LOCUS       NM_005816               4328 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD96 molecule (CD96), transcript variant 2, mRNA.
ACCESSION   NM_005816
VERSION     NM_005816.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4328)
  AUTHORS   Zhang,Q., Huang,T., Li,X., Liu,G., Xian,L., Mao,X., Lin,T., Fu,C.,
            Chen,X., Liang,W., Zheng,Y., Zhao,Y., Lin,Q., Xu,X., Lin,Y., Bu,J.,
            Wu,C., Zhou,M. and Shen,E.
  TITLE     Prognostic impact of enhanced CD96 expression on NK cells by
            TGF-beta1 in AML
  JOURNAL   Int Immunopharmacol 141, 112958 (2024)
   PUBMED   39159564
  REMARK    GeneRIF: Prognostic impact of enhanced CD96 expression on NK cells
            by TGF-beta1 in AML.
REFERENCE   2  (bases 1 to 4328)
  AUTHORS   ElMenshawy,N., El-Chennawi,F., Darwish,A., Foda,A., Atita,D. and
            Eissa,M.
  TITLE     CD44, CD90 and CD96 expression in immune thrombocytopenia purpura
            (ITP) patients
  JOURNAL   J Immunoassay Immunochem 44 (4), 326-337 (2023)
   PUBMED   36949573
  REMARK    GeneRIF: CD44, CD90 and CD96 expression in immune thrombocytopenia
            purpura (ITP) patients.
REFERENCE   3  (bases 1 to 4328)
  AUTHORS   Ohtsuki,S., Wang,C., Watanabe,R., Zhang,H., Akiyama,M., Bois,M.C.,
            Maleszewski,J.J., Warrington,K.J., Berry,G.J., Goronzy,J.J. and
            Weyand,C.M.
  TITLE     Deficiency of the CD155-CD96 immune checkpoint controls IL-9
            production in giant cell arteritis
  JOURNAL   Cell Rep Med 4 (4), 101012 (2023)
   PUBMED   37075705
  REMARK    GeneRIF: Deficiency of the CD155-CD96 immune checkpoint controls
            IL-9 production in giant cell arteritis.
REFERENCE   4  (bases 1 to 4328)
  AUTHORS   Li,J., Xia,Q., Di,C., Li,C., Si,H., Zhou,B., Yu,S., Li,Y.,
            Huang,J., Lu,Y., Huang,M., Liang,H., Liu,X. and Zhao,Q.
  TITLE     Tumor Cell-Intrinsic CD96 Mediates Chemoresistance and Cancer
            Stemness by Regulating Mitochondrial Fatty Acid beta-Oxidation
  JOURNAL   Adv Sci (Weinh) 10 (7), e2202956 (2023)
   PUBMED   36581470
  REMARK    GeneRIF: Tumor Cell-Intrinsic CD96 Mediates Chemoresistance and
            Cancer Stemness by Regulating Mitochondrial Fatty Acid
            beta-Oxidation.
REFERENCE   5  (bases 1 to 4328)
  AUTHORS   Feng,S., Isayev,O., Werner,J. and Bazhin,A.V.
  TITLE     CD96 as a Potential Immune Regulator in Cancers
  JOURNAL   Int J Mol Sci 24 (2), 1303 (2023)
   PUBMED   36674817
  REMARK    GeneRIF: CD96 as a Potential Immune Regulator in Cancers.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4328)
  AUTHORS   Hosen,N., Park,C.Y., Tatsumi,N., Oji,Y., Sugiyama,H., Gramatzki,M.,
            Krensky,A.M. and Weissman,I.L.
  TITLE     CD96 is a leukemic stem cell-specific marker in human acute myeloid
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 104 (26), 11008-11013 (2007)
   PUBMED   17576927
  REMARK    GeneRIF: CD96 is a cell surface marker present on many acute
            myeloid leukemia leukemic stem cells
REFERENCE   7  (bases 1 to 4328)
  AUTHORS   Fuchs,A., Cella,M., Giurisato,E., Shaw,A.S. and Colonna,M.
