LOCUS       NM_012072               6681 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens CD93 molecule (CD93), mRNA.
ACCESSION   NM_012072
VERSION     NM_012072.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6681)
  AUTHORS   Song,J., Wang,Y.L. and Chu,J.Q.
  TITLE     [Relationship of cerebrospinal fluid and serum levels of SIL-2R,
            eNOS, and CD93 with the progression and prognosis of viral
            encephalitis in children]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 26 (10), 1072-1077 (2024)
   PUBMED   39467677
  REMARK    GeneRIF: [Relationship of cerebrospinal fluid and serum levels of
            SIL-2R, eNOS, and CD93 with the progression and prognosis of viral
            encephalitis in children].
REFERENCE   2  (bases 1 to 6681)
  AUTHORS   Shen,Y., Wu,Y., Hao,M., Fu,M., Zhu,K., Luo,P. and Wang,J.
  TITLE     Clinicopathological association of CD93 expression in gastric
            adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (8), 400 (2024)
   PUBMED   39190192
  REMARK    GeneRIF: Clinicopathological association of CD93 expression in
            gastric adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6681)
  AUTHORS   Liu,H., Zhang,J., Zhao,Y., Fan,Z., Yang,Y., Mao,Y., Yang,J. and
            Ma,S.
  TITLE     CD93 regulates breast cancer growth and vasculogenic mimicry
            through the PI3K/AKT/SP2 signaling pathway activated by integrin
            beta1
  JOURNAL   J Biochem Mol Toxicol 38 (4), e23688 (2024)
   PUBMED   38511888
  REMARK    GeneRIF: CD93 regulates breast cancer growth and vasculogenic
            mimicry through the PI3K/AKT/SP2 signaling pathway activated by
            integrin beta1.
REFERENCE   4  (bases 1 to 6681)
  AUTHORS   Qu,J., Lin,L., Fu,G., Zheng,M., Geng,J., Sun,X. and Xing,L.
  TITLE     The analysis of multiple omics and examination of pathological
            images revealed the prognostic and therapeutic significances of
            CD93 in lung squamous cell carcinoma
  JOURNAL   Life Sci 339, 122422 (2024)
   PUBMED   38224815
  REMARK    GeneRIF: The analysis of multiple omics and examination of
            pathological images revealed the prognostic and therapeutic
            significances of CD93 in lung squamous cell carcinoma.
REFERENCE   5  (bases 1 to 6681)
  AUTHORS   Zhang,C., Nan,X., Zhang,B., Wu,H., Zeng,X., Song,Z., Li,S.,
            Wang,J., Xie,S., Zhang,G., Xiu,H., Wang,J., Guo,J., Wang,P.,
            Cai,Z., Zhen,Y. and Shen,Y.
  TITLE     Blockade of CD93 in pleural mesothelial cells fuels anti-lung tumor
            immune responses
  JOURNAL   Theranostics 14 (3), 1010-1028 (2024)
   PUBMED   38250037
  REMARK    GeneRIF: Blockade of CD93 in pleural mesothelial cells fuels
            anti-lung tumor immune responses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6681)
  AUTHORS   Nepomuceno,R.R., Henschen-Edman,A.H., Burgess,W.H. and Tenner,A.J.
  TITLE     cDNA cloning and primary structure analysis of C1qR(P), the human
            C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro
  JOURNAL   Immunity 6 (2), 119-129 (1997)
   PUBMED   9047234
REFERENCE   7  (bases 1 to 6681)
  AUTHORS   Joseph,K., Ghebrehiwet,B., Peerschke,E.I., Reid,K.B. and
            Kaplan,A.P.
  TITLE     Identification of the zinc-dependent endothelial cell binding
            protein for high molecular weight kininogen and factor XII:
            identity with the receptor that binds to the globular 'heads' of
            C1q (gC1q-R)
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8552-8557 (1996)
   PUBMED   8710908
REFERENCE   8  (bases 1 to 6681)
  AUTHORS   Eggleton,P., Lieu,T.S., Zappi,E.G., Sastry,K., Coburn,J.,
            Zaner,K.S., Sontheimer,R.D., Capra,J.D., Ghebrehiwet,B. and
            Tauber,A.I.
