LOCUS       NM_138477               4657 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens codanin 1 (CDAN1), mRNA.
ACCESSION   NM_138477 XM_938968
VERSION     NM_138477.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   Cai,L.H., Liu,C.C., Li,T., Zou,Y.D., Liu,M.H., Mao,Q. and Li,L.F.
  TITLE     Discovering a novel pathogenic CDAN1 variant using exome sequencing
            and bioinformatics analysis
  JOURNAL   Ann Hematol 102 (12), 3621-3623 (2023)
   PUBMED   37603059
  REMARK    GeneRIF: Discovering a novel pathogenic CDAN1 variant using exome
            sequencing and bioinformatics analysis.
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Wang,Y., Li,Q., Sun,X., Li,S., He,J., Zhang,M., Huang,L. and He,W.
  TITLE     [Whole exome sequencing analysis of compound heterozygous variants
            of CDAN1 gene in a Chinese family with non-immune hydrops fetalis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (12), 1899-1903 (2021)
   PUBMED   35012925
  REMARK    GeneRIF: [Whole exome sequencing analysis of compound heterozygous
            variants of CDAN1 gene in a Chinese family with non-immune hydrops
            fetalis].
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Olijnik,A.A., Roy,N.B.A., Scott,C., Marsh,J.A., Brown,J.,
            Lauschke,K., Ask,K., Roberts,N., Downes,D.J., Brolih,S.,
            Johnson,E., Xella,B., Proven,M., Hipkiss,R., Ryan,K., Frisk,P.,
            Makk,J., Stattin,E.M., Sadasivam,N., McIlwaine,L., Hill,Q.A.,
            Renella,R., Hughes,J.R., Gibbons,R.J., Groth,A., McHugh,P.J.,
            Higgs,D.R., Buckle,V.J. and Babbs,C.
  TITLE     Genetic and functional insights into CDA-I prevalence and
            pathogenesis
  JOURNAL   J Med Genet 58 (3), 185-195 (2021)
   PUBMED   32518175
  REMARK    GeneRIF: Genetic and functional insights into CDA-I prevalence and
            pathogenesis.
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Murphy,Z.C., Getman,M.R., Myers,J.A., Burgos Villar,K.N.,
            Leshen,E., Kurita,R., Nakamura,Y. and Steiner,L.A.
  TITLE     Codanin-1 mutations engineered in human erythroid cells demonstrate
            role of CDAN1 in terminal erythroid maturation
  JOURNAL   Exp Hematol 91, 32-38 (2020)
   PUBMED   33075436
  REMARK    GeneRIF: Codanin-1 mutations engineered in human erythroid cells
            demonstrate role of CDAN1 in terminal erythroid maturation.
REFERENCE   5  (bases 1 to 4657)
  AUTHORS   Swickley,G., Bloch,Y., Malka,L., Meiri,A., Noy-Lotan,S., Yanai,A.,
            Tamary,H. and Motro,B.
  TITLE     Characterization of the interactions between Codanin-1 and
            C15Orf41, two proteins implicated in congenital dyserythropoietic
            anemia type I disease
  JOURNAL   BMC Mol Cell Biol 21 (1), 18 (2020)
   PUBMED   32293259
  REMARK    GeneRIF: Characterization of the interactions between Codanin-1 and
            C15Orf41, two proteins implicated in congenital dyserythropoietic
            anemia type I disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4657)
  AUTHORS   Tamary,H., Offret,H., Dgany,O., Foliguet,B., Wickramasinghe,S.N.,
            Krasnov,T., Rumilly,F., Goujard,C., Feneant-Thibault,M., Cynober,T.
            and Delaunay,J.
  TITLE     Congenital dyserythropoietic anaemia, type I, in a Caucasian
            patient with retinal angioid streaks (homozygous Arg1042Trp
            mutation in codanin-1)
  JOURNAL   Eur J Haematol 80 (3), 271-274 (2008)
   PUBMED   18081704
  REMARK    GeneRIF: This second case of retinal angioid streaks in CDA I
            reports a patient homozygous for the Arg1042Trp mutation in
            codanin-1.