  TITLE     Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion
            by interacting with the poliovirus receptor (CD155)
  JOURNAL   J Immunol 172 (7), 3994-3998 (2004)
   PUBMED   15034010
  REMARK    GeneRIF: CD96 promotes natural killer (NK) cell adhesion to target
            cells expressing the poliovirus receptor (PVR), stimulates
            cytotoxicity of activated NK cells, and mediates acquisition of PVR
            from target cells.
REFERENCE   8  (bases 1 to 4328)
  AUTHORS   Gramatzki,M., Ludwig,W.D., Burger,R., Moos,P., Rohwer,P.,
            Grunert,C., Sendler,A., Kalden,J.R., Andreesen,R., Henschke,F. and
            Moldenhauer,G.
  TITLE     Antibodies TC-12 ('unique') and TH-111 (CD96) characterize T-cell
            acute lymphoblastic leukemia and a subgroup of acute myeloid
            leukemia
  JOURNAL   Exp Hematol 26 (13), 1209-1214 (1998)
   PUBMED   9845376
REFERENCE   9  (bases 1 to 4328)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   10 (bases 1 to 4328)
  AUTHORS   Wang,P.L., O'Farrell,S., Clayberger,C. and Krensky,A.M.
  TITLE     Identification and molecular cloning of tactile. A novel human T
            cell activation antigen that is a member of the Ig gene superfamily
  JOURNAL   J Immunol 148 (8), 2600-2608 (1992)
   PUBMED   1313846
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092916.6, AL833681.1 and
            AC055748.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005816.4.
            
            Summary: The protein encoded by this gene belongs to the
            immunoglobulin superfamily. It is a type I membrane protein. The
            protein may play a role in the adhesive interactions of activated T
            and NK cells during the late phase of the immune response. It may
            also function in antigen presentation. Alternative splicing
            generates multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1, resulting in a shorter protein
            (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352690.9/ ENSP00000342040.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC092916.6         47931-47965         c
            36-595              AL833681.1         1-560
            596-1413            AL833681.1         609-1426
            1414-1414           AC055748.21        100823-100823       c
            1415-2581           AL833681.1         1428-2594
            2582-4315           AC055748.21        85700-87433         c
            4316-4328           AC055748.21        85687-85699         c
FEATURES             Location/Qualifiers
     source          1..4328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13-q13.2"
     gene            1..4328
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /note="CD96 molecule"
                     /db_xref="GeneID:10225"
                     /db_xref="HGNC:HGNC:16892"
                     /db_xref="MIM:606037"
     exon            1..113
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1762
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; T-cell surface protein tactile; T cell
                     activation, increased late expression; cell surface
                     antigen CD96; t cell-activated increased late expression
                     protein"
                     /codon_start=1
                     /product="T-cell surface protein tactile isoform 2
                     precursor"
                     /protein_id="NP_005807.1"
                     /db_xref="CCDS:CCDS2958.1"
                     /db_xref="GeneID:10225"
                     /db_xref="HGNC:HGNC:16892"
                     /db_xref="MIM:606037"
                     /translation="MEKKWKYCAVYYIIQIHFVKGVWEKTVNTEENVYATLGSDVNLT