  TITLE     Calreticulin is released from activated neutrophils and binds to
            C1q and mannan-binding protein
  JOURNAL   Clin Immunol Immunopathol 72 (3), 405-409 (1994)
   PUBMED   8062452
REFERENCE   9  (bases 1 to 6681)
  AUTHORS   Ghebrehiwet,B., Peerschke,E.I., Hong,Y., Munoz,P. and Gorevic,P.D.
  TITLE     Short amino acid sequences derived from C1q receptor (C1q-R) show
            homology with the alpha chains of fibronectin and vitronectin
            receptors and collagen type IV
  JOURNAL   J Leukoc Biol 51 (6), 546-556 (1992)
   PUBMED   1377218
REFERENCE   10 (bases 1 to 6681)
  AUTHORS   Peerschke,E.I. and Ghebrehiwet,B.
  TITLE     Platelet C1q receptor interactions with collagen- and C1q-coated
            surfaces
  JOURNAL   J Immunol 145 (9), 2984-2988 (1990)
   PUBMED   2212670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U94333.1, BC028075.1 and
            AL118508.27.
            
            On Nov 23, 2018 this sequence version replaced NM_012072.3.
            
            Summary: The protein encoded by this gene is a cell-surface
            glycoprotein and type I membrane protein that was originally
            identified as a myeloid cell-specific marker. The encoded protein
            was once thought to be a receptor for C1q, but now is thought to
            instead be involved in intercellular adhesion and in the clearance
            of apoptotic cells. The intracellular cytoplasmic tail of this
            protein has been found to interact with moesin, a protein known to
            play a role in linking transmembrane proteins to the cytoskeleton
            and in the remodelling of the cytoskeleton. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.198432.1, AB209895.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246006.5/ ENSP00000246006.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-595               U94333.1           17-611
            596-2538            BC028075.1         591-2533
            2539-6681           AL118508.27        10589-14731         c
FEATURES             Location/Qualifiers
     source          1..6681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..6681
                     /gene="CD93"
                     /gene_synonym="C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1;
                     ECSM3; MXRA4"
                     /note="CD93 molecule"
                     /db_xref="GeneID:22918"
                     /db_xref="HGNC:HGNC:15855"
                     /db_xref="MIM:120577"
     exon            1..2066
                     /gene="CD93"
                     /gene_synonym="C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1;
                     ECSM3; MXRA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2091
                     /gene="CD93"
                     /gene_synonym="C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1;
                     ECSM3; MXRA4"
                     /note="matrix-remodelling associated 4; CD93 antigen;
                     complement component C1q receptor; C1q receptor 1; C1qR;
                     C1q/MBL/SPA receptor; matrix-remodeling-associated protein
                     4; complement component 1 q subcomponent receptor 1"
                     /codon_start=1
                     /product="complement component C1q receptor precursor"
                     /protein_id="NP_036204.2"