REFERENCE   7  (bases 1 to 4657)
  AUTHORS   Goede,J.S., Benz,R., Fehr,J., Schwarz,K. and Heimpel,H.
  TITLE     Congenital dyserythropoietic anemia type I with bone abnormalities,
            mutations of the CDAN I gene, and significant responsiveness to
            alpha-interferon therapy
  JOURNAL   Ann Hematol 85 (9), 591-595 (2006)
   PUBMED   16767397
  REMARK    GeneRIF: codanin-1 may play a role in the development of the
            skeleton.
REFERENCE   8  (bases 1 to 4657)
  AUTHORS   Dgany,O., Avidan,N., Delaunay,J., Krasnov,T., Shalmon,L.,
            Shalev,H., Eidelitz-Markus,T., Kapelushnik,J., Cattan,D.,
            Pariente,A., Tulliez,M., Cretien,A., Schischmanoff,P.O.,
            Iolascon,A., Fibach,E., Koren,A., Rossler,J., Le Merrer,M.,
            Yaniv,I., Zaizov,R., Ben-Asher,E., Olender,T., Lancet,D.,
            Beckmann,J.S. and Tamary,H.
  TITLE     Congenital dyserythropoietic anemia type I is caused by mutations
            in codanin-1
  JOURNAL   Am J Hum Genet 71 (6), 1467-1474 (2002)
   PUBMED   12434312
  REMARK    GeneRIF: Congenital dyserythropoietic anemia type I is caused by
            mutations in codanin-1
REFERENCE   9  (bases 1 to 4657)
  AUTHORS   Tamary,H., Shalev,H., Luria,D., Shaft,D., Zoldan,M., Shalmon,L.,
            Gruinspan,A., Stark,B., Chaison,M., Shinar,E., Resnitzky,P. and
            Zaizov,R.
  TITLE     Clinical features and studies of erythropoiesis in Israeli Bedouins
            with congenital dyserythropoietic anemia type I
  JOURNAL   Blood 87 (5), 1763-1770 (1996)
   PUBMED   8634422
REFERENCE   10 (bases 1 to 4657)
  AUTHORS   Tamary,H. and Dgany,O.
  TITLE     Congenital Dyserythropoietic Anemia Type I
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301759
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY112237.1, BC052568.1,
            AF525398.1, BC001092.2, BE884119.1 and AC090510.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 8, 2018 this sequence version replaced NM_138477.3.
            
            Summary: This gene encodes a protein that appears to play a role in
            nuclear envelope integrity, possibly related to microtubule
            attachments. Mutations in this gene cause congenital
            dyserythropoietic anemia type I, a disease resulting in
            morphological and functional abnormalities of erythropoiesis.
