LOCUS       NM_002414               1129 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD99 molecule (Xg blood group) (CD99), transcript
            variant 1, mRNA.
ACCESSION   NM_002414
VERSION     NM_002414.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1129)
  AUTHORS   Voinsky,I., Goldenberg-Bogner,O., Israel-Elgali,I., Volkov,H.,
            Puzianowska-Kuznicka,M., Shomron,N. and Gurwitz,D.
  TITLE     RNA sequencing comparing centenarian and middle-aged women
            lymphoblastoid cell lines identifies age-related dysregulated
            expression of genes encoding selenoproteins, heat shock proteins,
            CD99, and BID
  JOURNAL   Drug Dev Res 85 (7), e70011 (2024)
   PUBMED   39445501
  REMARK    GeneRIF: RNA sequencing comparing centenarian and middle-aged women
            lymphoblastoid cell lines identifies age-related dysregulated
            expression of genes encoding selenoproteins, heat shock proteins,
            CD99, and BID.
REFERENCE   2  (bases 1 to 1129)
  AUTHORS   Winschel,I., Willing,A., Engler,J.B., Walkenhorst,M., Meurs,N.,
            Binkle-Ladisch,L., Woo,M.S., Pfeffer,L.K., Sonner,J.K.,
            Borgmeyer,U., Hagen,S.H., Grunhagel,B., Claussen,J.M., Altfeld,M.
            and Friese,M.A.
  TITLE     Sex- and species-specific contribution of CD99 to T cell
            costimulation during multiple sclerosis
  JOURNAL   Biol Sex Differ 15 (1), 41 (2024)
   PUBMED   38750588
  REMARK    GeneRIF: Sex- and species-specific contribution of CD99 to T cell
            costimulation during multiple sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1129)
  AUTHORS   Feng,X., Wang,C., Ji,B., Qiao,J., Xu,Y., Zhu,S., Ji,Z., Zhou,B.,
            Tong,W. and Xu,W.
  TITLE     CD_99 G1 neutrophils modulate osteogenic differentiation of
            mesenchymal stem cells in the pathological process of ankylosing
            spondylitis
  JOURNAL   Ann Rheum Dis 83 (3), 324-334 (2024)
   PUBMED   37977819
  REMARK    GeneRIF: CD_99 G1 neutrophils modulate osteogenic differentiation
            of mesenchymal stem cells in the pathological process of ankylosing
            spondylitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1129)
  AUTHORS   De Feo,A., Manfredi,M., Mancarella,C., Maqueda,J.J., De Giorgis,V.,
            Pignochino,Y., Sciandra,M., Cristalli,C., Donadelli,M. and
            Scotlandi,K.
  TITLE     CD99 Modulates the Proteomic Landscape of Ewing Sarcoma Cells and
            Related Extracellular Vesicles
  JOURNAL   Int J Mol Sci 25 (3), 1588 (2024)
   PUBMED   38338867
  REMARK    GeneRIF: CD99 Modulates the Proteomic Landscape of Ewing Sarcoma
            Cells and Related Extracellular Vesicles.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1129)
  AUTHORS   Hahn,J.H., Kim,M.K., Choi,E.Y., Kim,S.H., Sohn,H.W., Ham,D.I.,
            Chung,D.H., Kim,T.J., Lee,W.J., Park,C.K., Ree,H.J. and Park,S.H.
  TITLE     CD99 (MIC2) regulates the LFA-1/ICAM-1-mediated adhesion of
            lymphocytes, and its gene encodes both positive and negative
            regulators of cellular adhesion
  JOURNAL   J Immunol 159 (5), 2250-2258 (1997)
   PUBMED   9278313
REFERENCE   6  (bases 1 to 1129)
  AUTHORS   Kovar,H., Dworzak,M., Strehl,S., Schnell,E., Ambros,I.M.,
            Ambros,P.F. and Gadner,H.
  TITLE     Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma
            and peripheral primitive neuroectodermal tumor
  JOURNAL   Oncogene 5 (7), 1067-1070 (1990)
   PUBMED   1695726
REFERENCE   7  (bases 1 to 1129)
  AUTHORS   Gelin,C., Aubrit,F., Phalipon,A., Raynal,B., Cole,S., Kaczorek,M.
            and Bernard,A.
  TITLE     The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion
            processes, is the MIC2 gene product
  JOURNAL   EMBO J 8 (11), 3253-3259 (1989)
   PUBMED   2479542
REFERENCE   8  (bases 1 to 1129)
  AUTHORS   Banting,G.S., Pym,B., Darling,S.M. and Goodfellow,P.N.
  TITLE     The MIC2 gene product: epitope mapping and structural prediction
            analysis define an integral membrane protein
  JOURNAL   Mol Immunol 26 (2), 181-188 (1989)
   PUBMED   2465491
REFERENCE   9  (bases 1 to 1129)
  AUTHORS   Goodfellow,P.J., Mondello,C., Darling,S.M., Pym,B., Little,P. and
            Goodfellow,P.N.
