LOCUS       NM_030911               3386 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens cytidine and dCMP deaminase domain containing 1
            (CDADC1), transcript variant 1, mRNA.
ACCESSION   NM_030911
VERSION     NM_030911.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Xu,Y., Li,L., Li,J. and Liu,Q.
  TITLE     Structural and biological function of NYD-SP15 as a new member of
            cytidine deaminases
  JOURNAL   Gene 583 (1), 36-47 (2016)
   PUBMED   26945630
  REMARK    GeneRIF: NYD-SP15 contained nuclear localization sequence and
            nuclear export-signal and could dynamically shuttle between the
            nucleus and cytoplasm.
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Liu,Q., Liu,J., Cao,Q., Sha,J., Zhou,Z., Wang,H. and Li,J.
  TITLE     NYD-SP15: a novel gene potentially involved in regulating
            testicular development and spermatogenesis
  JOURNAL   Biochem Genet 44 (7-8), 409-423 (2006)
   PUBMED   16955368
  REMARK    GeneRIF: NYD-SP15 protein plays an important role in testicular
            development and spermatogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA400049.1, BC125202.1 and BC048092.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030911.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.212505.1,
                                           SRR1660805.134379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251108.10/ ENSP00000251108.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               DA400049.1         15-574
            561-3054            BC125202.1         489-2982
            3055-3386           BC048092.1         3036-3367
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..3386
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /note="cytidine and dCMP deaminase domain containing 1"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
     exon            1..195
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1658
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /EC_number="3.5.4.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase NYD-SP15; cytidine and dCMP deaminase
                     domain-containing protein 1; testis development protein
                     NYD-SP15; cytidine deaminase"
                     /codon_start=1
                     /product="cytidine and dCMP deaminase domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_112173.1"
                     /db_xref="CCDS:CCDS9415.1"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
                     /translation="MKEAGQMQNLESARAGRSVSTQTGSMTGQIPRLSKVNLFTLLSL
                     WMELFPAEAQRQKSQKNEEGKHGPLGDNEERTRVSTDKRQVKRTGLVVVKNMKIVGLH
                     CSSEDLHAGQIALIKHGSRLKNCDLYFSRKPCSACLKMIVNAGVNRISYWPADPEISL
                     LTEASSSEDAKLDAKAVERLKSNSRAHVCVLLQPLVCYMVQFVEETSYKCDFIQKITK
                     TLPDANTDFYYECKQERIKEYEMLFLVSNEEMHKQILMTIGLENLCENPYFSNLRQNM
                     KDLILLLATVASSVPNFKHFGFYRSNPEQINEIHNQSLPQEIARHCMVQARLLAYRTE
                     DHKTGVGAVIWAEGKSRSCDGTGAMYFVGCGYNAFPVGSEYADFPHMDDKQKDREIRK
                     FRYIIHAEQNALTFRCQEIKPEERSMIFVTKCPCDECVPLIKGAGIKQIYAGDVDVGK
                     KKADISYMRFGELEGVSKFTWQLNPSGAYGLEQNEPERRENGVLRPVPQKEEQHQDKK
                     LRLGIH"
     exon            196..290
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            291..365
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            366..543
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1113
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1163
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1333
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1523
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1584
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..3386
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2540..2545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /note="hexamer: AATAAA"
     polyA_site      2562
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
     regulatory      3364..3369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /note="hexamer: AATAAA"
     polyA_site      3386
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /note="major polyA site"
ORIGIN      