            [provided by RefSeq, Jul 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356231.4/ ENSP00000348564.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                HY112237.1         1-21
            22-1287             BC052568.1         1-1266
            1288-1310           AF525398.1         1376-1398
            1311-4336           BC052568.1         1290-4315
            4337-4639           BC001092.2         2883-3185
            4640-4647           BE884119.1         201-208
            4648-4648           AC090510.4         84571-84571         c
            4649-4657           BE884119.1         209-217
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.2"
     gene            1..4657
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /note="codanin 1"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
     exon            1..116
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..3710
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /note="discs lost homolog; congenital dyserythropoietic
                     anemia, type I"
                     /codon_start=1
                     /product="codanin-1"
                     /protein_id="NP_612486.2"
                     /db_xref="CCDS:CCDS32209.1"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
                     /translation="MAAVLESLLREEVSVAAVVRWIARSTQGSEDNAGEAAALSSLRA
                     LRKEFVPFLLNFLREQSSRVLPQGPPTPAKTPGASAALPGRPGGPPRGSRGARSQLFP
                     PTEAQSTAAEAPLARRGGRRRGPGPARERGGRGLEEGVSGESLPGAGGRRLRGSGSPS
                     RPSLTLSDPPNLSNLEEFPPVGSVPPGPTGTKPSRRINPTPVSEERSLSKPKTCFTSP
                     PISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELG
                     SPLPSRTGSLTDEPADPARVSSRQRLELVALVYSSCIAENLVPNLFLELFFVFQLLTA
                     RRMVTAKDSDPELSPAVLDSLESPLFQSIHDCVFFAVQVLECHFQVLSNLDKGTLKLL
                     AENERLLCFSPALQGRLRAAYEGSVAKVSLVMPPSTQAVSFQPETDNRANFSSDRAFH
                     TFKKQRDVFYEVLREWEDHHEEPGWDFEKGLGSRIRAMMGQLSAACSHSHFVRLFQKQ
                     LLQMCQSPGGAGGTVLGEAPDVLSMLGADKLGRLWRLQERLMAPQSSGGPCPPPTFPG
                     CQGFFRDFILSASSFQFNQHLMDSLSLKIQELNGLALPQHEPNDEDGESDVDWQGERK
                     QFAVVLLSLRLLAKFLGFVAFLPYRGPEPPPTGELQDSILALRSQVPPVLDVRTLLQR
                     GLQARRAVLTVPWLVEFLSFADHVVPLLEYYRDIFTLLLRLHRSLVLSQESEGKMCFL
                     NKLLLLAVLGWLFQIPTVPEDLFFLEEGPSYAFEVDTVAPEHGLDNAPVVDQQLLYTC
                     CPYIGELRKLLASWVSGSSGRSGGFMRKITPTTTTSLGAQPSQTSQGLQAQLAQAFFH
                     NQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQLVTQGEEGGDPAQL
                     LEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSSAENIAVGLATEK
                     ACAWLSANITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISE
                     IKDVLSLAVGPRDPDEGVSPEHLEQLLGQLGQTLRCRQFLCPPAEQHLAKCSVELASL
                     LVADQIPILGPPAQYRLERGQARRLLHMLLSLWKEDFQGPVPLQLLLSPRNVGLLADT
                     RPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAEELATLSNLFLAEPH
                     LPEPQLRACELVQPNRGTVLAQS"
     exon            117..595
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            596..799
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            800..969
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1083
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1162
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1283
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1393
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1483
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1559