                     /db_xref="CCDS:CCDS13149.1"
                     /db_xref="GeneID:22918"
                     /db_xref="HGNC:HGNC:15855"
                     /db_xref="MIM:120577"
                     /translation="MATSMGLLLLLLLLLTQPGAGTGADTEAVVCVGTACYTAHSGKL
                     SAAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKG
                     KCLDPSLPLKGFSWVGGGEDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKW
                     SEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFA
                     SAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCF
                     EGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGY
                     QLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALG
                     RSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSF
                     HCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEG
                     TPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDS
                     SVATQNNDGTDGQKLLLFYILGTVVAILLLLALALGLLVYRKRRAKREEKKEKKPQNA
                     ADSYSWVPERAESRAMENQYSPTPGTDC"
     exon            2067..6681
                     /gene="CD93"
                     /gene_synonym="C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1;
                     ECSM3; MXRA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6664..6669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CD93"
                     /gene_synonym="C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1;
                     ECSM3; MXRA4"
                     /note="hexamer: AATAAA"
     polyA_site      6681
                     /gene="CD93"
                     /gene_synonym="C1qR(P); C1QR1; C1qRP; CDw93; dJ737E23.1;
                     ECSM3; MXRA4"
                     /note="major polyA site"
ORIGIN      
        1 gtgtccttct ctgcgccgga gtggctgcag ctcacccctc agctcccctt ggggcccagc
       61 tgggagccga gatagaagct cctgtcgccg ctgggcttct cgcctcccgc agagggccac
      121 acagagaccg ggatggccac ctccatgggc ctgctgctgc tgctgctgct gctcctgacc
      181 cagcccgggg cggggacggg agctgacacg gaggcggtgg tctgcgtggg gaccgcctgc
      241 tacacggccc actcgggcaa gctgagcgct gccgaggccc agaaccactg caaccagaac
      301 gggggcaacc tggccactgt gaagagcaag gaggaggccc agcacgtcca gcgagtactg
      361 gcccagctcc tgaggcggga ggcagccctg acggcgagga tgagcaagtt ctggattggg
      421 ctccagcgag agaagggcaa gtgcctggac cctagtctgc cgctgaaggg cttcagctgg
      481 gtgggcgggg gggaggacac gccttactct aactggcaca aggagctccg gaactcgtgc
      541 atctccaagc gctgtgtgtc tctgctgctg gacctgtccc agccgctcct tcccagccgc
      601 ctccccaagt ggtctgaggg cccctgtggg agcccaggct cccccggaag taacattgag
      661 ggcttcgtgt gcaagttcag cttcaaaggc atgtgccggc ctctggccct ggggggccca
      721 ggtcaggtga cctacaccac ccccttccag accaccagtt cctccttgga ggctgtgccc
      781 tttgcctctg cggccaatgt agcctgtggg gaaggtgaca aggacgagac tcagagtcat
      841 tatttcctgt gcaaggagaa ggcccccgat gtgttcgact ggggcagctc gggccccctc
      901 tgtgtcagcc ccaagtatgg ctgcaacttc aacaatgggg gctgccacca ggactgcttt
      961 gaaggggggg atggctcctt cctctgcggc tgccgaccag gattccggct gctggatgac
     1021 ctggtgacct gtgcctctcg aaacccttgc agctccagcc catgtcgtgg gggggccacg
     1081 tgcgtcctgg gaccccatgg gaaaaactac acgtgccgct gcccccaagg gtaccagctg
     1141 gactcgagtc agctggactg tgtggacgtg gatgaatgcc aggactcccc ctgtgcccag
     1201 gagtgtgtca acacccctgg gggcttccgc tgcgaatgct gggttggcta tgagccgggc