                     CQTQTVGFFVQMQWSKVTNKIDLIAVYHPQYGFYCAYGRPCESLVTFTETPENGSKWT
                     LHLRNMSCSVSGRYECMLVLYPEGIQTKIYNLLIQTHVTADEWNSNHTIEIEINQTLE
                     IPCFQNSSSKISSEFTYAWSVEDNGTQETLISQNHLISNSTLLKDRVKLGTDYRLHLS
                     PVQIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLL
                     KNVFPKANITWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSNKPAQSDN
                     LTIWCMALSPVPGNKVWNISSEKITFLLGSEISSTDPPLSVTESTLDTQPSPASSVSP
                     ARYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKSVSRIPSETY
                     SSSPSGAGSTLHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGMSWPVI
                     VAALLFCCMILFGLGVRKWCQYQKEIMERPPPFKPPPPPIKYTCIQEPNESDLPYHEM
                     ETL"
     exon            114..470
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            471..595
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            596..803
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            804..859
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            860..950
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1139
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1232
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1301
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1373
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1439
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1529
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1653
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..4328
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4175..4180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /note="hexamer: AATAAA"
     polyA_site      4197
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /note="major polyA site"
     regulatory      4295..4300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD96"
                     /gene_synonym="TACTILE"
                     /note="hexamer: AACAAG"
     polyA_site      4328
                     /gene="CD96"
                     /gene_synonym="TACTILE"
ORIGIN      
        1 aattgacttt gtgatcatta cagaaatgct ggtgtaaggt gttcagaaga caatggagaa
       61 aaaatggaaa tactgtgctg tctattacat catccagata cattttgtca agggagtttg
      121 ggaaaaaaca gtcaacacag aagaaaatgt ttatgctaca cttggctctg atgtcaacct
      181 gacctgccaa acacagacag taggcttctt cgtgcagatg caatggtcca aggtcaccaa
      241 taagatagac ctgattgctg tctatcatcc ccaatacggc ttctactgtg cctatgggag
      301 accctgtgag tcacttgtga ctttcacaga aactcctgag aatgggtcaa aatggactct
      361 gcacttaagg aatatgtctt gttcagtcag tggaaggtac gagtgtatgc ttgttctgta
      421 tccagagggc attcagacta aaatctacaa ccttctcatt cagacacacg ttacagcaga
      481 tgaatggaac agcaaccata cgatagaaat agagataaat cagactctgg aaataccatg
      541 ctttcaaaat agctcctcaa aaatttcatc tgagttcacc tatgcatggt cggtggagga
      601 taatggaact caggaaacac ttatctccca aaatcacctc atcagcaatt ccacattact
      661 taaagataga gtcaagcttg gtacagacta cagactccac ctctctccag tccaaatctt
      721 cgatgatggg cggaagttct cttgccacat tagagtcggt cctaacaaaa tcttgaggag
      781 ctccaccaca gtcaaggttt ttgctaaacc agaaatccct gtgattgtgg aaaataactc
      841 cacggatgtc ttggtagaga gaagatttac ctgcttacta aagaatgtat ttcccaaagc
      901 aaatatcaca tggtttatag atggaagttt tcttcatgat gaaaaagaag gaatatatat
      961 tactaatgaa gagagaaaag gcaaagatgg atttttggaa ctgaagtctg ttttaacaag
     1021 ggtacatagt aataaaccag cccaatcaga caacttgacc atttggtgta tggctctgtc
     1081 tccagtccca ggaaataaag tgtggaacat ctcatcagaa aagatcactt ttctcttagg
     1141 ttctgaaatt tcctcaacag accctccact gagtgttaca gaatctaccc ttgacaccca
     1201 accttctcca gccagcagtg tatctcctgc aagatatcca gctacatctt cagtgaccct
     1261 tgtagatgtg agtgccttga ggccaaacac cactcctcaa cccagcaatt ccagtatgac
