LOCUS       NM_006023               1321 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens cell division cycle 123 (CDC123), mRNA.
ACCESSION   NM_006023
VERSION     NM_006023.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1321)
  AUTHORS   Wang,Y., Pan,H., Gong,X., Wang,Z., Qin,X., Zhou,S., Zhu,C., Hu,X.,
            Chen,S., Liu,H., Jin,H., Pang,Q. and Wu,W.
  TITLE     CDC123 promotes Hepatocellular Carcinoma malignant progression by
            regulating CDKAL1
  JOURNAL   Pathol Res Pract 254, 154987 (2024)
   PUBMED   38237400
  REMARK    GeneRIF: CDC123 promotes Hepatocellular Carcinoma malignant
            progression by regulating CDKAL1.
REFERENCE   2  (bases 1 to 1321)
  AUTHORS   Song,N., Deng,L., Zeng,L., He,L., Liu,C., Liu,L. and Fu,R.
  TITLE     USP9X deubiquitinates and stabilizes CDC123 to promote breast
            carcinogenesis through regulating cell cycle
  JOURNAL   Mol Carcinog 62 (10), 1487-1503 (2023)
   PUBMED   37314216
  REMARK    GeneRIF: USP9X deubiquitinates and stabilizes CDC123 to promote
            breast carcinogenesis through regulating cell cycle.
REFERENCE   3  (bases 1 to 1321)
  AUTHORS   Cardenal Peralta,C., Vandroux,P., Neumann-Arnold,L., Panvert,M.,
            Fagart,J., Seufert,W., Mechulam,Y. and Schmitt,E.
  TITLE     Binding of human Cdc123 to eIF2gamma
  JOURNAL   J Struct Biol 215 (3), 108006 (2023)
   PUBMED   37507029
  REMARK    GeneRIF: Binding of human Cdc123 to eIF2gamma.
REFERENCE   4  (bases 1 to 1321)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1321)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1321)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1321)
  AUTHORS   Bieganowski,P., Shilinski,K., Tsichlis,P.N. and Brenner,C.
  TITLE     Cdc123 and checkpoint forkhead associated with RING proteins
            control the cell cycle by controlling eIF2gamma abundance
  JOURNAL   J Biol Chem 279 (43), 44656-44666 (2004)
   PUBMED   15319434
REFERENCE   8  (bases 1 to 1321)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   9  (bases 1 to 1321)
  AUTHORS   Onisto,M., Zeilante,P., Scannapieco,P., Pellati,D., Pozza,M.,
            Caenazzo,C., Negro,A. and Garbisa,S.
  TITLE     Expression study on D123 gene product: evidence for high positivity
            in testis
  JOURNAL   Exp Cell Res 242 (2), 451-459 (1998)
   PUBMED   9683532
REFERENCE   10 (bases 1 to 1321)
  AUTHORS   Okuda,A. and Kimura,G.
  TITLE     An amino acid change in novel protein D123 is responsible for
            temperature-sensitive G1-phase arrest in a mutant of rat fibroblast
            line 3Y1
  JOURNAL   Exp Cell Res 223 (2), 242-249 (1996)
   PUBMED   8601400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP367374.1, BC009598.1 and AW006077.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006023.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.45890.1,
                                           SRR5189658.92644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281141.9/ ENSP00000281141.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BP367374.1         227-235
            10-1076             BC009598.1         1-1067
            1077-1321           AW006077.1         3-247               c
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14-p13"
     gene            1..1321
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /note="cell division cycle 123"
                     /db_xref="GeneID:8872"
                     /db_xref="HGNC:HGNC:16827"
                     /db_xref="MIM:617708"
     exon            1..132
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1069
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /note="cell division cycle protein 123 homolog; PZ32;
                     HT-1080; cell division cycle 123 homolog"
                     /codon_start=1
                     /product="translation initiation factor eIF2 assembly
                     protein"
                     /protein_id="NP_006014.2"
                     /db_xref="CCDS:CCDS7090.1"
                     /db_xref="GeneID:8872"
                     /db_xref="HGNC:HGNC:16827"
                     /db_xref="MIM:617708"
                     /translation="MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTL
                     VVSGRDDPPTHSQPDSDDEAEEIQWSDDENTATLTAPEFPEFATKVQEAINSLGGSVF
                     PKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCI
                     EYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFK
                     KHIQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSE
                     VDAQEQDSPAFRCTNSEVTVQPSPYLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQE
                     DD"
     exon            133..204
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            205..262
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            263..295
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            296..391
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            392..498
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            499..547
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            548..623
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            624..746
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            747..775
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            776..904
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1042
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1321
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1299..1304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /note="hexamer: AATAAA"
     polyA_site      1321
                     /gene="CDC123"
                     /gene_synonym="C10orf7; D123"
                     /note="major polyA site"
ORIGIN      
        1 agagttccgg gagggtgcag gcaggagagg gaaaggcagc agcggcggca gctggaggat
       61 gaagaaggag catgtgcttc actgccagtt ctccgcgtgg tacccgttct tccgaggcgt
      121 taccatcaag agtgtcattc ttccacttcc tcagaatgtg aaggattatt tactcgatga
      181 tggaactctg gtggtttcag gaagggatga tccaccaaca cattctcagc cagacagtga
      241 tgatgaagca gaagaaatac agtggtctga tgatgagaac acagccacgc ttacggcacc
      301 agaatttcct gagtttgcca ctaaagtcca ggaagctatc aattccctcg ggggcagtgt
      361 ctttcctaag cttaattgga gtgccccaag ggatgcgtat tggatagcaa tgaatagttc
      421 tctgaaatgt aaaaccctca gcgacatctt tctgcttttc aagagttccg atttcatcac
      481 tcgtgacttc actcagccgt ttattcattg tactgatgat tctccagatc catgtataga
      541 atatgagctc gttctccgaa aatggtgtga attgattcct ggggctgagt ttcgatgttt
      601 tgtcaaggaa aacaagctta ttggtatttc tcaaagagac tacacacaat actatgatca
      661 tatttctaaa caaaaggaag aaattcgcag atgcatacaa gactttttca agaaacacat
      721 acagtacaaa ttcttagatg aagactttgt gttcgatata tacagagaca gtagggggaa
      781 ggtgtggctc attgacttta atccatttgg tgaagtcaca gattcactgc tgttcacctg
      841 ggaagaactg atatctgaga acaacttaaa cggcgatttt agtgaagttg acgctcaaga
      901 gcaggattcc ccagctttcc gttgcacaaa cagtgaagtg acagtccagc ccagccccta
      961 tttgagttac cggctaccca aggactttgt agacctctct actggggagg acgctcacaa
     1021 gctaatagac ttccttaagc tgaagagaaa tcagcaggag gacgactgat gagcgtactg
     1081 gaactggaga agaggaggcc ccgccccacc gctccgggag ctgctcatca gccgcaactt
     1141 cctgccgacc ctgatgcggg tgggccgagc agtgtggaca tcagccactt tttatattca
     1201 tgtacattca cctggggaaa aaaacggagg gactttgcta cttgtaaaaa taacataata
     1261 aatagatctt aaacatagga aaaccatact gttctgataa taaaatgctt tctatgaaat
     1321 a
//
