa aacagggtac aaccccctgc tgcacacgct agcatatctg gaacctacta
     3301 tgaaaatgaa aggaccctta taggtactca cagccctttc atgtaagtat gatctgatat
     3361 ttaggtcttc agaagcctgt aggtttcatt tctatgagga atcgaggagc gttacatcct
     3421 gatatccttc caggctgctt aagaatggac tgcttcgaca ctgaaagtgc tagttaaatg
     3481 gattcatatg aagtgcttta ctcccaacca ttgagttatt tataatgtat ttattagggg
     3541 agggtacctt gagtctatta tatatgcttc atcaaaacat cttgttcatg ttttatgttt
     3601 ttaaaaaagg catttgaatg aatgtttgac tcaggtttgt taaattaacc ttcagtaact
     3661 gcagtaccaa aaattacact caactgatga aaaaaacgaa ttgtatgatt taggaatcaa
     3721 aaactaaaat aagtggaatt atgtatcttt tctaaagtta aaaaagtaaa atattttatt
     3781 atgagttatt ataaaaattg gttaattgta taggaagatg acagtatttt tttcaagtta
     3841 tcataaaaag taattcagat gacatttgag aagtagggga aagggaatca tgttgacagt
     3901 tttagttctg tgaacactaa tttgtgtgaa gctattaaaa tgattgtaaa gttgactact
     3961 gtaaatttcc cataattatg tgtgtatatg tgtcatatgt atgtacatgt atatgtctaa
     4021 aaattacttt acacatgtgc ctacatagac acaccaagaa gtggatgtat ataatataga
     4081 aagtatatag caaagtaatt ttactctgat aataaaaatt gtttgacatg tattttgtta
     4141 tgaatagttt atcttccaaa agatattttg ctctatttta aagtgtagaa gaatacactg
     4201 ctaataaata ataaaagttt tattcaattt a
//