     1261 ggtcctggag agggggcctg tcaggatgtg gatgagtgtg ctctgggtcg ctcgccttgc
     1321 gcccagggct gcaccaacac agatggctca tttcactgct cctgtgagga gggctacgtc
     1381 ctggccgggg aggacgggac tcagtgccag gacgtggatg agtgtgtggg cccggggggc
     1441 cccctctgcg acagcttgtg cttcaacaca caagggtcct tccactgtgg ctgcctgcca
     1501 ggctgggtgc tggccccaaa tggggtctct tgcaccatgg ggcctgtgtc tctgggacca
     1561 ccatctgggc cccccgatga ggaggacaaa ggagagaaag aagggagcac cgtgccccgt
     1621 gctgcaacag ccagtcccac aaggggcccc gagggcaccc ccaaggctac acccaccaca
     1681 agtagacctt cgctgtcatc tgacgccccc atcacatctg ccccactcaa gatgctggcc
     1741 cccagtgggt ccccaggcgt ctggagggag cccagcatcc atcacgccac agctgcctct
     1801 ggcccccagg agcctgcagg tggggactcc tccgtggcca cacaaaacaa cgatggcact
     1861 gacgggcaaa agctgctttt attctacatc ctaggcaccg tggtggccat cctactcctg
     1921 ctggccctgg ctctggggct actggtctat cgcaagcgga gagcgaagag ggaggagaag
     1981 aaggagaaga agccccagaa tgcggcagac agttactcct gggttccaga gcgagctgag
     2041 agcagggcca tggagaacca gtacagtccg acacctggga cagactgctg aaagtgaggt
     2101 ggccctagag acactagagt caccagccac catcctcaga gctttgaact ccccattcca
     2161 aaggggcacc cacatttttt tgaaagactg gactggaatc ttagcaaaca attgtaagtc
     2221 tcctccttaa aggccccttg gaacatgcag gtattttcta cgggtgtttg atgttcctga
     2281 agtggaagct gtgtgttggc gtgccacggt ggggatttcg tgactctata atgattgtta
     2341 ctccccctcc cttttcaaat tccaatgtga ccaattccgg atcagggtgt gaggaggccg
     2401 gggctaaggg gctcccctga atatcttctc tgctcacttc caccatctaa gaggaaaagg
     2461 tgagttgctc atgctgatta ggattgaaat gatttgtttc tcttcctagg atgaaaacta
     2521 aatcaattaa ttattcaatt aggtaagaag atctggtttt ttggtcaaag ggaacatgtt
     2581 cggactggaa acatttcttt acatttgcat tcctccattt cgccagcaca agtcttgcta
     2641 aatgtgatac tgttgacatc ctccagaatg gccagaagtg caattaacct cttaggtggc
     2701 aaggaggcag gaagtgcctc tttagttctt acatttctaa tagccttggg tttatttgca
     2761 aaggaagctt gaaaaatatg agaaaagttg cttgaagtgc attacaggtg tttgtgaagt
     2821 cacataatct acggggctag ggcgagagag gccagggatt tgttcacaga tacttgaatt
     2881 aattcatcca aatgtactga ggttaccaca cacttgacta cggatgtgat caacactaac
     2941 aaggaaacaa attcaaggac aacctgtctt tgagccaggg caggcctcag acaccctgcc
     3001 tgtggccccg cctccacttc atcctgcccg gaatgccagt gctccgagct cagacagagg
     3061 aagccctgca gaaagttcca tcaggctgtt tcctaaagga tgtgtgaacg ggagatgatg
     3121 cactgtgttt tgaaagttgt cattttaaag cattttagca cagttcatag tccacagttg
     3181 atgcagcatc ctgagatttt aaatcctgaa gtgtgggtgg cgcacacacc aagtagggag
     3241 ctagtcaggc agtttgctta aggaactttt gttctctgtc tcttttcctt aaaattgggg
     3301 gtaaggaggg aaggaagagg gaaagagatg actaactaaa atcattttta cagcaaaaac
     3361 tgctcaaagc catttaaatt atatcctcat tttaaaagtt acatttgcaa atatttctcc
     3421 ctatgataat gtagtcgata gtgtgcactc tttctctctc tctctctctc tcacacacac
     3481 acacacacac acacacacac acacagagac acggcaccat tctgcctggg gcactggaac
     3541 acattcctgg gggtcaccga tggtcagagt cactagaagt tacctgagta tctctgggag
     3601 gcctcatgtc tcctgtgggc tttttaccac cactgtgcag gagaacagac agaggaaatg
     3661 tgtctccctc caaggcccca aagcctcaga gaaagggtgt ttctggtttt gccttagcaa
     3721 tgcatcggtc tctgaggtga cactctggag tggttgaagg gccacaaggt gcagggttaa
     3781 tactcttgcc agttttgaaa tatagatgct atggttcaga ttgtttttaa tagaaaacta
     3841 aaggggcagg ggaagtgaaa ggaaagatgg aggttttgtg cggctcgatg gggcatttgg
     3901 aacttctttt taaagtcatc tcatggtctc cagttttcag ttggaactct ggtgtttaac
