LOCUS       NM_001319212            2314 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens cell division cycle 14A (CDC14A), transcript variant
            6, mRNA.
ACCESSION   NM_001319212
VERSION     NM_001319212.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Partscht,P., Uddin,B. and Schiebel,E.
  TITLE     Human cells lacking CDC14A and CDC14B show differences in
            ciliogenesis but not in mitotic progression
  JOURNAL   J Cell Sci 134 (2), 224108 (2021)
   PUBMED   33328327
  REMARK    GeneRIF: Human cells lacking CDC14A and CDC14B show differences in
            ciliogenesis but not in mitotic progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Huang,Y., Zhu,Y., Zhang,Z., Li,Z. and Kong,C.
  TITLE     UNC5B mediates G2/M phase arrest of bladder cancer cells by binding
            to CDC14A and P53
  JOURNAL   Cancer Gene Ther 27 (12), 934-947 (2020)
   PUBMED   32372016
  REMARK    GeneRIF: UNC5B mediates G2/M phase arrest of bladder cancer cells
            by binding to CDC14A and P53.
            Erratum:[Cancer Gene Ther. 2022 Mar;29(3-4):398. doi:
            10.1038/s41417-021-00394-6.. PMID: 34671114]
REFERENCE   3  (bases 1 to 2314)
  AUTHORS   Hu,H., Yin,J.H., Shao,D.D., -L Wang,L., He,F., Huang,X.X.,
            Guo,H.L., Xiang,X.N., Zhu,S.S., Zhang,P.H. and Chen,J.S.
  TITLE     The phosphorylation of hCDC14A modulated by ZIPK regulates
            autophagy of murine pancreatic islet beta-TC3 cells upon glucose
            stimulation
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (19), 10028-10035 (2020)
   PUBMED   33090408
  REMARK    GeneRIF: The phosphorylation of hCDC14A modulated by ZIPK regulates
            autophagy of murine pancreatic islet beta-TC3 cells upon glucose
            stimulation.
REFERENCE   4  (bases 1 to 2314)
  AUTHORS   Mohseni,M., Akbari,M., Booth,K.T., Babanejad,M., Azaiez,H.,
            Ardalani,F., Arzhangi,S., Jalalvand,K., Nikzat,N., Ghodratpour,F.,
            Jamali,P., Adeli,O.A., Habibi,H., Kahrizi,K. and Najmabadi,H.
  TITLE     When transcripts matter: delineating between non-syndromic hearing
            loss DFNB32 and hearing impairment infertile male syndrome (HIIMS)
  JOURNAL   J Hum Genet 65 (7), 609-617 (2020)
   PUBMED   32231217
  REMARK    GeneRIF: When transcripts matter: delineating between non-syndromic
            hearing loss DFNB32 and hearing impairment infertile male syndrome
            (HIIMS).
REFERENCE   5  (bases 1 to 2314)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2314)
  AUTHORS   Mailand,N., Lukas,C., Kaiser,B.K., Jackson,P.K., Bartek,J. and
            Lukas,J.
  TITLE     Deregulated human Cdc14A phosphatase disrupts centrosome separation
            and chromosome segregation
  JOURNAL   Nat Cell Biol 4 (4), 317-322 (2002)
   PUBMED   11901424
  REMARK    GeneRIF: human Cdc14A phosphatase disrupts centrosome separation
            Erratum:[Nat Cell Biol. 2006 Aug;8(8):897]
REFERENCE   7  (bases 1 to 2314)
  AUTHORS   Bembenek,J. and Yu,H.
  TITLE     Regulation of the anaphase-promoting complex by the dual
            specificity phosphatase human Cdc14a
  JOURNAL   J Biol Chem 276 (51), 48237-48242 (2001)
   PUBMED   11598127
REFERENCE   8  (bases 1 to 2314)
  AUTHORS   Li,L., Ljungman,M. and Dixon,J.E.