  TITLE     Absence of methylation of a CpG-rich region at the 5' end of the
            MIC2 gene on the active X, the inactive X, and the Y chromosome
  JOURNAL   Proc Natl Acad Sci U S A 85 (15), 5605-5609 (1988)
   PUBMED   2456574
REFERENCE   10 (bases 1 to 1129)
  AUTHORS   Goodfellow,P.J., Darling,S.M., Thomas,N.S. and Goodfellow,P.N.
  TITLE     A pseudoautosomal gene in man
  JOURNAL   Science 234 (4777), 740-743 (1986)
   PUBMED   2877492
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010109.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002414.4.
            
            Summary: The protein encoded by this gene is a cell surface
            glycoprotein involved in leukocyte migration, T-cell adhesion,
            ganglioside GM1 and transmembrane protein transport, and T-cell
            death by a caspase-independent pathway. In addition, the encoded
            protein may have the ability to rearrange the actin cytoskeleton
            and may also act as an oncosuppressor in osteosarcoma. This gene is
            found in the pseudoautosomal region of chromosomes X and Y and
            escapes X-chromosome inactivation. There is a related pseudogene
            located immediately adjacent to this locus. [provided by RefSeq,
            Mar 2016].
            
            Transcript Variant: This variant (1, also known as type I) encodes
            the longest isoform (a, also known as CD99wt).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002584.2, M16279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381192.10/ ENSP00000370588.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1129              BC010109.2         109-1237
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..1129
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /note="CD99 molecule (Xg blood group)"
                     /db_xref="GeneID:4267"
                     /db_xref="HGNC:HGNC:7082"
                     /db_xref="MIM:313470"
                     /db_xref="MIM:450000"
     exon            1..133
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..624
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; MIC2 (monoclonal antibody 12E7); antigen
                     identified by monoclonal antibodies 12E7, F21 and O13;
                     CD99 antigen; surface antigen MIC2; E2 antigen; T-cell
                     surface glycoprotein E2; antigen identified by monoclonal
                     12E7, Y homolog; cell surface antigen 12E7; cell surface
                     antigen HBA-71; cell surface antigen O13"
                     /codon_start=1
                     /product="CD99 antigen isoform a precursor"
                     /protein_id="NP_002405.1"
                     /db_xref="CCDS:CCDS14119.1"
                     /db_xref="GeneID:4267"
                     /db_xref="HGNC:HGNC:7082"
                     /db_xref="MIM:313470"
                     /db_xref="MIM:450000"
                     /translation="MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIP
                     KKPSAGDDFDLGDAVVDGENDDPRPPNPPKPMPNPNPNHPSSSGSFSDADLADGVSGG
                     EGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAGAISSFIAYQKKKLCFKENAE
                     QGEVDMESHRNANAEPAVQRTLLEK"
     exon            134..166
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            167..214
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            215..259
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            260..328
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            329..376
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            377..427
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            428..541
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            542..598
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     exon            599..1129
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1113..1118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /note="hexamer: AAGAAA"
     polyA_site      1129
                     /gene="CD99"
                     /gene_synonym="HBA71; MIC2; MIC2X; MIC2Y; MSK5X"
                     /note="major polyA site"
ORIGIN      
        1 atctgtcctg ccgccttcgc ccacgccctg cactccggga ccgtccctgc gcgctctggg
       61 cgcaccatgg cccgcggggc tgcgctggcg ctgctgctct tcggcctgct gggtgttctg
      121 gtcgccgccc cggatggtgg tttcgattta tccgatgccc ttcctgacaa tgaaaacaag
      181 aaacccactg caatccccaa gaaacccagt gctggggatg actttgactt aggagatgct
      241 gttgttgatg gagaaaatga cgacccacga ccaccgaacc cacccaaacc gatgccaaat
      301 ccaaacccca accaccctag ttcctccggt agcttttcag atgctgacct tgcggatggc
      361 gtttcaggtg gagaaggaaa aggaggcagt gatggtggag gcagccacag gaaagaaggg
      421 gaagaggccg acgccccagg cgtgatcccc gggattgtgg gggctgtcgt ggtcgccgtg
      481 gctggagcca tctctagctt cattgcttac cagaaaaaga agctatgctt caaagaaaat
      541 gcagaacaag gggaggtgga catggagagc caccggaatg ccaacgcaga gccagctgtt
      601 cagcgtactc ttttagagaa atagaagatt gtcggcagaa acagcccagg cgttggcagc
      661 agggttagaa cagctgcctg aggctcctcc ctgaaggaca cctgcctgag agcagagatg
      721 gaggccttct gttcacggcg gattctttgt tttaatcttg cgatgtgctt tgcttgttgc
      781 tgggcggatg atgtttacta acgatgaatt ttacatccaa agggggatag gcacttggac
      841 ccccattctc caaggcccgg gggggcggtt tcccatggga tgtgaaaggc tggccattat
      901 taagtccctg taactcaaat gtcaacccca ccgaggcacc cccccgtccc ccagaatctt
      961 ggctgtttac aaatcacgtg tccatcgagc acgtctgaaa cccctggtag ccccgacttc
     1021 tttttaatta aaataaggta agcccttcaa tttgtttctt caatatttct ttcatttgta
     1081 gggatatttg tttttcatat cagactaata aaaagaaatt agaaaccaa
//
