LOCUS       NM_031462               3567 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CD99 molecule like 2 (CD99L2), transcript variant 1,
            mRNA.
ACCESSION   NM_031462
VERSION     NM_031462.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3567)
  AUTHORS   Rutledge,N.S., Ogungbe,F.T., Watson,R.L., Sullivan,D.P. and
            Muller,W.A.
  TITLE     Human CD99L2 Regulates a Unique Step in Leukocyte Transmigration
  JOURNAL   J Immunol 209 (5), 1001-1012 (2022)
   PUBMED   35914838
  REMARK    GeneRIF: Human CD99L2 Regulates a Unique Step in Leukocyte
            Transmigration.
REFERENCE   2  (bases 1 to 3567)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3567)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 3567)
  AUTHORS   McMichael,G., Bainbridge,M.N., Haan,E., Corbett,M., Gardner,A.,
            Thompson,S., van Bon,B.W., van Eyk,C.L., Broadbent,J., Reynolds,C.,
            O'Callaghan,M.E., Nguyen,L.S., Adelson,D.L., Russo,R.,
            Jhangiani,S., Doddapaneni,H., Muzny,D.M., Gibbs,R.A., Gecz,J. and
            MacLennan,A.H.
  TITLE     Whole-exome sequencing points to considerable genetic heterogeneity
            of cerebral palsy
  JOURNAL   Mol Psychiatry 20 (2), 176-182 (2015)
   PUBMED   25666757
  REMARK    GeneRIF: This study identified predicted pathogenic, hemizygous
            variants on chromosome X in disease genes CD99L2.
REFERENCE   5  (bases 1 to 3567)
  AUTHORS   Nam,G., Lee,Y.K., Lee,H.Y., Ma,M.J., Araki,M., Araki,K., Lee,S.,
            Lee,I.S. and Choi,E.Y.
  TITLE     Interaction of CD99 with its paralog CD99L2 positively regulates
            CD99L2 trafficking to cell surfaces
  JOURNAL   J Immunol 191 (11), 5730-5742 (2013)
   PUBMED   24133166
REFERENCE   6  (bases 1 to 3567)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   7  (bases 1 to 3567)
  AUTHORS   Schenkel,A.R., Dufour,E.M., Chew,T.W., Sorg,E. and Muller,W.A.
  TITLE     The murine CD99-related molecule CD99-like 2 (CD99L2) is an
            adhesion molecule involved in the inflammatory response
  JOURNAL   Cell Commun Adhes 14 (5), 227-237 (2007)
   PUBMED   18163232
REFERENCE   8  (bases 1 to 3567)
  AUTHORS   Suh,Y.H., Shin,Y.K., Kook,M.C., Oh,K.I., Park,W.S., Kim,S.H.,
            Lee,I.S., Park,H.J., Huh,T.L. and Park,S.H.
  TITLE     Cloning, genomic organization, alternative transcripts and
            expression analysis of CD99L2, a novel paralog of human CD99, and
            identification of evolutionary conserved motifs
  JOURNAL   Gene 307, 63-76 (2003)
   PUBMED   12706889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030536.1 and BC025729.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_031462.3.