  TITLE     The human Cdc14 phosphatases interact with and dephosphorylate the
            tumor suppressor protein p53
  JOURNAL   J Biol Chem 275 (4), 2410-2414 (2000)
   PUBMED   10644693
REFERENCE   9  (bases 1 to 2314)
  AUTHORS   Wong,A.K., Chen,Y., Lian,L., Ha,P.C., Petersen,K., Laity,K.,
            Carillo,A., Emerson,M., Heichman,K., Gupte,J., Tavtigian,S.V. and
            Teng,D.H.
  TITLE     Genomic structure, chromosomal location, and mutation analysis of
            the human CDC14A gene
  JOURNAL   Genomics 59 (2), 248-251 (1999)
   PUBMED   10409437
REFERENCE   10 (bases 1 to 2314)
  AUTHORS   Li,L., Ernsting,B.R., Wishart,M.J., Lohse,D.L. and Dixon,J.E.
  TITLE     A family of putative tumor suppressors is structurally and
            functionally conserved in humans and yeast
  JOURNAL   J Biol Chem 272 (47), 29403-29406 (1997)
   PUBMED   9367992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104457.2 and AL589990.9.
            
            On Aug 14, 2020 this sequence version replaced NM_001319212.1.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein tyrosine phosphatase family. It is highly
            similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine
            phosphatase involved in the exit of cell mitosis and initiation of
            DNA replication, suggesting a role in cell cycle control. This
            protein has been shown to interact with, and dephosphorylate tumor
            suppressor protein p53, and is thought to regulate the function of
            p53. Alternative splicing of this gene results in several
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) lacks an alternate exon
            compared to variant 2. The resulting isoform (6) is shorter at the
            C-terminus compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038979.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               AC104457.2         116149-116646       c
            499-589             AC104457.2         115300-115390       c
            590-665             AC104457.2         91531-91606         c
            666-758             AC104457.2         78328-78420         c
            759-838             AC104457.2         44851-44930         c
            839-905             AC104457.2         29154-29220         c
            906-968             AC104457.2         26156-26218         c
            969-1199            AC104457.2         6271-6501           c
            1200-1338           AL589990.9         804-942
            1339-1498           AL589990.9         17140-17299
            1499-1611           AL589990.9         27666-27778
            1612-1659           AL589990.9         28850-28897
            1660-1782           AL589990.9         30933-31055
            1783-2314           AL589990.9         31777-32308
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..2314
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /note="cell division cycle 14A"
                     /db_xref="GeneID:8556"
                     /db_xref="HGNC:HGNC:1718"
                     /db_xref="MIM:603504"
     exon            1..498
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            499..589
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            590..665
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            666..758
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            759..838
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            839..905
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            906..968
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1199
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1338
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     CDS             1241..2233
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 6 is encoded by transcript variant 6; CDC10
                     (cell division cycle 10, S. cerevisiae, homolog); dual
                     specificity protein phosphatase CDC14A; CDC14 cell
                     division cycle 14 homolog A"
                     /codon_start=1
                     /product="dual specificity protein phosphatase CDC14A