        1 agtgggccgt tgccttacag ttgctgagag gaggcgagag gcgggggcgc tagggccgag
       61 atcatgtctg actgggagag gtttccttgg cagcagagga cgctaggttt gggatgaaag
      121 aagctgggca gatgcaaaat ctggagagcg cgagggccgg gcggtcagtc agcacccaga
      181 ctggcagcat gaccggtcag ataccaaggc tttctaaagt caaccttttc actctgctca
      241 gcctctggat ggagctcttt ccagcagaag cccagcggca aaaatctcag aaaaatgaag
      301 agggaaagca tggaccctta ggagataatg aagagaggac cagagtatct actgacaaaa
      361 gacaggtaaa gagaactggt cttgtggtgg tgaaaaacat gaaaattgtt ggtctccact
      421 gttctagtga agatttacat gccgggcaga ttgctcttat taaacatggg tcaaggctga
      481 aaaactgtga tctttatttt tccagaaaac catgttctgc ttgtttgaaa atgattgtaa
      541 atgctggagt taaccgaatt tcatactggc ctgctgatcc agaaataagt ttgcttacgg
      601 aggcttctag ttctgaagat gcaaagttag atgccaaagc agtggaaaga ttgaagtcaa
      661 acagtcgggc ccatgtgtgt gtcttacttc aacctttggt gtgttatatg gtgcagtttg
      721 tagaggagac ctcttacaaa tgtgacttta ttcaaaaaat tacaaaaaca ttgccggatg
      781 ctaacactga cttttattat gaatgtaaac aagaaagaat aaaagaatat gaaatgttat
      841 ttttggtttc aaatgaagaa atgcataagc aaatactgat gactataggt ttggagaacc
      901 tgtgtgaaaa tccatacttt agcaatctaa ggcaaaacat gaaagacctt atcctacttt
      961 tggccacagt agcttccagt gtgccgaact ttaaacactt cggattttac cgtagcaatc
     1021 cagaacagat taatgaaatt cacaatcaaa gtttgccaca ggaaattgca aggcactgca
     1081 tggttcaggc caggttattg gcatatcgaa ctgaggatca taaaacagga gttggggcag
     1141 tcatttgggc agaagggaaa tctagaagtt gtgatggaac aggtgccatg tactttgtag
     1201 gatgtggtta caatgctttt cctgttggat ctgagtatgc tgacttccca cacatggatg
     1261 acaagcagaa agacagagaa ataaggaaat tcagatacat catacatgcg gaacagaatg
     1321 ccttgacatt taggtgtcaa gaaataaaac cagaagaaag aagcatgatt tttgtgacaa
     1381 agtgcccatg tgatgagtgt gtacctttaa ttaaaggtgc aggcataaaa caaatctatg
     1441 caggagatgt agatgttgga aaaaagaagg cagacatctc ttacatgagg ttcggggagc
     1501 ttgaaggtgt tagcaaattt acgtggcagc tgaatccatc aggagcttat ggtcttgaac
     1561 aaaatgagcc tgaaaggaga gaaaatggtg tgttgagacc tgtcccacag aaggaagagc
     1621 agcaccagga caagaagctg cgcctcggaa tccactaaga aggcctgtct acactgcagg
     1681 ggaacctcaa gaacttttca ttgcacttct aaaattcagc cttgttcatt cagaaaataa
     1741 ggatggattt tgtgaataat tgaaaagatt ttttaaggaa gctaatttat ttctaggata
     1801 caaatggtgt taataagaat atttgtcttt tagatttatg tgtgggtttt ccataatgta
     1861 gtagtgtgtt attttattac acgaaatgag ggagcaataa cttcaaccaa tgtaatcacc
     1921 aacagggact gatttctatt tatcttgact ttatattagc caatttgaaa gggtctgctt
     1981 cacaagaggt catgcctctg cagggaatca cacacctttt gagaaatatt aattcttttg
     2041 aattacaaga gtgacagtta gtaaactgct ccagggaaat aagtgtcatc ttttaagagt
     2101 cagtgtatag caaaccaaaa gatcacattt atacccaaag ctttctagta atcagaattt
     2161 acttaattag aattgactca taaaaataaa gttagtggac tttgtctcca tttttaaagt
     2221 atattttgta aatgttaatt ctgtggtcct gtttatcaca gactttgggt agcaatagga
     2281 agagagtgtt attctgagac agtgtcgctg cttgatatca ctgactcttg aaatcactaa
     2341 cagtgaacct caaatttggt tatgatgtta acagagaaga aatatttgag tctggaatat
     2401 tgaaactagc tttcctagaa ttccattaat aaatgctgct cccccatata gtcttccctt
     2461 ctgtataatt aacataggtt gtctcatggc tttgatcttc aaaaggaaga gccttttaaa
     2521 aacatttgcc aacctcaaga ataaatactg aaagtcttga aagtatggtc atttcagcta
     2581 ttccagattg ctgtctgtga tttctcacat ttttatttgc tgagaaacat tcagaaaatt
     2641 attccaaaaa tgaaggtaca ttttctgttc tctcctaggt tagagagggg tggcctgggg
     2701 tgcttcatga gaaatgtctt cctggatctg cggtggtcag gtttgcctct gcttttgttc
     2761 cctgcctttc cgccacatca cacggcctca ctgggcttcc taccagtttc tcagaattac
     2821 acgcacgacc atccaaacat tggctccatg ccagggctgt gactgcagcc tgtgtaggac
     2881 catggggagt tcagagtcat catacaaggc agccaagaac tgccataaac actacacaga
     2941 tggagggcat gggataggac aggagaggag gtgatgtaca cttagaggta actaaggcta
     3001 gtttgaaaac cgtgaattaa gatattctta tcagtataaa aacactgaga ttgcttacct
     3061 cccaaattgc tttattgtat taactctcat gcttcagctc ttggatttgt tgtttctaac
     3121 taacatgtca tgtacaccaa acattttata aatcaatcag taaatatttt gtaagaccca
     3181 aaatcctggc atattgccag gtctgtggat ttgcctgttg ggtgttggga tgggatatca
     3241 gaggaagaag catacaagtg ggaaaaactg tgattagaaa gggaaaaata ggcatttcca
     3301 cagtactatt aagagaggca tgataatgcc attttttttc ttctgtacaa ctggtcagat
     3361 ttcaataaat aatcattgat ggttta
//