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1765
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1886
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2033
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2200
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2288
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2378
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2433
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2567
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2671
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2830
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2894
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2973
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3122
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3230
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3294
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3476
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3584
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..4657
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4620..4625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /note="hexamer: AATAAA"
     polyA_site      4639
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcccca gagcgccccg accgggatgg cggccgtttt ggagtcgctg ctgcgagaag
       61 aggtgtcggt cgcagccgtc gtgcggtgga tcgcgcgcag cacccagggt tcggaggata
      121 acgctgggga ggcggccgcg ctgagctcac tccgggccct gcggaaagaa ttcgtaccgt
      181 tcctgttgaa cttcctgagg gagcagagca gccgcgtcct cccgcagggg cccccgaccc
      241 ccgccaagac cccgggcgcc tcggcagcct tgccagggag gccgggaggc ccgccgcggg
      301 gtagccgcgg ggcgcgcagc cagcttttcc ctccgaccga ggcccagagc accgctgccg
      361 aggcccctct ggcccgccgc gggggcagga ggcggggccc ggggccggcc cgcgagcgtg
      421 gaggccgcgg cctggaggag ggggtcagcg gggagagcct gcccggagcc gggggccgga
      481 ggcttagggg ctctggcagc cccagccgcc ccagcctcac gctgtctgat ccgccaaacc
      541 tcagcaacct ggaggagttc cctcccgtag gctcggttcc ccccggccct acagggacga
      601 agccttctcg caggatcaac ccaactccgg tgagcgaaga gcggtcactc tccaagccca
      661 agacctgctt cacctcaccc ccaatcagct gtgtccccag ttcccaaccc tcagccctgg
      721 acactagccc ttggggcctt ggccttcccc cagggtgcag aagtctgcaa gaggagcgag
      781 agatgctcag gaaggagcgc tctaagcagc tgcagcagtc acctaccccc acctgtccca
      841 ccccagaatt ggggtcgccc ctccccagcc ggacaggaag cctcacagat gaacctgcag
      901 accctgccag agtgtcttcc cgccagcgcc tggagcttgt agcccttgtt tactcctcgt
      961 gcattgctga gaacctggta ccaaacctct tcttggagct tttcttcgtc tttcagctcc
     1021 tcactgcccg gaggatggtg actgccaagg acagcgaccc tgaactaagt ccagctgtcc
     1081 tagattccct ggaaagtcca ctgttccaaa gcatccacga ttgtgtcttc tttgcagtgc
     1141 aggttttgga gtgtcacttt caggttcttt ccaacctgga caaagggacc ttgaagctgc
     1201 tggctgagaa tgagcggctg ctgtgcttct caccagctct gcaaggccgc cttcgagctg
     1261 cctatgaggg cagtgttgcc aaggtctctc tggtgatgcc tccctctact caagctgtct
     1321 cctttcagcc agagactgac aatcgtgcca acttctccag tgaccgagcc tttcatactt
     1381 ttaagaaaca gagggatgtg ttttatgagg tgctgcgaga gtgggaagat caccatgagg
     1441 agcctggctg ggattttgag aagggcttgg gcagcagaat cagggccatg atgggtcagc
     1501 tctccgcagc ctgcagccac agccactttg ttcggctttt ccaaaaacaa ctactccaga
     1561 tgtgtcagag ccctggtggt gctgggggca ccgtcttggg cgaggcccca gatgtgttga
     1621 gtatgctggg agctgacaag ctggggcggt tgtggcgcct acaggaacgg cttatggctc
     1681 ctcagagcag tggggggccc tgcccacccc ccaccttccc aggctgtcaa ggcttcttta
     1741 gggacttcat ccttagtgcc agcagcttcc agtttaacca gcatctcatg gacagtctga