     3961 acttaaggga gacaaaggct gtgtccattt ggcaaaactt ccttggccac gagactctag
     4021 gtgatgtgtg aagctgggca gtctgtggtg tggagagcag ccatctgtct ggccattcag
     4081 aggattctaa agacatggct ggatgcgctg ctgaccaaca tcagcactta aataaatgca
     4141 aatgcaacat ttctccctct gggccttgaa aatccttgcc cttatcattt ggggtgaagg
     4201 agacatttct gtccttggct tcccacagcc ccaacgcagt ctgtgtatga ttcctgggat
     4261 ccaacgagcc ctcctatttt cacagtgttc tgattgctct cacagcccag gcccatcgtc
     4321 tgttctctga atgcagccct gttctcaaca acagggaggt catggaaccc ctctgtggaa
     4381 cccacaaggg gagaaatggg tgataaagaa tccagttcct caaaaccttc cctggcaggc
     4441 tgggtccctc tcctgctggg tggtgctttc tcttgcacac cactcccacc acggggggag
     4501 agccagcaac ccaaccagac agctcaggtt gtgcatctga tggaaaccac tgggctcaaa
     4561 cacgtgcttt attctcctgt ttatttttgc tgttactttg aagcatggaa attcttgttt
     4621 gggggatctt ggggctacag tagtgggtaa acaaatgccc accggccaag aggccattaa
     4681 caaatcgtcc ttgtcctgag gggccccagc ttgctcgggc gtggcacagt ggggaatcca
     4741 agggtcacag tatggggaga ggtgcaccct gccacctgct aacttctcgc tagacacagt
     4801 gtttctgccc aggtgacctg ttcagcagca gaacaagcca gggccatggg gacgggggaa
     4861 gttttcactt ggagatggac accaagacaa tgaagatttg ttgtccaaat aggtcaataa
     4921 ttctgggaga ctcttggaaa aaactgaata tattcaggac caactctctc cctcccctca
     4981 tcccacatct caaagcagac aatgtaaaga gagaacatct cacacaccca gctcgccatg
     5041 cctactcatt cctgaatttc aggtgccatc actgctcttt ctttcttctt tgtcatttga
     5101 gaaaggatgc aggaggacaa ttcccacaga taatctgagg aatgcagaaa aaccagggca
     5161 ggacagttat cgacaatgca ttagaacttg gtgagcatcc tctgtagagg gactccaccc
     5221 ctgctcaaca gcttggcttc caggcaagac caaccacatc tggtctctgc cttcggtggc
     5281 ccacacacct aagcgtcatc gtcattgcca tagcatcatg atgcaacaca tctacgtgta
     5341 gcactacgac gttatgtttg ggtaatgtgg ggatgaactg catgaggctc tgattaagga
     5401 tgtggggaag tgggctgcgg tcactgtcgg ccttgcaagg ccacctggag gcctgtctgt
     5461 tagccagtgg tggaggagca aggcttcagg aagggccagc cacatgccat cttccctgcg
     5521 atcaggcaaa aaagtggaat taaaaagtca aacctttata tgcatgtgtt atgtccattt
     5581 tgcaggatga actgagttta aaagaatttt tttttctctt caagttgctt tgtcttttcc
     5641 atcctcatca caagcccttg tttgagtgtc ttatccctga gcaatctttc gatggatgga
     5701 gatgatcatt aggtactttt gtttcaacct ttattcctgt aaatatttct gtgaaaacta
     5761 ggagaacaga gatgagattt gacaaaaaaa aattgaatta aaaataacac agtcttttta
     5821 aaactaacat aggaaagcct ttcctattat ttctcttctt agcttctcca ttgtctaaat
     5881 caggaaaaca ggaaaacaca gctttctagc agctgcaaaa tggtttaatg ccccctacat
     5941 atttccatca ccttgaacaa tagctttagc ttgggaatct gagatatgat cccagaaaac
     6001 atctgtctct acttcggctg caaaacccat ggtttaaatc tatatggttt gtgcattttc
     6061 tcaactaaaa atagagatga taatccgaat tctccatata ttcactaatc aaagacacta
     6121 ttttcatact agattcctga gacaaatact cactgaaggg cttgtttaaa aataaattgt
     6181 gttttggtct gttcttgtag ataatgccct tctattttag gtagaagctc tggaatccct
     6241 ttattgtgct gttgctctta tctgcaaggt ggcaagcagt tcttttcagc agattttgcc
     6301 cactattcct ctgagctgaa gttctttgca tagatttggc ttaagcttga attagatccc
     6361 tgcaaaggct tgctctgtga tgtcagatgt aattgtaaat gtcagtaatc acttcatgaa
     6421 tgctaaatga gaatgtaagt atttttaaat gtgtgtattt caaatttgtt tgactaattc
     6481 tggaattaca agatttctat gcaggattta ccttcatcct gtgcatgttt cccaaactgt
     6541 gaggagggaa ggctcagaga tcgagcttct cctctgagtt ctaacaaaat ggtgctttga
     6601 gggtcagcct ttaggaaggt gcagctttgt tgtcctttga gctttctgtt atgtgcctat
     6661 cctaataaac tcttaaacac a
//