                     isoform 6"
                     /protein_id="NP_001306141.1"
                     /db_xref="GeneID:8556"
                     /db_xref="HGNC:HGNC:1718"
                     /db_xref="MIM:603504"
                     /translation="MKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDI
                     FRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQ
                     GDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALS
                     PSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTAS
                     PFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSY
                     TGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKKFNSAKEAF"
     exon            1339..1498
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1611
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1659
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1782
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2314
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /note="hexamer: AGTAAA"
     polyA_site      2314
                     /gene="CDC14A"
                     /gene_synonym="cdc14; DFNB105; DFNB32; DFNB35; hCDC14"
                     /note="major polyA site"
ORIGIN      
        1 agcagctgct gccagcccgc gggcactgaa gtcctcccgg ctgccgctcg agtagccacg
       61 ggcgcgatcg ggaccagaag tctcctcctc catgatcact ttggaagccg ggggaagact
      121 ttgccctgcc ctgagagctg gtctgcgttt cccaggcgcg gcggcggcgg agcagcagct
      181 gcagcagccg agtccaaata ggagcggcca cagccagggg cgtgagcgcc ccgcgcggag
      241 cgagctcggg ttcccctcgg aatgtccccg gggcgcccgg cgcgctgacc ccgaagccgc
      301 ctccgccttc ggcgcctgct gcctccctcg gccaggcttg ttgttcggga ctgtgagctt
      361 cctggctcct gggcagtggg gaagcccccg ggggcgagtg acttcagctg gccacgaccc
      421 agccctcccc cgtgcgtatc tcgcttaaga tggcagcgga gtcaggggaa ctaatcgggg
      481 cttgtgagtt catgaaagat cggttatatt ttgctacttt aaggaataga ccaaaaagca
      541 cagtaaatac ccactatttc tccatcgatg aggagctggt ctatgaaaat ttctatgcag
      601 attttggacc gctgaacttg gcaatggtgt acagatattg ctgcaaacta aacaagaaac
      661 taaaatcata cagtttgtca agaaagaaaa tagtgcacta cacctgtttt gaccaacgga
      721 aaagagcaaa tgcagcattt ttgataggtg cctatgcagt aatctattta aagaagacac
      781 cagaagaagc ctacagagca ctcctgtctg gctcaaaccc cccctatctt ccattcaggg
      841 atgcttcctt tggaaattgc acttacaatc tcaccattct cgactgtttg cagggaatca
      901 gaaagggatt acaacatgga ttttttgact ttgagacatt tgatgtggat gaatatgaac
      961 attatgaggt tatcctcttc acgcccctga agcctacttt ccttatttca aaaagcataa
     1021 tgtgactgca gttgtgaggc taaacaaaaa gatttatgag gcaaagcgct tcacagacgc
     1081 tggcttcgag cactatgacc tcttcttcat agatggcagc acacccagtg acaacatcgt
     1141 gcgaaggttc ctgaacatct gtgagaacac cgaaggggcc atcgccgttc actgcaaagc
     1201 tggtcttgga agaacaggga cattgatagc ctgttatgta atgaaacact acaggtttac
     1261 acatgctgaa ataattgctt ggattagaat atgccggcca ggctctatta taggacccca
     1321 gcagcacttc ctggaagaaa aacaagcatc gttgtgggtc caaggagaca ttttccgatc
     1381 caaactgaaa aatcgaccat ccagtgaagg aagtattaat aaaattcttt ctggcctaga
     1441 tgatatgtct attggtggaa atctttcaaa aacacaaaac atggaacgat ttggagagga
     1501 taacttagaa gatgatgatg tggaaatgaa aaatggtata acccagggag acaaactacg
     1561 tgccttaaaa agtcagagac agccacgtac ctcaccatcc tgtgcattta ggtcagatga
     1621 tacaaaagga catccaagag cagtgtccca gcctttcaga ttaagttcat ccctgcaagg
     1681 atctgcagtt actttgaaga catcaaaaat ggcactgtcc ccttcagcaa cggccaagag
     1741 gatcaacaga acttctttgt cttcgggtgc cactgtaaga agcttttcca taaactcccg
     1801 gctagccagt tctctaggga acttgaatgc tgcaacagat gatccagaga acaaaaagac
     1861 ctcctcatcc tctaaggcag gcttcacagc cagcccgttt accaacctct tgaatggcag
     1921 ctcccagcca actaccagaa attaccctga gctcaacaat aatcagtaca acagaagcag
     1981 caacagcaac gggggcaacc tgaacagccc cccaggcccc cacagcgcca agacagagga
     2041 gcacaccacc atcctccgac cctcctacac cgggctttct tcttcttcag cgagattcct
     2101 gagccgttct atccctgtaa gtgcgcagac accacctcct ggtcctcaga accctgaatg
     2161 caacttctgt gccttgcctt cccagccgag gctgccacca aagaaattta atagtgccaa
     2221 ggaagccttc tgagcgatgc cttccctctg tgctgtgaaa ctgtctatgc actacattct
     2281 gctagctcct cttcaagtaa acgccaagtc acaa
//