     1321 tacccgaggc ttcaactatc cctggacctc cagtgggaca gataccaaaa aatcagtttc
     1381 acggatacct agtgaaacat acagttcatc cccgtcaggt gcaggctcaa cacttcatga
     1441 caatgtcttt accagcacag ccagagcatt ttcagaagtc cccacaactg ccaatggatc
     1501 tacgaaaact aatcacgtcc atatcactgg tattgtggtc aataagccca aagatggaat
     1561 gtcctggcca gtgattgtag cagctttact cttttgctgc atgatattgt ttggtcttgg
     1621 agtgagaaaa tggtgtcagt accaaaaaga aataatggaa agacctccac ctttcaagcc
     1681 accaccacct cccatcaagt acacttgcat tcaagagccc aacgaaagtg atctgcctta
     1741 tcatgagatg gagaccctct agtctcgtga gactttgccc catggcagaa ctctgctgga
     1801 atcctattga gaaggtagac attgtgcttt attaatatag tcgctcttca gccatgcctt
     1861 tgctgcagct gaaatggaag tcagaagtga gtgacctgtt ttcccagcaa ctcaccctct
     1921 tccatctcca aacgcctgaa gcttaaccaa gagtgagagg atatgtcatg ttcacactca
     1981 atgcaattcg tagtggtttt cttgcttatg taagaagtac atattagtct gccatcttta
     2041 aaaaaaaata cagtattttc atttaaattc tctgatggag ggacaacaat ggtttcaact
     2101 gtatgcccat gcctgatcct cttatttgaa catctatcaa cattgtaaac tctttgccaa
     2161 aatcctgggg ctttgctgca ttccctaaga taattacagg aaaaagaaaa tgtaaaagtg
     2221 ctaacaaggc tgccaagtaa tggagaagta tggttagtct tcatattgaa attctgttgc
     2281 ttattttcat ggaaggaaac agaatacttt gcacaggaac cacattttca atcctccttc
     2341 actgtcttcc taccatgttc agcccagact cctgccacat ggaccaggat gaagagggat
     2401 caaagagata attagccaaa aacccagtag cctagaagat acaaaactcc actggcctct
     2461 aaaattatat tagccaagag tggtttcatt tgagtgcctt cgtgtgtatg tccatcaaac
     2521 tggaaccaaa ctgttttgta agtaaacagg cagcctaagc ccaaccctac tttctaattc
     2581 cagttattct ctttttcatc tggggattta cctgttcatt taatctgcct gttttgatct
     2641 gttttgaaaa agataaagag cctcaaatca gaccagcact gattaattaa ccctgctcct
     2701 accaatcttt tttaaagcag ttgaagcaga atgtataggt gtcagagaag aaacctagtc
     2761 agccagacgt gctctgtatt cagcaatagt ttgtgaatga ataaattact aatcctcctt
     2821 gtcgcttgaa accttcccac actccctgct ccaggaggga aaaacagatg ttgttgacag
     2881 atagagtgat aggcaaattc tgtgtggact ttagtcccaa aaggaaactt tagttcactt
     2941 gcagtatgct tatccttgac tgcacatgag aatgccttgt gcagagttat ttggagatta
     3001 tgtctttttc ttaaacacca tggctgtcac acttcagttc aattaaatca gaatgtctga
     3061 ggagtgagac acaggcatca acactctcaa atgattcaca tgttcagcca aagttgagaa
     3121 ccatcgagcc tgtggaagtt ctttctcatg gctcagaatc ttaggtaggt gcttaactct
     3181 tgtggtggcc agcctccaag atgagcccca gtgttcttgc ctcctactat tcacatcttt
     3241 atgtggtccc ctccaatgct gaatacagat gatttgtgta acctgaggcc aggattaagg
     3301 ggaggcaatc aatgcaccta gggaaaaaat ttaaggaggt attcacactc agggtcatgc
     3361 acttgcacaa tgttgagaat gagtaccact ctcaccattg gtatagccaa aaaagcttgg
     3421 aagtgaccaa ggctaggtca caaaatacac tgtggcttct tctttgatct ctctttgacc
     3481 atactgacac tgggaaaagc ccattcccat gccatgaaga caccaaggca gccctattga
     3541 gaaatctacc tgtcgtggcc gggcgcagtg gctcacgcct gtaatcccag cactttggga
     3601 ggccgaggtg ggtggatcac gaggtcagga gatcgagacc atcctggcta acacagtgaa
     3661 accccgtctc tactaaaaat acaaaaaatt agccgggtgt ggtgtcgggc acctgtagtc
     3721 ccagctactc aggaggctga ggcaggagaa gggtgggaac ccgggaggca gagcttgcag
     3781 tgagccgaga ttgtgccact gcacactcca atctgggtga aagaccgaga ctccgcctca
     3841 aaaaaaaaaa aaaaagaaag aaagaaagaa agaaagaaat ctacctgtca aggaactaag
     3901 gtattttgct aacaagcacc aacttgccag ccatgtaagg gagccatctt ggaagcagat
     3961 cctccagcct ccagtcaagt cttcagataa ttgcaacttc agttgatctt ttgaccaaga
     4021 cctcaagaga gccagaacta cccagctaag ccttttacta aatttctgaa cttctaacac
     4081 tattagataa taagtgctta ttgtttaaca ccattaattt tgagtataat ttgttacata
     4141 gcgacagata actatacagc tcaacaacta gaaaaataaa ctgtttacct gccttaatta
     4201 tttatcttta gttccttatt agttctcaag aaacaaatgc tagcttcata tgtatggctg
     4261 ttgctttgct tcatgtgtat ggctatttgt atttaacaag acttaatcat cagtaatttg
     4321 tatacaaa
//