            
            Summary: This gene encodes a cell-surface protein that is similar
            to CD99. A similar protein in mouse functions as an adhesion
            molecule during leukocyte extravasation. Alternate splicing results
            in multiple transcript variants. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) lacks an in-frame exon in the
            3' region, compared to variant 5. The resulting isoform (1, also
            referred to as E3'-E4'-E3-E4) lacks an internal segment, compared
            to isoform 5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358837.1, BC030536.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370377.8/ ENSP00000359403.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3564              BC030536.1         9-3572
            3565-3567           BC025729.1         4934-4936
FEATURES             Location/Qualifiers
     source          1..3567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..3567
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /note="CD99 molecule like 2"
                     /db_xref="GeneID:83692"
                     /db_xref="HGNC:HGNC:18237"
                     /db_xref="MIM:300846"
     exon            1..147
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..869
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MIC2 like 1; CD99 antigen-like protein 2;
                     MIC2-like protein 1"
                     /codon_start=1
                     /product="CD99 antigen-like protein 2 isoform 1 precursor"
                     /protein_id="NP_113650.2"
                     /db_xref="CCDS:CCDS35427.1"
                     /db_xref="GeneID:83692"
                     /db_xref="HGNC:HGNC:18237"
                     /db_xref="MIM:300846"
                     /translation="MVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQ
                     PWDHTTTTTTNRPGTTRAPAKPPGSGLDLADALDDQDDGRRKPGIGGRERWNHVTTTT
                     KRPVTTRAPANTLGNDFDLADALDDRNDRDDGRRKPIAGGGGFSDKDLEDIVGGGEYK
                     PDKGKGDGRYGSNDDPGSGMVAEPGTIAGVASALAMALIGAVSSYISYQQKKFCFSIQ
                     QGLNADYVKGENLEAVVCEEPQVKYSTLHTQSAEPPPPPEPARI"
     exon            148..210
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..282
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..357
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..426
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..510
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..576
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..615
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..735
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..801
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..3567
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /note="hexamer: AATAAA"
     polyA_site      3567
                     /gene="CD99L2"
                     /gene_synonym="CD99B; MIC2L1"
                     /note="major polyA site"
ORIGIN      
        1 ctcccgctcc tcctcggcct ccccttcggg cgctctcgcg ctaactgtgc tcctccgggg
       61 ccctccgcct gctcccagcc atggtggcct ggcgctcggc gttccttgtc tgcctcgctt
      121 tctccttggc caccctggtc cagcgaggat ctggggactt tgatgatttt aacctggagg
      181 atgcagtgaa agaaacttcc tcagtaaagc agccatggga ccacaccacc accaccacaa
      241 ccaataggcc aggaaccacc agagctccgg caaaacctcc aggtagtgga ttggacttgg
      301 ctgatgcttt ggatgatcaa gatgatggcc gcaggaaacc gggtatagga ggaagagaga
      361 gatggaacca tgtaaccacc acgaccaaga ggccagtaac caccagagct ccagcaaata
      421 ctttaggaaa tgattttgac ttggctgatg ccctggatga tcgaaatgat cgagatgatg
      481 gccgcaggaa accaattgct ggaggaggag gtttttcaga caaggatctt gaagacatag
      541 tagggggtgg agaatacaaa cctgacaagg gtaaaggtga tggccggtac ggcagcaatg