     1801 gcttgaagat ccaggagctc aatggtcttg ccctgcccca gcatgagccc aatgatgaag
     1861 acggggagtc agacgtagac tggcagggtg agcggaagca atttgctgtg gtgcttctta
     1921 gcctgagact tttggctaaa ttcctgggct ttgtggcttt cctgccatac cgggggcctg
     1981 aacctccccc gaccggtgag cttcaggact ccattctggc cctcaggagc caggtccctc
     2041 cggtcctgga tgtgcggact ctgctgcagc gagggctgca ggcccgccgg gcggtgctca
     2101 ccgtgccctg gctggtggag tttctctcct ttgctgacca tgttgttccc ttgctggaat
     2161 attaccggga catcttcact ctcctgctgc gcctgcaccg gagcttggtg ttgtcgcagg
     2221 agagtgaggg gaagatgtgt ttcctgaaca agctgctgct acttgctgtc ctgggctggc
     2281 ttttccagat tcccacagtc cctgaggact tgttctttct ggaagagggt ccctcatatg
     2341 cctttgaggt ggacacagta gccccagagc atggcttgga caatgcgcct gtggtggacc
     2401 agcagctgct ctacacctgc tgcccctaca tcggagagct ccggaaactg ctcgcttcgt
     2461 gggtgtcagg cagtagtgga cggagtgggg gcttcatgag gaaaatcacc cccaccacta
     2521 ccaccagcct gggagcccag ccttcccaga ccagccaggg gctgcaggca cagctcgccc
     2581 aggccttttt ccacaaccag ccgccctcct tgcgccggac cgtagagttc gtggcagaaa
     2641 gaattggatc aaactgtgtc aaacatatca aggctacact ggtggcagat ctggtgcgcc
     2701 aggcagagtc acttctccaa gagcagctgg tgacacaggg agaggaaggg ggagacccag
     2761 cccagctgtt ggagatcttg tgttcccagc tgtgccctca cggggcccag gcattggccc
     2821 tggggcggga gttctgtcaa aggaagagcc ctggggctgt gcgggcgctg cttccagagg
     2881 agaccccggc agccgttctg agcagtgcag agaacattgc tgtggggctt gcaacagaga
     2941 aagcctgtgc ttggctgtca gccaacatca cagcactgat caggagggag gtgaaagcag
     3001 cagtgagtcg cacacttcga gcccagggtc ctgaacctgc tgcccggggg gagcggaggg
     3061 gctgctcccg cgcctgtgag caccatgctc ccctcccctc ccacctcatc tccgagataa
     3121 aagacgtgct ctccttggcc gtggggccac gggaccctga cgagggagtc tccccagagc
     3181 atctggaaca gctcctaggc cagctgggcc agacgctgcg gtgccgccag ttcctgtgcc
     3241 cacctgctga gcagcatctg gcaaagtgct ctgtggagtt agcttccctc ctcgttgcag
     3301 atcaaattcc tatcctaggg cccccggcac agtacaggct ggagagaggg caggctcgaa
     3361 ggcttctgca catgctgctt tccttgtgga aggaagactt tcaggggccg gttccgctgc
     3421 agctgctgct gagcccaaga aatgtggggc ttctggcaga cacaaggcca agggagtggg
     3481 acttgctgct attcttgcta cgggagctgg tggagaaggg tctgatggga cggatggaga
     3541 tagaggcctg cctgggcagc ctccaccagg cccagtggcc aggggacttt gctgaagaat
     3601 tagcaacact gtctaatctg tttctagccg agccccacct gccagaaccc cagctaagag
     3661 cctgtgagtt ggtgcagcca aaccggggca ctgtgctggc ccagagctag ggctgagaag
     3721 tggccctgcc ttgggcattg caccagaacc ctggaccccc gcctcacgag gaggcccaag
     3781 tgcccaatgc agaccctcac tggttggggt gtagctgggt ctacagtcag acttcctgct
     3841 ctaagggtgt cactgcctgg catcccacca cgcgaatcct agaggaagga gagttggcct
     3901 gatttgggat tatggcagaa aagtccagag atgccagtcc tggagtagaa gaggtggtgt
     3961 ttgtttatct cttggatact aaatgaaatg aggtgtgtgg gcttgtcaac acagaattca
     4021 agcctcattt gctatcccag catctcttaa aactttgtag tcttggaatt catgacagag
     4081 gcaaatgact cctgcttaac ttatgaagaa agttaaaaca tgaatcttgg gagtctacat
     4141 tttcttatca ccaggagctg gactgccatc tccttataaa tgcctaacac aggccgggtc
     4201 tggtggctca tgcctgtaat cccagcactt tgagaggcct gaggtcggcg gactgcctga
     4261 ggtcaggaat tcaagaccag cctggccaac atggcaaaac cccatctcta ctaaaaataa
     4321 aaaaattatt agctgggcat ggtggtgtgt gcctgtaatc ccagctactc aggaggatga
     4381 ggcaggagac ctgcttgaac ctggaggtgg aggttgcagt gagccgaggt cgcaccactg
     4441 cactccagtc tgggtaacag agcgagactt tctagaaaaa gcctaacaaa cagataaggt
     4501 aggactcaac caactgaaac ctgactttcc ccctgtacct tcagcccctg tgcaggtagt
     4561 aacctcttga gacctctccc tgaccaggga ccaagcacag ggcatttaga gctttttaga
     4621 ataaactggt tttctttaac aagggcttga tgtctaa
//