      601 acgaccctgg atctggcatg gtggcagagc ctggcaccat tgccggggtg gccagcgccc
      661 tggccatggc cctcatcggt gccgtctcca gctacatctc ctaccagcag aagaagttct
      721 gcttcagcat tcagcagggt ctcaacgcag actacgtgaa gggagagaac ctggaagccg
      781 tggtatgtga ggaaccccaa gtgaaatact ccacgttgca cacgcagtct gcagagccgc
      841 cgccgccgcc cgaaccagcc cggatctgag ggccctgtcc agctgcaggc atgcacaatg
      901 gtgccaccgc ttgtcacccg gctcccccca ccccttcatt tggacccgca gctgctgtgc
      961 tgctctgtgc catcggctcc ttgttggtct gagtttcccg gatgagctct gggtgtttgt
     1021 gagtttggtt tctctgccct gccccaagcg tgctgagact tggtgccgaa attcaagagc
     1081 cagctctgat agaaagccag caccagcctc gggagctgct gagccaccaa ctcccaaagc
     1141 cagcctgcct ccagctttac tgagcacagg atgcgggggc caagatgatg ctgaggcctg
     1201 atgacattta tgcttagggg acaagagttt gaactcaagg gactgtgacc cctgcacact
     1261 ggagtggctc attgtggcag gtttctgcca atagacagcc cctgacagtg gcctcaagga
     1321 gctgcaggtg gggggctcag cctgcaccca cttggagccc ctgcaaggag cgaaccggtc
     1381 agcaccaagt aacaccacac acacgcagca cccaggatga tggtttcact tcagtcttcc
     1441 ccatcccagg ttttatgttg ctgggcttcc ggagagccgg tccaagcgga ggctttcagt
     1501 gatttaagta caaacatgca tctcgtgata gtcctgcctt gagagcttag gaatcttccg
     1561 gataagtatg aagcaattcg taggcctgtt tcccatctga ttccataggg ggctgggtgt
     1621 ggccttcggg ttgacatgag aaaggtcttt agcaatcatt tctgcaccgg agatgagttt
     1681 tatcctgtgt tggggagagg tgctcaccct ccaccctgtg tccctgtttt ggtagcaaga
     1741 gtgaccgatg tcaagaacga gcatcaaagc cagaatcctg cttgtttgct taaaaatgta
     1801 attgggggcg gcgggggagg agaggggaaa gagacattcg cttggtttag tgaaacgcag
     1861 gtgactttgt agctctgtgg tcagcctact tgtctgctct gagggagagt gcgtggggag
     1921 ccatgctcac cgtggcaaac acaggaaccc catgactcgc ccctcacctg gcgtggagct
     1981 gcctggtttg ggctggagca gagctggttt cctggaatgt tcctttggcc cacatatggt
     2041 tctgtcccgg tgagctctgt tgtcagaggc tcacgggaca gaaccacatg ctagggtcta
     2101 gggcccctgt ctactgatag tcagtttgct gtgtcagaaa gcacttctga aagcagatat
     2161 gagtcaccag acaggcagga tcttacaaaa ctcacgggcc tctttggtct gcatgatggc
     2221 cccatgcgtt tcataggctg tccactgagc gggattgtct gctgagtggg atgagccaac
     2281 tccagtttct taaggaaacc actggaatct gcagccccca catgcatctg tctaacgcat
     2341 gcctcgtgtt cgttttgcaa acatgcctgt ggtggagggt ggtcagttgt agccctgtgc
     2401 gtctcaaggc tgccttgtga ggccattccc agtgcgtgcc cttgagctcc ttaccacccc
     2461 ttttcctgct cggcccttta atccctgaca gacctggact gtgtggctga agggggacct
     2521 gcagcactgc agaaatgcct ctgcgtggtg ccatgaagga aagaaacctt ggcctggtct
     2581 cgagaagctt cccatgcttc aggaagttag taagggtggg gtggcttgca ggattggcct
     2641 gtttccaggg cctcccacac tcattggcca gattgtgaac tttgtcaggc ttgtccctcc
     2701 ctgataccaa gtatgtcgag aaccgatggc cccaccctct ggctggtgct gggccggagg
     2761 tggctatgga ggattttggc atgcgtggcc tgtcgccacc tggacagcgt gacctcaggg
     2821 gttgtccact ttacctttat ggtgaggcct gtcggatggc taagtccttg aaaccctaga
     2881 gctgtgacgt agaatatgtg ctgtctgtga gaccgtgttc ccaggagcac tgactgcagt
     2941 tgagagagac ccattttgct ctcccttacc gccccccgcc ccgggtgctt tctgcacaaa
     3001 gcctagagcc tggcactcaa gcccaccggt ggcagctcct agtgactgga catgcctgga
     3061 agacccctca gccttctgtt tgcagaacgt tcatttcagg agcttctcct tcccacagac
     3121 atcttacact tgctcgacac tgccacctgc agaagcctgg cgggctctgg tcaccatgtg
     3181 tctatctgaa ggttgcactg gccagcatgg gcctgtccca agcgagaggg gagacacagt
     3241 ggactgaaag gactggttga aagtggccaa tctctatcag cttaatttgg cagagaaaat
     3301 ttgtaacaac tctgagcaca tgctgggtga agtcacagct caaggaaaga taaagctggg
     3361 cggaaggagg tgtgcgtggc ttctggggtg ggacccagag gggaggctct gggacagggg
     3421 ctggggttca gtgccagggc cctgaggaag aaatggggac tgatctcaaa attccagaat
     3481 tccctgtaca tctgttcacg tgcttgtgtc caggtgtgac ttgtaaactg tctagtgttt
     3541 gcattaaata aaatggcacc gagcaga
//
